JP2013522315A5 - - Google Patents
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- Publication number
- JP2013522315A5 JP2013522315A5 JP2013500197A JP2013500197A JP2013522315A5 JP 2013522315 A5 JP2013522315 A5 JP 2013522315A5 JP 2013500197 A JP2013500197 A JP 2013500197A JP 2013500197 A JP2013500197 A JP 2013500197A JP 2013522315 A5 JP2013522315 A5 JP 2013522315A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- bacillus subtilis
- subtilis qst713
- administered
- symptom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 26
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 12
- 240000008371 Bacillus subtilis Species 0.000 claims 12
- 229940075615 Bacillus subtilis Drugs 0.000 claims 12
- 208000008665 Gastrointestinal Disease Diseases 0.000 claims 6
- 206010012735 Diarrhoea Diseases 0.000 claims 3
- 230000003115 biocidal Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drugs Drugs 0.000 claims 3
- 235000013305 food Nutrition 0.000 claims 3
- 201000002146 gastrointestinal system disease Diseases 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 201000008286 diarrhea Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000001717 pathogenic Effects 0.000 claims 2
- 230000000529 probiotic Effects 0.000 claims 2
- 239000006041 probiotic Substances 0.000 claims 2
- 235000018291 probiotics Nutrition 0.000 claims 2
- 208000004998 Abdominal Pain Diseases 0.000 claims 1
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 1
- 241000589876 Campylobacter Species 0.000 claims 1
- 241000193163 Clostridioides difficile Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 210000001035 Gastrointestinal Tract Anatomy 0.000 claims 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000002551 Irritable Bowel Syndrome Diseases 0.000 claims 1
- 241000186781 Listeria Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 1
- 201000009840 acute diarrhea Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003110 anti-inflammatory Effects 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 230000002708 enhancing Effects 0.000 claims 1
- 244000005709 gut microbiome Species 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229940079866 intestinal antibiotics Drugs 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (15)
- ヒトの健康を増進させるための組成物であって、バチルス・ズブチリスＱＳＴ７１３（ＮＲＲＬ受託番号Ｂ２１６６１）又はバチルス・ズブチリスＱＳＴ７１３を特定するすべての特徴を有するバチルス・ズブチリスＱＳＴ７１３の変異体を含み、ヒトの胃腸障害を予防または治療するのに有効な量で投与される、組成物。
- 前記組成物が、前記バチルス・ズブチリスＱＳＴ７１３を含む、請求項１に記載の組成物。
- 前記組成物が、前記バチルス・ズブチリスＱＳＴ７１３により生成された代謝産物をさらに含む、請求項２に記載の組成物。
- 前記胃腸障害の少なくとも１つの症状が、軽減又は緩和される、請求項１から３のいずれか１項に記載の組成物。
- 前記症状が、下痢、腹部痙攣、又は胃腸管の炎症である、請求項４に記載の組成物。
- 前記胃腸障害が、急性下痢、クロストリジウム・ディフィシル関連感染症、炎症性腸疾患、過敏性腸障害、及び抗生物質関連下痢からなる群から選択される、請求項１から３のいずれか１項に記載の組成物。
- 前記組成物が、健全な腸微生物叢を維持するのに有効な量で投与される、請求項１に記載の組成物。
- 前記組成物が、ヒトにおける病原性細菌の増殖を減少させるのに有効な量で投与され、
前記病原性細菌は、好ましくは、クロストリジウム属種、カンピロバクター属種、リステリア属種及びエシェリキア・コリからなる群から選択される、請求項１に記載の組成物。 - 前記組成物が、キャリアをさらに含む、請求項１に記載の組成物。
- 前記組成物が、他のプロバイオティクスと共に投与され、
前記プロバイオティクスは、好ましくは、サッカロミセス・ボウラディである、請求項１に記載の組成物。 - 前記組成物が、胃腸障害を予防又は治療するために使用される薬物と共に投与される、請求項１から３のいずれか１項に記載の組成物。
- 前記薬物が、抗生物質又は抗炎症薬であり、
前記組成物は、好ましくは、前記抗生物質の投与の完了後に投与される、請求項１１に記載の組成物。 - 前記組成物が、１日に１キログラム当たり約１×１０４ＣＦＵのバチルス・ズブチリスＱＳＴ７１３〜１日に１キログラム当たり約１×１０１２ＣＦＵのバチルス・ズブチリスＱＳＴ７１３の割合で、約３日間〜約７日間経口投与される、請求項１から３のいずれか１項に記載の組成物。
- ヒトにおける胃腸障害の少なくとも１つの症状を軽減するための組成物であって、（ｉ）前記障害の少なくとも１つの症状を軽減するのに有効な量のバチルス・ズブチリスＱＳＴ７１３又はバチルス・ズブチリスＱＳＴ７１３を特定するすべての特徴を有するバチルス・ズブチリスＱＳＴ７１３の変異体と、（ｉｉ）ヒト用の食料又は水以外の飲料とを含む、組成物。
- 前記バチルス・ズブチリスＱＳＴ７１３又は前記バチルス・ズブチリスＱＳＴ７１３の変異体の前記有効な量が、約１×１０３ＣＦＵ／ｇ食料〜約１×１０１０ＣＦＵ／ｇ食料である、請求項１４に記載の組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31499710P | 2010-03-17 | 2010-03-17 | |
| US61/314,997 | 2010-03-17 | ||
| PCT/US2011/028755 WO2011116155A1 (en) | 2010-03-17 | 2011-03-17 | Method for using a bacillus subtilis strain for prophylaxis and treatment of gastro-intestinal conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013522315A JP2013522315A (ja) | 2013-06-13 |
| JP2013522315A5 true JP2013522315A5 (ja) | 2014-05-08 |
| JP5830084B2 JP5830084B2 (ja) | 2015-12-09 |
Family
ID=44072771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500197A Active JP5830084B2 (ja) | 2010-03-17 | 2011-03-17 | 胃腸状態の予防及び処置にバチルス・ズブチリス菌株を使用する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9457054B2 (ja) |
| EP (1) | EP2547348B1 (ja) |
| JP (1) | JP5830084B2 (ja) |
| AU (1) | AU2011227226B2 (ja) |
| DK (1) | DK2547348T3 (ja) |
| ES (1) | ES2550059T3 (ja) |
| MY (1) | MY161197A (ja) |
| NZ (1) | NZ603065A (ja) |
| PL (1) | PL2547348T3 (ja) |
| WO (1) | WO2011116155A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2348880T3 (en) | 2008-09-17 | 2015-01-26 | Bayer Cropscience Lp | PROCEDURE FOR USING A BACILLUS SUBTILIS TRIAL FOR IMPROVING ANIMAL HEALTH |
| EP2547348B1 (en) | 2010-03-17 | 2015-05-20 | Bayer Cropscience LP | Method for using a bacillus subtilis strain for prophylaxis and treatment of gastro-intestinal conditions |
| CN103732064A (zh) | 2011-05-24 | 2014-04-16 | 拜尔作物科学有限合伙公司 | 聚烯杀真菌剂和非核糖体肽的协同组合和相关的使用方法 |
| WO2013126387A2 (en) * | 2012-02-21 | 2013-08-29 | Dupont Nutrition Biosciences Aps | Composition |
| FR3007654B1 (fr) * | 2013-06-27 | 2015-07-10 | Lesaffre & Cie | Composition de solute de rehydratation orale contenant des probiotiques |
| FR3007655B1 (fr) * | 2013-06-28 | 2016-12-23 | Lesaffre & Cie | Souche bacillus subtilis pour le traitement et/ou la prevention de maladies inflammatoires chroniques |
| JP6440463B2 (ja) * | 2013-11-15 | 2018-12-19 | プリマハム株式会社 | 抗菌作用を有するバチルス・メチロトロフィカス |
| MX2020000182A (es) * | 2017-06-30 | 2020-07-22 | Evonik Operations Gmbh | Cepa bacillus subtilis con actividad probiotica. |
| AU2019212338B2 (en) | 2018-01-24 | 2024-07-11 | Omnigen Research, Llc | Bacillus combination for administration to animals |
| US11278578B2 (en) * | 2018-09-02 | 2022-03-22 | Sanzyme Biologics Private Limited | Combination probiotic compositions and uses thereof |
| BE1027162B1 (nl) * | 2019-03-29 | 2020-11-05 | My Res Comm V | Bacillus coagulans en Bacillus subtilis voor de preventie en behandeling van functionele gastro-intestinale stoornissen |
| US11160838B2 (en) | 2019-08-09 | 2021-11-02 | Deerland Enzymes, Inc. | Antifungal and antimicrobial uses of Bacillus subtilis containing compositions |
| GB201911925D0 (en) * | 2019-08-20 | 2019-10-02 | Sporegen Ltd | Formulations for prevention or reduction of c. difficile infections |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62232343A (ja) | 1986-04-01 | 1987-10-12 | Kyodo Shiryo Kk | 幼豚用配合飼料 |
| JPS63209580A (ja) | 1987-02-25 | 1988-08-31 | Karupisu Shokuhin Kogyo Kk | バチルス・ズブチリスｃ−３１０２ |
| KR930001383B1 (ko) | 1990-10-31 | 1993-02-27 | 재단법인 한국화학연구소 | 신규의 바실러스 서브틸리스 아종 및 이로부터 생산되는 항진균 물질 krf-001 복합체의 용도 |
| US5785990A (en) | 1995-07-10 | 1998-07-28 | Merrick's, Inc. | Feed fortifier and enhancer for preruminant calves and method of using same |
| JP2979294B2 (ja) | 1996-10-02 | 1999-11-15 | カルピス株式会社 | 鳥類卵殻強度増強剤 |
| CZ302152B6 (cs) * | 1997-05-09 | 2010-11-18 | Agraquest, Inc. | Nový kmen Bacillus pro kontrolu onemocnení rostlin a napadení brouky rodu Diabrotica |
| US6103228A (en) * | 1997-05-09 | 2000-08-15 | Agraquest, Inc. | Compositions and methods for controlling plant pests |
| US6015553A (en) | 1997-08-22 | 2000-01-18 | Agraquest, Inc. | Bacillus subtilis strain for controlling insect and nematode pests |
| JP3260111B2 (ja) | 1997-10-09 | 2002-02-25 | 伊藤忠飼料株式会社 | 鳥類の給餌中止時の体重減少抑制方法及び腸内有害細菌減少方法 |
| US6461607B1 (en) | 1998-08-24 | 2002-10-08 | Ganeden Biotech, Inc. | Probiotic, lactic acid-producing bacteria and uses thereof |
| JP2000166583A (ja) | 1998-10-02 | 2000-06-20 | Shin Nihonsha:Kk | 枯草菌等が産生する無機物及びその酸塩と副産物及びその誘導体 |
| GB0124580D0 (en) | 2001-10-12 | 2001-12-05 | Univ Reading | New composition |
| GB0130789D0 (en) | 2001-12-21 | 2002-02-06 | King S College London | Application of spores |
| AR040927A1 (es) | 2002-04-10 | 2005-04-27 | Cooperativas Argentinas Cooper | Alimento para la crianza de vacunos neonatos y procedimiento de utilizacion. |
| AT413191B (de) | 2002-10-11 | 2005-12-15 | Erber Ag | Futtermittel- und/oder trinkwasserzusatz für nutztiere |
| US7247299B2 (en) * | 2002-11-27 | 2007-07-24 | Kemin Industries, Inc. | Antimicrobial compounds from Bacillus subtilis for use against animal and human pathogens |
| EP1472933A1 (en) | 2003-05-01 | 2004-11-03 | Chr. Hansen A/S | Improving health and/or nutritional status of an aquatic animal by aid of Bacillus licheniformis |
| WO2005010052A2 (en) | 2003-07-24 | 2005-02-03 | Cargill, Incorporated | Enhanced steep-water |
| RU2266747C1 (ru) | 2004-03-22 | 2005-12-27 | Кубанский государственный аграрный университет | Пробиотическая композиция для животных и птицы |
| JP2007054041A (ja) | 2005-07-29 | 2007-03-08 | Yodorinon Kenkyusho:Kk | 養鶏飼料並びに卵 |
| US20080057047A1 (en) | 2005-11-29 | 2008-03-06 | Benedikt Sas | Use of bacillus amyloliquefaciens PB6 for the prophylaxis or treatment of gastrointestinal and immuno-related diseases |
| US7754469B2 (en) * | 2005-11-30 | 2010-07-13 | Agtech Products, Inc | Microorganisms and methods for treating poultry |
| JP4968816B2 (ja) | 2006-03-08 | 2012-07-04 | 日本曹達株式会社 | バチルス属細菌の芽胞形成方法 |
| WO2007150052A1 (en) * | 2006-06-23 | 2007-12-27 | Equine Research Associates, Ltd | Animal nutritional supplement and method |
| EP2614717A1 (en) * | 2007-09-20 | 2013-07-17 | Basf Se | Combinations comprising a fungicidal strain and at least one additional fungicide |
| DK2348880T3 (en) | 2008-09-17 | 2015-01-26 | Bayer Cropscience Lp | PROCEDURE FOR USING A BACILLUS SUBTILIS TRIAL FOR IMPROVING ANIMAL HEALTH |
| US8227235B2 (en) | 2008-12-10 | 2012-07-24 | Alpharma, Llc | Compositions and methods for controlling diseases in animals |
| EP2547348B1 (en) | 2010-03-17 | 2015-05-20 | Bayer Cropscience LP | Method for using a bacillus subtilis strain for prophylaxis and treatment of gastro-intestinal conditions |
-
2011
- 2011-03-17 EP EP20110710383 patent/EP2547348B1/en active Active
- 2011-03-17 WO PCT/US2011/028755 patent/WO2011116155A1/en active Application Filing
- 2011-03-17 US US13/582,359 patent/US9457054B2/en active Active
- 2011-03-17 DK DK11710383.8T patent/DK2547348T3/da active
- 2011-03-17 JP JP2013500197A patent/JP5830084B2/ja active Active
- 2011-03-17 PL PL11710383T patent/PL2547348T3/pl unknown
- 2011-03-17 NZ NZ603065A patent/NZ603065A/en not_active IP Right Cessation
- 2011-03-17 MY MYPI2012700660A patent/MY161197A/en unknown
- 2011-03-17 ES ES11710383.8T patent/ES2550059T3/es active Active
- 2011-03-17 AU AU2011227226A patent/AU2011227226B2/en active Active
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