JP2013541010A5 - - Google Patents

Info

Publication number

JP2013541010A5

JP2013541010A5 JP2013533913A JP2013533913A JP2013541010A5 JP 2013541010 A5 JP2013541010 A5 JP 2013541010A5 JP 2013533913 A JP2013533913 A JP 2013533913A JP 2013533913 A JP2013533913 A JP 2013533913A JP 2013541010 A5 JP2013541010 A5 JP 2013541010A5

Authority

JP

Japan

Prior art keywords

concentration

pbmcs

pharmaceutical composition

glatiramer acetate

iii

Prior art date

2011-10-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 23
• 102000013691 Interleukin-17 Human genes 0.000 claims description 11
• 239000006228 supernatant Substances 0.000 claims description 10
• 210000004369 blood Anatomy 0.000 claims description 6
• 239000008280 blood Substances 0.000 claims description 6
• PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical compound O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 claims description 3
• PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 claims description 3
• 210000002966 serum Anatomy 0.000 claims description 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 17
• 108010072051 Glatiramer Acetate Proteins 0.000 claims 14
• FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 claims 14
• 229960003776 glatiramer acetate Drugs 0.000 claims 14
• 238000000034 method Methods 0.000 claims 13
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 8
• 102100037850 Interferon gamma Human genes 0.000 claims 8
• 108010074328 Interferon-gamma Proteins 0.000 claims 8
• 108010002350 Interleukin-2 Proteins 0.000 claims 8
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 8
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 8
• 201000006417 multiple sclerosis Diseases 0.000 claims 5
• 239000000090 biomarker Substances 0.000 claims 4
• 238000010254 subcutaneous injection Methods 0.000 claims 4
• 239000007929 subcutaneous injection Substances 0.000 claims 4
• 239000007864 aqueous solution Substances 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 239000001963 growth medium Substances 0.000 claims 2
• 238000010257 thawing Methods 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 238000009097 single-agent therapy Methods 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 description 3
• 108090000695 Cytokines Proteins 0.000 description 3
• 238000003556 assay Methods 0.000 description 2
• 238000004458 analytical method Methods 0.000 description 1
• 210000004027 cell Anatomy 0.000 description 1