JP2013535438A - トラマドールのジクロフェナク塩 - Google Patents

トラマドールのジクロフェナク塩 Download PDF

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Publication number
JP2013535438A
JP2013535438A JP2013519738A JP2013519738A JP2013535438A JP 2013535438 A JP2013535438 A JP 2013535438A JP 2013519738 A JP2013519738 A JP 2013519738A JP 2013519738 A JP2013519738 A JP 2013519738A JP 2013535438 A JP2013535438 A JP 2013535438A
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JP
Japan
Prior art keywords
pain
solvent
tramadol
diclofenac
compound
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JP2013519738A
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English (en)
Japanese (ja)
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JP2013535438A5 (enExample
Inventor
チャ−フイ チェン
ユ−リャン ファン
リャン−レーン クン
ミン−チャン ヤン
Original Assignee
ユン シン ファーマシューティカル インダストリアル カンパニー，リミティド
カールスバッド テクノロジー，インコーポレイテッド
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Application filed by ユン シン ファーマシューティカル インダストリアル カンパニー，リミティド, カールスバッド テクノロジー，インコーポレイテッド filed Critical ユン シン ファーマシューティカル インダストリアル カンパニー，リミティド
Publication of JP2013535438A publication Critical patent/JP2013535438A/ja
Publication of JP2013535438A5 publication Critical patent/JP2013535438A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
    • C07C211/55—Diphenylamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013519738A 2010-07-12 2011-07-11 トラマドールのジクロフェナク塩 Pending JP2013535438A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36334410P 2010-07-12 2010-07-12
US61/363,344 2010-07-12
PCT/US2011/043528 WO2012009262A2 (en) 2010-07-12 2011-07-11 Diclofenac salt of tramadol

Publications (2)

Publication Number Publication Date
JP2013535438A true JP2013535438A (ja) 2013-09-12
JP2013535438A5 JP2013535438A5 (enExample) 2014-08-28

Family

ID=45470017

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013519738A Pending JP2013535438A (ja) 2010-07-12 2011-07-11 トラマドールのジクロフェナク塩

Country Status (9)

Country Link
US (1) US20130065957A1 (enExample)
EP (1) EP2593096A4 (enExample)
JP (1) JP2013535438A (enExample)
KR (1) KR20130129070A (enExample)
CN (1) CN102970989A (enExample)
PH (1) PH12012502484A1 (enExample)
SG (1) SG185642A1 (enExample)
TW (1) TW201206421A (enExample)
WO (1) WO2012009262A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021127301A (ja) * 2020-02-12 2021-09-02 久光製薬株式会社 ジクロフェナクナトリウム含有貼付剤
JP2021127299A (ja) * 2020-02-12 2021-09-02 久光製薬株式会社 ジクロフェナクナトリウム含有貼付剤
US11872320B2 (en) 2021-02-25 2024-01-16 Hisamitsu Pharmaceutical Co., Inc. Method for treating osteoarthritis
US12178922B2 (en) 2016-12-28 2024-12-31 Hisamitsu Pharmaceutical Co., Inc. Patch with DMSO in adhesive layer

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022014395A1 (ja) * 2020-07-13 2022-01-20 日本碍子株式会社 精製方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003502360A (ja) * 1999-06-17 2003-01-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング トラマドールとジクロフェナクの固定組合せ物を投与するための経口投与形
JP2003502358A (ja) * 1999-06-17 2003-01-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング トラマドールとジクロフェナクの固定組合せ物を投与するための多層錠剤
JP2003508428A (ja) * 1999-08-31 2003-03-04 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 徐放される経口医薬投薬形
JP2004514692A (ja) * 2000-11-28 2004-05-20 グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング トラマドールとジクロフェナクの塩の懸濁液を含有する非経口投与可能な剤形
WO2008093686A1 (ja) * 2007-01-29 2008-08-07 Medrx Co., Ltd. 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途
WO2010043412A1 (en) * 2008-10-17 2010-04-22 Laboratorios Del Dr. Esteve, S.A. Co-crystals of tramadol and nsaids

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003502360A (ja) * 1999-06-17 2003-01-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング トラマドールとジクロフェナクの固定組合せ物を投与するための経口投与形
JP2003502358A (ja) * 1999-06-17 2003-01-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング トラマドールとジクロフェナクの固定組合せ物を投与するための多層錠剤
JP2003508428A (ja) * 1999-08-31 2003-03-04 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 徐放される経口医薬投薬形
JP2004514692A (ja) * 2000-11-28 2004-05-20 グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング トラマドールとジクロフェナクの塩の懸濁液を含有する非経口投与可能な剤形
WO2008093686A1 (ja) * 2007-01-29 2008-08-07 Medrx Co., Ltd. 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途
WO2010043412A1 (en) * 2008-10-17 2010-04-22 Laboratorios Del Dr. Esteve, S.A. Co-crystals of tramadol and nsaids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
平山令明, 有機化合物結晶作製ハンドブック, JPN6014035600, 2008, pages 17 - 23, ISSN: 0003215170 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12178922B2 (en) 2016-12-28 2024-12-31 Hisamitsu Pharmaceutical Co., Inc. Patch with DMSO in adhesive layer
JP2021127301A (ja) * 2020-02-12 2021-09-02 久光製薬株式会社 ジクロフェナクナトリウム含有貼付剤
JP2021127299A (ja) * 2020-02-12 2021-09-02 久光製薬株式会社 ジクロフェナクナトリウム含有貼付剤
US11872320B2 (en) 2021-02-25 2024-01-16 Hisamitsu Pharmaceutical Co., Inc. Method for treating osteoarthritis

Also Published As

Publication number Publication date
PH12012502484A1 (en) 2013-03-25
SG185642A1 (en) 2012-12-28
KR20130129070A (ko) 2013-11-27
WO2012009262A3 (en) 2012-04-19
WO2012009262A2 (en) 2012-01-19
EP2593096A2 (en) 2013-05-22
US20130065957A1 (en) 2013-03-14
TW201206421A (en) 2012-02-16
EP2593096A4 (en) 2014-02-26
CN102970989A (zh) 2013-03-13

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