JP2013528650A5 - - Google Patents
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- Publication number
- JP2013528650A5 JP2013528650A5 JP2013515459A JP2013515459A JP2013528650A5 JP 2013528650 A5 JP2013528650 A5 JP 2013528650A5 JP 2013515459 A JP2013515459 A JP 2013515459A JP 2013515459 A JP2013515459 A JP 2013515459A JP 2013528650 A5 JP2013528650 A5 JP 2013528650A5
- Authority
- JP
- Japan
- Prior art keywords
- ylthio
- bromo
- triazol
- acetic acid
- cyclopropylnaphthalen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 51
- -1 4-cyclopropylnaphthalen-1-yl Chemical group 0.000 claims 20
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 7
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 7
- 229960003459 allopurinol Drugs 0.000 claims 7
- 229940116269 uric acid Drugs 0.000 claims 7
- 201000005569 Gout Diseases 0.000 claims 6
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 5
- 241000282412 Homo Species 0.000 claims 4
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 claims 3
- BQSJTQLCZDPROO-UHFFFAOYSA-N febuxostat Chemical compound C1=C(C#N)C(OCC(C)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 BQSJTQLCZDPROO-UHFFFAOYSA-N 0.000 claims 3
- 229960005101 febuxostat Drugs 0.000 claims 3
- FGQFOYHRJSUHMR-UHFFFAOYSA-N lesinurad Chemical compound OC(=O)CSC1=NN=C(Br)N1C(C1=CC=CC=C11)=CC=C1C1CC1 FGQFOYHRJSUHMR-UHFFFAOYSA-N 0.000 claims 3
- 239000003064 xanthine oxidase inhibitor Substances 0.000 claims 3
- 201000001431 Hyperuricemia Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 1
- 229960000583 acetic acid Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35500410P | 2010-06-15 | 2010-06-15 | |
| US61/355,004 | 2010-06-15 | ||
| US41144910P | 2010-11-08 | 2010-11-08 | |
| US61/411,449 | 2010-11-08 | ||
| US201161430522P | 2011-01-06 | 2011-01-06 | |
| US61/430,522 | 2011-01-06 | ||
| US201161489420P | 2011-05-24 | 2011-05-24 | |
| US61/489,420 | 2011-05-24 | ||
| PCT/US2011/040398 WO2011159732A1 (en) | 2010-06-15 | 2011-06-14 | Treatment of gout and hyperuricemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013528650A JP2013528650A (ja) | 2013-07-11 |
| JP2013528650A5 true JP2013528650A5 (cg-RX-API-DMAC7.html) | 2014-06-05 |
| JP5964821B2 JP5964821B2 (ja) | 2016-08-03 |
Family
ID=45348529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515459A Expired - Fee Related JP5964821B2 (ja) | 2010-06-15 | 2011-06-14 | 痛風と高尿酸血症の処置 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9216179B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2582683B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5964821B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2802407C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1120473T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2582683T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2670700T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20180780T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE038265T2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT2582683T (cg-RX-API-DMAC7.html) |
| NO (1) | NO2019008I1 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2582683T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2582683T (cg-RX-API-DMAC7.html) |
| RS (1) | RS57275B1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI2582683T1 (cg-RX-API-DMAC7.html) |
| SM (1) | SMT201800266T1 (cg-RX-API-DMAC7.html) |
| TR (1) | TR201806828T4 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011159732A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201300055B (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3659601A1 (en) | 2010-03-30 | 2020-06-03 | Ardea Biosciences, Inc. | Treatment of gout |
| PT2582683T (pt) * | 2010-06-15 | 2018-05-25 | Ardea Biosciences Inc | Tratamento da gota e de hiperuricemia |
| CN104023723B (zh) * | 2011-11-03 | 2017-05-31 | 阿迪亚生命科学公司 | 3,4‑二取代的吡啶化合物、其使用方法以及包含该化合物的组合物 |
| AR091651A1 (es) | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| CN103613552A (zh) * | 2013-12-02 | 2014-03-05 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸钠的新晶型及其制备方法 |
| US9969701B2 (en) | 2013-12-20 | 2018-05-15 | Crystal Pharmatech Co., Ltd. | Salts and co-crystals of lesinurad |
| CN103755651A (zh) * | 2013-12-23 | 2014-04-30 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的盐的新晶型及其制备方法 |
| JP2015160847A (ja) * | 2014-02-28 | 2015-09-07 | ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ | 小分子のキサンチンオキシダーゼ阻害剤および使用方法 |
| CN105622531A (zh) | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
| WO2016203436A1 (en) * | 2015-06-19 | 2016-12-22 | Dr. Reddy's Laboratories Limited | Amorphous and amorphous solid dispersion of lesinurad and their preparation |
| EP3112334A1 (en) | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Process for manufacturing 1-cyclopropyl-naphthalenes |
| CN108289848A (zh) * | 2015-12-08 | 2018-07-17 | 阿迪亚生命科学公司 | 包含urat1的有效抑制剂的药物组合物 |
| US11447916B2 (en) | 2018-10-26 | 2022-09-20 | The Procter & Gamble Company | Paper towel rolls |
| CA3060211C (en) | 2018-10-26 | 2025-05-13 | The Procter & Gamble Company | TOILET PAPER ROLLS |
| CA3060180A1 (en) | 2018-10-26 | 2020-04-26 | The Procter & Gamble Company | Sanitary tissue product rolls |
| US11700979B2 (en) | 2018-10-26 | 2023-07-18 | The Procter & Gamble Company | Sanitary tissue product rolls |
| WO2021033773A1 (ja) * | 2019-08-21 | 2021-02-25 | 国立大学法人東京大学 | Ａｂｃｃ１１阻害剤 |
| CN110824067B (zh) * | 2019-12-11 | 2024-12-27 | 天津药物研究院有限公司 | 一种非布司他中基因毒性杂质的检测方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4914611B2 (ja) | 2003-12-26 | 2012-04-11 | キッセイ薬品工業株式会社 | ベンズイミダゾール誘導体及びその医薬用途 |
| US20060189811A1 (en) | 2004-07-23 | 2006-08-24 | Fujiyakuhin Co., Ltd. | Process for producing 1,2,4-triazole compound and intermediate therefor |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| PT2135608E (pt) | 2004-08-25 | 2012-01-13 | Ardea Biosciences Inc | S-triazolil-alfa-mercaptoacetanilidas como inibidores de transcritase inversa de vih |
| CN101646440A (zh) | 2007-01-19 | 2010-02-10 | 武田制药北美公司 | 使用黄嘌呤氧化还原酶抑制剂和抗炎剂预防痛风突发或减少痛风突发次数的方法 |
| US8084483B2 (en) * | 2007-11-27 | 2011-12-27 | Ardea Biosciences, Inc. | Compounds and compositions and methods of use |
| JP2012502049A (ja) * | 2008-09-04 | 2012-01-26 | アルディア バイオサイエンス，インク． | 尿酸値を調節するための化合物、組成物及びそれを使用する方法。 |
| US8173690B2 (en) * | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US20100160351A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| WO2010135530A2 (en) * | 2009-05-20 | 2010-11-25 | Ardea Biosciences, Inc. | Compounds, compositions and methods for modulating uric acid levels |
| EP2266966A1 (en) | 2009-06-11 | 2010-12-29 | Chemo Ibérica, S.A. | A process for the preparation of febuxostat |
| EA020183B1 (ru) | 2010-01-08 | 2014-09-30 | Ардеа Биосайнсиз, Инк. | Полиморфная, кристаллическая и мезофазная формы 2-(5-бром-4-(4-циклопропилнафталинил-1-ил)-4н-1,2,4-триазол-3-илтио)ацетата натрия и их применение |
| EP3659601A1 (en) * | 2010-03-30 | 2020-06-03 | Ardea Biosciences, Inc. | Treatment of gout |
| PT2582683T (pt) * | 2010-06-15 | 2018-05-25 | Ardea Biosciences Inc | Tratamento da gota e de hiperuricemia |
| US8933070B2 (en) * | 2010-07-02 | 2015-01-13 | University Health Network | Methods of targeting PTEN mutant diseases and compositions therefor |
| CN106176736A (zh) | 2010-10-15 | 2016-12-07 | 阿迪亚生命科学公司 | 用于治疗高尿酸血症及相关疾病的方法 |
| CA2817249C (en) * | 2010-12-30 | 2015-02-10 | Ardea Biosciences, Inc. | Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid and uses thereof |
| RS56225B1 (sr) | 2011-05-24 | 2017-11-30 | Ardea Biosciences Inc | Hipertenzija i hiperurikemija |
-
2011
- 2011-06-14 PT PT117963249T patent/PT2582683T/pt unknown
- 2011-06-14 HR HRP20180780TT patent/HRP20180780T1/hr unknown
- 2011-06-14 EP EP11796324.9A patent/EP2582683B1/en not_active Revoked
- 2011-06-14 CA CA2802407A patent/CA2802407C/en not_active Expired - Fee Related
- 2011-06-14 SI SI201131474T patent/SI2582683T1/en unknown
- 2011-06-14 WO PCT/US2011/040398 patent/WO2011159732A1/en not_active Ceased
- 2011-06-14 JP JP2013515459A patent/JP5964821B2/ja not_active Expired - Fee Related
- 2011-06-14 SM SM20180266T patent/SMT201800266T1/it unknown
- 2011-06-14 DK DK11796324.9T patent/DK2582683T3/en active
- 2011-06-14 HU HUE11796324A patent/HUE038265T2/hu unknown
- 2011-06-14 ES ES11796324.9T patent/ES2670700T3/es active Active
- 2011-06-14 LT LTEP11796324.9T patent/LT2582683T/lt unknown
- 2011-06-14 PL PL11796324T patent/PL2582683T3/pl unknown
- 2011-06-14 TR TR2018/06828T patent/TR201806828T4/tr unknown
- 2011-06-14 RS RS20180571A patent/RS57275B1/sr unknown
- 2011-06-14 US US13/704,192 patent/US9216179B2/en active Active
-
2013
- 2013-01-03 ZA ZA2013/00055A patent/ZA201300055B/en unknown
-
2015
- 2015-11-12 US US14/939,963 patent/US20160143889A1/en not_active Abandoned
-
2018
- 2018-05-18 CY CY20181100520T patent/CY1120473T1/el unknown
- 2018-09-19 US US16/135,153 patent/US20190015392A1/en not_active Abandoned
-
2019
- 2019-02-19 NO NO2019008C patent/NO2019008I1/no unknown
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