JP2013542999A5 - - Google Patents
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- JP2013542999A5 JP2013542999A5 JP2013539987A JP2013539987A JP2013542999A5 JP 2013542999 A5 JP2013542999 A5 JP 2013542999A5 JP 2013539987 A JP2013539987 A JP 2013539987A JP 2013539987 A JP2013539987 A JP 2013539987A JP 2013542999 A5 JP2013542999 A5 JP 2013542999A5
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- JP
- Japan
- Prior art keywords
- composition
- cells
- small molecule
- skin
- stem cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
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| WO2017184808A1 (en) * | 2016-04-20 | 2017-10-26 | University Of Southern California | Compounds and methods for increasing hematopoiesis |
| EP3655961A4 (en) * | 2017-07-17 | 2021-09-01 | Massachusetts Institute of Technology | HEALTHY AND SICK BARRIER TISSUE CELL ATLAS |
| WO2019094365A1 (en) | 2017-11-07 | 2019-05-16 | Neurostim Oab, Inc. | Non-invasive nerve activator with adaptive circuit |
| JP7605576B2 (ja) | 2018-07-25 | 2024-12-24 | ポーラ化成工業株式会社 | 皮膚老化改善剤のスクリーニング方法 |
| KR20220025834A (ko) | 2019-06-26 | 2022-03-03 | 뉴로스팀 테크놀로지스 엘엘씨 | 적응적 회로를 갖는 비침습적 신경 활성화기 |
| JP2023506713A (ja) | 2019-12-16 | 2023-02-20 | ニューロスティム テクノロジーズ エルエルシー | 昇圧電荷送達を用いた非侵襲性神経アクティベータ |
| KR102612610B1 (ko) * | 2020-02-07 | 2023-12-12 | 주식회사 한스파마 | 신경줄기세포의 제조방법 및 이로부터 얻어진 신경줄기세포 배양액을 유효성분으로 포함하는 피부 재생, 항산화, 항염증 및 상처 치료용 조성물 |
| US12486275B2 (en) | 2020-03-12 | 2025-12-02 | City Of Hope | Substituted pyrazino[2,1-c][1,2,4]triazines as Wnt/CBP/catenin signaling pathway inhibitors |
| CA3194606A1 (en) * | 2020-10-05 | 2022-04-14 | Fuqiang Ruan | Topical agents for dermatological applications |
| CN117083065A (zh) * | 2020-10-30 | 2023-11-17 | 庆应义塾 | 肌肉减少症相关疾病等的新颖治疗和预防 |
| WO2023114456A1 (en) * | 2021-12-17 | 2023-06-22 | Athira Pharma, Inc. | Uses of bicyclic compounds for the treatment of diseases |
| JP7178143B1 (ja) | 2022-03-17 | 2022-11-25 | 学校法人関西医科大学 | 爪幹細胞及び毛髪の成長を助長する外用剤 |
| AU2023366929A1 (en) | 2022-10-25 | 2025-05-08 | Veradermics, Incorporated | Compositions and methods of use for modified release minoxidil |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0267878A1 (en) | 1986-11-14 | 1988-05-18 | Ciba-Geigy Ag | N9-cyclopentyl-substituted adenine derivatives |
| US5262321A (en) | 1991-05-31 | 1993-11-16 | Dana-Farber Cancer Institute | DNA encoding p107 tumor suppressor |
| US5750336A (en) | 1994-02-10 | 1998-05-12 | The Salk Institute For Biological Studies | Assays for the identification of compounds which inhibit activation of cAMP and mitogen responsive genes |
| US5658784A (en) | 1994-04-14 | 1997-08-19 | Dana-Farber Cancer Institute, Inc. | Nucleic acid encoding transcription factor p300 and uses of p300 |
| IT1271007B (it) | 1994-09-13 | 1997-05-26 | Zambon Spa | Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare |
| US6184223B1 (en) | 1995-10-27 | 2001-02-06 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| WO1999037753A1 (en) | 1998-01-23 | 1999-07-29 | Newbiotics, Inc. | Enzyme catalyzed therapeutic agents |
| EP2308863A1 (en) | 2000-05-15 | 2011-04-13 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
| CN1333270A (zh) * | 2000-07-07 | 2002-01-30 | 上海博德基因开发有限公司 | 一种新的多肽——人cbp20蛋白47.74和编码这种多肽的多核苷酸 |
| US7671054B1 (en) | 2001-10-12 | 2010-03-02 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US20040072831A1 (en) | 2001-10-12 | 2004-04-15 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7566711B2 (en) | 2001-10-12 | 2009-07-28 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7232822B2 (en) | 2001-10-12 | 2007-06-19 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7576084B2 (en) | 2001-10-12 | 2009-08-18 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| TW200304371A (en) | 2002-02-22 | 2003-10-01 | Akzo Nobel Nv | Substituted 10-ary1-11H-benzo [b] fluorenes and 7-ary1-5, 6-dihydro-benz [a] anthracenes for selective effects on estrogen receptors |
| US6762185B1 (en) * | 2002-03-01 | 2004-07-13 | Choongwae Pharma Corporation | Compounds useful for treatment of cancer, compositions containing the same, and methods of their use |
| WO2004035587A1 (en) | 2002-10-17 | 2004-04-29 | Myriad Genetics, Inc. | Reverse-turn mimetics and composition and methods relating thereto |
| AU2004268647B2 (en) | 2003-08-28 | 2010-07-01 | Choongwae Pharma Corporation | Modulation of beta-catenin/TCF activated transcription |
| JP3722146B1 (ja) | 2004-06-16 | 2005-11-30 | セイコーエプソン株式会社 | プロジェクタおよび画像補正方法 |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| US7563825B1 (en) | 2005-03-18 | 2009-07-21 | Choongwae Pharma Corporation | Modulation of beta-catenin coactivator interactions to effect stem cell growth or differentiation |
| AU2006227776A1 (en) * | 2005-03-18 | 2006-09-28 | Institute For Chemical Genomics | Alpha-helix mimetics and methods relating to the treatment of fibrosis |
| US20080009500A1 (en) | 2005-11-08 | 2008-01-10 | Michael Kahn | Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders |
| ATE446509T1 (de) * | 2005-11-28 | 2009-11-15 | Choongwae Pharma Corp | Serumfreie expansion von zellen in kultur |
| EP2029142A4 (en) | 2006-05-30 | 2010-06-16 | Choongwae Pharma Corp | COMPOSITION FOR INDUCTION OR INHIBITION OF STEM CELL PROLIFERATION |
| KR20090060334A (ko) | 2006-09-08 | 2009-06-11 | 제넨테크, 인크. | Ｗｎｔ 길항제 및 ｗｎｔ-매개 장애의 진단 및 치료에서의 이의 용도 |
| CN101130799A (zh) * | 2007-08-06 | 2008-02-27 | 大连理工大学 | 利用几丁质生产生物能源物质的方法 |
| WO2010044485A1 (en) | 2008-10-14 | 2010-04-22 | Prism Biolab Corporation | Alpha helix mimetics in the treatment of cancer |
| WO2010124365A1 (en) * | 2009-04-27 | 2010-11-04 | Ottawa Hospital Research Institute | Compositions and methods for modulating stem cells and uses thereof |
| US9040531B2 (en) | 2009-05-07 | 2015-05-26 | Prism BioLab Co., Ltd. | Alpha helix mimetics and methods relating thereto |
| AU2011329854B2 (en) | 2010-11-16 | 2017-03-30 | University Of Southern California | CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells |
| EP2678341A1 (en) * | 2011-02-25 | 2014-01-01 | PRISM Pharma Co., Ltd. | Alpha helix mimetics and methods relating thereto |
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