JP2013531055A - プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 - Google Patents

プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 Download PDF

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JP2013531055A
JP2013531055A JP2013520197A JP2013520197A JP2013531055A JP 2013531055 A JP2013531055 A JP 2013531055A JP 2013520197 A JP2013520197 A JP 2013520197A JP 2013520197 A JP2013520197 A JP 2013520197A JP 2013531055 A JP2013531055 A JP 2013531055A
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pyrimidin
pyrrolidin
ylamino
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JP2013531055A5 (OSRAM
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ペリアー，トレバー，ロバート
ニュートン，ガリー，カール
スチュワート，マーク，リチャード
アキル，レハン
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ドメイネクス リミテッド
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JP2013520197A 2010-07-19 2011-07-18 プロテインキナーゼＩＫＫε及び／又はＴＢＫ−１の阻害剤としてのピリミジン化合物、それらの製造方法及びそれらを含む医薬組成物 Pending JP2013531055A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1012105.1A GB201012105D0 (en) 2010-07-19 2010-07-19 Novel pyrimidine compounds
GB1012105.1 2010-07-19
PCT/GB2011/001075 WO2012010826A1 (en) 2010-07-19 2011-07-18 Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them

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JP2013531055A true JP2013531055A (ja) 2013-08-01
JP2013531055A5 JP2013531055A5 (OSRAM) 2014-09-04

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US (1) US8962609B2 (OSRAM)
EP (1) EP2595964B1 (OSRAM)
JP (1) JP2013531055A (OSRAM)
CN (1) CN103119025B (OSRAM)
BR (1) BR112013001341A2 (OSRAM)
CA (1) CA2805567A1 (OSRAM)
GB (1) GB201012105D0 (OSRAM)
WO (1) WO2012010826A1 (OSRAM)

Cited By (4)

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Publication number Priority date Publication date Assignee Title
JP2018504415A (ja) * 2015-02-05 2018-02-15 エービー サイエンス 抗腫瘍活性を有する化合物
JP2020508341A (ja) * 2017-02-23 2020-03-19 ドメイネクス リミテッド Ｉｋｋｅ、ｔｂｋ１及び／又はｓｉｋ２キナーゼ阻害剤としての５−（ピリミジン−４−イル）−２−（ピロリジン−１−イル）ニコチノニトリル化合物
JP2020537671A (ja) * 2017-10-17 2020-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ピリミジンＴＢＫ／ＩＫＫεインヒビター化合物およびそれらの使用
JP2022529309A (ja) * 2019-04-08 2022-06-21 リンク ファーマシューティカルズ シーオー．エルティーディー． ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法

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CA2832919A1 (en) * 2011-04-12 2012-10-18 Ryan C. Holcomb Compounds, compositions, and therapeutic uses thereof
GB201114051D0 (en) 2011-08-15 2011-09-28 Domainex Ltd Compounds and their uses
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PT2812337T (pt) * 2012-02-09 2016-12-14 Merck Patent Gmbh Derivados de furo[3,2-b]piridina como inibidores de tbk1 e ikk
GB201303109D0 (en) * 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds
SG11201608303QA (en) 2014-04-04 2016-11-29 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
TW201613916A (en) 2014-06-03 2016-04-16 Gilead Sciences Inc TANK-binding kinase inhibitor compounds
JP6499282B2 (ja) 2014-09-26 2019-04-10 ギリアード サイエンシーズ， インコーポレイテッド Ｔａｎｋ結合キナーゼ阻害剤化合物として有用なアミノトリアジン誘導体
EP3347097B1 (en) * 2015-09-11 2021-02-24 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora
WO2017106556A1 (en) 2015-12-17 2017-06-22 Gilead Sciences, Inc. Tank-binding kinase inhibitor compounds
US10894784B2 (en) 2015-12-18 2021-01-19 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
TWI802605B (zh) 2017-10-17 2023-05-21 德商默克專利有限公司 嘧啶ＴＢＫ/ＩＫＫε抑制劑化合物及其用途
CN110862380A (zh) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 一种小分子化合物

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018504415A (ja) * 2015-02-05 2018-02-15 エービー サイエンス 抗腫瘍活性を有する化合物
US10570122B2 (en) 2015-02-05 2020-02-25 Ab Science Compounds with anti-tumoral activity
JP2020508341A (ja) * 2017-02-23 2020-03-19 ドメイネクス リミテッド Ｉｋｋｅ、ｔｂｋ１及び／又はｓｉｋ２キナーゼ阻害剤としての５−（ピリミジン−４−イル）−２−（ピロリジン−１−イル）ニコチノニトリル化合物
JP7136793B2 (ja) 2017-02-23 2022-09-13 ドメイネクス リミテッド Ｉｋｋｅ、ｔｂｋ１及び／又はｓｉｋ２キナーゼ阻害剤としての５－（ピリミジン－４－イル）－２－（ピロリジン－１－イル）ニコチノニトリル化合物
JP2020537671A (ja) * 2017-10-17 2020-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ピリミジンＴＢＫ／ＩＫＫεインヒビター化合物およびそれらの使用
JP7266592B2 (ja) 2017-10-17 2023-04-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ピリミジンＴＢＫ／ＩＫＫεインヒビター化合物およびそれらの使用
JP2022529309A (ja) * 2019-04-08 2022-06-21 リンク ファーマシューティカルズ シーオー．エルティーディー． ピラゾリル－アミノ－ピリミジニル誘導体のベンズエーテルとアニリン、およびその組成物と方法

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