JP2013536183A - 皮膚修復のための化合物及び方法 - Google Patents
皮膚修復のための化合物及び方法 Download PDFInfo
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- 239000008363 phosphate buffer Substances 0.000 description 1
- DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
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- 229920000747 poly(lactic acid) Polymers 0.000 description 1
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- 239000004626 polylactic acid Substances 0.000 description 1
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- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
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- 235000011164 potassium chloride Nutrition 0.000 description 1
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- 229960005205 prednisolone Drugs 0.000 description 1
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- 230000002335 preservative effect Effects 0.000 description 1
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- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 description 1
- 102000017953 prostanoid receptors Human genes 0.000 description 1
- 108050007059 prostanoid receptors Proteins 0.000 description 1
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- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
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- 239000002453 shampoo Substances 0.000 description 1
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- 230000037380 skin damage Effects 0.000 description 1
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- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
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- 229960001471 sodium selenite Drugs 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 229940001474 sodium thiosulfate Drugs 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
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- 239000007944 soluble tablet Substances 0.000 description 1
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- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
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- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
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- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000036575 thermal burns Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
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- 239000003071 vasodilator agent Substances 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36923210P | 2010-07-30 | 2010-07-30 | |
| US61/369,232 | 2010-07-30 | ||
| US41911510P | 2010-12-02 | 2010-12-02 | |
| US61/419,115 | 2010-12-02 | ||
| PCT/US2011/045833 WO2012016109A2 (en) | 2010-07-30 | 2011-07-29 | Compounds and methods for skin repair |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013536183A true JP2013536183A (ja) | 2013-09-19 |
| JP2013536183A5 JP2013536183A5 (enExample) | 2014-09-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2013523219A Pending JP2013536183A (ja) | 2010-07-30 | 2011-07-29 | 皮膚修復のための化合物及び方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20120136011A1 (enExample) |
| EP (1) | EP2598140B1 (enExample) |
| JP (1) | JP2013536183A (enExample) |
| KR (1) | KR20130130694A (enExample) |
| CN (1) | CN103068382A (enExample) |
| AR (1) | AR082428A1 (enExample) |
| AU (1) | AU2011282549A1 (enExample) |
| BR (1) | BR112013002319A2 (enExample) |
| CA (1) | CA2806982A1 (enExample) |
| CL (1) | CL2013000308A1 (enExample) |
| CO (1) | CO6680670A2 (enExample) |
| MX (1) | MX2013001227A (enExample) |
| NZ (1) | NZ607306A (enExample) |
| PH (1) | PH12013500205A1 (enExample) |
| RU (1) | RU2013108394A (enExample) |
| SG (1) | SG187653A1 (enExample) |
| TW (1) | TW201210601A (enExample) |
| WO (1) | WO2012016109A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8697458B2 (en) | 2009-04-22 | 2014-04-15 | Shat-R-Shield, Inc. | Silicone coated light-emitting diode |
| US8889123B2 (en) * | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8697057B2 (en) * | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8883139B2 (en) * | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
| US8900571B2 (en) * | 2010-08-19 | 2014-12-02 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8741281B2 (en) * | 2010-08-19 | 2014-06-03 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8926963B2 (en) * | 2010-08-19 | 2015-01-06 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| WO2012024072A1 (en) * | 2010-08-19 | 2012-02-23 | Allergan, Inc. | Compositions comprising adipose tissue and a pge2 analogue and their use in the treatment of a soft tissue condition |
| US9005605B2 (en) * | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8894992B2 (en) * | 2010-08-19 | 2014-11-25 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US20120142684A1 (en) * | 2010-12-02 | 2012-06-07 | Allergan, Inc. | Compounds and methods for skin repair |
| JP2015537028A (ja) * | 2012-11-16 | 2015-12-24 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 皮膚修復のための組成物および方法 |
| CA2890034A1 (en) * | 2012-11-16 | 2014-05-22 | Allergan, Inc. | Skin wound healing and scar reduction with prostaglandin ep4 agonist combinations |
| ES2730895T3 (es) * | 2013-09-27 | 2019-11-13 | Allergan Inc | Compuestos y métodos para reparación cutánea |
| RU2625548C1 (ru) * | 2015-04-29 | 2017-07-14 | Жанна Юрьевна Юсова | Способ коррекции возрастных изменений кожи лица |
| RU2663391C1 (ru) * | 2018-01-30 | 2018-08-03 | Игорь Николаевич Бондаренко | Способ эстетической коррекции мягких тканей лица |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000015608A1 (fr) * | 1998-09-14 | 2000-03-23 | Ono Pharmaceutical Co., Ltd. | Derives e de phenyl-prostaglandine a substitution-φ et medicaments les contenant comme ingredient actif |
| WO2004032965A1 (ja) * | 2002-10-10 | 2004-04-22 | Ono Pharmaceutical Co., Ltd. | 内因性修復因子産生促進剤 |
| JP2005139207A (ja) * | 1999-11-24 | 2005-06-02 | Ono Pharmaceut Co Ltd | 骨量低下疾患治療剤 |
| JP2006517587A (ja) * | 2003-02-11 | 2006-07-27 | アラーガン、インコーポレイテッド | 眼圧降下剤としての１０，１０−ジアルキルプロスタン酸誘導体 |
| JP2006321737A (ja) * | 2005-05-18 | 2006-11-30 | Ono Pharmaceut Co Ltd | Ｅｐ４アゴニストを含有する神経変性疾患の予防、治療および／または進展抑制剤 |
| JP2007023028A (ja) * | 2005-06-16 | 2007-02-01 | Ono Pharmaceut Co Ltd | 内耳疾患治療剤 |
| JP2008533158A (ja) * | 2005-03-17 | 2008-08-21 | アラーガン、インコーポレイテッド | 炎症性腸疾患の処置 |
| US20080234337A1 (en) * | 2004-08-10 | 2008-09-25 | Ono Pharmaceutical Co., Ltd. | Preventive and/or Remedy for Hyperkalemia Containing Ep4 Agonist |
| WO2008136519A1 (ja) * | 2007-05-08 | 2008-11-13 | National University Corporation, Hamamatsu University School Of Medicine | Ｅｐ４アゴニストを含有してなる細胞傷害性ｔ細胞の活性化剤 |
| JP2009532491A (ja) * | 2006-04-04 | 2009-09-10 | アラーガン インコーポレイテッド | プロスタグランジンｅｐ４作用薬 |
| JP2010513551A (ja) * | 2006-12-18 | 2010-04-30 | アラーガン インコーポレイテッド | 胃腸疾患の治療方法および組成物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811446A (en) * | 1997-04-18 | 1998-09-22 | Cytos Pharmaceuticals Llc | Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor |
| TWI249520B (en) * | 1998-07-15 | 2006-02-21 | Ono Pharmaceutical Co | 5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient |
| KR100826866B1 (ko) * | 2001-07-23 | 2008-05-06 | 오노 야꾸힝 고교 가부시키가이샤 | Ｅｐ４ 아고니스트를 유효 성분으로 하는 골량 저하질환의 치료제 |
| US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
| US6875787B2 (en) | 2003-02-11 | 2005-04-05 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| US7439372B2 (en) * | 2006-05-03 | 2008-10-21 | Allergan, Inc. | Therapeutic compounds |
| BRPI0720254A2 (pt) * | 2006-12-15 | 2014-01-07 | Glaxo Group Ltd | Derivados de benzamida como agonistas do receptor ep4 |
| GB0810615D0 (en) * | 2008-06-10 | 2008-07-16 | Glaxo Group Ltd | Novel pharmaceutical |
-
2011
- 2011-07-29 MX MX2013001227A patent/MX2013001227A/es not_active Application Discontinuation
- 2011-07-29 CN CN2011800404387A patent/CN103068382A/zh active Pending
- 2011-07-29 PH PH1/2013/500205A patent/PH12013500205A1/en unknown
- 2011-07-29 KR KR1020137004837A patent/KR20130130694A/ko not_active Withdrawn
- 2011-07-29 WO PCT/US2011/045833 patent/WO2012016109A2/en not_active Ceased
- 2011-07-29 AR ARP110102761A patent/AR082428A1/es unknown
- 2011-07-29 CA CA2806982A patent/CA2806982A1/en not_active Abandoned
- 2011-07-29 BR BR112013002319A patent/BR112013002319A2/pt not_active IP Right Cessation
- 2011-07-29 SG SG2013007430A patent/SG187653A1/en unknown
- 2011-07-29 EP EP11744157.6A patent/EP2598140B1/en not_active Not-in-force
- 2011-07-29 RU RU2013108394/15A patent/RU2013108394A/ru not_active Application Discontinuation
- 2011-07-29 TW TW100127126A patent/TW201210601A/zh unknown
- 2011-07-29 NZ NZ60730611A patent/NZ607306A/en not_active IP Right Cessation
- 2011-07-29 US US13/194,078 patent/US20120136011A1/en not_active Abandoned
- 2011-07-29 AU AU2011282549A patent/AU2011282549A1/en not_active Abandoned
- 2011-07-29 JP JP2013523219A patent/JP2013536183A/ja active Pending
-
2013
- 2013-01-30 CL CL2013000308A patent/CL2013000308A1/es unknown
- 2013-02-26 CO CO13038986A patent/CO6680670A2/es not_active Application Discontinuation
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000015608A1 (fr) * | 1998-09-14 | 2000-03-23 | Ono Pharmaceutical Co., Ltd. | Derives e de phenyl-prostaglandine a substitution-φ et medicaments les contenant comme ingredient actif |
| JP2005139207A (ja) * | 1999-11-24 | 2005-06-02 | Ono Pharmaceut Co Ltd | 骨量低下疾患治療剤 |
| WO2004032965A1 (ja) * | 2002-10-10 | 2004-04-22 | Ono Pharmaceutical Co., Ltd. | 内因性修復因子産生促進剤 |
| JP2010120964A (ja) * | 2002-10-10 | 2010-06-03 | Ono Pharmaceut Co Ltd | 内因性修復因子産生促進剤 |
| JP2006517587A (ja) * | 2003-02-11 | 2006-07-27 | アラーガン、インコーポレイテッド | 眼圧降下剤としての１０，１０−ジアルキルプロスタン酸誘導体 |
| US20080234337A1 (en) * | 2004-08-10 | 2008-09-25 | Ono Pharmaceutical Co., Ltd. | Preventive and/or Remedy for Hyperkalemia Containing Ep4 Agonist |
| JP2008533158A (ja) * | 2005-03-17 | 2008-08-21 | アラーガン、インコーポレイテッド | 炎症性腸疾患の処置 |
| JP2006321737A (ja) * | 2005-05-18 | 2006-11-30 | Ono Pharmaceut Co Ltd | Ｅｐ４アゴニストを含有する神経変性疾患の予防、治療および／または進展抑制剤 |
| JP2007023028A (ja) * | 2005-06-16 | 2007-02-01 | Ono Pharmaceut Co Ltd | 内耳疾患治療剤 |
| JP2009532491A (ja) * | 2006-04-04 | 2009-09-10 | アラーガン インコーポレイテッド | プロスタグランジンｅｐ４作用薬 |
| JP2010513551A (ja) * | 2006-12-18 | 2010-04-30 | アラーガン インコーポレイテッド | 胃腸疾患の治療方法および組成物 |
| WO2008136519A1 (ja) * | 2007-05-08 | 2008-11-13 | National University Corporation, Hamamatsu University School Of Medicine | Ｅｐ４アゴニストを含有してなる細胞傷害性ｔ細胞の活性化剤 |
Non-Patent Citations (4)
| Title |
|---|
| KYUNG-SOO CHUN ET AL.: "Cyclooxygenase-2 Inhibits UVB-Induced Apoptosis in Mouse Skin by Activating the Prostaglandin E2 Rec", CANCER RES, vol. 67, no. 5, JPN6015027165, 1 March 2007 (2007-03-01), pages 2015 - 2021, XP002662646, ISSN: 0003110042, DOI: 10.1158/0008-5472.can-06-3617 * |
| Y HONMA ET AL.: "Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induce", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 518, JPN6015027162, 7 June 2005 (2005-06-07), pages 56 - 62, ISSN: 0003110041 * |
| Y SAKAI ET AL.: "PROSTAGLANDIN E2 REGULATES THE EXPRESSION OF BASIC FIBROBLAST GROWTH FACTOR MESSENGER RNA IN NORMAL", KOBE J. MED. SCI, vol. 47, JPN6015027160, February 2001 (2001-02-01), pages 35 - 45, XP002974917, ISSN: 0003110040 * |
| 松本 邦夫、中村 敏一: "増殖因子による再生医療の展開−ＨＧＦを中心にして−", ＢＩＯＴＨＥＲＡＰＹ, vol. 第１５巻、第２号, JPN6015027158, March 2001 (2001-03-01), JP, pages 95 - 104, ISSN: 0003110039 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2806982A1 (en) | 2012-02-02 |
| RU2013108394A (ru) | 2014-09-10 |
| TW201210601A (en) | 2012-03-16 |
| WO2012016109A2 (en) | 2012-02-02 |
| EP2598140A2 (en) | 2013-06-05 |
| CN103068382A (zh) | 2013-04-24 |
| EP2598140B1 (en) | 2015-01-14 |
| AU2011282549A1 (en) | 2013-02-28 |
| MX2013001227A (es) | 2013-04-24 |
| CO6680670A2 (es) | 2013-05-31 |
| PH12013500205A1 (en) | 2017-08-23 |
| CL2013000308A1 (es) | 2013-04-12 |
| BR112013002319A2 (pt) | 2016-05-24 |
| KR20130130694A (ko) | 2013-12-02 |
| US20120136011A1 (en) | 2012-05-31 |
| WO2012016109A3 (en) | 2012-03-22 |
| NZ607306A (en) | 2015-03-27 |
| SG187653A1 (en) | 2013-03-28 |
| AR082428A1 (es) | 2012-12-05 |
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