JP2013544872A5 - - Google Patents
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- Publication number
- JP2013544872A5 JP2013544872A5 JP2013542577A JP2013542577A JP2013544872A5 JP 2013544872 A5 JP2013544872 A5 JP 2013544872A5 JP 2013542577 A JP2013542577 A JP 2013542577A JP 2013542577 A JP2013542577 A JP 2013542577A JP 2013544872 A5 JP2013544872 A5 JP 2013544872A5
- Authority
- JP
- Japan
- Prior art keywords
- heterocycle
- alkyl
- alkynyl
- alkenyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1021103.5A GB201021103D0 (en) | 2010-12-13 | 2010-12-13 | New compounds for the treatment of neurodegenerative diseases |
| GB1021103.5 | 2010-12-13 | ||
| PCT/EP2011/072568 WO2012080221A1 (en) | 2010-12-13 | 2011-12-13 | New compounds for the treatment of neurodegenerative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544872A JP2013544872A (ja) | 2013-12-19 |
| JP2013544872A5 true JP2013544872A5 (https=) | 2015-01-29 |
| JP6050241B2 JP6050241B2 (ja) | 2016-12-21 |
Family
ID=43567100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013542577A Expired - Fee Related JP6050241B2 (ja) | 2010-12-13 | 2011-12-13 | 神経変性疾患の治療のための新規化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9266832B2 (https=) |
| EP (1) | EP2651888B1 (https=) |
| JP (1) | JP6050241B2 (https=) |
| CN (1) | CN103261156B (https=) |
| CA (1) | CA2819171C (https=) |
| DK (1) | DK2651888T3 (https=) |
| ES (1) | ES2637288T3 (https=) |
| GB (1) | GB201021103D0 (https=) |
| HR (1) | HRP20171186T1 (https=) |
| HU (1) | HUE033277T2 (https=) |
| SI (1) | SI2651888T1 (https=) |
| WO (1) | WO2012080221A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201021104D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| GB201021103D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | New compounds for the treatment of neurodegenerative diseases |
| CA2935683A1 (en) * | 2013-12-30 | 2015-07-09 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| AP2016009347A0 (en) * | 2014-01-29 | 2016-07-31 | Neuropore Therapies Inc | Heteroarly amides as inhibitors of protein aggregation |
| CN104744353B (zh) * | 2015-03-31 | 2017-11-24 | 山东友帮生化科技有限公司 | 2‑氨基‑3‑碘‑5‑氯吡啶的合成方法 |
| CN105130978B (zh) * | 2015-07-22 | 2017-11-21 | 中国人民解放军军事医学科学院基础医学研究所 | 一种化合物及其在帕金森疾病方面的应用 |
| EP3328379B1 (en) | 2015-07-29 | 2021-07-28 | UCB Biopharma SRL | Bis-heteroaryl derivatives as modulators of protein aggregation |
| JP2019533022A (ja) | 2016-10-24 | 2019-11-14 | ユマニティ セラピューティクス，インコーポレーテッド | 化合物及びその使用 |
| EP3566055B1 (en) | 2017-01-06 | 2025-03-12 | Janssen Pharmaceutica NV | Scd inhibitor for the treatment of neurological disorders |
| CN110198938B (zh) | 2017-01-26 | 2023-03-14 | Ucb生物制药私人有限公司 | 作为蛋白质聚集调节剂的双-杂芳基衍生物 |
| EA201991755A1 (ru) | 2017-01-26 | 2020-01-22 | Юсб Байофарма Спрл | Бициклические бисгетероарильные производные в качестве модуляторов агрегации белков |
| KR20190112031A (ko) | 2017-01-26 | 2019-10-02 | 유씨비 바이오파마 에스피알엘 | 단백질 응집의 조절제로서의 알콕시 비스-헤테로아릴 유도체 |
| WO2018158160A1 (en) | 2017-02-28 | 2018-09-07 | Universitat Autonoma De Barcelona | (nitro-phenyl)-nitropyridine compounds for treating synucleinopathies |
| WO2019025424A1 (en) | 2017-08-04 | 2019-02-07 | Universitat Autonoma De Barcelona | COMPOUNDS FOR TREATING SYNUCLEINOPATHIES |
| CA3083000A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| WO2019161917A1 (en) | 2018-02-23 | 2019-08-29 | Universitat Autonoma De Barcelona | 4-substituted 1-ethenylsulfonyl-2-nitrobenzene compounds for treating synucleinopathies |
| WO2019183587A1 (en) | 2018-03-23 | 2019-09-26 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| MX2021003904A (es) | 2018-10-05 | 2021-10-26 | Annapurna Bio Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor apj. |
| WO2020154571A1 (en) | 2019-01-24 | 2020-07-30 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| WO2020198026A1 (en) * | 2019-03-22 | 2020-10-01 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| JP7731868B2 (ja) * | 2019-08-02 | 2025-09-01 | エースロット，インコーポレイテッド | ＴＤＰ－４３、α－シヌクレイン、ハンチンチンタンパク質及びタウタンパク質のオリゴマー形成に関連する疾患を治療するための小分子薬物、並びに関連する方法 |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3345376A (en) * | 1963-11-06 | 1967-10-03 | Upjohn Co | Polyhydro-6-methoxy-1-(3, 4, 5-trimethoxyphenyl)-9h-pyrido[3, 4-b]indoles |
| IL130169A (en) * | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
| US6306890B1 (en) | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
| GB9922171D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
| EP1284266A4 (en) | 2000-05-02 | 2005-11-16 | Meiji Seika Kaisha | NEW INDOIND DERIVATIVES WITH CHYME-INHIBITABLE ACTIVITIES AND METHOD FOR THEIR PREPARATION |
| DOP2002000332A (es) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
| DK1603570T5 (da) | 2003-02-26 | 2013-12-09 | Sugen Inc | Aminoheteroarylforbindelser som proteinkinaseinhibitorer |
| EP1781609A4 (en) | 2004-07-01 | 2009-07-29 | Univ California | INHIBITION OF A PDZ DOMAIN INTERACTION BY SMALL MOLECULES |
| WO2006058088A2 (en) | 2004-11-23 | 2006-06-01 | Ptc Therapeutics, Inc. | Carbazole, carboline and indole derivatives useful in the inhibition of vegf production |
| BRPI0613229A2 (pt) * | 2005-07-12 | 2011-01-04 | Bayer Cropscience Sa | compostos, processo para a preparação de composto, composição fungicida e método para o combate curativo ou preventivo de fungo fitopatogênico |
| EP2149552A1 (de) * | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
| CA2751534A1 (en) * | 2009-03-03 | 2010-09-10 | Pfizer Inc. | Novel phenyl imidazoles and phenyl triazoles as gamma-secretase modulators |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| ES2360435B1 (es) * | 2009-10-30 | 2012-05-04 | Consejo Superior De Investigaciones Cientificas (Csic) (70%) | Derivados de biss (aralquil) amino y sistemas (6+5)-heteroaromaticos y su uso en el tratamiento de patologias neurodegenerativas, incluida la enfermedad de alzheimer |
| WO2012042621A1 (ja) * | 2010-09-29 | 2012-04-05 | 味の素株式会社 | 塩味増強剤 |
| AU2011329233A1 (en) | 2010-11-15 | 2013-05-23 | Abbvie Deutschland Gmbh & Co Kg | NAMPT and ROCK inhibitors |
| GB201021103D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | New compounds for the treatment of neurodegenerative diseases |
| GB201021104D0 (en) | 2010-12-13 | 2011-01-26 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
-
2010
- 2010-12-13 GB GBGB1021103.5A patent/GB201021103D0/en not_active Ceased
-
2011
- 2011-12-13 HR HRP20171186TT patent/HRP20171186T1/hr unknown
- 2011-12-13 EP EP11805450.1A patent/EP2651888B1/en not_active Not-in-force
- 2011-12-13 SI SI201131263T patent/SI2651888T1/sl unknown
- 2011-12-13 US US13/993,723 patent/US9266832B2/en active Active
- 2011-12-13 CN CN201180059955.9A patent/CN103261156B/zh not_active Expired - Fee Related
- 2011-12-13 HU HUE11805450A patent/HUE033277T2/en unknown
- 2011-12-13 JP JP2013542577A patent/JP6050241B2/ja not_active Expired - Fee Related
- 2011-12-13 ES ES11805450.1T patent/ES2637288T3/es active Active
- 2011-12-13 CA CA2819171A patent/CA2819171C/en active Active
- 2011-12-13 DK DK11805450.1T patent/DK2651888T3/en active
- 2011-12-13 WO PCT/EP2011/072568 patent/WO2012080221A1/en not_active Ceased
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