JP2015511599A5 - - Google Patents
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- Publication number
- JP2015511599A5 JP2015511599A5 JP2014561543A JP2014561543A JP2015511599A5 JP 2015511599 A5 JP2015511599 A5 JP 2015511599A5 JP 2014561543 A JP2014561543 A JP 2014561543A JP 2014561543 A JP2014561543 A JP 2014561543A JP 2015511599 A5 JP2015511599 A5 JP 2015511599A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- seq
- polypeptide
- soluble
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 50
- 229920001184 polypeptide Polymers 0.000 claims 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 101150096839 Fcmr gene Proteins 0.000 claims 23
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 239000000178 monomer Substances 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 101000878510 Homo sapiens Fas apoptotic inhibitory molecule 3 Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 102000051981 human FCMR Human genes 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000003352 Hyper-IgM Immunodeficiency Syndrome Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029379 Neutrophilia Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 206010066130 hyper-IgM syndrome Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261612183P | 2012-03-16 | 2012-03-16 | |
| US61/612,183 | 2012-03-16 | ||
| US201261646143P | 2012-05-11 | 2012-05-11 | |
| US61/646,143 | 2012-05-11 | ||
| US201261731428P | 2012-11-29 | 2012-11-29 | |
| US61/731,428 | 2012-11-29 | ||
| PCT/IB2013/001179 WO2013136193A2 (en) | 2012-03-16 | 2013-03-14 | Methods and compositions for modulating toso activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017162409A Division JP6462800B2 (ja) | 2012-03-16 | 2017-08-25 | Ｔｏｓｏ活性を調節するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511599A JP2015511599A (ja) | 2015-04-20 |
| JP2015511599A5 true JP2015511599A5 (cg-RX-API-DMAC7.html) | 2016-04-21 |
| JP6200437B2 JP6200437B2 (ja) | 2017-09-20 |
Family
ID=48747619
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561543A Expired - Fee Related JP6200437B2 (ja) | 2012-03-16 | 2013-03-14 | Ｔｏｓｏ活性を調節するための方法および組成物 |
| JP2017162409A Expired - Fee Related JP6462800B2 (ja) | 2012-03-16 | 2017-08-25 | Ｔｏｓｏ活性を調節するための方法および組成物 |
| JP2018244907A Expired - Fee Related JP6744391B2 (ja) | 2012-03-16 | 2018-12-27 | Ｔｏｓｏ活性を調節するための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017162409A Expired - Fee Related JP6462800B2 (ja) | 2012-03-16 | 2017-08-25 | Ｔｏｓｏ活性を調節するための方法および組成物 |
| JP2018244907A Expired - Fee Related JP6744391B2 (ja) | 2012-03-16 | 2018-12-27 | Ｔｏｓｏ活性を調節するための方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9228006B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3626254A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6200437B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102143887B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN104394880B (cg-RX-API-DMAC7.html) |
| AU (3) | AU2013234046B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2867444C (cg-RX-API-DMAC7.html) |
| IL (1) | IL234683B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013136193A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3626254A1 (en) | 2012-03-16 | 2020-03-25 | University Health Network | Soluble toso protein and its use in treating autoimmune disorders |
| WO2015000059A1 (en) * | 2013-07-03 | 2015-01-08 | University Health Network | Antibodies to toso |
| MX374517B (es) | 2014-01-15 | 2025-03-06 | Medimmune Ltd | Anticuerpos especificos del virus respiratorio sincitial (vrs) y partes funcionales de los mismos. |
| CA2941697A1 (en) * | 2014-03-07 | 2015-09-11 | University Health Network | Methods and compositions for modifying the immune response |
| EP3009841A1 (en) * | 2014-10-14 | 2016-04-20 | Bernhard-Nocht-Institut für Tropenmedizin | Detection of IgM Antibodies using an immune complex (IC) ELISA |
| BR112017023646A2 (pt) | 2015-05-04 | 2018-07-17 | Apogenix Ag | proteínas agonistas de receptor de cd40 de cadeia simples |
| EP3098237B1 (en) * | 2015-05-28 | 2018-08-01 | Universität Zu Köln | Anti-toso chimeric antigen receptor and its use |
| CA3126295A1 (en) | 2019-01-18 | 2020-07-23 | University Health Network | Lilrb3-binding molecules and uses therefor |
| EA202192254A1 (ru) | 2019-02-15 | 2021-11-29 | Юниверсити Хелт Нетворк | Fcmr-связывающие молекулы и их применение |
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| DE229046T1 (de) | 1985-03-30 | 1987-12-17 | Marc Genf/Geneve Ballivet | Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren. |
| US6492107B1 (en) | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
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| ATE148348T1 (de) * | 1989-09-15 | 1997-02-15 | Tanox Biosystems Inc | Behandlung von einer autoimmun-krankheit |
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| WO1992002551A1 (en) | 1990-08-02 | 1992-02-20 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
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| RU2136311C1 (ru) | 1991-09-13 | 1999-09-10 | Чирон Корпорейшн | Иммуногенная полипептидная композиция, способ получения композиции, способ продуцирования и способ обнаружения антител, набор |
| EP0641353A4 (en) * | 1991-11-18 | 1997-07-02 | Tanox Biosystems Inc | ANTISENSE OLIGONUCLEOTIDES FOR ISOTYPE-SPECIFIC SUPPRESSION OF IMMUNOGLOBULIN PRODUCTION. |
| DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
| EP1291360A1 (en) | 1991-12-13 | 2003-03-12 | Xoma Corporation | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
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| RU2566264C2 (ru) | 2009-08-17 | 2015-10-20 | Дзе Пенн Стейт Рисерч Фаундейшн | Применение ингибиторов nkg2d для лечения сердечно-сосудистых и метаболических заболеваний, таких как диабет 2 типа |
| EP3626254A1 (en) | 2012-03-16 | 2020-03-25 | University Health Network | Soluble toso protein and its use in treating autoimmune disorders |
| US11392902B2 (en) | 2017-06-06 | 2022-07-19 | United Parcel Service Of America, Inc. | Systems, methods, apparatuses and computer program products for providing notification of items for pickup and delivery |
-
2013
- 2013-03-14 EP EP19186831.4A patent/EP3626254A1/en not_active Withdrawn
- 2013-03-14 KR KR1020147028977A patent/KR102143887B1/ko not_active Expired - Fee Related
- 2013-03-14 CA CA2867444A patent/CA2867444C/en not_active Expired - Fee Related
- 2013-03-14 US US13/831,031 patent/US9228006B2/en not_active Expired - Fee Related
- 2013-03-14 WO PCT/IB2013/001179 patent/WO2013136193A2/en not_active Ceased
- 2013-03-14 CN CN201380023772.0A patent/CN104394880B/zh not_active Expired - Fee Related
- 2013-03-14 JP JP2014561543A patent/JP6200437B2/ja not_active Expired - Fee Related
- 2013-03-14 AU AU2013234046A patent/AU2013234046B2/en not_active Ceased
- 2013-03-14 EP EP13734483.4A patent/EP2825191B1/en active Active
-
2014
- 2014-09-16 IL IL234683A patent/IL234683B/en active IP Right Grant
- 2014-11-12 US US14/539,872 patent/US9321824B2/en not_active Expired - Fee Related
- 2014-11-12 US US14/539,879 patent/US9670265B2/en not_active Expired - Fee Related
- 2014-11-12 US US14/539,884 patent/US9624289B2/en not_active Expired - Fee Related
-
2017
- 2017-05-01 US US15/583,788 patent/US10822388B2/en not_active Expired - Fee Related
- 2017-08-25 JP JP2017162409A patent/JP6462800B2/ja not_active Expired - Fee Related
- 2017-12-05 AU AU2017272172A patent/AU2017272172B2/en not_active Ceased
-
2018
- 2018-12-27 JP JP2018244907A patent/JP6744391B2/ja not_active Expired - Fee Related
-
2019
- 2019-06-28 AU AU2019204594A patent/AU2019204594B2/en not_active Expired - Fee Related
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