JP2013535209A5 - - Google Patents
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- Publication number
- JP2013535209A5 JP2013535209A5 JP2013522265A JP2013522265A JP2013535209A5 JP 2013535209 A5 JP2013535209 A5 JP 2013535209A5 JP 2013522265 A JP2013522265 A JP 2013522265A JP 2013522265 A JP2013522265 A JP 2013522265A JP 2013535209 A5 JP2013535209 A5 JP 2013535209A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- seq
- primer
- nucleic acid
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 16
- 150000007523 nucleic acids Chemical group 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108010067902 Peptide Library Proteins 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 230000006044 T cell activation Effects 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims 3
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims 3
- 239000007795 chemical reaction product Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000030741 antigen processing and presentation Effects 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10008233.8 | 2010-08-06 | ||
| EP10008233 | 2010-08-06 | ||
| PCT/EP2011/063538 WO2012017081A1 (en) | 2010-08-06 | 2011-08-05 | Identification of t cell target antigens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016197135A Division JP2017038609A (ja) | 2010-08-06 | 2016-10-05 | Ｔ細胞の標的抗原の同定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013535209A JP2013535209A (ja) | 2013-09-12 |
| JP2013535209A5 true JP2013535209A5 (enExample) | 2014-08-28 |
| JP6192537B2 JP6192537B2 (ja) | 2017-09-06 |
Family
ID=44023005
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013522265A Expired - Fee Related JP6192537B2 (ja) | 2010-08-06 | 2011-08-05 | Ｔ細胞の標的抗原の同定 |
| JP2016197135A Withdrawn JP2017038609A (ja) | 2010-08-06 | 2016-10-05 | Ｔ細胞の標的抗原の同定 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016197135A Withdrawn JP2017038609A (ja) | 2010-08-06 | 2016-10-05 | Ｔ細胞の標的抗原の同定 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9678061B2 (enExample) |
| EP (3) | EP2982766B1 (enExample) |
| JP (2) | JP6192537B2 (enExample) |
| CA (1) | CA2806440A1 (enExample) |
| WO (1) | WO2012017081A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3059337T3 (da) | 2009-01-15 | 2019-07-22 | Adaptive Biotechnologies Corp | Adaptive immunity profiling og metoder til frembringelse af monoklonale antibodier |
| CA3114877C (en) * | 2011-09-15 | 2023-09-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing hla-a1- or hla-cw7-restricted mage |
| EP3388535B1 (en) * | 2011-12-09 | 2021-03-24 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| JP6362543B2 (ja) | 2012-02-23 | 2018-07-25 | ジュノ セラピューティクス ゲーエムベーハー | 細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離 |
| DK2823060T3 (en) * | 2012-03-05 | 2018-05-28 | Adaptive Biotechnologies Corp | Determination of associated immune receptor chains from frequency-matched subunits |
| EP3091089B1 (en) | 2012-05-08 | 2019-01-23 | Adaptive Biotechnologies Corporation | Method for measuring and calibrating amplification bias in multiplexed pcr reactions |
| US20140065629A1 (en) * | 2012-08-29 | 2014-03-06 | Israel Barken | Methods of treating diseases |
| US20140065098A1 (en) * | 2012-08-29 | 2014-03-06 | Israel Barken | Method to augment immune system in response to disease or injury |
| US10150996B2 (en) | 2012-10-19 | 2018-12-11 | Adaptive Biotechnologies Corp. | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US20140356318A1 (en) * | 2013-05-28 | 2014-12-04 | Israel Barken | Adoptive cell therapy with specific regulatory lymphocytes |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| JP6164759B2 (ja) | 2013-11-21 | 2017-07-19 | Ｒｅｐｅｒｔｏｉｒｅ Ｇｅｎｅｓｉｓ株式会社 | Ｔ細胞受容体およびｂ細胞受容体レパトアの解析システムならびにその治療および診断への利用 |
| WO2015143558A1 (en) | 2014-03-27 | 2015-10-01 | British Columbia Cancer Agency Branch | T-cell epitope identification |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| LT3132247T (lt) | 2014-04-16 | 2021-12-10 | Juno Therapeutics Gmbh | Ląstelių populiacijos padauginimo būdai, rinkiniai ir priemonės |
| IL313845A (en) | 2014-04-23 | 2024-08-01 | Juno Therapeutics Inc | Methods for enriching or producing immune cell populations for adoptive therapy |
| EP3172325B1 (en) | 2014-07-22 | 2023-06-28 | The University of Notre Dame du Lac | Molecular constructs and uses thereof |
| CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| US11047008B2 (en) | 2015-02-24 | 2021-06-29 | Adaptive Biotechnologies Corporation | Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing |
| WO2016161273A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| EP3112375A1 (en) | 2015-07-03 | 2017-01-04 | Ludwig-Maximilians-Universität München | Antigenic peptides for the diagnosis, therapy monitoring and/or treatment of psoriasis vulgaris |
| US10928392B2 (en) * | 2015-09-25 | 2021-02-23 | Abvitro Llc | High throughput process for T cell receptor target identification of natively-paired T cell receptor sequences |
| HK1258932A1 (zh) | 2015-10-22 | 2019-11-22 | Juno Therapeutics Gmbh | 用於转导的方法、反应剂盒、反应剂和设备 |
| US11466253B2 (en) | 2015-10-22 | 2022-10-11 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| CN108474791B (zh) | 2015-10-22 | 2022-07-08 | 朱诺治疗学有限公司 | 培养细胞的方法及用于该方法的试剂盒和设备 |
| US20180320230A1 (en) * | 2015-10-27 | 2018-11-08 | Arizona Board Of Regents On Behalf Of Arizona State University | High throughput identification of t-cell recognition antigens and epitopes |
| CN108884140B (zh) | 2015-12-03 | 2022-10-25 | 朱诺治疗学股份有限公司 | 修饰的嵌合受体及相关组合物和方法 |
| CA3036992A1 (en) * | 2016-09-16 | 2018-03-22 | Memorial Sloan Kettering Cancer Center | Methods and compositions for t-cell epitope screening |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| JP7582779B2 (ja) * | 2016-11-07 | 2024-11-13 | ジェノヴィー エービー | Ｔ細胞レセプターの同族抗原との相互作用の発見及び特徴決定のための遺伝子操作された二部構成細胞デバイス |
| CA3039420A1 (en) | 2016-11-07 | 2018-05-11 | Genovie Ab | A two-part device for t-cell receptor synthesis and stable genomic integration to tcr-presenting cells |
| CA3038917A1 (en) | 2016-11-07 | 2018-05-11 | Genovie Ab | An engineered multi-component system for identification and characterisation of t-cell receptors and t-cell antigens |
| MA49288A (fr) | 2017-04-27 | 2020-03-04 | Juno Therapeutics Gmbh | Reactifs particulaires oligomères et leurs méthodes d'utilisation |
| WO2018213803A1 (en) * | 2017-05-19 | 2018-11-22 | Neon Therapeutics, Inc. | Immunogenic neoantigen identification |
| KR20200063215A (ko) | 2017-10-06 | 2020-06-04 | 오슬로 유니버시테시케후스 에이치에프 | 키메라 항원 수용체 |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| SG11202010262TA (en) | 2018-04-19 | 2020-11-27 | Baylor College Medicine | Reprogramming cd4 t cells into cytotoxic cd8 cells by forced expression of cd8ab and class 1 restricted t cell receptors |
| SG11202101204TA (en) | 2018-08-09 | 2021-03-30 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| EP3842550A4 (en) * | 2018-08-24 | 2022-06-29 | Repertoire Genesis Incorporation | Method for analyzing functional subunit pair gene of t cell receptor and b cell receptor |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
| CN114807125B (zh) * | 2022-05-20 | 2023-09-12 | 纳昂达(南京)生物科技有限公司 | 测序文库接头、测序文库及其构建方法、提升ngs建库连接效率的方法 |
| CN121100267A (zh) | 2022-12-09 | 2025-12-09 | 朱诺治疗学股份有限公司 | 使用全息成像预测细胞表型的机器学习方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037135A (en) | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
| US20010053523A1 (en) * | 1995-06-02 | 2001-12-20 | M&E Biotech A/S. | Method for identification of biologically active peptides and nucleic acids |
| WO1997029183A2 (en) * | 1996-02-08 | 1997-08-14 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for transforming dendritic cells and activating t cells |
| US6429286B1 (en) | 1997-04-16 | 2002-08-06 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Immunoregulatory molecules for costimulatory signal transduction |
| US6872518B2 (en) * | 1997-09-22 | 2005-03-29 | University Of Rochester | Methods for selecting polynucleotides encoding T cell epitopes |
| DE10009341A1 (de) * | 2000-02-22 | 2001-09-06 | Florian Kern | Verfahren zur antigen-spezifischen Stimulation von T-Lymphozyten |
| JP4812951B2 (ja) | 2001-03-21 | 2011-11-09 | 一般財団法人化学及血清療法研究所 | 特異性不明のｔ細胞のクローン化法及びその認識ペプチドリガンドの同定方法 |
| ATE388448T1 (de) | 2001-04-13 | 2008-03-15 | Inst Nat Sante Rech Med | Verfahren zur analyse von t-lymphozyten über die t-lymphozytrezeptoren eines organismus |
| US20030003485A1 (en) * | 2001-05-15 | 2003-01-02 | Ludwig Institute For Cancer Research | Methods for identifying antigens |
| WO2003068800A2 (en) | 2002-02-13 | 2003-08-21 | Ludwig Institute For Cancer Research | Isolated peptides which bind to hla molecules and uses thereof |
| AU2006311255A1 (en) * | 2005-11-10 | 2007-05-18 | The University Of Chicago | HCV-reactiveT cell receptors |
| JP5292550B2 (ja) * | 2007-03-23 | 2013-09-18 | 静岡県 | Ｔ細胞レセプターβ鎖遺伝子及びα鎖遺伝子 |
| GB0712670D0 (en) * | 2007-06-29 | 2007-08-08 | King S College London | Isolated peptides and uses thereof |
| WO2009137255A2 (en) * | 2008-04-16 | 2009-11-12 | Hudsonalpha Institute For Biotechnology | Method for evaluating and comparing immunorepertoires |
| US7892202B2 (en) | 2008-05-09 | 2011-02-22 | Merit Medical Systems, Inc. | System and method for inflation syringe with improved display |
| EP2364368B1 (en) * | 2008-11-07 | 2014-01-15 | Sequenta, Inc. | Methods of monitoring conditions by sequence analysis |
-
2011
- 2011-08-05 EP EP15181740.0A patent/EP2982766B1/en not_active Not-in-force
- 2011-08-05 EP EP18165023.5A patent/EP3376225A1/en not_active Withdrawn
- 2011-08-05 JP JP2013522265A patent/JP6192537B2/ja not_active Expired - Fee Related
- 2011-08-05 US US13/814,263 patent/US9678061B2/en not_active Expired - Fee Related
- 2011-08-05 CA CA2806440A patent/CA2806440A1/en not_active Abandoned
- 2011-08-05 WO PCT/EP2011/063538 patent/WO2012017081A1/en not_active Ceased
- 2011-08-05 EP EP11739098.9A patent/EP2601521B1/en not_active Not-in-force
-
2016
- 2016-10-05 JP JP2016197135A patent/JP2017038609A/ja not_active Withdrawn
-
2017
- 2017-05-05 US US15/587,636 patent/US20170240884A1/en not_active Abandoned
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