SG185642A1 - Diclofenac salt of tramadol - Google Patents
Diclofenac salt of tramadol Download PDFInfo
- Publication number
- SG185642A1 SG185642A1 SG2012084810A SG2012084810A SG185642A1 SG 185642 A1 SG185642 A1 SG 185642A1 SG 2012084810 A SG2012084810 A SG 2012084810A SG 2012084810 A SG2012084810 A SG 2012084810A SG 185642 A1 SG185642 A1 SG 185642A1
- Authority
- SG
- Singapore
- Prior art keywords
- pain
- tramadol
- solvent
- diclofenac
- compound
- Prior art date
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- 229960004380 tramadol Drugs 0.000 title claims description 70
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title claims description 69
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
- C07C211/55—Diphenylamines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US36334410P | 2010-07-12 | 2010-07-12 | |
| PCT/US2011/043528 WO2012009262A2 (en) | 2010-07-12 | 2011-07-11 | Diclofenac salt of tramadol |
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| SG185642A1 true SG185642A1 (en) | 2012-12-28 |
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| SG2012084810A SG185642A1 (en) | 2010-07-12 | 2011-07-11 | Diclofenac salt of tramadol |
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| Country | Link |
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| US (1) | US20130065957A1 (enExample) |
| EP (1) | EP2593096A4 (enExample) |
| JP (1) | JP2013535438A (enExample) |
| KR (1) | KR20130129070A (enExample) |
| CN (1) | CN102970989A (enExample) |
| PH (1) | PH12012502484A1 (enExample) |
| SG (1) | SG185642A1 (enExample) |
| TW (1) | TW201206421A (enExample) |
| WO (1) | WO2012009262A2 (enExample) |
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| JP7069042B2 (ja) | 2016-12-28 | 2022-05-17 | 久光製薬株式会社 | 貼付剤 |
| JP6744512B1 (ja) * | 2020-02-12 | 2020-08-19 | 久光製薬株式会社 | ジクロフェナクナトリウム含有貼付剤 |
| JP6761553B1 (ja) * | 2020-02-12 | 2020-09-23 | 久光製薬株式会社 | ジクロフェナクナトリウム含有貼付剤 |
| WO2022014396A1 (ja) * | 2020-07-13 | 2022-01-20 | 日本碍子株式会社 | 精製方法 |
| US11872320B2 (en) | 2021-02-25 | 2024-01-16 | Hisamitsu Pharmaceutical Co., Inc. | Method for treating osteoarthritis |
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|---|---|---|---|---|
| DE19927689A1 (de) * | 1999-06-17 | 2000-12-21 | Gruenenthal Gmbh | Orale Darreichungsformen zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac |
| DE19927688A1 (de) * | 1999-06-17 | 2000-12-21 | Gruenenthal Gmbh | Mehrschichttablette zur Verabreichung einer fixen Kombination von Tramadol und Diclofenac |
| DE19940944B4 (de) * | 1999-08-31 | 2006-10-12 | Grünenthal GmbH | Retardierte, orale, pharmazeutische Darreichungsformen |
| DE10059020A1 (de) * | 2000-11-28 | 2002-05-29 | Gruenenthal Gmbh | Parenteral applizierbare Darreichungsformen |
| WO2008093686A1 (ja) * | 2007-01-29 | 2008-08-07 | Medrx Co., Ltd. | 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途 |
| EP2177215A1 (en) * | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
-
2011
- 2011-07-11 SG SG2012084810A patent/SG185642A1/en unknown
- 2011-07-11 EP EP11807342.8A patent/EP2593096A4/en not_active Withdrawn
- 2011-07-11 PH PH1/2012/502484A patent/PH12012502484A1/en unknown
- 2011-07-11 CN CN2011800318362A patent/CN102970989A/zh active Pending
- 2011-07-11 KR KR1020127032253A patent/KR20130129070A/ko not_active Withdrawn
- 2011-07-11 WO PCT/US2011/043528 patent/WO2012009262A2/en not_active Ceased
- 2011-07-11 JP JP2013519738A patent/JP2013535438A/ja active Pending
- 2011-07-12 TW TW100124569A patent/TW201206421A/zh unknown
-
2012
- 2012-11-01 US US13/666,786 patent/US20130065957A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW201206421A (en) | 2012-02-16 |
| PH12012502484A1 (en) | 2013-03-25 |
| WO2012009262A3 (en) | 2012-04-19 |
| CN102970989A (zh) | 2013-03-13 |
| WO2012009262A2 (en) | 2012-01-19 |
| KR20130129070A (ko) | 2013-11-27 |
| US20130065957A1 (en) | 2013-03-14 |
| EP2593096A4 (en) | 2014-02-26 |
| JP2013535438A (ja) | 2013-09-12 |
| EP2593096A2 (en) | 2013-05-22 |
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