TWI636994B - Dkk1抗體及使用方法 - Google Patents

Dkk1抗體及使用方法 Download PDF

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Publication number
TWI636994B
TWI636994B TW105125647A TW105125647A TWI636994B TW I636994 B TWI636994 B TW I636994B TW 105125647 A TW105125647 A TW 105125647A TW 105125647 A TW105125647 A TW 105125647A TW I636994 B TWI636994 B TW I636994B
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TW
Taiwan
Prior art keywords
antibody
antibodies
seq
dkk1
bone
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TW105125647A
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English (en)
Chinese (zh)
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TW201710291A (zh
Inventor
威廉 葛林森 理查
盧瀗鍹
華祖 凱
李朝陽
弗瑞德艾瑞克W 賈科波斯
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安美基公司
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Publication of TW201710291A publication Critical patent/TW201710291A/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW105125647A 2010-10-27 2011-10-27 Dkk1抗體及使用方法 TWI636994B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40712810P 2010-10-27 2010-10-27
US61/407,128 2010-10-27

Publications (2)

Publication Number Publication Date
TW201710291A TW201710291A (zh) 2017-03-16
TWI636994B true TWI636994B (zh) 2018-10-01

Family

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Family Applications (2)

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TW100139221A TWI636993B (zh) 2010-10-27 2011-10-27 Dkk1抗體及使用方法
TW105125647A TWI636994B (zh) 2010-10-27 2011-10-27 Dkk1抗體及使用方法

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TW100139221A TWI636993B (zh) 2010-10-27 2011-10-27 Dkk1抗體及使用方法

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Country Link
US (3) US9879072B2 (cg-RX-API-DMAC7.html)
EP (3) EP3838922A1 (cg-RX-API-DMAC7.html)
JP (2) JP6066912B2 (cg-RX-API-DMAC7.html)
AR (2) AR083740A1 (cg-RX-API-DMAC7.html)
AU (3) AU2011319843C1 (cg-RX-API-DMAC7.html)
CA (2) CA2815181C (cg-RX-API-DMAC7.html)
ES (1) ES2863626T3 (cg-RX-API-DMAC7.html)
MX (3) MX354481B (cg-RX-API-DMAC7.html)
TW (2) TWI636993B (cg-RX-API-DMAC7.html)
WO (1) WO2012058393A2 (cg-RX-API-DMAC7.html)

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CN113645996B (zh) * 2019-02-01 2024-04-02 新石生物制药有限公司 抗claudin 18抗体及其使用方法
CN112121147B (zh) * 2019-06-24 2023-07-04 中国人民解放军海军特色医学中心 多肽在治疗或预防骨髓瘤药物中的应用、多肽、核酸、药物及重组表达载体
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Publication number Publication date
ES2863626T3 (es) 2021-10-11
MX382826B (es) 2025-03-13
TW201710291A (zh) 2017-03-16
WO2012058393A2 (en) 2012-05-03
JP2017043619A (ja) 2017-03-02
AU2018201333A1 (en) 2018-03-15
JP6066912B2 (ja) 2017-01-25
AU2016203722A1 (en) 2016-06-23
AU2018201333B2 (en) 2020-01-16
CA3085710A1 (en) 2012-05-03
MX2013004726A (es) 2013-08-29
US12297260B2 (en) 2025-05-13
EP3219725A3 (en) 2017-11-22
TW201305198A (zh) 2013-02-01
TWI636993B (zh) 2018-10-01
EP3219725A2 (en) 2017-09-20
AU2011319843B2 (en) 2016-03-10
EP2632951B1 (en) 2017-08-02
MX354481B (es) 2018-03-07
CA2815181C (en) 2020-09-15
US10800839B2 (en) 2020-10-13
AR083740A1 (es) 2013-03-20
EP3219725B1 (en) 2020-12-16
MX2021001494A (es) 2021-04-28
US20180111985A1 (en) 2018-04-26
WO2012058393A3 (en) 2012-10-04
US9879072B2 (en) 2018-01-30
EP2632951A2 (en) 2013-09-04
JP6353500B2 (ja) 2018-07-04
CA2815181A1 (en) 2012-05-03
US20210040189A1 (en) 2021-02-11
AR118047A2 (es) 2021-09-15
AU2011319843A1 (en) 2013-05-09
JP2013545734A (ja) 2013-12-26
US20130209475A1 (en) 2013-08-15
AU2011319843C1 (en) 2017-02-02
EP3838922A1 (en) 2021-06-23

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