JP2013545734A5 - - Google Patents
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- JP2013545734A5 JP2013545734A5 JP2013536812A JP2013536812A JP2013545734A5 JP 2013545734 A5 JP2013545734 A5 JP 2013545734A5 JP 2013536812 A JP2013536812 A JP 2013536812A JP 2013536812 A JP2013536812 A JP 2013536812A JP 2013545734 A5 JP2013545734 A5 JP 2013545734A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- seq
- nos
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims 13
- 101000864646 Homo sapiens Dickkopf-related protein 1 Proteins 0.000 claims 9
- 102000050762 human DKK1 Human genes 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 102100024952 Protein CBFA2T1 Human genes 0.000 claims 4
- 208000020084 Bone disease Diseases 0.000 claims 2
- 102100030074 Dickkopf-related protein 1 Human genes 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100034201 Sclerostin Human genes 0.000 claims 1
- 108050006698 Sclerostin Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40712810P | 2010-10-27 | 2010-10-27 | |
| US61/407,128 | 2010-10-27 | ||
| PCT/US2011/058025 WO2012058393A2 (en) | 2010-10-27 | 2011-10-27 | Dkk1 antibodies and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016175266A Division JP6353500B2 (ja) | 2010-10-27 | 2016-09-08 | Ｄｋｋ１抗体およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545734A JP2013545734A (ja) | 2013-12-26 |
| JP2013545734A5 true JP2013545734A5 (cg-RX-API-DMAC7.html) | 2014-08-21 |
| JP6066912B2 JP6066912B2 (ja) | 2017-01-25 |
Family
ID=44910313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013536812A Active JP6066912B2 (ja) | 2010-10-27 | 2011-10-27 | Ｄｋｋ１抗体およびその使用方法 |
| JP2016175266A Active JP6353500B2 (ja) | 2010-10-27 | 2016-09-08 | Ｄｋｋ１抗体およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016175266A Active JP6353500B2 (ja) | 2010-10-27 | 2016-09-08 | Ｄｋｋ１抗体およびその使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9879072B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP3838922A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6066912B2 (cg-RX-API-DMAC7.html) |
| AR (2) | AR083740A1 (cg-RX-API-DMAC7.html) |
| AU (3) | AU2011319843C1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA3085710A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2863626T3 (cg-RX-API-DMAC7.html) |
| MX (3) | MX354481B (cg-RX-API-DMAC7.html) |
| TW (2) | TWI636994B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012058393A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101469329B (zh) | 1998-11-27 | 2012-10-24 | 达尔文发现有限公司 | 增加骨矿化的组合物和方法 |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
| US7982013B2 (en) | 2008-09-26 | 2011-07-19 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| AU2011235904B2 (en) | 2010-04-01 | 2015-10-08 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| SMT202000095T1 (it) | 2010-05-14 | 2020-03-13 | Amgen Inc | Formulazioni di anticorpi anti-sclerostina ad alta concentrazione |
| US9403882B2 (en) | 2010-06-07 | 2016-08-02 | Joshua Rabbani | Sulfation of Wnt pathway proteins |
| US11167011B2 (en) | 2010-06-07 | 2021-11-09 | Enzo Biochem, Inc. | Methods for treating bone loss using sclerostin peptides |
| US9617323B2 (en) | 2010-06-07 | 2017-04-11 | Joshua Rabbani | Sulfonated sclerostin, antibodies, epitopes and methods for identification and use therefor |
| US9493541B2 (en) | 2010-06-07 | 2016-11-15 | Joshua Rabbani | Antibodies specific for sulfated sclerostin |
| ES2863626T3 (es) * | 2010-10-27 | 2021-10-11 | Amgen Inc | Anticuerpos DKK1 y métodos de uso |
| EP2681242B1 (en) * | 2011-03-01 | 2018-01-24 | Amgen Inc. | Sclerostin and dkk-1 bispecific binding agents |
| MX338078B (es) | 2011-03-25 | 2016-04-01 | Amgen Inc | Cristales de anticuerpos anti-esclerostina y formulaciones de los mismos. |
| LT2739311T (lt) | 2011-08-04 | 2018-06-11 | Amgen Inc. | Kaulų tarpų defektų gydymo būdas |
| WO2013101451A1 (en) | 2011-12-28 | 2013-07-04 | Amgen Inc. | Method of treating alvelor bone loss through the use of anti-sclerostin antibodies |
| EP2836512B1 (en) | 2012-04-11 | 2018-10-24 | F.Hoffmann-La Roche Ag | Improved antibody light chains |
| CN104619342A (zh) | 2012-07-05 | 2015-05-13 | Ucb医药有限公司 | 骨疾病的治疗 |
| JP2015536933A (ja) | 2012-10-23 | 2015-12-24 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| AU2014212081A1 (en) | 2013-02-04 | 2015-08-13 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| MA41142A (fr) | 2014-12-12 | 2017-10-17 | Amgen Inc | Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement |
| WO2017127706A1 (en) * | 2016-01-22 | 2017-07-27 | Yale University | Compositions and methods for inhibiting dkk-1 |
| GB201604124D0 (en) | 2016-03-10 | 2016-04-27 | Ucb Biopharma Sprl | Pharmaceutical formulation |
| JP2020502218A (ja) | 2016-12-21 | 2020-01-23 | メレオ バイオファーマ ３ リミテッド | 骨形成不全症の処置における抗スクレロスチン抗体の使用 |
| JP7191833B2 (ja) * | 2017-01-30 | 2022-12-19 | 中外製薬株式会社 | 抗スクレロスチン抗体およびその使用 |
| CA3076630A1 (en) * | 2017-10-04 | 2019-04-11 | Amgen Inc. | Transthyretin immunoglobulin fusions |
| CN112368051A (zh) * | 2018-03-23 | 2021-02-12 | 马萨诸塞大学 | 用于治疗骨病的基因治疗剂 |
| IL316596A (en) | 2018-03-30 | 2024-12-01 | Amgen Inc | C-terminal antibody variants |
| WO2019213285A1 (en) * | 2018-05-02 | 2019-11-07 | Ortheus, Inc. | Systems and methods for local modulation of wnt signaling |
| CN113645996B (zh) * | 2019-02-01 | 2024-04-02 | 新石生物制药有限公司 | 抗claudin 18抗体及其使用方法 |
| CN112121147B (zh) * | 2019-06-24 | 2023-07-04 | 中国人民解放军海军特色医学中心 | 多肽在治疗或预防骨髓瘤药物中的应用、多肽、核酸、药物及重组表达载体 |
| CN112180094A (zh) * | 2019-07-04 | 2021-01-05 | 上海东慈生物科技有限公司 | Dkk1抑制剂在预防和/或治疗肿瘤恶病质与糖尿病伴随疾病中的应用 |
| TR201920272A1 (tr) * | 2019-12-15 | 2021-06-21 | Uludamar Altay | Dental i̇mplantlar, greft materyalleri̇ ve prf i̇le osseoi̇ntegrasyonun artirilmasi i̇çi̇n bi̇r terapöti̇k kompozi̇syon ve bunun lokal kullanim yöntemleri̇ |
| US20250122271A1 (en) * | 2022-01-28 | 2025-04-17 | Shanghai Junshi Biosciences Co., Ltd. | Anti-dkk1 antibody, pharmaceutical composition thereof, and use thereof |
| WO2024253462A1 (ko) * | 2023-06-07 | 2024-12-12 | 중앙대학교 산학협력단 | 스클레로스틴 억제제를 유효성분으로 포함하는 당뇨병성 안질환 예방 또는 치료용 약학적 조성물 |
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-
2011
- 2011-10-27 ES ES17169408T patent/ES2863626T3/es active Active
- 2011-10-27 AR ARP110103984A patent/AR083740A1/es active IP Right Grant
- 2011-10-27 EP EP20213270.0A patent/EP3838922A1/en active Pending
- 2011-10-27 TW TW105125647A patent/TWI636994B/zh active
- 2011-10-27 TW TW100139221A patent/TWI636993B/zh active
- 2011-10-27 AU AU2011319843A patent/AU2011319843C1/en active Active
- 2011-10-27 JP JP2013536812A patent/JP6066912B2/ja active Active
- 2011-10-27 MX MX2013004726A patent/MX354481B/es active IP Right Grant
- 2011-10-27 EP EP17169408.6A patent/EP3219725B1/en active Active
- 2011-10-27 CA CA3085710A patent/CA3085710A1/en active Pending
- 2011-10-27 WO PCT/US2011/058025 patent/WO2012058393A2/en not_active Ceased
- 2011-10-27 MX MX2017013617A patent/MX382826B/es unknown
- 2011-10-27 CA CA2815181A patent/CA2815181C/en active Active
- 2011-10-27 EP EP11779531.0A patent/EP2632951B1/en active Active
- 2011-10-27 US US13/878,619 patent/US9879072B2/en active Active
-
2013
- 2013-04-26 MX MX2021001494A patent/MX2021001494A/es unknown
-
2016
- 2016-06-03 AU AU2016203722A patent/AU2016203722A1/en not_active Abandoned
- 2016-09-08 JP JP2016175266A patent/JP6353500B2/ja active Active
-
2017
- 2017-12-13 US US15/841,065 patent/US10800839B2/en active Active
-
2018
- 2018-02-23 AU AU2018201333A patent/AU2018201333B2/en active Active
-
2020
- 2020-02-10 AR ARP200100356A patent/AR118047A2/es unknown
- 2020-09-09 US US17/015,212 patent/US12297260B2/en active Active
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