JP2013544872A5 - - Google Patents
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- Publication number
- JP2013544872A5 JP2013544872A5 JP2013542577A JP2013542577A JP2013544872A5 JP 2013544872 A5 JP2013544872 A5 JP 2013544872A5 JP 2013542577 A JP2013542577 A JP 2013542577A JP 2013542577 A JP2013542577 A JP 2013542577A JP 2013544872 A5 JP2013544872 A5 JP 2013544872A5
- Authority
- JP
- Japan
- Prior art keywords
- heterocycle
- alkyl
- alkynyl
- alkenyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1021103.5A GB201021103D0 (en) | 2010-12-13 | 2010-12-13 | New compounds for the treatment of neurodegenerative diseases |
| GB1021103.5 | 2010-12-13 | ||
| PCT/EP2011/072568 WO2012080221A1 (en) | 2010-12-13 | 2011-12-13 | New compounds for the treatment of neurodegenerative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544872A JP2013544872A (ja) | 2013-12-19 |
| JP2013544872A5 true JP2013544872A5 (https=) | 2015-01-29 |
| JP6050241B2 JP6050241B2 (ja) | 2016-12-21 |
Family
ID=43567100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013542577A Expired - Fee Related JP6050241B2 (ja) | 2010-12-13 | 2011-12-13 | 神経変性疾患の治療のための新規化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9266832B2 (https=) |
| EP (1) | EP2651888B1 (https=) |
| JP (1) | JP6050241B2 (https=) |
| CN (1) | CN103261156B (https=) |
| CA (1) | CA2819171C (https=) |
| DK (1) | DK2651888T3 (https=) |
| ES (1) | ES2637288T3 (https=) |
| GB (1) | GB201021103D0 (https=) |
| HR (1) | HRP20171186T1 (https=) |
| HU (1) | HUE033277T2 (https=) |
| SI (1) | SI2651888T1 (https=) |
| WO (1) | WO2012080221A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201021103D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | New compounds for the treatment of neurodegenerative diseases |
| GB201021104D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| BR112016015449A8 (pt) * | 2013-12-30 | 2020-06-09 | Lifesci Pharmaceuticals Inc | compostos inibidores terapêuticos, composição farmacêutica os compreendendo e uso dos mesmos |
| EA032374B1 (ru) * | 2014-01-29 | 2019-05-31 | ЮСиБи БАЙОФАРМА СПРЛ | Гетероарильные амиды в качестве ингибиторов агрегации белков |
| CN104744353B (zh) * | 2015-03-31 | 2017-11-24 | 山东友帮生化科技有限公司 | 2‑氨基‑3‑碘‑5‑氯吡啶的合成方法 |
| CN105130978B (zh) * | 2015-07-22 | 2017-11-21 | 中国人民解放军军事医学科学院基础医学研究所 | 一种化合物及其在帕金森疾病方面的应用 |
| ES2885049T3 (es) | 2015-07-29 | 2021-12-13 | UCB Biopharma SRL | Derivados de bis-heteroarilo como moduladores de la agregación de proteínas |
| US11970486B2 (en) | 2016-10-24 | 2024-04-30 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
| EA201991650A1 (ru) | 2017-01-06 | 2020-01-20 | Юманити Терапьютикс, Инк. | Способы лечения неврологических расстройств |
| US10913735B2 (en) | 2017-01-26 | 2021-02-09 | UCB Biopharma SRL | Bis-heteroaryl derivatives as modulators of protein aggregation |
| CN110167937B (zh) | 2017-01-26 | 2022-03-29 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的二环双-杂芳基衍生物 |
| WO2018138085A1 (en) | 2017-01-26 | 2018-08-02 | Ucb Biopharma Sprl | Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation |
| EP3589616A1 (en) | 2017-02-28 | 2020-01-08 | Universitat Autònoma de Barcelona | (nitro-phenyl)-nitropyridine compounds for treating synucleinopathies |
| WO2019025424A1 (en) | 2017-08-04 | 2019-02-07 | Universitat Autonoma De Barcelona | COMPOUNDS FOR TREATING SYNUCLEINOPATHIES |
| CA3083000A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| WO2019161917A1 (en) | 2018-02-23 | 2019-08-29 | Universitat Autonoma De Barcelona | 4-substituted 1-ethenylsulfonyl-2-nitrobenzene compounds for treating synucleinopathies |
| BR112020019191A2 (pt) | 2018-03-23 | 2021-01-05 | Yumanity Therapeutics, Inc. | Compostos e seus usos |
| JP7640458B2 (ja) | 2018-10-05 | 2025-03-05 | アンナプルナ バイオ インコーポレイテッド | Ａｐｊ受容体活性に関連する状態を処置するための化合物および組成物 |
| MX2021008903A (es) | 2019-01-24 | 2021-11-04 | Yumanity Therapeutics Inc | Compuestos y usos de los mismos. |
| WO2020198026A1 (en) * | 2019-03-22 | 2020-10-01 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| CA3148602A1 (en) | 2019-08-02 | 2021-02-11 | Acelot, Inc. | Small molecule drugs and related methods for treatment of diseases related to tdp-43, alpha-synuclein, huntingtin's protein and tau protein oligomer formation |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3202669A (en) | 1963-11-06 | 1965-08-24 | Upjohn Co | 6-methoxy-1-(3, 4, 5-trimethoxy phenyl)-9h-pyrido [3, 4-b] indole and its acid addition salts |
| IL130169A (en) | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
| US6306890B1 (en) * | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
| GB9922171D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
| CA2411165A1 (en) * | 2000-05-02 | 2002-12-11 | Meiji Seika Kaisha, Ltd. | Novel indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof |
| DOP2002000332A (es) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
| CA2517256C (en) * | 2003-02-26 | 2013-04-30 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
| MX2007000150A (es) | 2004-07-01 | 2007-03-30 | Univ California | Inhibicion de moleculas pequenas de la interaccion del domini pdz. |
| US8143257B2 (en) | 2004-11-23 | 2012-03-27 | Ptc Therapeutics, Inc. | Substituted phenols as active agents inhibiting VEGF production |
| WO2007006734A1 (en) * | 2005-07-12 | 2007-01-18 | Bayer Cropscience Sa | New benzoheterocyclylethylbenzamide derivatives |
| EP2149552A1 (de) * | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
| US20120053165A1 (en) * | 2009-03-03 | 2012-03-01 | Pfizer Inc. | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| ES2360435B1 (es) * | 2009-10-30 | 2012-05-04 | Consejo Superior De Investigaciones Cientificas (Csic) (70%) | Derivados de biss (aralquil) amino y sistemas (6+5)-heteroaromaticos y su uso en el tratamiento de patologias neurodegenerativas, incluida la enfermedad de alzheimer |
| WO2012042621A1 (ja) * | 2010-09-29 | 2012-04-05 | 味の素株式会社 | 塩味増強剤 |
| AU2011329233A1 (en) * | 2010-11-15 | 2013-05-23 | Abbvie Deutschland Gmbh & Co Kg | NAMPT and ROCK inhibitors |
| GB201021104D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| GB201021103D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | New compounds for the treatment of neurodegenerative diseases |
-
2010
- 2010-12-13 GB GBGB1021103.5A patent/GB201021103D0/en not_active Ceased
-
2011
- 2011-12-13 EP EP11805450.1A patent/EP2651888B1/en not_active Not-in-force
- 2011-12-13 CA CA2819171A patent/CA2819171C/en active Active
- 2011-12-13 DK DK11805450.1T patent/DK2651888T3/en active
- 2011-12-13 SI SI201131263T patent/SI2651888T1/sl unknown
- 2011-12-13 US US13/993,723 patent/US9266832B2/en active Active
- 2011-12-13 WO PCT/EP2011/072568 patent/WO2012080221A1/en not_active Ceased
- 2011-12-13 HR HRP20171186TT patent/HRP20171186T1/hr unknown
- 2011-12-13 CN CN201180059955.9A patent/CN103261156B/zh not_active Expired - Fee Related
- 2011-12-13 JP JP2013542577A patent/JP6050241B2/ja not_active Expired - Fee Related
- 2011-12-13 HU HUE11805450A patent/HUE033277T2/en unknown
- 2011-12-13 ES ES11805450.1T patent/ES2637288T3/es active Active
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