JP2014074724A5 - - Google Patents
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- JP2014074724A5 JP2014074724A5 JP2014006601A JP2014006601A JP2014074724A5 JP 2014074724 A5 JP2014074724 A5 JP 2014074724A5 JP 2014006601 A JP2014006601 A JP 2014006601A JP 2014006601 A JP2014006601 A JP 2014006601A JP 2014074724 A5 JP2014074724 A5 JP 2014074724A5
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- JP
- Japan
- Prior art keywords
- cancer
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- amount
- biological sample
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 claims 34
- 238000000034 method Methods 0.000 claims 25
- 201000011510 cancer Diseases 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 14
- 239000012472 biological sample Substances 0.000 claims 9
- 239000000556 agonist Substances 0.000 claims 7
- 238000003556 assay Methods 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000000833 heterodimer Substances 0.000 claims 3
- 201000007270 liver cancer Diseases 0.000 claims 3
- 208000014018 liver neoplasm Diseases 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 230000002596 correlated effect Effects 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 239000000710 homodimer Substances 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 229960000575 trastuzumab Drugs 0.000 claims 2
- OONFNUWBHFSNBT-HXUWFJFHSA-N AEE788 Chemical compound C1CN(CC)CCN1CC1=CC=C(C=2NC3=NC=NC(N[C@H](C)C=4C=CC=CC=4)=C3C=2)C=C1 OONFNUWBHFSNBT-HXUWFJFHSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 206010073069 Hepatic cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
- 238000000225 bioluminescence resonance energy transfer Methods 0.000 claims 1
- 201000000053 blastoma Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000000875 corresponding effect Effects 0.000 claims 1
- 201000008184 embryoma Diseases 0.000 claims 1
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 1
- 229960004891 lapatinib Drugs 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- JXLVPHOTGHZUCE-ZSIUJALASA-N methyl n-[4-[5-chloro-2-[(1s)-1-[[(e)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-3-morpholin-4-yl-3-oxopropyl]-1h-imidazol-4-yl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OC)=CC=C1C1=C(Cl)NC([C@H](CC(=O)N2CCOCC2)NC(=O)\C=C\C=2C(=CC=C(Cl)C=2)N2N=NN=C2)=N1 JXLVPHOTGHZUCE-ZSIUJALASA-N 0.000 claims 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 230000004850 protein–protein interaction Effects 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 201000005102 vulva cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14502909P | 2009-01-15 | 2009-01-15 | |
| US61/145,029 | 2009-01-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546408A Division JP2012515353A (ja) | 2009-01-15 | 2010-01-15 | Ｈｅｒ−２発現の測定による患者の反応を判定する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014074724A JP2014074724A (ja) | 2014-04-24 |
| JP2014074724A5 true JP2014074724A5 (OSRAM) | 2014-08-28 |
| JP5615986B2 JP5615986B2 (ja) | 2014-10-29 |
Family
ID=42340111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546408A Withdrawn JP2012515353A (ja) | 2009-01-15 | 2010-01-15 | Ｈｅｒ−２発現の測定による患者の反応を判定する方法 |
| JP2014006601A Active JP5615986B2 (ja) | 2009-01-15 | 2014-01-17 | Ｈｅｒ−２発現の測定による患者の反応を判定する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546408A Withdrawn JP2012515353A (ja) | 2009-01-15 | 2010-01-15 | Ｈｅｒ−２発現の測定による患者の反応を判定する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20100233732A1 (OSRAM) |
| EP (1) | EP2387717B1 (OSRAM) |
| JP (2) | JP2012515353A (OSRAM) |
| KR (1) | KR20110120890A (OSRAM) |
| CN (1) | CN102439452B (OSRAM) |
| AU (1) | AU2010204576A1 (OSRAM) |
| BR (1) | BRPI1007048A2 (OSRAM) |
| CA (1) | CA2749817A1 (OSRAM) |
| ES (1) | ES2526519T3 (OSRAM) |
| IL (1) | IL214067A0 (OSRAM) |
| SG (1) | SG172984A1 (OSRAM) |
| WO (1) | WO2010083463A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040229294A1 (en) | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| US20040091850A1 (en) * | 2002-11-08 | 2004-05-13 | Travis Boone | Single cell analysis of membrane molecules |
| US7402398B2 (en) | 2003-07-17 | 2008-07-22 | Monogram Biosciences, Inc. | Measuring receptor homodimerization |
| CA2706763C (en) | 2007-11-27 | 2013-07-30 | Laboratory Corporation Of America Holdings | Enhanced method for detecting and/or quantifying an analyte in a sample |
| US10416162B2 (en) | 2007-12-20 | 2019-09-17 | Monogram Biosciences, Inc. | Her2 diagnostic methods |
| EP2438442B1 (en) | 2008-12-01 | 2017-08-09 | Laboratory Corporation of America Holdings | Methods and assays for measuring p95 and/or p95 complexes in a sample and antibodies specific for p95 |
| US11401344B2 (en) | 2008-12-01 | 2022-08-02 | Laboratory Corporation Of America Holdings | Methods for determining the likelihood of survival and for predicting likelihood of metastasis in cancer patients |
| JP5746051B2 (ja) | 2009-01-15 | 2015-07-08 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | Ｈｅｒ−３の測定による患者の反応を判定する方法 |
| SG10201505769PA (en) | 2010-07-27 | 2015-09-29 | Genomic Health Inc | Method for using gene expression to determine prognosis of prostate cancer |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| SG194609A1 (en) | 2011-05-19 | 2013-12-30 | Lab Corp America Holdings | Methods for determining the likelihood of survival and for predicting likelihood of metastasis in cancer patients |
| FR2993668B1 (fr) * | 2012-07-17 | 2015-07-03 | Cisbio Bioassays | Methode theranostique basee sur la detection de dimeres her2-her2 |
| JP6402173B2 (ja) * | 2013-04-05 | 2018-10-10 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | Ｈｅｒ３の検出に基づく癌の診断、予後予測、および処置を容易にするためのシステムおよび方法 |
| CN107003323B (zh) | 2014-11-25 | 2019-06-04 | 文塔纳医疗系统公司 | 使用化学连接和半抗原转移的邻近测定法 |
| WO2017014694A1 (en) * | 2015-07-23 | 2017-01-26 | National University Of Singapore | Wbp2 as a co-prognostic factor with her2 for stratification of patients for treatment |
| JP2019515252A (ja) | 2016-03-15 | 2019-06-06 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | 細胞間のタンパク質相互作用を評価する方法 |
| ES2897217T3 (es) | 2016-09-30 | 2022-02-28 | Hoffmann La Roche | Anticuerpos biespecíficos frente a p95HER2 |
| JP6922444B2 (ja) * | 2016-11-11 | 2021-08-18 | コニカミノルタ株式会社 | 蛍光ナノ粒子を用いた、病理学的完全奏効（ｐＣＲ）の予測を支援するための検査支援方法 |
| US20210239702A1 (en) * | 2018-06-14 | 2021-08-05 | Memorial Sloan Kettering Cancer Center | Methods for predicting responsiveness of lung cancer patients to her2-targeting therapies |
| WO2020080891A1 (ko) * | 2018-10-19 | 2020-04-23 | 주식회사 프로티나 | 유방암 재발 예측 방법 |
| KR20230134232A (ko) | 2022-03-14 | 2023-09-21 | 부산대학교 산학협력단 | 백금계 항암제에 대한 난소암 환자의 약물 반응성 예측용 다중 바이오마커 조성물 및 이를 이용한 진단방법 |
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| US10416162B2 (en) * | 2007-12-20 | 2019-09-17 | Monogram Biosciences, Inc. | Her2 diagnostic methods |
| EP2438442B1 (en) * | 2008-12-01 | 2017-08-09 | Laboratory Corporation of America Holdings | Methods and assays for measuring p95 and/or p95 complexes in a sample and antibodies specific for p95 |
| JP5746051B2 (ja) * | 2009-01-15 | 2015-07-08 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | Ｈｅｒ−３の測定による患者の反応を判定する方法 |
-
2010
- 2010-01-15 EP EP10732178.8A patent/EP2387717B1/en not_active Revoked
- 2010-01-15 CN CN201080009544.4A patent/CN102439452B/zh not_active Expired - Fee Related
- 2010-01-15 SG SG2011051000A patent/SG172984A1/en unknown
- 2010-01-15 JP JP2011546408A patent/JP2012515353A/ja not_active Withdrawn
- 2010-01-15 KR KR1020117018898A patent/KR20110120890A/ko not_active Withdrawn
- 2010-01-15 US US12/688,766 patent/US20100233732A1/en not_active Abandoned
- 2010-01-15 WO PCT/US2010/021272 patent/WO2010083463A1/en not_active Ceased
- 2010-01-15 AU AU2010204576A patent/AU2010204576A1/en not_active Abandoned
- 2010-01-15 CA CA2749817A patent/CA2749817A1/en not_active Abandoned
- 2010-01-15 ES ES10732178.8T patent/ES2526519T3/es active Active
- 2010-01-15 BR BRPI1007048A patent/BRPI1007048A2/pt not_active Application Discontinuation
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2011
- 2011-07-13 IL IL214067A patent/IL214067A0/en unknown
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2014
- 2014-01-17 JP JP2014006601A patent/JP5615986B2/ja active Active
- 2014-07-02 US US14/322,317 patent/US20140370523A1/en not_active Abandoned
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2016
- 2016-06-15 US US15/183,151 patent/US20170082626A1/en not_active Abandoned
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