JP2012521358A5 - - Google Patents
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- JP2012521358A5 JP2012521358A5 JP2012500998A JP2012500998A JP2012521358A5 JP 2012521358 A5 JP2012521358 A5 JP 2012521358A5 JP 2012500998 A JP2012500998 A JP 2012500998A JP 2012500998 A JP2012500998 A JP 2012500998A JP 2012521358 A5 JP2012521358 A5 JP 2012521358A5
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- 239000003446 ligand Substances 0.000 claims description 10
- 230000008685 targeting Effects 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims 11
- 238000009472 formulation Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- PYSRRFNXTXNWCD-UHFFFAOYSA-N 3-(2-phenylethenyl)furan-2,5-dione Chemical compound O=C1OC(=O)C(C=CC=2C=CC=CC=2)=C1 PYSRRFNXTXNWCD-UHFFFAOYSA-N 0.000 claims 1
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 229920000147 Styrene maleic anhydride Polymers 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 239000002981 blocking agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 210000001163 endosome Anatomy 0.000 claims 1
- 230000000799 fusogenic effect Effects 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000008191 permeabilizing agent Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001562 poly(N-(2-hydroxypropyl)methacrylamide) Polymers 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920002643 polyglutamic acid Polymers 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108020004418 ribosomal RNA Proteins 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16182809P | 2009-03-20 | 2009-03-20 | |
| US61/161,828 | 2009-03-20 | ||
| PCT/US2010/028000 WO2010108108A2 (en) | 2009-03-20 | 2010-03-19 | Polyamine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015018143A Division JP6190401B2 (ja) | 2009-03-20 | 2015-02-02 | ポリアミン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012521358A JP2012521358A (ja) | 2012-09-13 |
| JP2012521358A5 true JP2012521358A5 (https=) | 2014-10-16 |
| JP5782602B2 JP5782602B2 (ja) | 2015-09-24 |
Family
ID=42359538
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500998A Active JP5782602B2 (ja) | 2009-03-20 | 2010-03-19 | ポリアミン誘導体 |
| JP2015018143A Active JP6190401B2 (ja) | 2009-03-20 | 2015-02-02 | ポリアミン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015018143A Active JP6190401B2 (ja) | 2009-03-20 | 2015-02-02 | ポリアミン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8460696B2 (https=) |
| EP (1) | EP2414322B1 (https=) |
| JP (2) | JP5782602B2 (https=) |
| KR (2) | KR101906392B1 (https=) |
| CN (2) | CN104922676B (https=) |
| AU (1) | AU2010226434A1 (https=) |
| CA (1) | CA2755963C (https=) |
| ES (1) | ES2931174T3 (https=) |
| PT (1) | PT2414322T (https=) |
| WO (1) | WO2010108108A2 (https=) |
Families Citing this family (102)
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| CA2927045A1 (en) * | 2006-10-03 | 2008-04-10 | Muthiah Manoharan | Lipid containing formulations |
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- 2010-03-19 CN CN201510146197.4A patent/CN104922676B/zh active Active
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- 2010-03-19 AU AU2010226434A patent/AU2010226434A1/en not_active Abandoned
- 2010-03-19 WO PCT/US2010/028000 patent/WO2010108108A2/en not_active Ceased
- 2010-03-19 EP EP10709947.5A patent/EP2414322B1/en active Active
- 2010-03-19 KR KR1020177033391A patent/KR101906392B1/ko active Active
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