JP2013532677A5 - - Google Patents
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- Publication number
- JP2013532677A5 JP2013532677A5 JP2013521146A JP2013521146A JP2013532677A5 JP 2013532677 A5 JP2013532677 A5 JP 2013532677A5 JP 2013521146 A JP2013521146 A JP 2013521146A JP 2013521146 A JP2013521146 A JP 2013521146A JP 2013532677 A5 JP2013532677 A5 JP 2013532677A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- formulation
- composition according
- pharmaceutically acceptable
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 20
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 12
- 238000009472 formulation Methods 0.000 claims 9
- 239000011734 sodium Substances 0.000 claims 9
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 239000003755 preservative agent Substances 0.000 claims 4
- 230000002335 preservative effect Effects 0.000 claims 4
- 229910052783 alkali metal Inorganic materials 0.000 claims 3
- -1 alkali metal cation Chemical class 0.000 claims 3
- 239000012669 liquid formulation Substances 0.000 claims 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 3
- 230000000087 stabilizing effect Effects 0.000 claims 2
- 239000007972 injectable composition Substances 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10171428.5 | 2010-07-30 | ||
| EP10171428A EP2417982A1 (en) | 2010-07-30 | 2010-07-30 | Stabilization of gonadotropins |
| PCT/EP2011/062986 WO2012013742A2 (en) | 2010-07-30 | 2011-07-28 | Stabilization of fsh |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015245748A Division JP2016102127A (ja) | 2010-07-30 | 2015-12-17 | Ｆｓｈの安定化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532677A JP2013532677A (ja) | 2013-08-19 |
| JP2013532677A5 true JP2013532677A5 (https=) | 2014-09-11 |
| JP5860047B2 JP5860047B2 (ja) | 2016-02-16 |
Family
ID=43216624
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013521146A Active JP5860047B2 (ja) | 2010-07-30 | 2011-07-28 | Ｆｓｈの安定化 |
| JP2015245748A Pending JP2016102127A (ja) | 2010-07-30 | 2015-12-17 | Ｆｓｈの安定化 |
| JP2017212395A Active JP6522711B2 (ja) | 2010-07-30 | 2017-11-02 | Ｆｓｈの安定化 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015245748A Pending JP2016102127A (ja) | 2010-07-30 | 2015-12-17 | Ｆｓｈの安定化 |
| JP2017212395A Active JP6522711B2 (ja) | 2010-07-30 | 2017-11-02 | Ｆｓｈの安定化 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US8993732B2 (https=) |
| EP (3) | EP2417982A1 (https=) |
| JP (3) | JP5860047B2 (https=) |
| KR (2) | KR101991756B1 (https=) |
| CN (2) | CN105106939A (https=) |
| AR (1) | AR082776A1 (https=) |
| AU (1) | AU2011284702C1 (https=) |
| BR (1) | BR112013002312B1 (https=) |
| CA (1) | CA2805864A1 (https=) |
| DK (1) | DK2598160T3 (https=) |
| ES (1) | ES2623634T3 (https=) |
| HR (1) | HRP20170386T1 (https=) |
| HU (1) | HUE033592T2 (https=) |
| IL (2) | IL223821A (https=) |
| JO (1) | JO3229B1 (https=) |
| LT (1) | LT2598160T (https=) |
| MX (2) | MX356951B (https=) |
| NZ (2) | NZ606366A (https=) |
| PL (1) | PL2598160T3 (https=) |
| PT (1) | PT2598160T (https=) |
| RS (1) | RS55772B1 (https=) |
| RU (1) | RU2574012C2 (https=) |
| SA (1) | SA114350786B1 (https=) |
| SI (1) | SI2598160T1 (https=) |
| TW (1) | TWI439283B (https=) |
| WO (1) | WO2012013742A2 (https=) |
| ZA (1) | ZA201209497B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| EP2417982A1 (en) * | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| AP2016009159A0 (en) * | 2013-11-12 | 2016-04-30 | Cadila Healthcare Ltd | Formulation for gonadotropins |
| CN105727260A (zh) * | 2016-02-03 | 2016-07-06 | 华侨大学 | 一种卵泡刺激素的长效制剂 |
| GB201603280D0 (en) * | 2016-02-24 | 2016-04-13 | Ferring Bv | Stable liquid gonadotropin formulation |
| FR3083089A1 (fr) * | 2018-06-29 | 2020-01-03 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| TW201938190A (zh) | 2017-12-07 | 2019-10-01 | 法商阿道洽公司 | 包含至少一具有pi從5.8至8.5之基礎胰島素以及一帶有羧酸鹽電荷及疏水基之共聚胺基酸的ph 7之可注射溶液 |
| TWI813604B (zh) | 2017-12-07 | 2023-09-01 | 法商阿道洽公司 | 包含至少一具有pi從5.8至8.5之基礎胰島素以及一帶有羧酸鹽電荷及疏水基之共聚胺基酸的可注射ph7溶液 |
| FR3084584B1 (fr) * | 2018-08-03 | 2020-11-06 | Adocia | Solution injectable a ph 7 comprenant du glucagon humain et un compose amphiphile porteur de radicaux hydrophobes |
| FR3084586B1 (fr) * | 2018-08-03 | 2020-11-06 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un compose amphiphile porteur de radicaux hydrophobes |
| JP7425459B2 (ja) * | 2019-10-11 | 2024-01-31 | 株式会社シノテスト | 安定化されたｈｍｇｂ１含有溶液 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT814841E (pt) | 1995-03-21 | 2002-03-28 | Applied Research Systems | Formulacoes liquidas de hcg |
| DE69733889T3 (de) * | 1996-05-29 | 2009-10-22 | Delsitech Oy | Lösliche oxide für biologische anwendungen |
| IL122732A0 (en) * | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
| US20030166525A1 (en) * | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
| IL140984A0 (en) * | 1998-07-23 | 2002-02-10 | Lilly Co Eli | Fsh and fsh variant formulations, products and methods |
| BRPI0508798A (pt) * | 2004-04-07 | 2007-09-04 | Ares Trading Sa | formulação lìquida de hormÈnio de crescimento, composição farmacêutica, forma de apresentação da formulação lìquida de hormÈnio de crescimento e uso da formulação lìquida de hormÈnio de crescimento |
| KR101105871B1 (ko) * | 2005-09-27 | 2012-01-16 | 주식회사 엘지생명과학 | 인 난포자극호르몬의 안정한 용액 제형 |
| NZ586588A (en) * | 2008-02-08 | 2012-10-26 | Biogenerix Ag | Formulation of ( follice stimulating hormone) fsh and varients with benzalkonium chloride and benzyl alcohol |
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| CN101614748A (zh) * | 2008-06-25 | 2009-12-30 | 上海新波生物技术有限公司 | 促卵泡激素时间分辨免疫荧光分析法及试剂盒 |
| EP3366692A1 (en) * | 2009-06-22 | 2018-08-29 | Amgen, Inc | Refolding proteins using a chemically controlled redox state |
| RU2553375C2 (ru) * | 2010-02-12 | 2015-06-10 | Интас Биофармасьютикалс Лимитед | Жидкий состав фолликулостимулирующего гормона |
| EP2417982A1 (en) * | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
-
2010
- 2010-07-30 EP EP10171428A patent/EP2417982A1/en not_active Withdrawn
-
2011
- 2011-07-21 JO JOP/2011/0231A patent/JO3229B1/ar active
- 2011-07-25 TW TW100126190A patent/TWI439283B/zh active
- 2011-07-28 CA CA2805864A patent/CA2805864A1/en active Pending
- 2011-07-28 SI SI201131132A patent/SI2598160T1/sl unknown
- 2011-07-28 HR HRP20170386TT patent/HRP20170386T1/hr unknown
- 2011-07-28 PL PL11736111T patent/PL2598160T3/pl unknown
- 2011-07-28 CN CN201510508334.4A patent/CN105106939A/zh active Pending
- 2011-07-28 KR KR1020187001203A patent/KR101991756B1/ko active Active
- 2011-07-28 RS RS20170265A patent/RS55772B1/sr unknown
- 2011-07-28 US US13/704,771 patent/US8993732B2/en active Active
- 2011-07-28 MX MX2016010733A patent/MX356951B/es unknown
- 2011-07-28 NZ NZ606366A patent/NZ606366A/en unknown
- 2011-07-28 AU AU2011284702A patent/AU2011284702C1/en active Active
- 2011-07-28 BR BR112013002312-0A patent/BR112013002312B1/pt active IP Right Grant
- 2011-07-28 MX MX2013000681A patent/MX341464B/es active IP Right Grant
- 2011-07-28 EP EP16195020.9A patent/EP3144010A1/en not_active Withdrawn
- 2011-07-28 KR KR1020137002504A patent/KR101820115B1/ko active Active
- 2011-07-28 JP JP2013521146A patent/JP5860047B2/ja active Active
- 2011-07-28 HU HUE11736111A patent/HUE033592T2/hu unknown
- 2011-07-28 RU RU2012157154/15A patent/RU2574012C2/ru active
- 2011-07-28 ES ES11736111.3T patent/ES2623634T3/es active Active
- 2011-07-28 EP EP11736111.3A patent/EP2598160B1/en active Active
- 2011-07-28 DK DK11736111.3T patent/DK2598160T3/en active
- 2011-07-28 WO PCT/EP2011/062986 patent/WO2012013742A2/en not_active Ceased
- 2011-07-28 NZ NZ628962A patent/NZ628962A/en unknown
- 2011-07-28 CN CN201180037221.0A patent/CN103052398B/zh active Active
- 2011-07-28 PT PT117361113T patent/PT2598160T/pt unknown
- 2011-07-28 LT LTEP11736111.3T patent/LT2598160T/lt unknown
- 2011-07-29 AR ARP110102766A patent/AR082776A1/es not_active Application Discontinuation
- 2011-07-30 SA SA114350786A patent/SA114350786B1/ar unknown
-
2012
- 2012-12-13 ZA ZA2012/09497A patent/ZA201209497B/en unknown
- 2012-12-24 IL IL223821A patent/IL223821A/en active IP Right Grant
-
2015
- 2015-02-25 US US14/631,382 patent/US9463221B2/en active Active
- 2015-12-17 JP JP2015245748A patent/JP2016102127A/ja active Pending
-
2016
- 2016-09-06 US US15/257,402 patent/US20170216405A1/en not_active Abandoned
-
2017
- 2017-01-03 IL IL249920A patent/IL249920A0/en unknown
- 2017-11-02 JP JP2017212395A patent/JP6522711B2/ja active Active
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