JP2013529900A5 - - Google Patents
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- Publication number
- JP2013529900A5 JP2013529900A5 JP2013511528A JP2013511528A JP2013529900A5 JP 2013529900 A5 JP2013529900 A5 JP 2013529900A5 JP 2013511528 A JP2013511528 A JP 2013511528A JP 2013511528 A JP2013511528 A JP 2013511528A JP 2013529900 A5 JP2013529900 A5 JP 2013529900A5
- Authority
- JP
- Japan
- Prior art keywords
- antagonist
- cell activator
- cell
- nucleotide sequence
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005557 antagonist Substances 0.000 claims 18
- 239000012190 activator Substances 0.000 claims 12
- 210000003719 b-lymphocyte Anatomy 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000000746 purification Methods 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 2
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 2
- 230000003042 antagnostic effect Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 108010028006 B-Cell Activating Factor Proteins 0.000 claims 1
- 230000003844 B-cell-activation Effects 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 108700002109 Transmembrane Activator and CAML Interactor Proteins 0.000 claims 1
- 102000050862 Transmembrane Activator and CAML Interactor Human genes 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000004440 column chromatography Methods 0.000 claims 1
- 201000006754 cone-rod dystrophy Diseases 0.000 claims 1
- 201000000464 cone-rod dystrophy 2 Diseases 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 239000012516 mab select resin Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101839059A CN101851278B (zh) | 2010-05-26 | 2010-05-26 | B细胞激活因子拮抗剂及其制备方法与用途 |
| PCT/CN2011/074687 WO2011147320A1 (zh) | 2010-05-26 | 2011-05-26 | B细胞激活因子拮抗剂及其制备方法与用途 |
| CN201010183905.9 | 2011-05-26 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151930A Division JP6320973B2 (ja) | 2010-05-26 | 2015-07-31 | Ｂ細胞活性化因子の拮抗物質、その調製方法及び利用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013529900A JP2013529900A (ja) | 2013-07-25 |
| JP2013529900A5 true JP2013529900A5 (cg-RX-API-DMAC7.html) | 2014-12-04 |
Family
ID=42802979
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511528A Pending JP2013529900A (ja) | 2010-05-26 | 2011-05-26 | Ｂ細胞活性化因子の拮抗物質、その調製方法及び利用法 |
| JP2015151930A Active JP6320973B2 (ja) | 2010-05-26 | 2015-07-31 | Ｂ細胞活性化因子の拮抗物質、その調製方法及び利用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015151930A Active JP6320973B2 (ja) | 2010-05-26 | 2015-07-31 | Ｂ細胞活性化因子の拮抗物質、その調製方法及び利用法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9290582B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2578603B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2013529900A (cg-RX-API-DMAC7.html) |
| KR (2) | KR20130043642A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101851278B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011147320A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101851278B (zh) | 2010-05-26 | 2013-03-13 | 石药集团中奇制药技术（石家庄）有限公司 | B细胞激活因子拮抗剂及其制备方法与用途 |
| CN106220740A (zh) * | 2016-08-18 | 2016-12-14 | 中山大学 | 可溶性蛋白baff在b细胞体外培养及扩增的应用 |
| PE20230494A1 (es) | 2020-05-08 | 2023-03-23 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras inhibidoras de april y baff y metodos de uso de las mismas |
| TW202440636A (zh) | 2023-03-21 | 2024-10-16 | 美商傳記５５有限公司 | Ｃｄ１９／ｃｄ３８多特異性抗體 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA83458C2 (uk) * | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| MEP21708A (en) * | 2001-05-24 | 2010-06-10 | Zymogenetics Inc | Taci-immunoglobulin fusion proteins |
| PL377119A1 (pl) | 2001-08-03 | 2006-01-23 | Genentech, Inc. | Peptydy TACIs i BR3 i ich zastosowanie |
| DK2272868T3 (en) * | 2003-06-05 | 2015-06-15 | Genentech Inc | Combination therapy for B-cell diseases |
| WO2005005462A2 (en) | 2003-06-05 | 2005-01-20 | Genentech, Inc. | Blys antagonists and uses thereof |
| MX2007008017A (es) * | 2004-12-31 | 2007-09-12 | Genentech Inc | Polipeptidos que se ligan a br3 y usos de los mismos. |
| JP2010501622A (ja) | 2006-08-28 | 2010-01-21 | アレス トレーディング ソシエテ アノニム | Ｆｃ−融合タンパク質の精製法 |
| SI2139517T1 (sl) * | 2007-03-27 | 2013-09-30 | Zymogenetics, Inc. | Kombinacija inhibicije BLyS in mikofenolat mofetila za zdravljenje avtoimunske bolezni |
| EP2350286B1 (en) * | 2008-10-07 | 2016-07-20 | The Regents of The University of California | Recombinant nell protein production |
| CN101851278B (zh) * | 2010-05-26 | 2013-03-13 | 石药集团中奇制药技术（石家庄）有限公司 | B细胞激活因子拮抗剂及其制备方法与用途 |
-
2010
- 2010-05-26 CN CN2010101839059A patent/CN101851278B/zh active Active
-
2011
- 2011-05-26 US US13/699,903 patent/US9290582B2/en active Active
- 2011-05-26 WO PCT/CN2011/074687 patent/WO2011147320A1/zh not_active Ceased
- 2011-05-26 KR KR1020127033484A patent/KR20130043642A/ko not_active Ceased
- 2011-05-26 KR KR1020167020322A patent/KR101810551B1/ko active Active
- 2011-05-26 EP EP11786092.4A patent/EP2578603B1/en active Active
- 2011-05-26 JP JP2013511528A patent/JP2013529900A/ja active Pending
-
2015
- 2015-07-31 JP JP2015151930A patent/JP6320973B2/ja active Active