JP2013524837A5 - - Google Patents
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- JP2013524837A5 JP2013524837A5 JP2013508153A JP2013508153A JP2013524837A5 JP 2013524837 A5 JP2013524837 A5 JP 2013524837A5 JP 2013508153 A JP2013508153 A JP 2013508153A JP 2013508153 A JP2013508153 A JP 2013508153A JP 2013524837 A5 JP2013524837 A5 JP 2013524837A5
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- JP
- Japan
- Prior art keywords
- composition
- reprogramming
- poly
- postnatal
- genetically modified
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32898810P | 2010-04-28 | 2010-04-28 | |
| US61/328,988 | 2010-04-28 | ||
| US36429510P | 2010-07-14 | 2010-07-14 | |
| US61/364,295 | 2010-07-14 | ||
| PCT/US2011/033938 WO2011139688A2 (en) | 2010-04-28 | 2011-04-26 | Methods for generating cardiomyocytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524837A JP2013524837A (ja) | 2013-06-20 |
| JP2013524837A5 true JP2013524837A5 (https=) | 2015-05-28 |
| JP5988961B2 JP5988961B2 (ja) | 2016-09-07 |
Family
ID=44904333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013508153A Active JP5988961B2 (ja) | 2010-04-28 | 2011-04-26 | 心筋細胞を発生させるための方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9517250B2 (https=) |
| EP (1) | EP2563907B1 (https=) |
| JP (1) | JP5988961B2 (https=) |
| WO (1) | WO2011139688A2 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US7907222B2 (en) | 2005-09-08 | 2011-03-15 | Universal Electronics Inc. | System and method for simplified setup of a universal remote control |
| US11769398B2 (en) | 2005-09-08 | 2023-09-26 | Universal Electronics Inc. | System and method for widget-assisted setup of a universal remote control |
| US9852615B2 (en) | 2011-03-25 | 2017-12-26 | Universal Electronics Inc. | System and method for facilitating appliance control via a smart device |
| JP5988961B2 (ja) | 2010-04-28 | 2016-09-07 | ザ ジェイ. デヴィッド グラッドストーン インスティテューツ | 心筋細胞を発生させるための方法 |
| JP2013534525A (ja) * | 2010-06-23 | 2013-09-05 | ヴィヴォスクリプト,インコーポレイテッド | 心臓疾患の治療のために遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法 |
| AU2012220702B2 (en) * | 2011-02-22 | 2016-12-15 | The Board Of Regents Of The University Of Texas System | Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes |
| EP2734622B1 (en) * | 2011-07-19 | 2018-09-05 | Vivoscript, Inc. | Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage |
| US9828585B2 (en) | 2011-08-30 | 2017-11-28 | The J. David Gladstone Instututes | Methods for generating cardiomyocytes |
| US9019435B2 (en) | 2011-09-22 | 2015-04-28 | Universal Electronics Inc. | System and method for configuring controlling device functionality |
| US10593195B2 (en) | 2011-10-28 | 2020-03-17 | Universal Electronics Inc. | System and method for optimized appliance control |
| US11295603B2 (en) | 2011-10-28 | 2022-04-05 | Universal Electronics Inc. | System and method for optimized appliance control |
| US10937308B2 (en) | 2011-10-28 | 2021-03-02 | Universal Electronics Inc. | System and method for optimized appliance control |
| US11756412B2 (en) | 2011-10-28 | 2023-09-12 | Universal Electronics Inc. | Systems and methods for associating services and/or devices with a voice assistant |
| US9449500B2 (en) | 2012-08-08 | 2016-09-20 | Universal Electronics Inc. | System and method for optimized appliance control |
| EP2776071B1 (en) | 2011-11-09 | 2018-08-08 | Cedars-Sinai Medical Center | Transcription factor-based generation of pacemaker cells and methods of using same |
| JP2013240308A (ja) * | 2012-05-23 | 2013-12-05 | Kagoshima Univ | ヒトES/iPS細胞における遺伝子発現方法 |
| EP3563859B1 (en) | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Cardiosphere-derived exosomes for tissue regeneration |
| US10130637B2 (en) | 2012-11-02 | 2018-11-20 | Duke University | Inhibition of histone methyltransferase for cardiac reprogramming |
| EP3329779B1 (en) * | 2012-11-02 | 2019-06-05 | Cornell University | Angiogenic conditioning to enhance cardiac cellular reprogramming of fibroblasts of the infarcted myocardium |
| EP3060649A4 (en) | 2013-10-23 | 2017-07-12 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Reprogramming cardiomyocytes with one transcription factor |
| US11377639B2 (en) * | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| DE102013114671B4 (de) | 2013-12-20 | 2015-10-29 | Universität Rostock | Verfahren zur Erzeugung von Sinusknotenzellen ("Herz-Schrittmacherzellen") aus Stammzellen |
| JP2015213441A (ja) * | 2014-05-08 | 2015-12-03 | 学校法人慶應義塾 | 心筋様細胞の作製方法及びそれに用いる培地 |
| US10081816B1 (en) * | 2014-07-03 | 2018-09-25 | Nant Holdings Ip, Llc | Mechanical transfection devices and methods |
| US10760040B1 (en) | 2014-07-03 | 2020-09-01 | NanoCav, LLC | Mechanical transfection devices and methods |
| EP4494699A3 (en) | 2014-10-03 | 2025-04-30 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| WO2016056438A1 (ja) * | 2014-10-06 | 2016-04-14 | 学校法人 慶應義塾 | 心筋様細胞の作製方法及びそれに用いる心筋様細胞の作製用組成物 |
| EP3259346B1 (en) * | 2015-02-20 | 2024-08-07 | Baylor College of Medicine | P63 inactivation for the treatment of heart failure |
| EP3269402B1 (en) * | 2015-03-12 | 2025-10-22 | Adeka Corporation | Anti-adhesion material and substitute biomembrane using decellularized tissue |
| WO2017123662A1 (en) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| WO2017151717A1 (en) * | 2016-03-01 | 2017-09-08 | French Brent A | Compositions and methods for adeno-associated virus mediated gene expression in myofibroblast-like cells |
| EP3431593A4 (en) * | 2016-03-15 | 2019-11-13 | Keio University | METHOD FOR THE DIRECT PREPARATION OF A CARDIGENT CELL OR MYOCARDIAL CELL FROM FIBROBLAST |
| AU2017244205A1 (en) * | 2016-03-30 | 2018-10-25 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Enhanced direct cardiac reprogramming |
| US11433116B2 (en) | 2016-04-14 | 2022-09-06 | Cedars-Sinai Medical Center | GJA1 isoforms protect against metabolic stress |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| EP3474868A4 (en) * | 2016-06-27 | 2020-07-29 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | MODIFIED GLYCOPROTEINS. |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| WO2018055235A1 (en) | 2016-09-21 | 2018-03-29 | University Of Helsinki | Isoxazole-amides for treating cardiac diseases |
| JP7336769B2 (ja) | 2017-04-19 | 2023-09-01 | シーダーズ―シナイ メディカル センター | 骨格筋ジストロフィーを治療する方法及び組成物 |
| US20200216813A1 (en) * | 2017-06-21 | 2020-07-09 | Mogrify Limited | Cell reprogramming to cardiomyocytes |
| WO2019126068A1 (en) | 2017-12-20 | 2019-06-27 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| CN111684059A (zh) | 2018-01-30 | 2020-09-18 | 株式会社片冈制作所 | 心肌细胞的制备方法 |
| EP3749344A4 (en) | 2018-02-05 | 2022-01-26 | Cedars-Sinai Medical Center | METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS |
| JP7450945B2 (ja) | 2018-08-30 | 2024-03-18 | テナヤ セラピューティクス, インコーポレイテッド | ミオカルディンおよびascl1を用いた心細胞リプログラミング |
| EP3947700A4 (en) | 2019-04-01 | 2023-01-04 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| WO2020227489A1 (en) * | 2019-05-08 | 2020-11-12 | Cedars-Sinai Medical Center | Therapeutically active cells and exosomes |
| WO2020247957A2 (en) * | 2019-06-06 | 2020-12-10 | President And Fellows Of Harvard College | Cardiomyocytes and compositions and methods for producing the same |
| WO2021050877A1 (en) * | 2019-09-11 | 2021-03-18 | Icahn School Of Medicine At Mount Sinai | Compositions including molecules of modified mrna and methods of using the same |
| WO2021112115A1 (ja) * | 2019-12-03 | 2021-06-10 | 学校法人自治医科大学 | 心筋細胞の成熟方法、心筋細胞の成熟度評価方法、成熟心筋細胞の純化方法、創薬支援方法、心疾患の治療方法、成熟心筋細胞マーカー、レポーター細胞、成熟心筋細胞、心筋細胞成熟度評価装置、心筋細胞成熟度評価プログラム、心筋細胞成熟キット、及び心筋細胞純化キット |
| US12552838B2 (en) | 2020-04-20 | 2026-02-17 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| BR112023006305A2 (pt) | 2020-10-09 | 2023-05-09 | Tenaya Therapeutics Inc | Métodos e composições de terapia gênica com placofilina-2 |
| CN113046308A (zh) * | 2021-03-05 | 2021-06-29 | 苏州大学附属第二医院 | 促进心脏损伤后修复的一类新型成纤维细胞及其标识方法 |
| WO2023201207A1 (en) | 2022-04-11 | 2023-10-19 | Tenaya Therapeutics, Inc. | Adeno-associated virus with engineered capsid |
| CN120390645A (zh) | 2023-01-10 | 2025-07-29 | 庆应义塾 | 心脏舒张功能改善剂和心脏舒张功能改善剂的筛选方法 |
| WO2025129079A1 (en) * | 2023-12-13 | 2025-06-19 | Tenaya Therapeutics, Inc. | Cardiac-specific promoters for gene therapy |
| WO2026009883A1 (ja) * | 2024-07-03 | 2026-01-08 | 慶應義塾 | 心筋ダイレクトリプログラミングのための組換えアデノ随伴ウイルスベクター |
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| EP2542669B1 (en) | 2010-03-05 | 2015-01-21 | Texas Heart Institute | Ets2 and mesp1 generate cardiac progenitors from fibroblasts |
| JP5988961B2 (ja) | 2010-04-28 | 2016-09-07 | ザ ジェイ. デヴィッド グラッドストーン インスティテューツ | 心筋細胞を発生させるための方法 |
| JP2013534525A (ja) * | 2010-06-23 | 2013-09-05 | ヴィヴォスクリプト,インコーポレイテッド | 心臓疾患の治療のために遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法 |
| US9828585B2 (en) | 2011-08-30 | 2017-11-28 | The J. David Gladstone Instututes | Methods for generating cardiomyocytes |
-
2011
- 2011-04-26 JP JP2013508153A patent/JP5988961B2/ja active Active
- 2011-04-26 EP EP11777910.8A patent/EP2563907B1/en active Active
- 2011-04-26 US US13/642,391 patent/US9517250B2/en active Active
- 2011-04-26 WO PCT/US2011/033938 patent/WO2011139688A2/en not_active Ceased
-
2014
- 2014-03-19 US US14/219,541 patent/US9517251B2/en active Active
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