JP2013532132A5 - - Google Patents
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- Publication number
- JP2013532132A5 JP2013532132A5 JP2013510716A JP2013510716A JP2013532132A5 JP 2013532132 A5 JP2013532132 A5 JP 2013532132A5 JP 2013510716 A JP2013510716 A JP 2013510716A JP 2013510716 A JP2013510716 A JP 2013510716A JP 2013532132 A5 JP2013532132 A5 JP 2013532132A5
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- JP
- Japan
- Prior art keywords
- group
- compound
- branched
- saturated
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 20
- 229920006395 saturated elastomer Polymers 0.000 claims 10
- 238000000034 method Methods 0.000 claims 6
- 125000004417 unsaturated alkyl group Chemical group 0.000 claims 5
- 125000000524 functional group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 3
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- -1 antibodies Proteins 0.000 claims 2
- ZPWOOKQUDFIEIX-UHFFFAOYSA-N cyclooctyne Chemical compound C1CCCC#CCC1 ZPWOOKQUDFIEIX-UHFFFAOYSA-N 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 235000019833 protease Nutrition 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims 1
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 125000001743 benzylic group Chemical group 0.000 claims 1
- 229920001222 biopolymer Polymers 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000001143 conditioned effect Effects 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 125000003147 glycosyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 235000019419 proteases Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1053921 | 2010-05-20 | ||
| FR1053921A FR2960153B1 (fr) | 2010-05-20 | 2010-05-20 | Nouveaux bras autoreactifs et prodrogues les comprenant |
| PCT/IB2011/052184 WO2011145068A1 (fr) | 2010-05-20 | 2011-05-18 | Nouveaux bras autoréactifs et prodrogues les comprenant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532132A JP2013532132A (ja) | 2013-08-15 |
| JP2013532132A5 true JP2013532132A5 (https=) | 2014-06-26 |
| JP6223824B2 JP6223824B2 (ja) | 2017-11-01 |
Family
ID=43063203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510716A Active JP6223824B2 (ja) | 2010-05-20 | 2011-05-18 | 新規な自己反応性アーム及び同物を含むプロドラッグ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9000135B2 (https=) |
| EP (1) | EP2571528B1 (https=) |
| JP (1) | JP6223824B2 (https=) |
| CA (1) | CA2799773C (https=) |
| ES (1) | ES2666562T3 (https=) |
| FR (1) | FR2960153B1 (https=) |
| WO (1) | WO2011145068A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3017298B1 (fr) * | 2014-02-07 | 2016-03-04 | Centre Nat Rech Scient | Conjugues et pro-drogues pour le traitement du cancer et de maladies inflammatoires |
| KR101628872B1 (ko) | 2014-05-28 | 2016-06-09 | 주식회사 레고켐 바이오사이언스 | 자가-희생 기를 포함하는 화합물 |
| EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| US10538534B2 (en) * | 2015-03-06 | 2020-01-21 | Colorado State University Research Foundation | Synthesis and utility of new capgroup largazole analogs |
| KR102368068B1 (ko) | 2015-08-24 | 2022-02-25 | 삼성전자주식회사 | 반도체 소자 제조용 조성물 및 이를 이용하는 반도체 소자의 제조 방법 |
| KR102847350B1 (ko) * | 2015-11-25 | 2025-08-19 | 주식회사 리가켐바이오사이언스 | 분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법 |
| HRP20240795T1 (hr) | 2015-11-25 | 2024-09-13 | Ligachem Biosciences Inc. | Konjugati koji se sastoje od samozapaljujućih skupina i postupci povezani s njima |
| AU2016359234B2 (en) | 2015-11-25 | 2022-09-08 | Ligachem Biosciences Inc. | Conjugates comprising peptide groups and methods related thereto |
| KR102085798B1 (ko) | 2016-12-28 | 2020-03-06 | 주식회사 인투셀 | 베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물 |
| MX2019011655A (es) | 2017-03-29 | 2019-12-19 | Legochem Biosciences Inc | Profarmaco de dimero de pirrolobenzodiazepina y compuesto conjugado ligando-conector de este. |
| EP3624854B1 (en) | 2017-05-16 | 2026-04-15 | Université de Strasbourg | Protein-drug conjugates and their use in the treatment of cancers |
| CA3095146A1 (en) * | 2018-04-03 | 2019-10-10 | Syndivia | Conjugate of cytotoxic drug and prodrug form of said conjugate |
| JP7459063B2 (ja) | 2018-05-09 | 2024-04-01 | レゴケム バイオサイエンシズ， インク． | 抗－ｃｄ１９抗体薬物複合体に関連する組成物および方法 |
| KR102258299B1 (ko) * | 2019-03-21 | 2021-05-28 | 고려대학교 산학협력단 | 대장암 선택적 항암 치료진단제 |
| KR20210028544A (ko) | 2019-09-04 | 2021-03-12 | 주식회사 레고켐 바이오사이언스 | 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도 |
| US12227522B2 (en) | 2020-12-21 | 2025-02-18 | Colorado State University Research Foundation | Synthesis of structural analogs of largazole and associated compounds |
| EP4274619A4 (en) * | 2021-01-08 | 2025-09-24 | Lycia Therapeutics Inc | BIFUNCTIONAL FOLATE RECEPTOR-BINDING COMPOUNDS |
| US20240216525A1 (en) | 2021-03-30 | 2024-07-04 | Mablink Bioscience | Enzyme-triggered self-reacting linker having improved physicochemical and pharmacological properties |
| EP4359414A4 (en) * | 2021-06-24 | 2026-01-21 | Lycia Therapeutics Inc | BIFOCTIONAL FOLATE RECEPTOR-BINDING COMPOUNDS |
| AU2022310356A1 (en) | 2021-07-14 | 2024-01-25 | Lycia Therapeutics, Inc. | Asgpr cell surface receptor binding compounds and conjugates |
| FR3126982B1 (fr) | 2021-09-14 | 2023-09-15 | Centre Nat Rech Scient | Vecteurs ciblant la beta-d-n-acetylglucosaminidase |
| CN121358769A (zh) * | 2023-05-17 | 2026-01-16 | 昂科医药 | Ph敏感性抗ctla-4抗体及其用途 |
| EP4534101A1 (en) | 2023-10-02 | 2025-04-09 | Eli Lilly and Company | Antibody drug conjugate (adc) targeting nectin 4 and comprising an exatecan payload |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
| US4379166A (en) * | 1981-08-03 | 1983-04-05 | Schering Corporation | Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols |
| OA09501A (en) * | 1990-06-05 | 1992-11-15 | Glaxo Group Limited Angleterre | Dichloroaniline compound. |
| FR2676058B1 (fr) | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
| EP0647450A1 (en) * | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Improved prodrugs for enzyme mediated activation |
| JP4157600B2 (ja) * | 1994-08-19 | 2008-10-01 | ラ レフィオン バロンネ | 化合物、製剤用組成物及びこれらを含む診断装置とこれらの利用 |
| FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
| US20060088475A1 (en) * | 2004-05-10 | 2006-04-27 | Northwestern University | Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase |
| EP2098533A1 (en) | 2008-03-07 | 2009-09-09 | Pharmachemie B.V. | Esters of glucuronide prodrugs of anthracyclines and method of preparation and use in tumor-selective chemotherapy |
-
2010
- 2010-05-20 FR FR1053921A patent/FR2960153B1/fr not_active Expired - Fee Related
-
2011
- 2011-05-18 WO PCT/IB2011/052184 patent/WO2011145068A1/fr not_active Ceased
- 2011-05-18 JP JP2013510716A patent/JP6223824B2/ja active Active
- 2011-05-18 ES ES11724800.5T patent/ES2666562T3/es active Active
- 2011-05-18 EP EP11724800.5A patent/EP2571528B1/fr active Active
- 2011-05-18 US US13/699,173 patent/US9000135B2/en active Active
- 2011-05-18 CA CA2799773A patent/CA2799773C/fr active Active
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