JP2012516686A5 - - Google Patents
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- Publication number
- JP2012516686A5 JP2012516686A5 JP2011548377A JP2011548377A JP2012516686A5 JP 2012516686 A5 JP2012516686 A5 JP 2012516686A5 JP 2011548377 A JP2011548377 A JP 2011548377A JP 2011548377 A JP2011548377 A JP 2011548377A JP 2012516686 A5 JP2012516686 A5 JP 2012516686A5
- Authority
- JP
- Japan
- Prior art keywords
- cftr
- cell
- seq
- nucleic acid
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 47
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 238000004113 cell culture Methods 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- SRZQYTPACFNBMN-UHFFFAOYSA-N n-[5-[2-(2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide;hydrobromide Chemical compound Br.COC1=CC=CC=C1NC1=NC(C2=C(N=C(NC(=O)C=3C=CC=CC=3)S2)C)=CS1 SRZQYTPACFNBMN-UHFFFAOYSA-N 0.000 claims 1
- 230000001766 physiological effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14931209P | 2009-02-02 | 2009-02-02 | |
| US61/149,312 | 2009-02-02 | ||
| PCT/US2010/022778 WO2010088630A2 (en) | 2009-02-02 | 2010-02-01 | Cell lines expressing cftr and methods of using them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012516686A JP2012516686A (ja) | 2012-07-26 |
| JP2012516686A5 true JP2012516686A5 (enExample) | 2013-03-21 |
Family
ID=42396394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548377A Pending JP2012516686A (ja) | 2009-02-02 | 2010-02-01 | Ｃｆｔｒを発現する細胞株およびそれらを使用する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20120058918A1 (enExample) |
| EP (1) | EP2393930A4 (enExample) |
| JP (1) | JP2012516686A (enExample) |
| CA (1) | CA2751215A1 (enExample) |
| MX (1) | MX2011008131A (enExample) |
| WO (1) | WO2010088630A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100297674A1 (en) * | 2008-01-22 | 2010-11-25 | Chromocell Corporation | NOVEL CELL LINES EXPRESSING NaV AND METHODS USING THEM |
| NZ601353A (en) * | 2008-02-01 | 2014-06-27 | Chromocell Corp | Cell lines and methods for making and using them |
| US8945848B2 (en) | 2009-07-31 | 2015-02-03 | Chromocell Corporation | Methods and compositions for identifying and validating modulators of cell fate |
| US20120302573A1 (en) * | 2011-05-25 | 2012-11-29 | Paul Francis Jackson | Methods of inhibiting pro matrix metalloproteinase activation |
| US20130014288A1 (en) * | 2011-06-06 | 2013-01-10 | Carnegie Mellon University | Novel reporter-tagged recombinant membrane proteins with transmembrane linkers |
| FR2999191B1 (fr) * | 2012-12-12 | 2016-02-05 | Lesaffre & Cie | Souches probiotiques pour le traitement et/ou la prevention de la diarrhee |
| AU2017264612A1 (en) * | 2016-05-09 | 2018-11-22 | Proteostasis Therapeutics, Inc. | Methods of identifying CFTR modulators |
| EP3684463B1 (en) | 2017-09-19 | 2025-05-14 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11318277B2 (en) | 2017-12-31 | 2022-05-03 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| US11452839B2 (en) | 2018-09-14 | 2022-09-27 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| CN111910008B (zh) * | 2020-08-21 | 2022-05-31 | 云南农业大学 | 一种鸡生长发育相关的分子标记及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020164782A1 (en) * | 1999-02-10 | 2002-11-07 | Gregory Richard J. | Adenovirus vectors for gene therapy |
| WO2001003722A1 (en) * | 1999-07-09 | 2001-01-18 | Mayo Foundation For Medical Education And Research | Cftr polypeptides, fragments thereof and methods of use to overcome biosynthetic misprocessing |
| WO2004020596A2 (en) * | 2002-08-30 | 2004-03-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Polypeptides for increasing mutant cftr channel activity |
| WO2005120497A2 (en) * | 2004-06-04 | 2005-12-22 | The Regents Of The University Of California | Compounds having activity in increasing ion transport by mutant-cftr and uses thereof |
| CA2600869A1 (en) * | 2005-03-18 | 2006-09-28 | The Regents Of The University Of California | Compounds having activity in correcting mutant-cftr processing and uses thereof |
| KR101599062B1 (ko) * | 2005-04-13 | 2016-03-02 | 아스트라제네카 아베 | 감마 카르복실화를 필요로 하는 단백질 생산용 벡터를 포함하는 숙주 세포 |
| JP2009537179A (ja) * | 2006-05-19 | 2009-10-29 | ザ スクリップス リサーチ インスティテュート | 蛋白質ミスフォールディングの処置 |
| US7989675B2 (en) * | 2007-03-28 | 2011-08-02 | University Of Iowa Research Foundation | Method of identifying compounds using a transgenic pig model of cystic fibrosis |
-
2010
- 2010-02-01 WO PCT/US2010/022778 patent/WO2010088630A2/en not_active Ceased
- 2010-02-01 US US13/147,327 patent/US20120058918A1/en not_active Abandoned
- 2010-02-01 JP JP2011548377A patent/JP2012516686A/ja active Pending
- 2010-02-01 EP EP10736545A patent/EP2393930A4/en not_active Withdrawn
- 2010-02-01 CA CA2751215A patent/CA2751215A1/en not_active Abandoned
- 2010-02-01 MX MX2011008131A patent/MX2011008131A/es not_active Application Discontinuation
-
2014
- 2014-11-24 US US14/552,192 patent/US20150315554A1/en not_active Abandoned
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