JP2013542940A5 - - Google Patents
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- Publication number
- JP2013542940A5 JP2013542940A5 JP2013533267A JP2013533267A JP2013542940A5 JP 2013542940 A5 JP2013542940 A5 JP 2013542940A5 JP 2013533267 A JP2013533267 A JP 2013533267A JP 2013533267 A JP2013533267 A JP 2013533267A JP 2013542940 A5 JP2013542940 A5 JP 2013542940A5
- Authority
- JP
- Japan
- Prior art keywords
- fluticasone
- optionally
- pharmaceutical composition
- indacaterol
- ciclesonide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 229960002714 fluticasone Drugs 0.000 claims 15
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 15
- 229960004078 indacaterol Drugs 0.000 claims 14
- QZZUEBNBZAPZLX-QFIPXVFZSA-N indacaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 QZZUEBNBZAPZLX-QFIPXVFZSA-N 0.000 claims 14
- LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 claims 10
- 229960003728 ciclesonide Drugs 0.000 claims 10
- 229960002848 formoterol Drugs 0.000 claims 8
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims 8
- 239000003246 corticosteroid Substances 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 229940110309 tiotropium Drugs 0.000 claims 6
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical group O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims 6
- 230000002757 inflammatory effect Effects 0.000 claims 5
- 230000000414 obstructive effect Effects 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 230000000241 respiratory effect Effects 0.000 claims 5
- 208000023504 respiratory system disease Diseases 0.000 claims 5
- 239000000556 agonist Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- XTULMSXFIHGYFS-VLSRWLAYSA-N fluticasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4[C@@H](F)C[C@H]3[C@@H]2C[C@H]1C)C(=O)SCF)C(=O)C1=CC=CO1 XTULMSXFIHGYFS-VLSRWLAYSA-N 0.000 claims 4
- 239000000812 cholinergic antagonist Substances 0.000 claims 3
- 229940071648 metered dose inhaler Drugs 0.000 claims 3
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 2
- 230000001078 anti-cholinergic effect Effects 0.000 claims 2
- 229940021593 formoterol and fluticasone Drugs 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000008139 complexing agent Substances 0.000 claims 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 229960001469 fluticasone furoate Drugs 0.000 claims 1
- 229960004735 indacaterol maleate Drugs 0.000 claims 1
- IREJFXIHXRZFER-PCBAQXHCSA-N indacaterol maleate Chemical compound OC(=O)\C=C/C(O)=O.N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 IREJFXIHXRZFER-PCBAQXHCSA-N 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002357 osmotic agent Substances 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 239000003380 propellant Substances 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229960000257 tiotropium bromide Drugs 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2847MU2010 | 2010-10-12 | ||
| IN2847/MUM/2010 | 2010-10-12 | ||
| IN69/MUM/2011 | 2011-01-10 | ||
| IN69MU2011 | 2011-01-10 | ||
| IN106/MUM/2011 | 2011-01-12 | ||
| IN106MU2011 | 2011-01-12 | ||
| IN135/MUM/2011 | 2011-01-14 | ||
| IN135MU2011 | 2011-01-14 | ||
| IN143/MUM/2011 | 2011-01-17 | ||
| IN143MU2011 | 2011-01-17 | ||
| PCT/GB2011/001115 WO2012049444A1 (en) | 2010-10-12 | 2011-07-25 | Pharmaceutical composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016197697A Division JP2017039746A (ja) | 2010-10-12 | 2016-10-06 | 医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013542940A JP2013542940A (ja) | 2013-11-28 |
| JP2013542940A5 true JP2013542940A5 (https=) | 2014-09-11 |
Family
ID=44651863
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013533267A Pending JP2013542940A (ja) | 2010-10-12 | 2011-07-25 | 医薬組成物 |
| JP2016197697A Pending JP2017039746A (ja) | 2010-10-12 | 2016-10-06 | 医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016197697A Pending JP2017039746A (ja) | 2010-10-12 | 2016-10-06 | 医薬組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10179139B2 (https=) |
| EP (1) | EP2627325A1 (https=) |
| JP (2) | JP2013542940A (https=) |
| KR (2) | KR20180028563A (https=) |
| CN (2) | CN107998109A (https=) |
| AU (1) | AU2011315315B2 (https=) |
| BR (1) | BR112013008974A2 (https=) |
| CA (1) | CA2814445A1 (https=) |
| MX (1) | MX2013004137A (https=) |
| NZ (1) | NZ609358A (https=) |
| RU (1) | RU2642624C2 (https=) |
| WO (1) | WO2012049444A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103096897A (zh) | 2010-07-16 | 2013-05-08 | 希普拉有限公司 | 包含r(+)布地奈德和一种或多种支气管扩张剂的药物组合物 |
| KR20180028563A (ko) | 2010-10-12 | 2018-03-16 | 시플라 리미티드 | 약학 조성물 |
| CN103784420A (zh) * | 2014-02-18 | 2014-05-14 | 青岛市城阳区人民医院 | 马来酸茚达特罗液体制剂及其制备方法 |
| US20170189329A1 (en) * | 2014-07-29 | 2017-07-06 | 3M Innovative Properties Company | Method of preparing a pharmaceutical composition |
| JP6940416B2 (ja) * | 2015-05-01 | 2021-09-29 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 多剤脆性マトリックス組成物 |
| EA036707B1 (ru) * | 2015-05-18 | 2020-12-10 | Гленмарк Спешелти С.А. | Ингаляционный раствор тиотропия для небулайзерного распыления |
| CN114712337A (zh) * | 2016-09-19 | 2022-07-08 | 墨西哥氟石股份公司 | 药物组合物 |
| GB2554090A (en) * | 2016-09-19 | 2018-03-28 | Mexichem Fluor Sa De Cv | Pharmaceutical compound |
| MX2019003103A (es) * | 2016-09-19 | 2019-08-01 | Mexichem Fluor Sa De Cv | Composicion farmaceutica. |
| TR201712424A2 (tr) * | 2017-08-21 | 2019-03-21 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Kuru toz i̇nhalasyon bi̇leşi̇mleri̇ |
| WO2019142214A1 (en) * | 2018-01-19 | 2019-07-25 | Cipla Limited | Pharmaceutical composition comprising tiotropium for inhalation |
| WO2019146188A1 (ja) | 2018-01-24 | 2019-08-01 | ソニー株式会社 | 情報処理装置および情報処理方法 |
| AU2019282562A1 (en) * | 2018-06-04 | 2021-01-21 | Lupin Inc. | Stable pharmaceutical compositions for pressurized metered dose inhalers |
| US20200163955A1 (en) * | 2018-11-22 | 2020-05-28 | Glenmark Specialty S.A. | Sterile compositions of indacaterol suitable for nebulization |
| US20200215051A1 (en) * | 2019-01-03 | 2020-07-09 | Glenmark Specialty S.A. | Nebulization composition comprising tiotropium and indacaterol |
| CN113853197B (zh) * | 2019-10-11 | 2022-08-30 | 四川海思科制药有限公司 | 一种吸入溶液药物组合物及其制备方法 |
| CN110840864B (zh) * | 2019-12-20 | 2022-02-22 | 广州健康元呼吸药物工程技术有限公司 | 一种β2受体激动剂吸入气雾剂及包含该吸入气雾剂的产品 |
| CN111467498A (zh) * | 2020-05-14 | 2020-07-31 | 王兆霖 | 药物组合物制剂 |
| EP4221707A4 (en) | 2020-09-29 | 2024-08-28 | Aerorx Therapeutics LLC | Liquid formulations of indacaterol |
| JP2025538083A (ja) * | 2022-11-03 | 2025-11-26 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | ホルモテロール又はその薬学的に許容される塩を使用して貧血を治療する方法 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9700135D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| US6120752A (en) * | 1997-05-21 | 2000-09-19 | 3M Innovative Properties Company | Medicinal aerosol products containing formulations of ciclesonide and related steroids |
| US5879715A (en) | 1997-09-02 | 1999-03-09 | Ceramem Corporation | Process and system for production of inorganic nanoparticles |
| GB9903759D0 (en) | 1999-02-18 | 1999-04-14 | Novartis Ag | Organic compounds |
| GB9913083D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| GB0009591D0 (en) | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Medical combinations |
| AU2001252588A1 (en) | 2000-04-28 | 2001-11-12 | Tanabe Seiyaku Co., Ltd. | Method for preparing microsphere |
| FI20002216A0 (fi) | 2000-10-06 | 2000-10-06 | Orion Yhtymae Oyj | Yhdistelmäpartikkelit astman hoitoon |
| GB0029562D0 (en) | 2000-12-04 | 2001-01-17 | Novartis Ag | Organic compounds |
| US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| DE10130371A1 (de) | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
| DE60321311D1 (de) | 2002-02-04 | 2008-07-10 | Glaxo Group Ltd | Zubereitung zur inhalation enthaltend ein glucocorticoid und einen beta 2-adrenorezeptor agonisten |
| WO2004019985A1 (en) | 2002-08-29 | 2004-03-11 | Cipla Ltd | Pharmaceutical products and compositions comprising specific anticholinergic agents, beta-2 agonists and corticosteroids |
| AU2003263717A1 (en) | 2002-09-25 | 2004-04-19 | Astrazeneca Ab | A COMBINATION OF A LONG-ACTING Beta2-AGONIST AND A GLUCOCORTICOSTEROID IN THE TREATMENT OF FIBROTIC DISEASES |
| US7879833B2 (en) | 2002-12-12 | 2011-02-01 | Nycomed Gmbh | Combination medicament |
| US6962006B2 (en) | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
| WO2004110460A1 (en) * | 2003-06-13 | 2004-12-23 | Altana Pharma Ag | Formoterol and ciclesonide combination |
| SE527200C2 (sv) | 2003-06-19 | 2006-01-17 | Microdrug Ag | Inhalatoranordning samt kombinerade doser av formaterol och fluticason |
| SE527190C2 (sv) | 2003-06-19 | 2006-01-17 | Microdrug Ag | Inhalatoranordning samt kombinerade doser av en beta2-agonist, ett antikolinergiskt medel och ett antiinflammatorisk steroid |
| US20050258288A1 (en) | 2003-11-26 | 2005-11-24 | E. I. Du Pont De Nemours And Company | High pressure media milling system and process of forming particles |
| US20060008498A1 (en) | 2004-07-12 | 2006-01-12 | Chen Tzer-Fen D | Nano-particle production |
| DE102004056578A1 (de) | 2004-11-23 | 2006-05-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalative Arzneimittel enthaltend ein neues Anticholinergikum, Formoterol und ein Steroid |
| CN101102740A (zh) | 2005-01-07 | 2008-01-09 | 卫材R&D管理有限公司 | 药用组合物以及其制备方法 |
| EP2484382A1 (en) | 2005-03-30 | 2012-08-08 | Schering Corporation | Medicament comprising a phosphodiesterase IV inhibitor in an inhalable form |
| GB0511066D0 (en) * | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| NZ591969A (en) * | 2005-12-21 | 2012-05-25 | Meda Pharma Gmbh & Co Kg | Combination of anticholinergics, glucocorticoids, beta2-adrenoceptor agonists, PDE 4 inhibitor and antileukotriene for the treatment of inflammatory diseases |
| WO2008064357A2 (en) | 2006-11-22 | 2008-05-29 | University Of Florida Research Foundation, Inc. | Nanoparticles for protection of cells from oxidative stress |
| EP2124915A2 (en) | 2007-02-19 | 2009-12-02 | Cipla Limited | Pharmaceutical combinations of at least two bronchodilators or of a bronchodilator with a corticosteroid |
| TWI405590B (zh) | 2007-04-06 | 2013-08-21 | 活效製藥股份有限公司 | 微粉碎化有機化合物粒子之製法 |
| JP5109515B2 (ja) | 2007-07-17 | 2012-12-26 | 株式会社ジェイテクト | 摺動式トリポード形等速ジョイント |
| EP2197444A1 (en) * | 2007-09-12 | 2010-06-23 | Glaxo Group Limited | Novel combination of therapeutic agents |
| DE102007054885A1 (de) | 2007-11-15 | 2009-05-20 | Evonik Degussa Gmbh | Verfahren zur Fraktionierung oxidischer Nanopartikel durch Querstrom-Membranfiltration |
| FR2929136B1 (fr) | 2008-03-25 | 2011-11-11 | Sprainnov | Procede et tete de pulverisation, procede et tour associes pour fabriquer un produit pulverulent |
| CA2729644C (en) * | 2008-07-18 | 2018-05-29 | Prosonix Limited | Process for improving crystallinity |
| CN101474191B (zh) * | 2009-01-21 | 2011-03-23 | 李虎山 | 一种治疗哮喘和慢性阻塞性肺病的药物组合物 |
| US8668901B2 (en) * | 2009-02-04 | 2014-03-11 | Activaero Gmbh Research & Development | Use of a glucocorticoid composition for the treatment of severe and uncontrolled asthma |
| EP2221048A1 (en) | 2009-02-18 | 2010-08-25 | Siegfried Generics International AG | Pharmaceutical composition for inhalation |
| US20120160944A1 (en) | 2009-04-24 | 2012-06-28 | Aaron Dodd | Method for the production of commercial nanoparticle and micro particle powders |
| GB0918431D0 (en) * | 2009-10-21 | 2009-12-09 | Prosonix Ltd | Process for improving crystallinity |
| KR20180028563A (ko) | 2010-10-12 | 2018-03-16 | 시플라 리미티드 | 약학 조성물 |
-
2011
- 2011-07-25 KR KR1020187006863A patent/KR20180028563A/ko not_active Ceased
- 2011-07-25 CA CA2814445A patent/CA2814445A1/en not_active Abandoned
- 2011-07-25 NZ NZ60935811A patent/NZ609358A/en not_active IP Right Cessation
- 2011-07-25 AU AU2011315315A patent/AU2011315315B2/en not_active Ceased
- 2011-07-25 JP JP2013533267A patent/JP2013542940A/ja active Pending
- 2011-07-25 CN CN201711377918.8A patent/CN107998109A/zh active Pending
- 2011-07-25 CN CN2011800597356A patent/CN103269694A/zh active Pending
- 2011-07-25 WO PCT/GB2011/001115 patent/WO2012049444A1/en not_active Ceased
- 2011-07-25 US US13/879,145 patent/US10179139B2/en active Active
- 2011-07-25 RU RU2013119938A patent/RU2642624C2/ru not_active IP Right Cessation
- 2011-07-25 EP EP11752315.9A patent/EP2627325A1/en not_active Ceased
- 2011-07-25 BR BR112013008974A patent/BR112013008974A2/pt not_active IP Right Cessation
- 2011-07-25 KR KR1020137012107A patent/KR20140025308A/ko not_active Ceased
- 2011-07-25 MX MX2013004137A patent/MX2013004137A/es unknown
-
2016
- 2016-10-06 JP JP2016197697A patent/JP2017039746A/ja active Pending
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