JP2013532976A5 - - Google Patents
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- JP2013532976A5 JP2013532976A5 JP2013516795A JP2013516795A JP2013532976A5 JP 2013532976 A5 JP2013532976 A5 JP 2013532976A5 JP 2013516795 A JP2013516795 A JP 2013516795A JP 2013516795 A JP2013516795 A JP 2013516795A JP 2013532976 A5 JP2013532976 A5 JP 2013532976A5
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- JP
- Japan
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- complementary
- oligoribonucleotide
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- free
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- Granted
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- 230000000295 complement effect Effects 0.000 claims description 46
- 108091027075 5S-rRNA precursor Proteins 0.000 claims description 26
- 229930010555 Inosine Natural products 0.000 claims description 21
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims description 21
- 229960003786 inosine Drugs 0.000 claims description 21
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims description 20
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims description 20
- 239000000556 agonist Substances 0.000 claims description 17
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims description 16
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims description 16
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims description 16
- 239000002773 nucleotide Substances 0.000 claims description 11
- 108091033319 polynucleotide Proteins 0.000 claims description 10
- 102000040430 polynucleotide Human genes 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 230000004936 stimulating effect Effects 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 108020000411 Toll-like receptor Proteins 0.000 claims 2
- 102000002689 Toll-like receptor Human genes 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 108010041986 DNA Vaccines Proteins 0.000 claims 1
- 229940021995 DNA vaccine Drugs 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 229960004784 allergens Drugs 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- -1 antibodies Substances 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 125000004431 deuterium atom Chemical group 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 238000003795 desorption Methods 0.000 description 3
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 1
- 229940029575 guanosine Drugs 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35854310P | 2010-06-25 | 2010-06-25 | |
| US61/358,543 | 2010-06-25 | ||
| US41948810P | 2010-12-03 | 2010-12-03 | |
| US61/419,488 | 2010-12-03 | ||
| US201161435434P | 2011-01-24 | 2011-01-24 | |
| US61/435,434 | 2011-01-24 | ||
| PCT/US2011/041796 WO2012027017A2 (en) | 2010-06-25 | 2011-06-24 | Novel agonists of toll-like receptor 3 and methods of their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532976A JP2013532976A (ja) | 2013-08-22 |
| JP2013532976A5 true JP2013532976A5 (https=) | 2014-09-04 |
| JP6076899B2 JP6076899B2 (ja) | 2017-02-08 |
Family
ID=45556324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516795A Expired - Fee Related JP6076899B2 (ja) | 2010-06-25 | 2011-06-24 | Ｔｏｌｌ様レセプター３の新規アゴニストおよびその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8492358B2 (https=) |
| EP (1) | EP2588143B1 (https=) |
| JP (1) | JP6076899B2 (https=) |
| CA (1) | CA2802721C (https=) |
| ES (1) | ES2620748T3 (https=) |
| WO (1) | WO2012027017A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05013658A (es) * | 2003-06-11 | 2006-03-02 | Hybridon Inc | Oligonucleotidos inmunomoduladores estabilizados. |
| JP2014532400A (ja) * | 2011-10-31 | 2014-12-08 | リボックス・ゲーエムベーハー | 免疫賦活用の二本鎖ｒｎａ |
| TWI516593B (zh) | 2012-06-11 | 2016-01-11 | 義守大學 | 一種聚核苷酸用以製備減緩疼痛藥物之用途 |
| WO2016187459A1 (en) | 2015-05-20 | 2016-11-24 | The Regents Of The University Of California | Method for generating human dendritic cells for immunotherapy |
| MX2018005274A (es) | 2015-10-30 | 2019-09-19 | The Regents Of The Universtiy Of California | Metodos para la generacion de celulas-t a partir de celulas madre y metodos inmunoterapeuticos que utilizan las celulas-t. |
| AU2017339841B2 (en) * | 2016-10-06 | 2024-11-14 | Engeneic Molecular Delivery Pty Ltd | Bacterial minicells for delivering nucleic acid adjuvants and methods of using the same |
| US20240384268A1 (en) * | 2021-04-08 | 2024-11-21 | Hudson Institute of Medical Research | Oligonucleotides |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2021008B1 (en) * | 2006-04-07 | 2015-12-02 | Idera Pharmaceuticals, Inc. | Stabilized immune modulatory rna (simra) compounds for tlr7 and tlr8 |
| EP2134172A4 (en) * | 2007-03-05 | 2011-06-01 | Univ Utah State | RESTRICTIVE AGONIST OF THE TOLL LIKE RECEPTOR 3 |
| KR20100051041A (ko) * | 2007-03-07 | 2010-05-14 | 엔벤타 바이오파마슈티칼스 코퍼레이션 | 이중-가닥 봉쇄형 핵산 조성물 |
| JP2011518116A (ja) | 2008-02-21 | 2011-06-23 | ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション | トール様受容体３拮抗薬としての超小型ｒｎａ |
| HUE026718T2 (en) * | 2008-10-23 | 2016-07-28 | Hemispherx Biopharma Inc | Double-stranded ribonucleic acid with robust physico-chemical properties and very specific biological activity |
| CA2752694A1 (en) | 2009-02-10 | 2010-08-19 | Idera Pharmaceuticals, Inc. | Synthetic rna-based agonists of tlr7 |
-
2011
- 2011-06-24 CA CA2802721A patent/CA2802721C/en active Active
- 2011-06-24 ES ES11820310.8T patent/ES2620748T3/es active Active
- 2011-06-24 US US13/168,494 patent/US8492358B2/en not_active Expired - Fee Related
- 2011-06-24 JP JP2013516795A patent/JP6076899B2/ja not_active Expired - Fee Related
- 2011-06-24 EP EP11820310.8A patent/EP2588143B1/en not_active Not-in-force
- 2011-06-24 WO PCT/US2011/041796 patent/WO2012027017A2/en not_active Ceased
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