JP2013527832A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013527832A5 JP2013527832A5 JP2013501354A JP2013501354A JP2013527832A5 JP 2013527832 A5 JP2013527832 A5 JP 2013527832A5 JP 2013501354 A JP2013501354 A JP 2013501354A JP 2013501354 A JP2013501354 A JP 2013501354A JP 2013527832 A5 JP2013527832 A5 JP 2013527832A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- poe sorbitan
- polyethylene glycol
- set composition
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 21
- 229920001214 Polysorbate 60 Polymers 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 16
- 238000000034 method Methods 0.000 claims 13
- 239000002202 Polyethylene glycol Substances 0.000 claims 12
- 229920001223 polyethylene glycol Polymers 0.000 claims 12
- 239000007864 aqueous solution Substances 0.000 claims 8
- 238000009472 formulation Methods 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 239000008118 PEG 6000 Substances 0.000 claims 2
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 2
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 claims 2
- 230000004845 protein aggregation Effects 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31632610P | 2010-03-22 | 2010-03-22 | |
| US61/316,326 | 2010-03-22 | ||
| PCT/US2011/029206 WO2011119487A2 (en) | 2010-03-22 | 2011-03-21 | Compositions and methods useful for stabilizing protein-containing formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016094543A Division JP6742805B2 (ja) | 2010-03-22 | 2016-05-10 | タンパク質含有製剤の安定化に有用な組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013527832A JP2013527832A (ja) | 2013-07-04 |
| JP2013527832A5 true JP2013527832A5 (enExample) | 2014-05-08 |
| JP5937059B2 JP5937059B2 (ja) | 2016-06-22 |
Family
ID=43977896
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501354A Active JP5937059B2 (ja) | 2010-03-22 | 2011-03-21 | タンパク質含有製剤の安定化に有用な組成物及び方法 |
| JP2016094543A Active JP6742805B2 (ja) | 2010-03-22 | 2016-05-10 | タンパク質含有製剤の安定化に有用な組成物及び方法 |
| JP2018201804A Active JP6791929B2 (ja) | 2010-03-22 | 2018-10-26 | タンパク質含有製剤の安定化に有用な組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016094543A Active JP6742805B2 (ja) | 2010-03-22 | 2016-05-10 | タンパク質含有製剤の安定化に有用な組成物及び方法 |
| JP2018201804A Active JP6791929B2 (ja) | 2010-03-22 | 2018-10-26 | タンパク質含有製剤の安定化に有用な組成物及び方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9662395B2 (enExample) |
| EP (2) | EP3513810A1 (enExample) |
| JP (3) | JP5937059B2 (enExample) |
| KR (3) | KR102218495B1 (enExample) |
| CN (3) | CN106983862A (enExample) |
| BR (1) | BR112012021873B8 (enExample) |
| CA (2) | CA2792125C (enExample) |
| ES (1) | ES2722201T3 (enExample) |
| HR (1) | HRP20190751T1 (enExample) |
| MX (1) | MX354867B (enExample) |
| PL (1) | PL2550018T3 (enExample) |
| RU (1) | RU2584232C2 (enExample) |
| SI (1) | SI2550018T1 (enExample) |
| TR (1) | TR201905081T4 (enExample) |
| WO (1) | WO2011119487A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102218495B1 (ko) | 2010-03-22 | 2021-02-19 | 제넨테크, 인크. | 단백질-함유 제제의 안정화에 유용한 조성물 및 방법 |
| HK1201857A1 (en) * | 2011-10-31 | 2015-09-11 | F. Hoffmann-La Roche Ag | Antibody formulations |
| DK3071237T3 (da) * | 2013-11-21 | 2024-09-09 | Genmab As | Lyofiliseret formulering af antistoflægemiddelkonjugat |
| US11058768B2 (en) | 2014-04-16 | 2021-07-13 | Biocon Ltd. | Stable protein formulations comprising a molar excess of sorbitol |
| IS3008B (is) | 2014-05-14 | 2018-12-15 | Calor ehf | Stöðgandi lausnir fyrir prótín og peptíð |
| EP2946766B1 (en) | 2014-05-23 | 2016-03-02 | Ares Trading S.A. | Liquid pharmaceutical composition |
| ES2600488T3 (es) | 2014-05-23 | 2017-02-09 | Ares Trading S.A. | Composición farmacéutica líquida |
| EP3053572A1 (en) * | 2015-02-06 | 2016-08-10 | Ares Trading S.A. | Liquid pharmaceutical composition |
| US12115227B2 (en) * | 2016-01-13 | 2024-10-15 | Genmab A/S | Formulation for antibody and drug conjugate thereof |
| CN106771148B (zh) * | 2016-12-28 | 2018-03-06 | 广州华弘生物科技有限公司 | 一种免疫球蛋白m检测试剂盒及检测方法 |
| CN106771244B (zh) * | 2016-12-28 | 2018-02-02 | 广州华弘生物科技有限公司 | 一种纤维蛋白原定量检测试剂盒及检测方法 |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| EP3745129A4 (en) * | 2018-03-23 | 2021-03-24 | Konica Minolta, Inc. | MARKED ANTIBODY DISPERSION LIQUID AND KIT FOR SPFS |
| UA130009C2 (uk) | 2018-05-07 | 2025-10-15 | Генмаб А/С | Спосіб лікування раку за допомогою комбінації антитіла до pd-1 і кон'югата антитіла до тканинного фактора і лікарського засобу |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| KR20210145152A (ko) * | 2019-04-01 | 2021-12-01 | 제넨테크, 인크. | 단백질-함유 제제들의 안정화를 위한 조성물들 및 방법들 |
| US11513602B2 (en) | 2019-09-10 | 2022-11-29 | Wagner Spray Tech Corporation | Gesture control of a fluid application system |
| CN111964942A (zh) * | 2020-08-28 | 2020-11-20 | 湖南海尚仪器设备有限公司 | 基于工业环境污染物检测的采样方法 |
| CN116507319A (zh) * | 2020-11-16 | 2023-07-28 | W.L.戈尔及同仁股份有限公司 | 不含浊点的制剂、方法和预填充多剂量注射装置 |
| CN112816684B (zh) * | 2021-01-07 | 2024-08-30 | 武汉华美生物工程有限公司 | 血清淀粉样蛋白a的校准品稀释液、其制备方法及其应用 |
| KR20240125027A (ko) * | 2021-12-20 | 2024-08-19 | 베링거 인겔하임 인터내셔날 게엠베하 | 수성 제형 중 폴리소르베이트 20의 산화 분해도를 측정하는 방법 |
| WO2025194043A1 (en) * | 2024-03-15 | 2025-09-18 | Regeneron Pharmaceuticals, Inc. | Polysorbate and polyoxyethylene sorbitan as excipients for stable protein formulations |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB845274A (en) * | 1955-10-06 | 1960-08-17 | Gen Foods Corp | Improved gelatin composition |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4515893A (en) | 1979-04-26 | 1985-05-07 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells |
| EP0040409B1 (de) | 1980-05-21 | 1984-11-14 | Siemens Aktiengesellschaft | Mosaiktafel mit geschlossener Frontseite |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| AU3722984A (en) * | 1984-01-05 | 1985-07-11 | Manlab Pty. Ltd. | Reagents for immunoassay at elevated temperatures |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5091178A (en) | 1986-02-21 | 1992-02-25 | Oncogen | Tumor therapy with biologically active anti-tumor antibodies |
| US4925673A (en) | 1986-08-18 | 1990-05-15 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| US5183746A (en) | 1986-10-27 | 1993-02-02 | Schering Aktiengesellschaft | Formulation processes for pharmaceutical compositions of recombinant β- |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| JPS6475433A (en) * | 1987-09-16 | 1989-03-22 | Teijin Ltd | Remedy for herpes simplex virus infection |
| DE3863908D1 (de) * | 1987-11-27 | 1991-08-29 | Akzo Nv | Stabilisierung von antikoerpern. |
| US5091313A (en) | 1988-08-05 | 1992-02-25 | Tanox Biosystems, Inc. | Antigenic epitopes of IgE present on B cell but not basophil surface |
| US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
| WO1989012463A1 (en) | 1988-06-21 | 1989-12-28 | Genentech, Inc. | Method and therapeutic compositions for the treatment of myocardial infarction |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5945098A (en) * | 1990-02-01 | 1999-08-31 | Baxter International Inc. | Stable intravenously-administrable immune globulin preparation |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| WO1993000807A1 (en) * | 1991-07-03 | 1993-01-21 | Cryolife, Inc. | Method for stabilization of biomaterials |
| ES2193136T3 (es) | 1991-08-14 | 2003-11-01 | Genentech Inc | Variantes de inmunoglubina para receptores especificos de fc epsilon. |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| EP0656789B1 (en) | 1992-08-21 | 1997-12-17 | Genentech, Inc. | Method for treating a lfa-1-mediated disorder |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| ES2151541T3 (es) | 1992-12-02 | 2001-01-01 | Alkermes Inc | Microesferas que contienen hormona del crecimiento de liberacion prolongada. |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| US5714338A (en) | 1993-12-10 | 1998-02-03 | Genentech, Inc. | Methods for diagnosis of allergy |
| EP0739214B1 (en) | 1994-01-18 | 1998-03-18 | Genentech, Inc. | A METHOD OF TREATMENT OF PARASITIC INFECTION USING IgE ANTAGONISTS |
| EP0749488A1 (en) | 1994-03-03 | 1996-12-27 | Genentech, Inc. | Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders |
| BR9509201A (pt) | 1994-09-09 | 1997-12-30 | Takeda Chemical Industries Ltd | Preparação de liberação sustemtada uso de um sal de metal polivalente insolúvel em água ou ligeiramente solúvel em água e processo para produzir uma preparação de liberação sustentada |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| EP0831787B1 (en) | 1995-06-07 | 2001-08-22 | Alkermes Controlled Therapeutics, Inc. | Composition for sustained release of human growth hormone |
| AU6267896A (en) | 1995-06-07 | 1996-12-30 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth oftumors |
| ZA965368B (en) | 1995-07-14 | 1997-01-14 | Novo Nordisk As | A pharmaceutical formulation |
| EP1297847A3 (en) | 1996-01-23 | 2003-05-07 | Genentech, Inc. | Anti-CD18 antibodies in stroke |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US6037454A (en) | 1996-11-27 | 2000-03-14 | Genentech, Inc. | Humanized anti-CD11a antibodies |
| KR100532178B1 (ko) | 1996-11-27 | 2005-12-01 | 제넨테크, 인크. | 인간화 항-ＣＤ11ａ 항체 |
| ES2236634T3 (es) | 1997-04-07 | 2005-07-16 | Genentech, Inc. | Anticuerpos anti-vegf. |
| ES2293682T5 (es) | 1997-05-15 | 2011-11-17 | Genentech, Inc. | Anticuerpo anti-apo2. |
| US5994511A (en) | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| GEP20104998B (en) | 1999-06-25 | 2010-06-10 | Genentech Inc | Humanized antibody which binds erbb2 and blocks activation by ligand receptor of erbb2 (variants) and use of the composition comprising these antibodies methods for treating cancer |
| EP1218035A2 (en) * | 1999-09-29 | 2002-07-03 | The Trustees Of The University Of Pennsylvania | Rapid peg-modification of viral vectors |
| US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
| DK1226177T3 (da) | 1999-10-29 | 2008-10-06 | Genentech Inc | Antistofsammensætninger mod anti-prostata stamcelle-antigen (PSCA) og anvendelser deraf |
| UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| IL155002A0 (en) | 2000-10-12 | 2003-10-31 | Genentech Inc | Reduced-viscosity concentrated protein formulations |
| US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| WO2003033658A2 (en) | 2001-10-17 | 2003-04-24 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| CN100522999C (zh) | 2002-02-14 | 2009-08-05 | 免疫医疗公司 | 抗cd20抗体及其融合蛋白和使用方法 |
| WO2004035607A2 (en) | 2002-10-17 | 2004-04-29 | Genmab A/S | Human monoclonal antibodies against cd20 |
| PT1572744E (pt) | 2002-12-16 | 2010-09-07 | Genentech Inc | Variantes de imunoglobulina e utilizações destas |
| US20050158303A1 (en) | 2003-04-04 | 2005-07-21 | Genentech, Inc. | Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations |
| DK1610820T4 (da) | 2003-04-04 | 2013-11-04 | Genentech Inc | Høj-koncentration antistof- og proteinformuleringer |
| NZ543960A (en) | 2003-05-09 | 2008-11-28 | Univ Duke | CD20-specific antibodies and methods of employing same |
| AR044388A1 (es) | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
| EP1663158A2 (en) * | 2003-06-24 | 2006-06-07 | Baxter International Inc. | Specific delivery of drugs to the brain |
| JP4818917B2 (ja) | 2003-08-08 | 2011-11-16 | イミューノメディクス、インコーポレイテッド | 腫瘍および罹患細胞のアポトーシスを誘発するための二重特異性抗体 |
| US8147832B2 (en) | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
| JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| RU2430112C2 (ru) | 2005-06-20 | 2011-09-27 | Дженентек, Инк. | Композиции и способы диагностики и лечения опухоли |
| WO2007019232A2 (en) * | 2005-08-03 | 2007-02-15 | Immunogen, Inc. | Immunoconjugate formulations |
| ZA200800146B (en) * | 2005-08-03 | 2009-10-28 | Immunogen Inc | Immunoconjugate formulations |
| NZ621174A (en) * | 2008-01-15 | 2015-09-25 | Abbvie Deutschland | Powdered protein compositions and methods of making same |
| WO2010030670A2 (en) * | 2008-09-10 | 2010-03-18 | Genentech, Inc. | Compositions and methods for the prevention of oxidative degradation of proteins |
| CA2754528A1 (en) | 2009-03-06 | 2010-09-10 | Genetech, Inc. | Antibody formulation |
| KR102218495B1 (ko) * | 2010-03-22 | 2021-02-19 | 제넨테크, 인크. | 단백질-함유 제제의 안정화에 유용한 조성물 및 방법 |
| AU2012275233A1 (en) * | 2011-06-30 | 2013-11-28 | Genentech, Inc. | Anti-c-met antibody formulations |
| JP5731726B1 (ja) | 2014-06-26 | 2015-06-10 | 楽天株式会社 | 情報処理装置、情報処理方法及び情報処理プログラム |
-
2011
- 2011-03-21 KR KR1020197025585A patent/KR102218495B1/ko active Active
- 2011-03-21 MX MX2012010612A patent/MX354867B/es active IP Right Grant
- 2011-03-21 SI SI201131707T patent/SI2550018T1/sl unknown
- 2011-03-21 CN CN201610895373.9A patent/CN106983862A/zh active Pending
- 2011-03-21 BR BR112012021873A patent/BR112012021873B8/pt active IP Right Grant
- 2011-03-21 RU RU2012144626/15A patent/RU2584232C2/ru active
- 2011-03-21 EP EP19156621.5A patent/EP3513810A1/en active Pending
- 2011-03-21 HR HRP20190751TT patent/HRP20190751T1/hr unknown
- 2011-03-21 EP EP11711232.6A patent/EP2550018B1/en active Active
- 2011-03-21 TR TR2019/05081T patent/TR201905081T4/tr unknown
- 2011-03-21 CA CA2792125A patent/CA2792125C/en active Active
- 2011-03-21 CA CA3027749A patent/CA3027749A1/en not_active Abandoned
- 2011-03-21 CN CN201510472469.XA patent/CN104998269B/zh active Active
- 2011-03-21 CN CN201180018192.3A patent/CN103124564B/zh active Active
- 2011-03-21 ES ES11711232T patent/ES2722201T3/es active Active
- 2011-03-21 KR KR1020177036456A patent/KR20180000342A/ko not_active Ceased
- 2011-03-21 WO PCT/US2011/029206 patent/WO2011119487A2/en not_active Ceased
- 2011-03-21 PL PL11711232T patent/PL2550018T3/pl unknown
- 2011-03-21 KR KR1020127024667A patent/KR101878369B1/ko active Active
- 2011-03-21 JP JP2013501354A patent/JP5937059B2/ja active Active
-
2012
- 2012-09-21 US US13/624,381 patent/US9662395B2/en active Active
-
2016
- 2016-05-10 JP JP2016094543A patent/JP6742805B2/ja active Active
-
2017
- 2017-04-25 US US15/497,068 patent/US20170224820A1/en not_active Abandoned
-
2018
- 2018-10-26 JP JP2018201804A patent/JP6791929B2/ja active Active
-
2019
- 2019-09-27 US US16/586,698 patent/US20200023063A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013527832A5 (enExample) | ||
| RU2012144626A (ru) | Композиции и способы, используемые для стабилизации белоксодержащих готовых форм | |
| JP2016537969A5 (enExample) | ||
| Zhu et al. | Nanoencapsulation of functional food ingredients | |
| WO2014141152A3 (en) | Low concentration antibody formulations | |
| WO2014066468A8 (en) | Stable, low viscosity antibody formulation | |
| HK1213174A1 (zh) | 穩定的含水依那西普製劑 | |
| PH12014502778A1 (en) | Antibody formulation | |
| WO2012076670A3 (en) | Antibody formulation | |
| WO2013164789A3 (en) | Lyophilised and aqueous anti-cd40 antibody formulations | |
| AR051574A1 (es) | Procedimiento de preparacion de un producto en polvo | |
| BR112021019612A2 (pt) | Formulações, recipiente, artigo de fabricação, método para produzir a formulação e método para inibir a agregação de uma proteína presente em uma solução aquosa | |
| ZA201908610B (en) | Il-15 protein complex pharmaceutical composition and uses thereof | |
| Panda et al. | Molecular interactions of choline based ionic liquids with water at different temperatures: An experimental study | |
| WO2016008401A8 (zh) | 一种含多西他赛的药物组合物 | |
| GB201122430D0 (en) | Reconstitution method for high concentration dry protein formulation | |
| JP2017088527A5 (enExample) | ||
| EA201500694A1 (ru) | Монолитная лекарственная форма для модифицированного высвобождения комбинации активных ингредиентов | |
| WO2011151418A8 (en) | Nanosuspension formulation comprising a polydimethylsiloxane hydrophobic phase | |
| CN105125497B (zh) | 一种n(2)-l-丙氨酰-l-谷氨酰胺注射剂的制备方法 | |
| WO2011133894A3 (en) | Protein drug formulations and packages | |
| TH158853A (th) | กระบวนการเตรียมสูตรผสมนมสำหรับทารก (Process for preparing infant formula) | |
| JP2016088850A5 (enExample) | ||
| Khutoryanskiy | Showcasing research by Michael T. Cook, Sarah L. Smith and Vitaliy V. Khutoryanskiy from the University of Reading and University of Hertfordshire, UK | |
| TH171894A (th) | วิธีการเตรียมองค์ประกอบผงแห้งสำหรับสูดดม |