JP2013536864A5 - - Google Patents
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- Publication number
- JP2013536864A5 JP2013536864A5 JP2013527286A JP2013527286A JP2013536864A5 JP 2013536864 A5 JP2013536864 A5 JP 2013536864A5 JP 2013527286 A JP2013527286 A JP 2013527286A JP 2013527286 A JP2013527286 A JP 2013527286A JP 2013536864 A5 JP2013536864 A5 JP 2013536864A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- crystalline form
- thrombosis
- item
- stroke
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37933910P | 2010-09-01 | 2010-09-01 | |
| US61/379,339 | 2010-09-01 | ||
| US201161454396P | 2011-03-18 | 2011-03-18 | |
| US61/454,396 | 2011-03-18 | ||
| PCT/US2011/050057 WO2012031017A1 (en) | 2010-09-01 | 2011-08-31 | CRYSTALLINE FORMS OF A FACTOR Xa INHIBITOR |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015187427A Division JP2015232046A (ja) | 2010-09-01 | 2015-09-24 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2017221050A Division JP2018024709A (ja) | 2010-09-01 | 2017-11-16 | 第Ｘａ因子阻害剤の結晶形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013536864A JP2013536864A (ja) | 2013-09-26 |
| JP2013536864A5 true JP2013536864A5 (cg-RX-API-DMAC7.html) | 2014-10-09 |
Family
ID=45773260
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527286A Pending JP2013536864A (ja) | 2010-09-01 | 2011-08-31 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2015187427A Pending JP2015232046A (ja) | 2010-09-01 | 2015-09-24 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2017221050A Pending JP2018024709A (ja) | 2010-09-01 | 2017-11-16 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2019081907A Pending JP2019135258A (ja) | 2010-09-01 | 2019-04-23 | 第Ｘａ因子阻害剤の結晶形態 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015187427A Pending JP2015232046A (ja) | 2010-09-01 | 2015-09-24 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2017221050A Pending JP2018024709A (ja) | 2010-09-01 | 2017-11-16 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2019081907A Pending JP2019135258A (ja) | 2010-09-01 | 2019-04-23 | 第Ｘａ因子阻害剤の結晶形態 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8946269B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2611779B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP2013536864A (cg-RX-API-DMAC7.html) |
| CN (1) | CN103261161B (cg-RX-API-DMAC7.html) |
| AR (1) | AR082804A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011295909B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2810004C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2603084T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL224698A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ608442A (cg-RX-API-DMAC7.html) |
| PT (1) | PT2611779T (cg-RX-API-DMAC7.html) |
| TW (1) | TW201221128A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012031017A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8980876B2 (en) | 2010-10-28 | 2015-03-17 | The Procter & Gamble Company | Inhibition of microbial growth by aconitase inhibition |
| US20150224091A1 (en) * | 2011-08-31 | 2015-08-13 | Portola Pharmaceuticals, Inc. | Prevention and treatment of thrombosis in medically ill patients |
| JP6227878B2 (ja) * | 2012-03-16 | 2017-11-08 | ラクステラ・インコーポレイテッドＬｕｘｔｅｒａ，Ｉｎｃ． | 光インターポーザのための方法及びシステム |
| US9200268B2 (en) | 2012-12-27 | 2015-12-01 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| US20140346397A1 (en) | 2012-12-27 | 2014-11-27 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| CN104693114B (zh) * | 2013-12-10 | 2019-08-16 | 四川海思科制药有限公司 | 一种贝曲西班的改进的制备方法 |
| CN105085387A (zh) * | 2014-05-20 | 2015-11-25 | 四川海思科制药有限公司 | 贝曲西班盐及其制备方法和用途 |
| WO2017091757A1 (en) * | 2015-11-24 | 2017-06-01 | Portola Pharmaceuticals, Inc. | Isotopically enriched betrixaban |
| CN106995405A (zh) * | 2016-01-25 | 2017-08-01 | 重庆医药工业研究院有限责任公司 | 一种贝曲西班马来酸盐无定型物及其制备方法 |
| EP3463352A4 (en) * | 2016-06-02 | 2019-10-30 | Dr. Reddy S Laboratories Limited | POLYMORPH OF BETRIXABAN AND ITS MALEATE SALT |
| EP3254674A1 (en) | 2016-06-08 | 2017-12-13 | Sandoz Ag | Pharmaceutical compositions of betrixaban maleate |
| EP3293174A1 (en) | 2016-09-09 | 2018-03-14 | Sandoz Ag | Crystalline salts of betrixaban |
| WO2018069936A1 (en) | 2016-10-13 | 2018-04-19 | Mylan Laboratories Limited | Polymorphs and solid dispersion of betrixaban and methods for the preparation thereof |
| CN107382897B (zh) * | 2017-07-10 | 2021-05-04 | 浙江宏元药业股份有限公司 | 一种贝曲西班的中间体及其制备方法和应用 |
| EP3510996A1 (en) * | 2018-01-11 | 2019-07-17 | Sandoz AG | Pharmaceutical compositions of betrixaban |
| CN108570003A (zh) * | 2018-06-01 | 2018-09-25 | 浙江宏元药业股份有限公司 | 一种贝曲西班马来酸盐的一水无定形及其制备方法 |
| CN113905715B (zh) | 2019-06-28 | 2025-04-15 | 宝洁公司 | 光增强处理方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226238D0 (en) | 1992-12-16 | 1993-02-10 | Scherer Ltd R P | Encapsulation apparatus and process |
| US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| NZ519984A (en) * | 2000-01-07 | 2004-03-26 | Transform Pharmaceuticals Inc | High-throughput formation, identification, and analysis of diverse solid-forms |
| ES2254385T3 (es) | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
| US6627646B2 (en) | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
| DE10322469A1 (de) | 2003-05-19 | 2004-12-16 | Bayer Healthcare Ag | Heterocyclische Verbindungen |
| CN1968922A (zh) | 2004-06-18 | 2007-05-23 | 米伦纽姆医药公司 | 因子xa抑制剂 |
| US7696352B2 (en) | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
| ATE549317T1 (de) | 2005-11-08 | 2012-03-15 | Millennium Pharm Inc | Pharmazeutische salze und polymorphe aus n-(5- chloro-2-pyridinyl)-2-ää4- ä(dimethylamino)iminomethylübenzoylüaminoü-5- methoxy-benzamid, einem faktor-xa-hemmer |
| NZ572418A (en) | 2006-05-05 | 2011-08-26 | Millennium Pharm Inc | Factor xa inhibitors |
| US20080051578A1 (en) | 2006-08-24 | 2008-02-28 | Georg Dahmann | Substituted biaryls, process for their manufacture and use thereof as medicaments |
| US8524907B2 (en) | 2006-11-02 | 2013-09-03 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor Xa inhibitor |
| ES2409090T3 (es) | 2006-12-08 | 2013-06-24 | Millennium Pharmaceuticals, Inc. | Formulaciones de dosis unitaria y métodos para el tratamiento de trombosis con un inhibidor oral del factor Xa |
| US20080293704A1 (en) | 2007-01-05 | 2008-11-27 | Millennium Pharmaceuticals, Inc. | FACTOR Xa INHIBITORS |
| JP5469595B2 (ja) | 2007-04-13 | 2014-04-16 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 第Ｘａ因子阻害薬として作用する化合物との併用抗凝固療法 |
| NZ599556A (en) | 2007-05-02 | 2013-10-25 | Portola Pharm Inc | Combination therapy with a compound acting as a platelet adp receptor inhibitor |
| DK2915564T3 (da) | 2007-09-28 | 2021-02-08 | Alexion Pharma Inc | Antidoter mod faktor XA-inhibitorer og fremgangsmåder til anvendelse deraf |
| JP5709316B2 (ja) * | 2008-11-14 | 2015-04-30 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 第Ｘａ因子阻害剤のための解毒剤および血液凝固剤と組み合わせて該解毒剤を使用する方法 |
| CA2784904C (en) | 2009-12-17 | 2017-10-10 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing factor xa inhibitors |
| AR082803A1 (es) | 2010-09-01 | 2013-01-09 | Portola Pharm Inc | Metodos y formulaciones para el tratamiento de la trombosis con betrixaban y un inhibidor de la glicoproteina p |
-
2011
- 2011-08-30 AR ARP110103159A patent/AR082804A1/es unknown
- 2011-08-30 TW TW100131157A patent/TW201221128A/zh unknown
- 2011-08-31 CN CN201180052042.4A patent/CN103261161B/zh not_active Expired - Fee Related
- 2011-08-31 CA CA2810004A patent/CA2810004C/en not_active Expired - Fee Related
- 2011-08-31 WO PCT/US2011/050057 patent/WO2012031017A1/en not_active Ceased
- 2011-08-31 ES ES11757467.3T patent/ES2603084T3/es active Active
- 2011-08-31 PT PT117574673T patent/PT2611779T/pt unknown
- 2011-08-31 AU AU2011295909A patent/AU2011295909B2/en not_active Ceased
- 2011-08-31 JP JP2013527286A patent/JP2013536864A/ja active Pending
- 2011-08-31 US US13/223,023 patent/US8946269B2/en active Active
- 2011-08-31 NZ NZ60844211A patent/NZ608442A/en not_active IP Right Cessation
- 2011-08-31 EP EP11757467.3A patent/EP2611779B1/en not_active Not-in-force
-
2013
- 2013-02-13 IL IL224698A patent/IL224698A/en active IP Right Grant
-
2015
- 2015-09-24 JP JP2015187427A patent/JP2015232046A/ja active Pending
-
2017
- 2017-11-16 JP JP2017221050A patent/JP2018024709A/ja active Pending
-
2019
- 2019-04-23 JP JP2019081907A patent/JP2019135258A/ja active Pending
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