CN103119025B - 作为蛋白激酶IKKε和/或TBK-1抑制剂的嘧啶化合物、其制备方法、以及含有其的药物组合物 - Google Patents

作为蛋白激酶IKKε和/或TBK-1抑制剂的嘧啶化合物、其制备方法、以及含有其的药物组合物 Download PDF

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CN103119025B
CN103119025B CN201180045048.9A CN201180045048A CN103119025B CN 103119025 B CN103119025 B CN 103119025B CN 201180045048 A CN201180045048 A CN 201180045048A CN 103119025 B CN103119025 B CN 103119025B
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pyrimidine
amino
pyrrolidin
compound
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CN103119025A (zh
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T·R·佩里尔
G·K·牛顿
M·R·斯图尔特
R·阿齐尔
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Domainex Ltd
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  • Chemical & Material Sciences (AREA)
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CN201180045048.9A 2010-07-19 2011-07-18 作为蛋白激酶IKKε和/或TBK-1抑制剂的嘧啶化合物、其制备方法、以及含有其的药物组合物 Expired - Fee Related CN103119025B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1012105.1A GB201012105D0 (en) 2010-07-19 2010-07-19 Novel pyrimidine compounds
GB1012105.1 2010-07-19
PCT/GB2011/001075 WO2012010826A1 (en) 2010-07-19 2011-07-18 Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
CN103119025A CN103119025A (zh) 2013-05-22
CN103119025B true CN103119025B (zh) 2015-09-09

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US (1) US8962609B2 (https=)
EP (1) EP2595964B1 (https=)
JP (1) JP2013531055A (https=)
CN (1) CN103119025B (https=)
BR (1) BR112013001341A2 (https=)
CA (1) CA2805567A1 (https=)
GB (1) GB201012105D0 (https=)
WO (1) WO2012010826A1 (https=)

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GB201114051D0 (en) 2011-08-15 2011-09-28 Domainex Ltd Compounds and their uses
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GB201303109D0 (en) * 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds
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TW201613916A (en) 2014-06-03 2016-04-16 Gilead Sciences Inc TANK-binding kinase inhibitor compounds
NZ729618A (en) 2014-09-26 2018-07-27 Gilead Sciences Inc Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds
ES2796276T3 (es) * 2015-02-05 2020-11-26 Ab Science Compuestos con actividad antitumoral
WO2017044434A1 (en) * 2015-09-11 2017-03-16 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use
EP3394044A1 (en) 2015-12-17 2018-10-31 Gilead Sciences, Inc. Tank-binding kinase inhibitor compounds
WO2017102091A1 (en) 2015-12-18 2017-06-22 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
GB201702947D0 (en) * 2017-02-23 2017-04-12 Domainex Ltd Novel compounds
US20230019491A1 (en) * 2017-10-17 2023-01-19 Srinivasa R. Karra PYRIMIDINE TBK/IKKe INHIBITOR COMPOUNDS AND USES THEREOF
BR112020007549A2 (pt) 2017-10-17 2020-09-24 Merck Patent Gmbh compostos inibidores de pirimidina tbk/ikképsilon e uso dos mesmos
WO2020206588A1 (en) * 2019-04-08 2020-10-15 Lynk Pharmaceuticals Co., Ltd. Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
CN110862380A (zh) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物

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CN1860104A (zh) * 2003-07-30 2006-11-08 西克拉塞尔有限公司 作为激酶抑制剂的2－氨基苯基－4－苯基嘧啶
CN101600697A (zh) * 2007-01-05 2009-12-09 赛诺菲-安万特 作为药物、药物组合物和特别地作为ikk抑制剂的新型苯基(4-苯基嘧啶-2-基)胺衍生物、它们的制备
WO2011046970A1 (en) * 2009-10-12 2011-04-21 Myrexis, Inc. Amino - pyrimidine compounds as inhibitors of tbkl and/or ikk epsilon

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GB201012105D0 (en) 2010-09-01
WO2012010826A1 (en) 2012-01-26
EP2595964A1 (en) 2013-05-29
US20130267491A1 (en) 2013-10-10
CN103119025A (zh) 2013-05-22
HK1181753A1 (en) 2013-11-15
EP2595964B1 (en) 2015-04-29
CA2805567A1 (en) 2012-01-26
BR112013001341A2 (pt) 2016-05-17
US8962609B2 (en) 2015-02-24
JP2013531055A (ja) 2013-08-01

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