JP2013531055A - プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 - Google Patents

プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 Download PDF

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JP2013531055A
JP2013531055A JP2013520197A JP2013520197A JP2013531055A JP 2013531055 A JP2013531055 A JP 2013531055A JP 2013520197 A JP2013520197 A JP 2013520197A JP 2013520197 A JP2013520197 A JP 2013520197A JP 2013531055 A JP2013531055 A JP 2013531055A
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pyrimidin
pyrrolidin
ylamino
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ペリアー，トレバー，ロバート
ニュートン，ガリー，カール
スチュワート，マーク，リチャード
アキル，レハン
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ドメイネクス リミテッド
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JP2013520197A 2010-07-19 2011-07-18 プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 Pending JP2013531055A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1012105.1A GB201012105D0 (en) 2010-07-19 2010-07-19 Novel pyrimidine compounds
GB1012105.1 2010-07-19
PCT/GB2011/001075 WO2012010826A1 (en) 2010-07-19 2011-07-18 Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them

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JP2013531055A true JP2013531055A (ja) 2013-08-01
JP2013531055A5 JP2013531055A5 (https=) 2014-09-04

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US (1) US8962609B2 (https=)
EP (1) EP2595964B1 (https=)
JP (1) JP2013531055A (https=)
CN (1) CN103119025B (https=)
BR (1) BR112013001341A2 (https=)
CA (1) CA2805567A1 (https=)
GB (1) GB201012105D0 (https=)
WO (1) WO2012010826A1 (https=)

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JP2018504415A (ja) * 2015-02-05 2018-02-15 エービー サイエンス 抗腫瘍活性を有する化合物
JP2020508341A (ja) * 2017-02-23 2020-03-19 ドメイネクス リミテッド Ｉｋｋｅ、ｔｂｋ１及び／又はｓｉｋ２キナーゼ阻害剤としての５−（ピリミジン−４−イル）−２−（ピロリジン−１−イル）ニコチノニトリル化合物
JP2020537671A (ja) * 2017-10-17 2020-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ピリミジンＴＢＫ／ＩＫＫεインヒビター化合物およびそれらの使用
JP2022529309A (ja) * 2019-04-08 2022-06-21 リンク ファーマシューティカルズ シーオー．エルティーディー． ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法

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GB201114051D0 (en) 2011-08-15 2011-09-28 Domainex Ltd Compounds and their uses
DE102011112978A1 (de) * 2011-09-09 2013-03-14 Merck Patent Gmbh Benzonitrilderivate
HRP20161578T1 (hr) * 2012-02-09 2016-12-30 Merck Patent Gmbh Derivati furo[3, 2-b]piridina kao inhibitori tbk1 i ikk
GB201303109D0 (en) * 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds
KR102359214B1 (ko) 2014-04-04 2022-02-07 델 마 파마슈티컬스 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
TW201613916A (en) 2014-06-03 2016-04-16 Gilead Sciences Inc TANK-binding kinase inhibitor compounds
NZ729618A (en) 2014-09-26 2018-07-27 Gilead Sciences Inc Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds
WO2017044434A1 (en) * 2015-09-11 2017-03-16 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use
EP3394044A1 (en) 2015-12-17 2018-10-31 Gilead Sciences, Inc. Tank-binding kinase inhibitor compounds
WO2017102091A1 (en) 2015-12-18 2017-06-22 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
BR112020007549A2 (pt) 2017-10-17 2020-09-24 Merck Patent Gmbh compostos inibidores de pirimidina tbk/ikképsilon e uso dos mesmos
CN110862380A (zh) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018504415A (ja) * 2015-02-05 2018-02-15 エービー サイエンス 抗腫瘍活性を有する化合物
US10570122B2 (en) 2015-02-05 2020-02-25 Ab Science Compounds with anti-tumoral activity
JP2020508341A (ja) * 2017-02-23 2020-03-19 ドメイネクス リミテッド Ｉｋｋｅ、ｔｂｋ１及び／又はｓｉｋ２キナーゼ阻害剤としての５−（ピリミジン−４−イル）−２−（ピロリジン−１−イル）ニコチノニトリル化合物
JP7136793B2 (ja) 2017-02-23 2022-09-13 ドメイネクス リミテッド Ｉｋｋｅ、ｔｂｋ１及び／又はｓｉｋ２キナーゼ阻害剤としての５－（ピリミジン－４－イル）－２－（ピロリジン－１－イル）ニコチノニトリル化合物
JP2020537671A (ja) * 2017-10-17 2020-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ピリミジンＴＢＫ／ＩＫＫεインヒビター化合物およびそれらの使用
JP7266592B2 (ja) 2017-10-17 2023-04-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ピリミジンＴＢＫ／ＩＫＫεインヒビター化合物およびそれらの使用
JP2022529309A (ja) * 2019-04-08 2022-06-21 リンク ファーマシューティカルズ シーオー．エルティーディー． ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法

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