JP2013534244A5 - - Google Patents
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- Publication number
- JP2013534244A5 JP2013534244A5 JP2013524832A JP2013524832A JP2013534244A5 JP 2013534244 A5 JP2013534244 A5 JP 2013534244A5 JP 2013524832 A JP2013524832 A JP 2013524832A JP 2013524832 A JP2013524832 A JP 2013524832A JP 2013534244 A5 JP2013534244 A5 JP 2013534244A5
- Authority
- JP
- Japan
- Prior art keywords
- depot
- item
- water
- viscosity modifier
- emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 57
- 239000000243 solution Substances 0.000 claims description 25
- 239000004034 viscosity adjusting agent Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 17
- 239000000839 emulsion Substances 0.000 claims description 17
- 108010059993 Vancomycin Proteins 0.000 claims description 13
- 239000013543 active substance Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 239000003921 oil Substances 0.000 claims description 9
- 150000003904 phospholipids Chemical class 0.000 claims description 9
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 8
- 229930182566 Gentamicin Natural products 0.000 claims description 8
- 229960002518 gentamicin Drugs 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 229960003165 vancomycin Drugs 0.000 claims description 8
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 8
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- RDEIXVOBVLKYNT-VQBXQJRRSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]o Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)C(C)N)N)[C@@H](N)C[C@H]1N.O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-VQBXQJRRSA-N 0.000 claims description 5
- 239000007764 o/w emulsion Substances 0.000 claims description 5
- 239000003002 pH adjusting agent Substances 0.000 claims description 5
- 229960001572 vancomycin hydrochloride Drugs 0.000 claims description 5
- LCTORFDMHNKUSG-XTTLPDOESA-N vancomycin monohydrochloride Chemical compound Cl.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 LCTORFDMHNKUSG-XTTLPDOESA-N 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- 208000031650 Surgical Wound Infection Diseases 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- 229960002885 histidine Drugs 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- 235000006109 methionine Nutrition 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960004452 methionine Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940060184 oil ingredients Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37550210P | 2010-08-20 | 2010-08-20 | |
| US61/375,502 | 2010-08-20 | ||
| PCT/US2010/061015 WO2012023955A1 (en) | 2010-08-20 | 2010-12-17 | Phospholipid depot |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013534244A JP2013534244A (ja) | 2013-09-02 |
| JP2013534244A5 true JP2013534244A5 (cg-RX-API-DMAC7.html) | 2014-01-30 |
| JP5752248B2 JP5752248B2 (ja) | 2015-07-22 |
Family
ID=43928096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524832A Expired - Fee Related JP5752248B2 (ja) | 2010-08-20 | 2010-12-17 | リン脂質デポー |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9132144B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2605751A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5752248B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101793101B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103179951B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010359346B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013003934A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2809022C (cg-RX-API-DMAC7.html) |
| MX (1) | MX366099B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ608210A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2595865C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012023955A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201301833B (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11090444B2 (en) | 2018-06-15 | 2021-08-17 | James T. Doubet | Syringe adapter for medication |
| US11097058B2 (en) | 2018-06-15 | 2021-08-24 | James T. Doubet | Syringe adapter for medication |
| US11337894B2 (en) | 2018-06-15 | 2022-05-24 | James T. Doubet | Syringe adapter for animal medication |
| US10709850B2 (en) | 2018-06-15 | 2020-07-14 | James T. Doubet | Syringe adapter for medication |
| DK1962805T3 (en) | 2005-12-08 | 2016-09-26 | Insmed Inc | Lipid-based compositions of the anti-infective agents for the treatment of lung infections |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| CA2809022C (en) * | 2010-08-20 | 2017-01-03 | Dr. Reddy`S Laboratories, Inc. | Phospholipid depot |
| CA2814577C (en) * | 2010-10-22 | 2019-06-04 | Dr. Reddy`S Laboratories, Inc. | Use of storage stable viscous phospholipid depot to treat wounds |
| EP2846773A4 (en) | 2012-05-10 | 2015-12-30 | Painreform Ltd | DEPOT FORMULATIONS OF A LOCAL ANESTHETICS AND METHOD FOR THE MANUFACTURE THEREOF |
| CA2891487A1 (en) | 2012-11-29 | 2014-06-05 | Insmed Incorporated | Stabilized vancomycin formulations |
| AU2015247588B2 (en) * | 2014-04-16 | 2018-08-30 | Biomet Manufacturing, Llc | Methods for coating implant surfaces to treat surgical infections |
| CN106456704A (zh) | 2014-04-16 | 2017-02-22 | Veyx-药物有限公司 | 兽药组合物和其应用 |
| CA2945181C (en) | 2014-04-28 | 2022-10-18 | Orphomed, Inc. | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
| ES2926985T3 (es) | 2014-05-15 | 2022-10-31 | Insmed Inc | Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas |
| CA3003151A1 (en) * | 2015-11-18 | 2017-05-26 | Insmed Incorporated | Compositions and methods for treating bacterial infections |
| CN107522735A (zh) * | 2017-09-21 | 2017-12-29 | 安徽元创科技有限公司 | 以溶剂法生产低粘度磷脂产品的方法 |
| US11571386B2 (en) | 2018-03-30 | 2023-02-07 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| US20190388625A1 (en) | 2018-06-15 | 2019-12-26 | James T. Doubet | Syringe adapter for medication |
| USD890925S1 (en) | 2018-06-15 | 2020-07-21 | James T. Doubet | Syringe adapter for medication |
| CA3110931A1 (en) * | 2018-10-21 | 2020-04-30 | James T. DOUBET | Syringe adapter for medication |
| BR112021013527A2 (pt) * | 2019-01-11 | 2021-09-21 | University Of Washington | Composições farmacêuticas de combinação e métodos das mesmas |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4252793A (en) | 1979-06-18 | 1981-02-24 | American Lecithin Company | Injectable lecithin preparation |
| NZ223660A (en) | 1987-03-05 | 1990-11-27 | Liposome Co Inc | Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity |
| CH681427A5 (cg-RX-API-DMAC7.html) | 1987-07-01 | 1993-03-31 | Zambon Spa | |
| SI9300468A (en) | 1992-10-14 | 1994-06-30 | Hoffmann La Roche | Injectable composition for the sustained release of biologically active compounds |
| US5672358A (en) * | 1994-06-21 | 1997-09-30 | Ascent Pharmaceuticals, Inc. | Controlled release aqueous emulsion |
| JPH0881360A (ja) * | 1994-07-13 | 1996-03-26 | Wakamoto Pharmaceut Co Ltd | 安定な脂肪乳剤 |
| US5693337A (en) | 1994-07-13 | 1997-12-02 | Wakamoto Pharmaceutical Co., Ltd. | Stable lipid emulsion |
| US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
| US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| IL139177A0 (en) | 2000-10-20 | 2001-11-25 | S C Republic Dev S R L | Sustained release drug delivery system |
| US20050049209A1 (en) * | 2003-08-06 | 2005-03-03 | Chen Andrew Xian | Pharmaceutical compositions for delivering macrolides |
| CN101027065A (zh) * | 2004-06-15 | 2007-08-29 | 陈献 | 磷脂组合物及其制备和使用方法 |
| US8557861B2 (en) * | 2004-09-28 | 2013-10-15 | Mast Therapeutics, Inc. | Low oil emulsion compositions for delivering taxoids and other insoluble drugs |
| WO2007133711A2 (en) * | 2006-05-12 | 2007-11-22 | Adventrx Pharmaceuticals, Inc. | Pharmaceutical compositions for vein irritating drugs |
| US7547455B2 (en) * | 2006-09-20 | 2009-06-16 | Academia Sinica | Cancer and inflammatory disorder treatment |
| RU2376012C1 (ru) * | 2008-05-20 | 2009-12-20 | Федеральное государственное учреждение здравоохранения Волгоградский научно-исследовательский противочумный институт Роспотребнадзора | Способ получения комбинированного липосомального антибактериального препарата |
| CA2809022C (en) * | 2010-08-20 | 2017-01-03 | Dr. Reddy`S Laboratories, Inc. | Phospholipid depot |
-
2010
- 2010-12-17 CA CA2809022A patent/CA2809022C/en active Active
- 2010-12-17 JP JP2013524832A patent/JP5752248B2/ja not_active Expired - Fee Related
- 2010-12-17 BR BR112013003934A patent/BR112013003934A2/pt active Search and Examination
- 2010-12-17 RU RU2013112353/15A patent/RU2595865C2/ru active
- 2010-12-17 KR KR1020137006779A patent/KR101793101B1/ko not_active Expired - Fee Related
- 2010-12-17 EP EP10795596.5A patent/EP2605751A1/en not_active Withdrawn
- 2010-12-17 NZ NZ608210A patent/NZ608210A/en not_active IP Right Cessation
- 2010-12-17 AU AU2010359346A patent/AU2010359346B2/en not_active Ceased
- 2010-12-17 MX MX2013002005A patent/MX366099B/es active IP Right Grant
- 2010-12-17 CN CN201080069723.7A patent/CN103179951B/zh not_active Expired - Fee Related
- 2010-12-17 WO PCT/US2010/061015 patent/WO2012023955A1/en not_active Ceased
-
2011
- 2011-09-23 US US13/242,778 patent/US9132144B2/en not_active Expired - Fee Related
-
2013
- 2013-03-11 ZA ZA2013/01833A patent/ZA201301833B/en unknown
-
2015
- 2015-07-07 US US14/793,552 patent/US9522169B2/en not_active Expired - Fee Related
-
2016
- 2016-11-10 US US15/347,949 patent/US9682040B2/en not_active Expired - Fee Related
-
2017
- 2017-05-15 US US15/595,248 patent/US20170246109A1/en not_active Abandoned
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