JP2013529210A - Ｓｓｔｒ５アンタゴニストとしてのスピロイソオキサゾリン化合物 - Google Patents

Ｓｓｔｒ５アンタゴニストとしてのスピロイソオキサゾリン化合物 Download PDF

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Publication number
JP2013529210A
JP2013529210A JP2013511232A JP2013511232A JP2013529210A JP 2013529210 A JP2013529210 A JP 2013529210A JP 2013511232 A JP2013511232 A JP 2013511232A JP 2013511232 A JP2013511232 A JP 2013511232A JP 2013529210 A JP2013529210 A JP 2013529210A
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JP
Japan
Prior art keywords
halogen
substituted
mmol
alkyl
methyl
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JP2013511232A
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English (en)
Japanese (ja)
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JP2013529210A5 (cg-RX-API-DMAC7.html
Inventor
ダフイー，ジヨゼフ・エル
バオ，ジヤンミン
オンデイカ，デブラ・エル
テイアガラヤン，スリラム
シヤオ，パトリツク
イエ，フオン
カテイパリー，レヴアテイ
フインケ，ポール・イー
ザン，イー
プロトキン，ミカエル・エイ
ロメロ，エフ・アンソニー
モニンカー，レモンド
フセイン，ザヒド
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Merck and Co Inc
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Merck and Co Inc
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Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2013529210A publication Critical patent/JP2013529210A/ja
Publication of JP2013529210A5 publication Critical patent/JP2013529210A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2013511232A 2010-05-18 2011-05-13 Ｓｓｔｒ５アンタゴニストとしてのスピロイソオキサゾリン化合物 Withdrawn JP2013529210A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34568310P 2010-05-18 2010-05-18
US61/345,683 2010-05-18
PCT/US2011/036367 WO2011146324A1 (en) 2010-05-18 2011-05-13 Spiro isoxazoline compounds as sstr5 antagonists

Publications (2)

Publication Number Publication Date
JP2013529210A true JP2013529210A (ja) 2013-07-18
JP2013529210A5 JP2013529210A5 (cg-RX-API-DMAC7.html) 2014-06-26

Family

ID=44991994

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013511232A Withdrawn JP2013529210A (ja) 2010-05-18 2011-05-13 Ｓｓｔｒ５アンタゴニストとしてのスピロイソオキサゾリン化合物

Country Status (8)

Country Link
US (1) US20130040978A1 (cg-RX-API-DMAC7.html)
EP (1) EP2571356A4 (cg-RX-API-DMAC7.html)
JP (1) JP2013529210A (cg-RX-API-DMAC7.html)
AR (1) AR081401A1 (cg-RX-API-DMAC7.html)
AU (1) AU2011256444B2 (cg-RX-API-DMAC7.html)
CA (1) CA2799414A1 (cg-RX-API-DMAC7.html)
TW (1) TW201200524A (cg-RX-API-DMAC7.html)
WO (1) WO2011146324A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015146561A1 (ja) * 2014-03-26 2015-10-01 住友精化株式会社 臭化芳香族エステル化合物の製造方法
JP2022501342A (ja) * 2018-09-18 2022-01-06 クリネティックス ファーマシューティカルズ，インク． ソマトスタチンモジュレーターとその使用

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8742110B2 (en) 2010-08-18 2014-06-03 Merck Sharp & Dohme Corp. Spiroxazolidinone compounds
US20150166528A1 (en) 2012-06-14 2015-06-18 Basf Se Pesticidal methods using substituted 3-pyridyl thiazole compounds and derivatives for combating animal pests
FR3000064A1 (fr) 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes de type spiroisoxazoline ayant une activite potentialisatrice de l'activite d'un antibiotique-composition et produit pharmaceutiques comprenant de tels composes
JP6247697B2 (ja) * 2013-03-14 2017-12-13 武田薬品工業株式会社 スピロアゼチジンイソキサゾール誘導体及びそのｓｓｔｒ５アンタゴニストとしての使用
EP3083642B1 (en) * 2013-12-17 2018-09-05 Merck Sharp & Dohme Corp. Fused bicyclic isoxazolines as inhibitors of cholesterol ester transfer protein
CN104945416B (zh) * 2014-03-24 2017-11-17 中国科学院上海药物研究所 一类螺异噁唑啉衍生物、其制备方法及医药用途
EP3174537B1 (en) * 2014-07-29 2021-06-23 Merck Sharp & Dohme Corp. Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein
TW201712012A (zh) 2015-06-16 2017-04-01 美國禮來大藥廠 ２－側氧基－１，３，８－三氮雜螺［４．５］癸－３－基羧酸衍生物
CN110088089B (zh) 2016-10-25 2023-08-29 勃林格殷格翰国际有限公司 苄基氨基吡啶基环丙烷甲酸、药物组合物及其用途
US10793530B2 (en) 2017-01-26 2020-10-06 Boehringer Ingelheim International Gmbh Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
JP7023969B2 (ja) 2017-01-26 2022-02-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンジルアミノピリジルシクロプロパンカルボン酸、その医薬組成物及び使用
EP3596062A4 (en) 2017-03-16 2020-08-26 Crinetics Pharmaceuticals, Inc. SOMATOSTATIN MODULATORS AND THEIR USES
EP3752498B1 (en) 2018-02-12 2023-06-28 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
TWI841768B (zh) 2019-08-14 2024-05-11 美商克林提克斯醫藥股份有限公司 非肽生長抑制素(somatostatin)5型受體激動劑及其用途
IL291985A (en) 2019-10-07 2022-06-01 Kallyope Inc Gpr119 agonists
EP4073075A4 (en) * 2019-12-03 2023-12-27 Kallyope, Inc. Sstr5 antagonists
PH12022552277A1 (en) 2020-02-28 2024-03-04 Kallyope Inc Gpr40 agonists
UY39222A (es) 2020-05-19 2021-11-30 Kallyope Inc Activadores de la ampk
EP4172162A4 (en) 2020-06-26 2024-08-07 Kallyope, Inc. AMPK ACTIVATORS
WO2022177974A1 (en) 2021-02-17 2022-08-25 Crinetics Pharmaceuticals, Inc. Crystalline forms of a somatostatin modulator
CN115215787A (zh) * 2021-04-19 2022-10-21 中国科学院上海药物研究所 生长抑素受体5拮抗剂及其用途
CN116354961B (zh) * 2021-12-27 2025-07-25 中国科学院上海药物研究所 生长抑素受体5拮抗剂及其药物组合物及用途
CN114230552B (zh) * 2021-12-29 2023-11-03 江苏广域化学有限公司 三氟甲氧基二苯并噻吩、其制备方法及相关中间体的制备方法
WO2024129614A1 (en) 2022-12-13 2024-06-20 Crinetics Pharmaceuticals, Inc. Somatostatin subtype-2 receptor (sst2r) targeted therapeutics and uses thereof
CN115819186B (zh) * 2023-02-14 2023-05-16 广东银珠医药科技有限公司 一种3,5-二氯苯甲醇的新型制备方法
CN120752056A (zh) 2023-03-27 2025-10-03 思可海雅药品株式会社 生长激素分泌促进剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939418A (en) * 1995-12-21 1999-08-17 The Dupont Merck Pharmaceutical Company Isoxazoline, isothiazoline and pyrazoline factor Xa inhibitors
AU6780398A (en) * 1997-03-28 1998-10-22 Du Pont Merck Pharmaceutical Company, The Heterocyclic integrin inhibitor prodrugs
DE102005044813A1 (de) * 2005-05-19 2007-10-04 Grünenthal GmbH Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
AR055395A1 (es) * 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
BRPI0615449A2 (pt) * 2005-09-02 2011-05-17 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método de tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de sst do subtipo 5 e uso desses compostos
BRPI0617673C1 (pt) * 2005-10-19 2012-05-22 Ranbaxy Lab Ltd composições de inibidores de fosfodiesterase do tipo iv

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015146561A1 (ja) * 2014-03-26 2015-10-01 住友精化株式会社 臭化芳香族エステル化合物の製造方法
JPWO2015146561A1 (ja) * 2014-03-26 2017-04-13 住友精化株式会社 臭化芳香族エステル化合物の製造方法
JP2022501342A (ja) * 2018-09-18 2022-01-06 クリネティックス ファーマシューティカルズ，インク． ソマトスタチンモジュレーターとその使用
JP7431813B2 (ja) 2018-09-18 2024-02-15 クリネティックス ファーマシューティカルズ，インク． ソマトスタチンモジュレーターとその使用

Also Published As

Publication number Publication date
EP2571356A1 (en) 2013-03-27
US20130040978A1 (en) 2013-02-14
CA2799414A1 (en) 2011-11-24
AR081401A1 (es) 2012-08-29
TW201200524A (en) 2012-01-01
WO2011146324A1 (en) 2011-11-24
AU2011256444A1 (en) 2012-10-18
EP2571356A4 (en) 2013-11-20
AU2011256444B2 (en) 2014-07-10

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