JP5964821B2 - 痛風と高尿酸血症の処置 - Google Patents
痛風と高尿酸血症の処置 Download PDFInfo
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- JP5964821B2 JP5964821B2 JP2013515459A JP2013515459A JP5964821B2 JP 5964821 B2 JP5964821 B2 JP 5964821B2 JP 2013515459 A JP2013515459 A JP 2013515459A JP 2013515459 A JP2013515459 A JP 2013515459A JP 5964821 B2 JP5964821 B2 JP 5964821B2
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- gout
- uric acid
- bromo
- ylthio
- triazol
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US35500410P | 2010-06-15 | 2010-06-15 | |
| US61/355,004 | 2010-06-15 | ||
| US41144910P | 2010-11-08 | 2010-11-08 | |
| US61/411,449 | 2010-11-08 | ||
| US201161430522P | 2011-01-06 | 2011-01-06 | |
| US61/430,522 | 2011-01-06 | ||
| US201161489420P | 2011-05-24 | 2011-05-24 | |
| US61/489,420 | 2011-05-24 | ||
| PCT/US2011/040398 WO2011159732A1 (en) | 2010-06-15 | 2011-06-14 | Treatment of gout and hyperuricemia |
Publications (3)
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| JP2013528650A JP2013528650A (ja) | 2013-07-11 |
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| JP5964821B2 true JP5964821B2 (ja) | 2016-08-03 |
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| EP3659601A1 (en) | 2010-03-30 | 2020-06-03 | Ardea Biosciences, Inc. | Treatment of gout |
| PT2582683T (pt) * | 2010-06-15 | 2018-05-25 | Ardea Biosciences Inc | Tratamento da gota e de hiperuricemia |
| CN104023723B (zh) * | 2011-11-03 | 2017-05-31 | 阿迪亚生命科学公司 | 3,4‑二取代的吡啶化合物、其使用方法以及包含该化合物的组合物 |
| AR091651A1 (es) | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| CN103613552A (zh) * | 2013-12-02 | 2014-03-05 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸钠的新晶型及其制备方法 |
| US9969701B2 (en) | 2013-12-20 | 2018-05-15 | Crystal Pharmatech Co., Ltd. | Salts and co-crystals of lesinurad |
| CN103755651A (zh) * | 2013-12-23 | 2014-04-30 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的盐的新晶型及其制备方法 |
| JP2015160847A (ja) * | 2014-02-28 | 2015-09-07 | ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ | 小分子のキサンチンオキシダーゼ阻害剤および使用方法 |
| CN105622531A (zh) | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
| WO2016203436A1 (en) * | 2015-06-19 | 2016-12-22 | Dr. Reddy's Laboratories Limited | Amorphous and amorphous solid dispersion of lesinurad and their preparation |
| EP3112334A1 (en) | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Process for manufacturing 1-cyclopropyl-naphthalenes |
| CN108289848A (zh) * | 2015-12-08 | 2018-07-17 | 阿迪亚生命科学公司 | 包含urat1的有效抑制剂的药物组合物 |
| US11447916B2 (en) | 2018-10-26 | 2022-09-20 | The Procter & Gamble Company | Paper towel rolls |
| CA3060211C (en) | 2018-10-26 | 2025-05-13 | The Procter & Gamble Company | TOILET PAPER ROLLS |
| CA3060180A1 (en) | 2018-10-26 | 2020-04-26 | The Procter & Gamble Company | Sanitary tissue product rolls |
| US11700979B2 (en) | 2018-10-26 | 2023-07-18 | The Procter & Gamble Company | Sanitary tissue product rolls |
| WO2021033773A1 (ja) * | 2019-08-21 | 2021-02-25 | 国立大学法人東京大学 | Ａｂｃｃ１１阻害剤 |
| CN110824067B (zh) * | 2019-12-11 | 2024-12-27 | 天津药物研究院有限公司 | 一种非布司他中基因毒性杂质的检测方法 |
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| JP4914611B2 (ja) | 2003-12-26 | 2012-04-11 | キッセイ薬品工業株式会社 | ベンズイミダゾール誘導体及びその医薬用途 |
| US20060189811A1 (en) | 2004-07-23 | 2006-08-24 | Fujiyakuhin Co., Ltd. | Process for producing 1,2,4-triazole compound and intermediate therefor |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| PT2135608E (pt) | 2004-08-25 | 2012-01-13 | Ardea Biosciences Inc | S-triazolil-alfa-mercaptoacetanilidas como inibidores de transcritase inversa de vih |
| CN101646440A (zh) | 2007-01-19 | 2010-02-10 | 武田制药北美公司 | 使用黄嘌呤氧化还原酶抑制剂和抗炎剂预防痛风突发或减少痛风突发次数的方法 |
| US8084483B2 (en) * | 2007-11-27 | 2011-12-27 | Ardea Biosciences, Inc. | Compounds and compositions and methods of use |
| JP2012502049A (ja) * | 2008-09-04 | 2012-01-26 | アルディア バイオサイエンス，インク． | 尿酸値を調節するための化合物、組成物及びそれを使用する方法。 |
| US8173690B2 (en) * | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US20100160351A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| WO2010135530A2 (en) * | 2009-05-20 | 2010-11-25 | Ardea Biosciences, Inc. | Compounds, compositions and methods for modulating uric acid levels |
| EP2266966A1 (en) | 2009-06-11 | 2010-12-29 | Chemo Ibérica, S.A. | A process for the preparation of febuxostat |
| EA020183B1 (ru) | 2010-01-08 | 2014-09-30 | Ардеа Биосайнсиз, Инк. | Полиморфная, кристаллическая и мезофазная формы 2-(5-бром-4-(4-циклопропилнафталинил-1-ил)-4н-1,2,4-триазол-3-илтио)ацетата натрия и их применение |
| EP3659601A1 (en) * | 2010-03-30 | 2020-06-03 | Ardea Biosciences, Inc. | Treatment of gout |
| PT2582683T (pt) * | 2010-06-15 | 2018-05-25 | Ardea Biosciences Inc | Tratamento da gota e de hiperuricemia |
| US8933070B2 (en) * | 2010-07-02 | 2015-01-13 | University Health Network | Methods of targeting PTEN mutant diseases and compositions therefor |
| CN106176736A (zh) | 2010-10-15 | 2016-12-07 | 阿迪亚生命科学公司 | 用于治疗高尿酸血症及相关疾病的方法 |
| CA2817249C (en) * | 2010-12-30 | 2015-02-10 | Ardea Biosciences, Inc. | Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid and uses thereof |
| RS56225B1 (sr) | 2011-05-24 | 2017-11-30 | Ardea Biosciences Inc | Hipertenzija i hiperurikemija |
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| WO2011159732A1 (en) | 2011-12-22 |
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| EP2582683A1 (en) | 2013-04-24 |
| US20160143889A1 (en) | 2016-05-26 |
| PT2582683T (pt) | 2018-05-25 |
| JP2013528650A (ja) | 2013-07-11 |
| CY1120473T1 (el) | 2019-07-10 |
| CA2802407C (en) | 2018-01-23 |
| SI2582683T1 (en) | 2018-07-31 |
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| LT2582683T (lt) | 2018-06-11 |
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| CA2802407A1 (en) | 2011-12-22 |
| EP2582683B1 (en) | 2018-03-21 |
| RS57275B1 (sr) | 2018-08-31 |
| NO2019008I1 (no) | 2019-02-19 |
| TR201806828T4 (tr) | 2018-06-21 |
| US20190015392A1 (en) | 2019-01-17 |
| DK2582683T3 (en) | 2018-06-06 |
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