JP2013543861A5 - - Google Patents
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- Publication number
- JP2013543861A5 JP2013543861A5 JP2013538319A JP2013538319A JP2013543861A5 JP 2013543861 A5 JP2013543861 A5 JP 2013543861A5 JP 2013538319 A JP2013538319 A JP 2013538319A JP 2013538319 A JP2013538319 A JP 2013538319A JP 2013543861 A5 JP2013543861 A5 JP 2013543861A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- compound
- carbon
- alkyl group
- dihydroquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 229910052799 carbon Inorganic materials 0.000 claims 13
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 210000000963 osteoblast Anatomy 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 3
- 210000004504 adult stem cell Anatomy 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000037147 Hypercalcaemia Diseases 0.000 claims 1
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 206010027452 Metastases to bone Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
- 206010031264 Osteonecrosis Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000027067 Paget disease of bone Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000016738 bone Paget disease Diseases 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 229940125904 compound 1 Drugs 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- 229940126214 compound 3 Drugs 0.000 claims 1
- 229940125898 compound 5 Drugs 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 230000018109 developmental process Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 230000000148 hypercalcaemia Effects 0.000 claims 1
- 208000030915 hypercalcemia disease Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 210000002997 osteoclast Anatomy 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1004445 | 2010-11-16 | ||
| FR1004445A FR2967353B1 (fr) | 2010-11-16 | 2010-11-16 | Derives de quinolinone |
| PCT/IB2011/055096 WO2012066478A1 (fr) | 2010-11-16 | 2011-11-15 | Dérivés de quinolinone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013543861A JP2013543861A (ja) | 2013-12-09 |
| JP2013543861A5 true JP2013543861A5 (https=) | 2014-11-20 |
| JP5914509B2 JP5914509B2 (ja) | 2016-05-11 |
Family
ID=45346524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538319A Expired - Fee Related JP5914509B2 (ja) | 2010-11-16 | 2011-11-15 | キノリノン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9061997B2 (https=) |
| EP (1) | EP2640388B1 (https=) |
| JP (1) | JP5914509B2 (https=) |
| CA (1) | CA2817388C (https=) |
| ES (1) | ES2651015T3 (https=) |
| FR (1) | FR2967353B1 (https=) |
| WO (1) | WO2012066478A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2967498B1 (fr) * | 2010-11-16 | 2015-01-02 | Centre Nat Rech Scient | Utilisation de derives de quinolinone comme outil de recherche |
| JP6647287B2 (ja) | 2014-09-23 | 2020-02-14 | アクティブ バイオテック エイビー | 多発性骨髄腫の治療に使用するためのキノリンカルボキサミド |
| JP2020525448A (ja) * | 2017-06-23 | 2020-08-27 | ニューヨーク ソサエティ フォー ザ ラプチャード アンド クリップルド メインティニング ザ ホスピタル フォー スペシャル サージェリー | ソニックヘッジホッグシグナル伝達経路を介する脊椎円板変性を治療する組成物、使用及び方法 |
| CN114196623B (zh) * | 2021-11-12 | 2024-01-16 | 青岛大学附属医院 | 喹啉酮化合物作为骨髓间干细胞成骨分化促进剂的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52670B1 (en) * | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
| SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
| HRP20000904A2 (en) * | 1998-07-06 | 2001-12-31 | Janssen Pharmaceutica Nv | Farnesyl protein transferase inhibitors for treating arthropathies |
| JP2008504233A (ja) * | 2004-04-23 | 2008-02-14 | パラテック ファーマシューティカルズ インコーポレイテッド | 転写因子調節化合物およびその使用法 |
| CN1955175A (zh) * | 2004-10-28 | 2007-05-02 | 中国医学科学院药物研究所 | 香豆素衍生物及其制法和其药物组合物与用途 |
| WO2007124617A1 (fr) * | 2006-04-28 | 2007-11-08 | Institute Of Mataria Medica, Chinese Academy Of Medical Sciences | Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations |
| WO2008014307A2 (en) * | 2006-07-26 | 2008-01-31 | Novartis Ag | Inhibitors of undecaprenyl pyrophosphate synthase |
| US8183236B2 (en) * | 2007-04-12 | 2012-05-22 | University Of Southern California | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics |
-
2010
- 2010-11-16 FR FR1004445A patent/FR2967353B1/fr active Active
-
2011
- 2011-11-15 JP JP2013538319A patent/JP5914509B2/ja not_active Expired - Fee Related
- 2011-11-15 EP EP11794858.8A patent/EP2640388B1/fr not_active Not-in-force
- 2011-11-15 ES ES11794858.8T patent/ES2651015T3/es active Active
- 2011-11-15 WO PCT/IB2011/055096 patent/WO2012066478A1/fr not_active Ceased
- 2011-11-15 US US13/885,089 patent/US9061997B2/en not_active Expired - Fee Related
- 2011-11-15 CA CA2817388A patent/CA2817388C/fr not_active Expired - Fee Related
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