JP2013538566A5 - - Google Patents

Info

Publication number

JP2013538566A5

JP2013538566A5 JP2013523643A JP2013523643A JP2013538566A5 JP 2013538566 A5 JP2013538566 A5 JP 2013538566A5 JP 2013523643 A JP2013523643 A JP 2013523643A JP 2013523643 A JP2013523643 A JP 2013523643A JP 2013538566 A5 JP2013538566 A5 JP 2013538566A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

dom7h

acid sequence

variant

Prior art date

2011-08-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 20
• 238000006467 substitution reaction Methods 0.000 claims 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 6
• 102000009027 Albumins Human genes 0.000 claims 5
• 108010088751 Albumins Proteins 0.000 claims 5
• 108060003951 Immunoglobulin Proteins 0.000 claims 4
• 238000010494 dissociation reaction Methods 0.000 claims 4
• 230000005593 dissociations Effects 0.000 claims 4
• 102000018358 immunoglobulin Human genes 0.000 claims 4
• 108020001507 fusion proteins Proteins 0.000 claims 3
• 102000037865 fusion proteins Human genes 0.000 claims 3
• 239000003446 ligand Substances 0.000 claims 3
• 102000008100 Human Serum Albumin Human genes 0.000 claims 2
• 108091006905 Human Serum Albumin Proteins 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• HAYVTMHUNMMXCV-IMJSIDKUSA-N Cys-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CS HAYVTMHUNMMXCV-IMJSIDKUSA-N 0.000 claims 1
• OPINTGHFESTVAX-BQBZGAKWSA-N Gln-Arg Chemical group NC(=O)CC[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N OPINTGHFESTVAX-BQBZGAKWSA-N 0.000 claims 1
• 102000006395 Globulins Human genes 0.000 claims 1
• 108010044091 Globulins Proteins 0.000 claims 1
• QNBYCZTZNOVDMI-HGNGGELXSA-N Ile-His Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 QNBYCZTZNOVDMI-HGNGGELXSA-N 0.000 claims 1
• LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical group CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims 1
• 241000282567 Macaca fascicularis Species 0.000 claims 1
• BXNGIHFNNNSEOS-UWVGGRQHSA-N Phe-Asn Chemical compound NC(=O)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 BXNGIHFNNNSEOS-UWVGGRQHSA-N 0.000 claims 1
• JMCOUWKXLXDERB-WMZOPIPTSA-N Phe-Trp Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)C1=CC=CC=C1 JMCOUWKXLXDERB-WMZOPIPTSA-N 0.000 claims 1
• NFDYGNFETJVMSE-BQBZGAKWSA-N Ser-Leu Chemical group CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CO NFDYGNFETJVMSE-BQBZGAKWSA-N 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 108010083476 phenylalanyltryptophan Proteins 0.000 claims 1