JP2013536180A5 - - Google Patents
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- Publication number
- JP2013536180A5 JP2013536180A5 JP2013521998A JP2013521998A JP2013536180A5 JP 2013536180 A5 JP2013536180 A5 JP 2013536180A5 JP 2013521998 A JP2013521998 A JP 2013521998A JP 2013521998 A JP2013521998 A JP 2013521998A JP 2013536180 A5 JP2013536180 A5 JP 2013536180A5
- Authority
- JP
- Japan
- Prior art keywords
- growth factor
- protein
- factor
- soluble polymer
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZESQVNWRUDEXNZ-UHFFFAOYSA-N NOCCOCCON Chemical compound NOCCOCCON ZESQVNWRUDEXNZ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36918610P | 2010-07-30 | 2010-07-30 | |
| US61/369,186 | 2010-07-30 | ||
| PCT/US2011/045873 WO2012016131A1 (en) | 2010-07-30 | 2011-07-29 | Nucleophilic catalysts for oxime linkage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015118007A Division JP2015164958A (ja) | 2010-07-30 | 2015-06-11 | オキシム連結のための求核触媒 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536180A JP2013536180A (ja) | 2013-09-19 |
| JP2013536180A5 true JP2013536180A5 (https=) | 2018-04-12 |
| JP6325818B2 JP6325818B2 (ja) | 2018-05-16 |
Family
ID=44629987
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013521998A Active JP6325818B2 (ja) | 2010-07-30 | 2011-07-29 | オキシム連結のための求核触媒 |
| JP2015118007A Withdrawn JP2015164958A (ja) | 2010-07-30 | 2015-06-11 | オキシム連結のための求核触媒 |
| JP2017099807A Withdrawn JP2017137358A (ja) | 2010-07-30 | 2017-05-19 | オキシム連結のための求核触媒 |
| JP2019064338A Withdrawn JP2019116501A (ja) | 2010-07-30 | 2019-03-28 | オキシム連結のための求核触媒 |
| JP2019064337A Active JP6757823B2 (ja) | 2010-07-30 | 2019-03-28 | オキシム連結のための求核触媒 |
| JP2020196260A Active JP7054407B2 (ja) | 2010-07-30 | 2020-11-26 | オキシム連結のための求核触媒 |
| JP2021212106A Active JP7258999B2 (ja) | 2010-07-30 | 2021-12-27 | オキシム連結のための求核触媒 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015118007A Withdrawn JP2015164958A (ja) | 2010-07-30 | 2015-06-11 | オキシム連結のための求核触媒 |
| JP2017099807A Withdrawn JP2017137358A (ja) | 2010-07-30 | 2017-05-19 | オキシム連結のための求核触媒 |
| JP2019064338A Withdrawn JP2019116501A (ja) | 2010-07-30 | 2019-03-28 | オキシム連結のための求核触媒 |
| JP2019064337A Active JP6757823B2 (ja) | 2010-07-30 | 2019-03-28 | オキシム連結のための求核触媒 |
| JP2020196260A Active JP7054407B2 (ja) | 2010-07-30 | 2020-11-26 | オキシム連結のための求核触媒 |
| JP2021212106A Active JP7258999B2 (ja) | 2010-07-30 | 2021-12-27 | オキシム連結のための求核触媒 |
Country Status (26)
| Country | Link |
|---|---|
| EP (3) | EP3505186B1 (https=) |
| JP (7) | JP6325818B2 (https=) |
| KR (6) | KR102229967B1 (https=) |
| CN (3) | CN108079311A (https=) |
| AR (1) | AR082941A1 (https=) |
| AU (1) | AU2011282571C1 (https=) |
| BR (1) | BR112013001611B1 (https=) |
| CA (1) | CA2806684C (https=) |
| CY (1) | CY1121943T1 (https=) |
| DK (1) | DK2598172T3 (https=) |
| EA (2) | EA201691292A1 (https=) |
| ES (1) | ES2731626T3 (https=) |
| HR (1) | HRP20190990T1 (https=) |
| HU (1) | HUE043790T2 (https=) |
| LT (1) | LT2598172T (https=) |
| MX (1) | MX346271B (https=) |
| NZ (1) | NZ605972A (https=) |
| PL (1) | PL2598172T3 (https=) |
| PT (1) | PT2598172T (https=) |
| RS (1) | RS58900B1 (https=) |
| SG (2) | SG10201913078SA (https=) |
| SI (1) | SI2598172T1 (https=) |
| SM (1) | SMT201900351T1 (https=) |
| TR (1) | TR201908836T4 (https=) |
| TW (1) | TWI534152B (https=) |
| WO (1) | WO2012016131A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| TR201908836T4 (tr) * | 2010-07-30 | 2019-07-22 | Baxalta GmbH | Oksim bağına yönelik nükleofilik katalizörler. |
| BR112013015898A2 (pt) | 2010-12-22 | 2018-06-26 | Baxter International Inc. | derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada. |
| MY190257A (en) | 2012-04-16 | 2022-04-11 | Cantab Biopharmaceuticals Patents Ltd | Optimised subcutaneous therapeutic agents |
| AU2013204754C1 (en) * | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
| MA39711A (fr) * | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
| WO2017062832A1 (en) | 2015-10-08 | 2017-04-13 | Nektar Therapeutics | Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist |
| SG11201804666QA (en) * | 2015-12-03 | 2018-06-28 | Baxalta Inc | Factor viii with extended half-life and reduced ligand-binding properties |
| JP7618383B2 (ja) | 2016-07-22 | 2025-01-21 | ネクター セラピューティクス | オキシム含有リンケージを有する第ｖｉｉｉ因子部分のコンジュゲート |
| IL270634B2 (en) | 2017-05-15 | 2025-06-01 | Nektar Therapeutics | Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods |
| US11845989B2 (en) | 2019-01-23 | 2023-12-19 | Regeneron Pharmaceuticals, Inc. | Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors |
| MX2021008797A (es) | 2019-01-23 | 2022-01-31 | Regeneron Pharma | Tratamiento de afecciones oftalmicas con inhibidores de proteinas relacionadas a angiopoyetina 7 (angptl7). |
| US11865134B2 (en) | 2021-02-26 | 2024-01-09 | Regeneron Pharmaceuticals, Inc. | Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (ANGPTL7) inhibitors |
| WO2025133203A1 (en) * | 2023-12-22 | 2025-06-26 | Pam Theragnostics Gmbh | Compounds and methods for a long-lasting pam |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54113492A (en) | 1978-02-24 | 1979-09-05 | Sanyo Chem Ind Ltd | Preparation of glucoprotein derivative |
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| US5250421A (en) | 1986-01-03 | 1993-10-05 | Genetics Institute, Inc. | Method for producing factor VIII:C-type proteins |
| US5198349A (en) | 1986-01-03 | 1993-03-30 | Genetics Institute, Inc. | Method for producing factor VIII:C and analogs |
| JPH0387173A (ja) | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体 |
| US5846951A (en) | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
| CA2124690C (en) | 1992-10-02 | 2007-09-11 | Thomas Osterberg | Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer |
| WO1994028024A1 (en) * | 1993-06-01 | 1994-12-08 | Enzon, Inc. | Carbohydrate-modified polymer conjugates with erythropoietic activity |
| US5621039A (en) | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| US5574187A (en) * | 1994-10-06 | 1996-11-12 | Uniroyal Chemical Company, Inc. | Process of preparing para substituted phenylamines |
| WO1996040662A2 (en) | 1995-06-07 | 1996-12-19 | Cellpro, Incorporated | Aminooxy-containing linker compounds and their application in conjugates |
| US6531298B2 (en) | 1997-07-21 | 2003-03-11 | The University Of North Carolina At Chapel Hill | Factor IX antihemophilic factor with increased clotting activity |
| US7074878B1 (en) | 1999-12-10 | 2006-07-11 | Harris J Milton | Hydrolytically degradable polymers and hydrogels made therefrom |
| US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
| DE60116137T2 (de) | 2000-05-16 | 2006-08-24 | Lipoxen Technologies Ltd. | Derivatisierung von proteinen in wässrigem lösungsmittel |
| US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| EP1446438A2 (en) | 2001-11-07 | 2004-08-18 | Nektar Therapeutics Al, Corporation | Branched polymers and their conjugates |
| BR0314227A (pt) | 2002-09-11 | 2005-10-25 | Fresenius Kabi De Gmbh | Derivados de amido de hidroxialquila |
| PL1620118T3 (pl) | 2003-04-08 | 2014-11-28 | Yeda Res & Dev | Leki odwracalnie pegylowane |
| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| CN1863549A (zh) * | 2003-08-08 | 2006-11-15 | 费森尤斯卡比德国有限公司 | 通过肟连接基团进行连接的聚合物和蛋白质的缀合物 |
| WO2005014655A2 (en) * | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
| BRPI0412671A (pt) | 2003-08-08 | 2006-10-03 | Fresenius Kabi De Gmbh | conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima |
| EP1654290B1 (en) | 2003-08-12 | 2019-03-13 | Lipoxen Technologies Limited | Sialic acid derivatives for protein derivatisation and conjugation |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| CN1897812B (zh) | 2003-12-03 | 2011-08-17 | 生物种属学股份公司 | 糖聚乙二醇化的粒细胞集落刺激因子 |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| EP3184551A1 (en) | 2004-08-12 | 2017-06-28 | Lipoxen Technologies Limited | Sialic acid derivatives |
| WO2006031811A2 (en) | 2004-09-10 | 2006-03-23 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
| CN101163506B (zh) | 2004-12-27 | 2012-09-26 | 巴克斯特国际公司 | 聚合物-von Willebrand因子偶联物 |
| HUE025208T2 (en) | 2005-06-16 | 2016-03-29 | Nektar Therapeutics | Conjugates with degradable binding and polymer reagents useful in the preparation of such conjugates |
| US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| WO2008025856A2 (en) * | 2006-09-01 | 2008-03-06 | Novo Nordisk Health Care Ag | Modified glycoproteins |
| CN101535339B (zh) * | 2006-09-01 | 2014-11-12 | 诺沃-诺迪斯克保健股份有限公司 | 改性糖蛋白 |
| PT2101821E (pt) | 2006-12-15 | 2014-10-03 | Baxter Int | Fator conjugado viia-ácido (poli)siálico com prolongamento do tempo de meia vida in vivo |
| WO2009028573A1 (ja) * | 2007-08-27 | 2009-03-05 | National University Corporation Nagoya University | 血液凝固障害におけるリバビリンの利用 |
| GB0908393D0 (en) * | 2009-05-15 | 2009-06-24 | Almac Sciences Scotland Ltd | Labelling method |
| JP5909755B2 (ja) * | 2009-07-27 | 2016-04-27 | リポクセン テクノロジーズ リミテッド | 非血液凝固タンパク質の糖ポリシアル酸化 |
| ES2597954T3 (es) * | 2009-07-27 | 2017-01-24 | Baxalta GmbH | Conjugados de proteína de la coagulación sanguínea |
| JP2013500726A (ja) * | 2009-07-31 | 2013-01-10 | バイエル・ヘルスケア・エルエルシー | 改変第ｉｘ因子ポリペプチドおよびその使用 |
| TR201908836T4 (tr) * | 2010-07-30 | 2019-07-22 | Baxalta GmbH | Oksim bağına yönelik nükleofilik katalizörler. |
-
2011
- 2011-07-29 TR TR2019/08836T patent/TR201908836T4/tr unknown
- 2011-07-29 EA EA201691292A patent/EA201691292A1/ru unknown
- 2011-07-29 LT LTEP11741727.9T patent/LT2598172T/lt unknown
- 2011-07-29 PT PT11741727T patent/PT2598172T/pt unknown
- 2011-07-29 KR KR1020207030594A patent/KR102229967B1/ko active Active
- 2011-07-29 NZ NZ60597211A patent/NZ605972A/en unknown
- 2011-07-29 SI SI201131742T patent/SI2598172T1/sl unknown
- 2011-07-29 CN CN201810089901.0A patent/CN108079311A/zh active Pending
- 2011-07-29 WO PCT/US2011/045873 patent/WO2012016131A1/en not_active Ceased
- 2011-07-29 SG SG10201913078SA patent/SG10201913078SA/en unknown
- 2011-07-29 SG SG2013005160A patent/SG187171A1/en unknown
- 2011-07-29 AU AU2011282571A patent/AU2011282571C1/en active Active
- 2011-07-29 AR ARP110102758A patent/AR082941A1/es active IP Right Grant
- 2011-07-29 SM SM20190351T patent/SMT201900351T1/it unknown
- 2011-07-29 KR KR1020197010071A patent/KR102088852B1/ko active Active
- 2011-07-29 KR KR1020137004971A patent/KR101969601B1/ko active Active
- 2011-07-29 HR HRP20190990TT patent/HRP20190990T1/hr unknown
- 2011-07-29 ES ES11741727T patent/ES2731626T3/es active Active
- 2011-07-29 HU HUE11741727A patent/HUE043790T2/hu unknown
- 2011-07-29 TW TW100126974A patent/TWI534152B/zh active
- 2011-07-29 EP EP18208032.5A patent/EP3505186B1/en active Active
- 2011-07-29 RS RS20190779A patent/RS58900B1/sr unknown
- 2011-07-29 KR KR1020217018874A patent/KR102325780B1/ko active Active
- 2011-07-29 EP EP11741727.9A patent/EP2598172B1/en active Active
- 2011-07-29 CN CN2011800476351A patent/CN103370082A/zh active Pending
- 2011-07-29 KR KR1020217007514A patent/KR102269494B1/ko active Active
- 2011-07-29 CN CN201810090885.7A patent/CN108079312A/zh active Pending
- 2011-07-29 JP JP2013521998A patent/JP6325818B2/ja active Active
- 2011-07-29 EP EP21207146.8A patent/EP4023247A1/en active Pending
- 2011-07-29 DK DK11741727.9T patent/DK2598172T3/da active
- 2011-07-29 KR KR1020207006813A patent/KR102172133B1/ko active Active
- 2011-07-29 MX MX2013001261A patent/MX346271B/es active IP Right Grant
- 2011-07-29 BR BR112013001611-6A patent/BR112013001611B1/pt active IP Right Grant
- 2011-07-29 CA CA2806684A patent/CA2806684C/en active Active
- 2011-07-29 PL PL11741727T patent/PL2598172T3/pl unknown
- 2011-07-29 EA EA201300190A patent/EA025738B9/ru not_active IP Right Cessation
-
2015
- 2015-06-11 JP JP2015118007A patent/JP2015164958A/ja not_active Withdrawn
-
2017
- 2017-05-19 JP JP2017099807A patent/JP2017137358A/ja not_active Withdrawn
-
2019
- 2019-03-28 JP JP2019064338A patent/JP2019116501A/ja not_active Withdrawn
- 2019-03-28 JP JP2019064337A patent/JP6757823B2/ja active Active
- 2019-06-19 CY CY20191100632T patent/CY1121943T1/el unknown
-
2020
- 2020-11-26 JP JP2020196260A patent/JP7054407B2/ja active Active
-
2021
- 2021-12-27 JP JP2021212106A patent/JP7258999B2/ja active Active
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