JP2012514983A5 - - Google Patents

Info

Publication number

JP2012514983A5

JP2012514983A5 JP2011545540A JP2011545540A JP2012514983A5 JP 2012514983 A5 JP2012514983 A5 JP 2012514983A5 JP 2011545540 A JP2011545540 A JP 2011545540A JP 2011545540 A JP2011545540 A JP 2011545540A JP 2012514983 A5 JP2012514983 A5 JP 2012514983A5

Authority

JP

Japan

Prior art keywords

cell

composition

cells

pluripotent

cultured

Prior art date

2010-01-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 210000004027 cell Anatomy 0.000 claims 26
• 239000000203 mixture Substances 0.000 claims 21
• 238000000034 method Methods 0.000 claims 13
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 7
• 208000015122 neurodegenerative disease Diseases 0.000 claims 7
• 229930002330 retinoic acid Natural products 0.000 claims 7
• 229960001727 tretinoin Drugs 0.000 claims 7
• 108020004999 messenger RNA Proteins 0.000 claims 6
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 5
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 5
• 102000007469 Actins Human genes 0.000 claims 4
• 108010085238 Actins Proteins 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 4
• 210000004748 cultured cell Anatomy 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 230000004770 neurodegeneration Effects 0.000 claims 3
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims 2
• 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 206010003246 arthritis Diseases 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 210000000130 stem cell Anatomy 0.000 claims 2
• 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 1
• 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
• 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
• 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 1
• 102000003729 Neprilysin Human genes 0.000 claims 1
• 108090000028 Neprilysin Proteins 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
• GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 claims 1
• 108010081355 beta 2-Microglobulin Proteins 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 229940000406 drug candidate Drugs 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 210000004698 lymphocyte Anatomy 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 238000010186 staining Methods 0.000 claims 1
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 1
• 239000000725 suspension Substances 0.000 claims 1