JP2014094965A5 - - Google Patents
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- Publication number
- JP2014094965A5 JP2014094965A5 JP2014016565A JP2014016565A JP2014094965A5 JP 2014094965 A5 JP2014094965 A5 JP 2014094965A5 JP 2014016565 A JP2014016565 A JP 2014016565A JP 2014016565 A JP2014016565 A JP 2014016565A JP 2014094965 A5 JP2014094965 A5 JP 2014094965A5
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- active ingredient
- solute
- ultrasonic
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 12
- 239000002904 solvent Substances 0.000 claims 7
- 239000004480 active ingredient Substances 0.000 claims 6
- 239000012296 anti-solvent Substances 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 239000000168 bronchodilator agent Substances 0.000 claims 1
- 239000012876 carrier material Substances 0.000 claims 1
- 239000007810 chemical reaction solvent Substances 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 229960000289 fluticasone propionate Drugs 0.000 claims 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical group C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 1
- 238000002664 inhalation therapy Methods 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- 230000006911 nucleation Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0705159.2 | 2007-03-19 | ||
| GBGB0705159.2A GB0705159D0 (en) | 2007-03-19 | 2007-03-19 | Process for making crystals |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554087A Division JP2010522154A (ja) | 2007-03-19 | 2008-03-18 | 結晶の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014094965A JP2014094965A (ja) | 2014-05-22 |
| JP2014094965A5 true JP2014094965A5 (cg-RX-API-DMAC7.html) | 2014-12-04 |
| JP5808830B2 JP5808830B2 (ja) | 2015-11-10 |
Family
ID=38008612
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554087A Pending JP2010522154A (ja) | 2007-03-19 | 2008-03-18 | 結晶の製造方法 |
| JP2014016565A Active JP5808830B2 (ja) | 2007-03-19 | 2014-01-31 | 結晶の製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554087A Pending JP2010522154A (ja) | 2007-03-19 | 2008-03-18 | 結晶の製造方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9162160B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2134457B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2010522154A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101636223B (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0809275A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2680105C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2701728T3 (cg-RX-API-DMAC7.html) |
| GB (2) | GB0705159D0 (cg-RX-API-DMAC7.html) |
| IL (1) | IL200802A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2456066C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008114052A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0705159D0 (en) * | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
| AU2009272445B2 (en) | 2008-07-18 | 2012-11-22 | Circassia Limited | Process for improving crystallinity |
| GB0900080D0 (en) * | 2009-01-06 | 2009-02-11 | Prosonix Ltd | An apparatus and process for producing crystals |
| GB0918431D0 (en) | 2009-10-21 | 2009-12-09 | Prosonix Ltd | Process for improving crystallinity |
| EP2360147A1 (en) | 2010-02-22 | 2011-08-24 | CHIESI FARMACEUTICI S.p.A. | Process for preparing crystalline particles of a salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino] ethyl]-2(1H)-quinolinone (carmoterol) |
| KR101730684B1 (ko) | 2010-04-01 | 2017-04-26 | 키에시 파르마슈티시 엣스. 피. 에이. | 흡입용 건조 분말을 위한 담체 입자 제조 방법 |
| WO2012088604A1 (en) | 2010-12-30 | 2012-07-05 | Dalhousie University | Transition metal compound particles and methods of production |
| EP2500072A1 (en) | 2011-03-15 | 2012-09-19 | LEK Pharmaceuticals d.d. | A novel process of residual solvent removal |
| GB201113662D0 (en) | 2011-08-08 | 2011-09-21 | Prosonix Ltd | Pharmaceutical compositions |
| US9919816B2 (en) * | 2011-11-28 | 2018-03-20 | Nanomakers | Valve and sealed container for submicron particles, and method for using same |
| ES2727474T3 (es) | 2012-05-08 | 2019-10-16 | Nicox Ophthalmics Inc | Nanocristales de propionato de fluticasona |
| US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| CN102872612B (zh) * | 2012-10-15 | 2013-11-27 | 中国工程物理研究院化工材料研究所 | 超声结晶器 |
| US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| WO2014118532A1 (en) | 2013-01-31 | 2014-08-07 | Prosonix Limited | Pharmaceutical compositions comprising multi-component crystalline particles suitable for use in inhalation therapy |
| GB201301721D0 (en) * | 2013-01-31 | 2013-03-20 | Prosonix Ltd | Pharmaceutical Preparations |
| CN103172476A (zh) * | 2013-04-08 | 2013-06-26 | 中国工程物理研究院化工材料研究所 | 一种亚微米颗粒1-氧-二氨基-3,5-二硝基吡嗪炸药的制备方法 |
| US9469548B2 (en) * | 2015-02-20 | 2016-10-18 | Hydro Dynamics, Inc. | Continuous hydrodynamic cavitation crystallization |
| CN105037253A (zh) * | 2015-05-27 | 2015-11-11 | 上海应用技术学院 | 一种超声逼晶法提纯化合物的方法 |
| CN105664816B (zh) * | 2016-03-17 | 2017-11-03 | 杭州成功超声设备有限公司 | 将基于振幅控制的超声波设备用于化工装置的三步式方法 |
| EP3369468A1 (en) * | 2017-02-23 | 2018-09-05 | Covaris, Inc. | Acoustic energy-based control of particle count in crystallization |
| US10583085B2 (en) | 2017-05-17 | 2020-03-10 | Chiesi Farmaceutici S.P.A. | Carrier particles for dry powder formulations for inhalation |
| WO2020020957A1 (en) | 2018-07-27 | 2020-01-30 | Chiesi Farmaceutici S.P.A. | Novel carrier particles for dry powder formulations for inhalation |
| CN110330335A (zh) * | 2019-07-19 | 2019-10-15 | 中国工程物理研究院化工材料研究所 | 铋基卤化物陶瓷材料、制备方法及x射线探测器 |
| CA3148236A1 (en) | 2019-07-22 | 2021-01-28 | Canopy Growth Corporation | Continuous crystallization of cannabinoids in a stirred-tank reactor |
| CN110773079B (zh) * | 2019-11-18 | 2022-03-01 | 江苏博迁新材料股份有限公司 | 一种超声喷雾法制备超细粉球的方法 |
| CN112972384B (zh) * | 2019-12-02 | 2022-03-18 | 长风药业股份有限公司 | 一种格隆溴铵和茚达特罗原料药微粉混合物的制备方法 |
| GB2599890A (en) | 2020-08-18 | 2022-04-20 | Ashe Robert | Improved loop reactor |
| CN114307840B (zh) * | 2022-01-08 | 2022-09-16 | 安徽省农业科学院棉花研究所 | 一种有机配方肥热返料设备 |
| CN115634635B (zh) * | 2022-10-20 | 2025-03-18 | 江苏瑞祥化工有限公司 | 一种高纯度粒状2,5-二氯苯胺的制备装置及制备方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2033254C1 (ru) * | 1988-02-23 | 1995-04-20 | Александр Петрович Пляскин | Способ обработки материалов и устройство для его осуществления |
| GB9310030D0 (en) * | 1993-05-15 | 1993-06-30 | Scras | Dry processed particles and process for the preparation of the same |
| US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
| EP1011856B1 (en) * | 1997-08-05 | 2003-04-09 | Microfluidics International Corporation | Multiple stream high pressure mixer/reactor |
| US6465015B1 (en) * | 1998-02-24 | 2002-10-15 | Arch Chemicals, Inc. | Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles |
| GB9828721D0 (en) * | 1998-12-24 | 1999-02-17 | Glaxo Group Ltd | Novel apparatus and process |
| ES2251965T3 (es) * | 1999-01-29 | 2006-05-16 | Bristol-Myers Squibb Company | Aparato y procedimiento de cristalizacion por ultrasonidos con chorros en colision. |
| GB9919693D0 (en) | 1999-08-19 | 1999-10-20 | Rhone Poulenc Rorer Ltd | Process |
| GB9925934D0 (en) * | 1999-11-03 | 1999-12-29 | Glaxo Group Ltd | Novel apparatus and process |
| US6620351B2 (en) * | 2000-05-24 | 2003-09-16 | Auburn University | Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer |
| GB0015981D0 (en) * | 2000-06-29 | 2000-08-23 | Glaxo Group Ltd | Novel process for preparing crystalline particles |
| GB0016002D0 (en) * | 2000-06-29 | 2000-08-23 | Glaxo Group Ltd | Novel process for preparing crystalline particles |
| GB0016040D0 (en) * | 2000-06-29 | 2000-08-23 | Glaxo Group Ltd | Novel process for preparing crystalline particles |
| US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
| ES2261730T3 (es) * | 2001-05-05 | 2006-11-16 | Accentus Plc | Formacion de cristales pequeños. |
| DE60214012T2 (de) * | 2001-08-29 | 2006-12-21 | Dow Global Technologies, Inc., Midland | Verfahren zur herstellung kristalliner arzneimittelteilchen durch ausfällung |
| GB0125604D0 (en) | 2001-10-25 | 2001-12-19 | Glaxo Group Ltd | Novel process |
| GB0201400D0 (en) * | 2002-01-22 | 2002-03-13 | Glaxo Group Ltd | Novel apparatus and process |
| GB0219815D0 (en) * | 2002-08-24 | 2002-10-02 | Accentus Plc | Preparation of small crystals |
| US20040197275A1 (en) * | 2002-10-17 | 2004-10-07 | Ecole Polytechnique Federale De Lausanne | Process for the manufacture of powders of inhalable medicaments |
| GB0300339D0 (en) * | 2003-01-08 | 2003-02-05 | Bradford Particle Design Ltd | Particle formation |
| DK1610878T3 (da) | 2003-02-21 | 2014-12-01 | Univ Bath | Fremgangsmåde til fremstilling af partikler |
| US7041144B2 (en) * | 2003-03-04 | 2006-05-09 | Five Star Technologies, Inc. | Hydrodynamic cavitation crystallization process |
| US20080194868A1 (en) * | 2003-03-04 | 2008-08-14 | Kozyuk Oleg V | Hydrodynamic cavitation crystallization device and process |
| JP2004276334A (ja) * | 2003-03-13 | 2004-10-07 | Ricoh Co Ltd | 感熱記録材料 |
| US20060150892A1 (en) * | 2003-04-29 | 2006-07-13 | Akzo Nobel N.V. | Processes Involving the Use of Antisolvent Crystallisation |
| DE602004016311D1 (de) | 2003-04-29 | 2008-10-16 | Organon Nv | Verfahren zur verfestigung, bei welchem ein anti-lösungsmittel benutzt wird |
| GB0319797D0 (en) * | 2003-08-26 | 2003-09-24 | Leuven K U Res & Dev | Particle size reduction of poorly soluble drugs |
| WO2005042219A1 (en) * | 2003-10-24 | 2005-05-12 | Ferro Corporation | Method of forming particles |
| JP2005177746A (ja) * | 2003-11-28 | 2005-07-07 | Mitsubishi Chemicals Corp | 有機化合物微粒子の製造方法 |
| EP1688169A4 (en) * | 2003-11-28 | 2008-10-01 | Mitsubishi Chem Corp | PROCESS FOR PRODUCING FINE PARTICLES OF AN ORGANIC COMPOUND |
| GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
| KR20080110807A (ko) * | 2006-03-14 | 2008-12-19 | 머크 앤드 캄파니 인코포레이티드 | 마이크로 분쇄 및 마이크로-시드상의 결정화에 의한 결정성유기 미세입자 조성물의 생성 방법과 장치 및 이의 용도 |
| US20080075777A1 (en) * | 2006-07-31 | 2008-03-27 | Kennedy Michael T | Apparatus and methods for preparing solid particles |
| GB0705159D0 (en) * | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
| GB0711680D0 (en) * | 2007-06-18 | 2007-07-25 | Prosonix Ltd | Process |
| EP2360147A1 (en) * | 2010-02-22 | 2011-08-24 | CHIESI FARMACEUTICI S.p.A. | Process for preparing crystalline particles of a salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino] ethyl]-2(1H)-quinolinone (carmoterol) |
-
2007
- 2007-03-19 GB GBGB0705159.2A patent/GB0705159D0/en not_active Ceased
-
2008
- 2008-03-18 CA CA2680105A patent/CA2680105C/en active Active
- 2008-03-18 EP EP08719036.9A patent/EP2134457B1/en active Active
- 2008-03-18 WO PCT/GB2008/050191 patent/WO2008114052A1/en not_active Ceased
- 2008-03-18 GB GB0804995.9A patent/GB2447761B/en active Active
- 2008-03-18 CN CN200880008925.3A patent/CN101636223B/zh active Active
- 2008-03-18 US US12/531,322 patent/US9162160B2/en active Active
- 2008-03-18 ES ES08719036T patent/ES2701728T3/es active Active
- 2008-03-18 RU RU2009138325/05A patent/RU2456066C2/ru not_active IP Right Cessation
- 2008-03-18 BR BRPI0809275-3A2A patent/BRPI0809275A2/pt not_active Application Discontinuation
- 2008-03-18 JP JP2009554087A patent/JP2010522154A/ja active Pending
-
2009
- 2009-09-08 IL IL200802A patent/IL200802A/en active IP Right Grant
-
2014
- 2014-01-31 JP JP2014016565A patent/JP5808830B2/ja active Active
-
2015
- 2015-09-15 US US14/854,750 patent/US10143991B2/en active Active
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