JP2013532497A - 浸透と作用の増強 - Google Patents
浸透と作用の増強 Download PDFInfo
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- JP2013532497A JP2013532497A JP2013519975A JP2013519975A JP2013532497A JP 2013532497 A JP2013532497 A JP 2013532497A JP 2013519975 A JP2013519975 A JP 2013519975A JP 2013519975 A JP2013519975 A JP 2013519975A JP 2013532497 A JP2013532497 A JP 2013532497A
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Abstract
Description
・陽極層、
・オプションで正孔注入層(HIL)、
・オプションで正孔輸送層(HTL)および/または電子空乏層(EBL)、
・放射層(EML)、
・電子輸送層(ETL)および/または正孔空乏層(HBL)、
・オプションで電子注入層(EIL)、
・陰極層、
・オプションで第二の基層。
本発明はまた、本発明による皮膚システムで人間または動物を治療する方法に関する。方法の詳細は、皮膚システムと皮膚システムの使用に関する本発明内に開示されるものから直接転写され得る。
a)本発明による薄い光源、
b)有効成分または有効成分の合成物またはその調剤
の個別のパッケージから構成されるセット(キット)に関する。
例1
材料
本発明の絆創膏の光源は、次の装置構造、基層/陽極/バッファ層または正孔注入層/中間層/放射層/陰極およびカプセル層を有している。さらに放射波長を調節するために、オプションで、カプセル層の上に追加ダウン変換層が使用されてもよい。
発光装置の準備
発光装置、OLEDとOLECの両方の準備が、図2に概略的に示される。
DEV1、DEV2、DEV3の評価
装置Dev1ないしDEV3が、熟練者によく知られた方法によって分析される。VILカーブと電界発光スペクトルが記録される。
赤外(IR)放射装置DEV4ないしDEV6の準備
IR装置は、DEV1〜3とダウン変換燐光体Phos1を使用することによって準備される。
生体外皮膚浸透および皮膚水和の決定
皮膚浸透分析に使用することができる生体外技術は、L. Simonsen and A. Fullerton, Skin Pharmacology and Physiology 2007, 20, 230-236に詳細に説明されている。本発明による研究の結果を確認し、公表データと比較するために、L. SimonsenとA. Fullertonによって開示されるような技術的セッティングもここにおいて用いられる。ここに概説されるような研究は、このように、当業者によく知られた方法によっておこなわれる。
Claims (20)
- 少なくとも一つの光源と薬事的および/または美容的有効成分の少なくとも一つの浸透および/または作用の増強に使用される少なくとも一つの薬事的および/または美容的有効成分を備えている皮膚システムにおいて、少なくとも一つの前記光源が、少なくとも一つの無機発光ダイオード(LED)および/または少なくとも一つの有機発光装置を備えている薄い光源であることを特徴とする皮膚システム。
- 前記光源が、580と700nmの間の帯域中に最大放射をもつ赤色光および/または700nmと3mmの間の帯域中に最大放射をもつ赤外放射を発することを特徴とする請求項1に記載の皮膚システム。
- 前記有機発光装置が、有機発光ダイオード(OLED)とポリマー発光ダイオード(PLED)と有機発光電気化学セル(OLEC)から選ばれることを特徴とする請求項1または2に記載の皮膚システム。
- 前記光源がさらに、前記発光装置からの光を吸収し、580と700nmの間の帯域中に最大放射をもつ赤色光および/または700nmと3mmの間の帯域中に最大放射をもつ赤外放射を再び発するダウン変換媒体を備えていることを特徴とする請求項1ないし3の一つ以上に記載の皮膚システム。
- 前記少なくとも一つの光源と前記少なくとも一つの薬事的および/または美容的有効成分の両方が同じ装置に組み込まれていることを特徴とする請求項1ないし4の一つ以上に記載の皮膚システム。
- 前記少なくとも一つの光源がある装置上に配置され、前記少なくとも一つの薬事的および/または美容的有効成分が空間的に異なる実体を表わすことを特徴とする請求項1ないし4の一つ以上に記載の皮膚システム。
- 前記装置が、フラットパネル、湾曲パネル、絆創膏、包帯、毛布、寝袋、スリーブ、埋込可能プローブ、経鼻胃管、チェストドレイン、パッド、ステント、膏薬、あらゆる種類の衣服、口の中の少なくとも一つの歯を覆う装置から選ばれることを特徴とする請求項5および6に記載の皮膚システム。
- 人間および動物皮膚を通した薬事的および/または美容的有効成分の浸透の増強体としての使用のための請求項1ないし7の一つ以上に記載の皮膚システム。
- 薬事的および/または美容的有効成分の作用の増強体としての使用のための請求項1ないし8の一つ以上に記載の皮膚システム。
- 急性および慢性的疼痛、筋肉痛、関節硬直、筋肉緊張および硬直、気分障害、閉経期、骨粗鬆症、アンギナ、急性損傷、関節炎、ニコチン中毒、ウイルス感染、炎症、腫瘍および癌の治療および/または予防のための請求項1ないし9の一つ以上に記載の皮膚システム。
- 前記皮膚システムが経皮システムであることを特徴とする請求項1ないし10の一つ以上に記載の皮膚システム。
- 前記皮膚システムが皮膚膏薬であることを特徴とする請求項1ないし10の一つ以上に記載の皮膚システム。
- 皮膚または毛の一般的な状態のケア、保護または改善のための請求項1ないし12の一つ以上に記載の皮膚システムの使用。
- 皮膚または毛の時間および/または光および/または環境に誘発された老化過程、特に皮膚乾燥およびしわ発生および/または色素障害の治療および/または予防のための、および/または、皮膚へのUV線の悪影響の治療および/または予防のための請求項13に記載の使用。
- 平らでない皮膚、好ましくは、しわ、細かな線、肌荒れ、大きい毛穴の皮膚、セルライトの治療および/または予防のための請求項13または14に記載の使用。
- 早い皮膚の老化の治療および/または予防のための、特に皮膚の光または老化に誘発されたしわの治療および/または予防のための、色素沈着および角化症アクチニカ(actinica)の治療および/または予防のための、正常な皮膚の老化または皮膚の光に誘発された老化に関連するすべての疾病の治療および/または予防のための請求項13ないし15の一つ以上に記載の使用。
- 分化と細胞増殖に関する欠陥のある角質化に関連する皮膚疾病の治療および/または予防のための、特に尋常性座瘡、コメドニカ座瘡(acne comedonica)、多形性の座瘡、しゅさ性座瘡、節のある座瘡、集簇性座瘡、年齢関連の座瘡、副作用として生じる座瘡、ソラリス座瘡(acne solaris)、薬物関連の座瘡またはプロフェッショナリス座瘡(acne professionalis)の治療および/または予防のための、角質化の他の障害、特に魚鱗癬、魚鱗癬様の状態、ダリエ病、手掌足底の角化症(keratosis palmoplantaris)、白斑症、白斑症様の状態(leukoplasiform states)、皮膚および粘膜の(バッカル)湿疹(苔癬)の治療および/または予防のための、欠陥のある角質化に関連があり、炎症性および/または免疫アレルギー性成分を有している他の皮膚疾病、特に皮膚、粘膜および手指および足指の爪に関する乾癬の形式、および乾癬のリウマチ、および皮膚アトピー、湿疹または呼吸性アトピー、またはさらに歯肉の肥厚のすべての治療および/または予防のための請求項13ないし16の一つ以上に記載の使用。
- ウイルス原因であるかもしれない真皮または表皮の良性または悪性の病的増殖物、尋常性ゆうぜい、青年性扁平ゆうぜい、肬贅状表皮異形成、口の乳頭腫、フロリダ乳頭腫(papillomatosis florida)のすべて、およびUV放射によって引き起こされ得る病的増殖物、特にバーソセルラーレ上皮腫(epithelioma baso-cellulare)およびスピノセルラーレ上皮腫(epithelioma spinocellulare)の治療および/または予防のための請求項13ないし17の一つ以上に記載の使用。
- 請求項1ないし12の一つ以上に記載の皮膚システムで人間または動物を治療する方法。
- 人間および/または動物の皮膚を通した薬事的および/または美容的有効成分の浸透の増強のための薄い光源の使用において、前記薄い光源が、OLED、PLEDおよびOLECから選ばれることを特徴とする使用。
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KR101830458B1 (ko) | 2018-02-20 |
US20130116616A1 (en) | 2013-05-09 |
US9597527B2 (en) | 2017-03-21 |
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WO2012010238A1 (en) | 2012-01-26 |
EP2593185A1 (en) | 2013-05-22 |
US10130827B2 (en) | 2018-11-20 |
KR20180019248A (ko) | 2018-02-23 |
JP6158082B2 (ja) | 2017-07-05 |
JP2016152924A (ja) | 2016-08-25 |
KR101906132B1 (ko) | 2018-10-10 |
JP6227690B2 (ja) | 2017-11-08 |
KR20130128373A (ko) | 2013-11-26 |
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