JP2013522286A - スピロ環化合物ならびに治療薬及び診断プローブとしてのその使用 - Google Patents

スピロ環化合物ならびに治療薬及び診断プローブとしてのその使用 Download PDF

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JP2013522286A
JP2013522286A JP2012557645A JP2012557645A JP2013522286A JP 2013522286 A JP2013522286 A JP 2013522286A JP 2012557645 A JP2012557645 A JP 2012557645A JP 2012557645 A JP2012557645 A JP 2012557645A JP 2013522286 A JP2013522286 A JP 2013522286A
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oxa
morpholino
azaspiro
heptan
triazin
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JP2013522286A5 (OSRAM
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クミルヤノヴィク，ウラジミール
クミルヤノヴィク，ナターシャ
ギーゼ，ベルント
ヴァイマン，マティアス
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Universitaet Basel
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Universitaet Basel
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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JP2012557645A 2010-03-15 2011-03-11 スピロ環化合物ならびに治療薬及び診断プローブとしてのその使用 Pending JP2013522286A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1004200.0 2010-03-15
GBGB1004200.0A GB201004200D0 (en) 2010-03-15 2010-03-15 Spirocyclic compounds and their use as therapeutic agents and diagnostic probes
PCT/IB2011/051047 WO2011114275A1 (en) 2010-03-15 2011-03-11 Spirocyclic compounds and their use as therapeutic agents and diagnostic probes

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JP2013522286A true JP2013522286A (ja) 2013-06-13
JP2013522286A5 JP2013522286A5 (OSRAM) 2014-04-17

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Country Link
US (1) US20130040934A1 (OSRAM)
EP (1) EP2547684A1 (OSRAM)
JP (1) JP2013522286A (OSRAM)
KR (1) KR20130086520A (OSRAM)
CN (1) CN102939292A (OSRAM)
AU (1) AU2011228703A1 (OSRAM)
BR (1) BR112012023320A2 (OSRAM)
CA (1) CA2791737A1 (OSRAM)
GB (1) GB201004200D0 (OSRAM)
MX (1) MX2012010655A (OSRAM)
NZ (1) NZ602292A (OSRAM)
RU (1) RU2012143689A (OSRAM)
SG (1) SG184062A1 (OSRAM)
WO (1) WO2011114275A1 (OSRAM)
ZA (1) ZA201206580B (OSRAM)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017518052A (ja) * 2014-06-06 2017-07-06 ブルーバード バイオ， インコーポレイテッド 改善されたｔ細胞組成物
US10624960B2 (en) 2014-12-12 2020-04-21 Bluebird Bio, Inc. BCMA chimeric antigen receptors
US10774343B2 (en) 2014-04-25 2020-09-15 Bluebird Bio, Inc. MND promoter chimeric antigen receptors
JP2021501778A (ja) * 2017-11-06 2021-01-21 メッドシャイン ディスカバリー インコーポレイテッド ｍＴＯＲＣ１／２二重阻害剤としてのピリドピリミジン系化合物
JP2021532157A (ja) * 2018-08-01 2021-11-25 アラクセス ファーマ エルエルシー がんを処置するための複素環式スピロ化合物およびその使用方法
US11479755B2 (en) 2015-12-07 2022-10-25 2Seventy Bio, Inc. T cell compositions
JP2023505485A (ja) * 2019-12-04 2023-02-09 シーエイチディーアイ ファウンデーション，インコーポレーテッド Ａｔｍキナーゼ阻害剤及び組成物並びにそれらの使用の方法
US12109234B2 (en) 2016-11-04 2024-10-08 2Seventy Bio, Inc. Anti-BCMA CAR T cell compositions
US12234244B2 (en) 2013-10-10 2025-02-25 Araxes Pharma Llc Substituted piperazines as inhibitors of KRAS G12C
US12291722B2 (en) 2014-04-25 2025-05-06 2Seventy Bio, Inc. Methods for manufacturing adoptive cell therapies

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6026544B2 (ja) 2011-09-27 2016-11-16 ノバルティス アーゲー 変異体ｉｄｈの阻害剤としての３−ピリミジン−４−イル−オキサゾリジン−２−オン類
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
HK1213251A1 (zh) 2013-03-14 2016-06-30 Novartis Ag 作为突变idh抑制剂的3-嘧啶-4-基-恶唑烷-2-酮化合物
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
MX2015015130A (es) * 2013-05-01 2016-02-18 Hoffmann La Roche Compuestos de biheteroarilo y usos de los mismos.
CN103483345B (zh) * 2013-09-25 2016-07-06 中山大学 Pi3k激酶抑制剂、包含其的药物组合物及其应用
CN104557871B (zh) * 2013-10-28 2017-05-03 上海汇伦生命科技有限公司 具有螺环取代基的芳基吗啉类化合物，其制备方法和用途
SG10201900455YA (en) 2014-07-24 2019-02-27 Bluebird Bio Inc Bcma chimeric antigen receptors
MX2017005484A (es) 2014-10-31 2017-10-20 Indivior Uk Ltd Compuestos antagonistas del receptor de dopamina d3.
EP3231799A1 (en) * 2016-04-14 2017-10-18 Universität Basel 4-(azetidin-1-yl)pyrimidine derivatives with anti-mitotic and anti-proliferative activity
JP2020502224A (ja) * 2016-12-21 2020-01-23 日本たばこ産業株式会社 ヤヌスキナーゼ阻害剤の結晶形
EP3573971A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
WO2018140599A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
CN110382482A (zh) 2017-01-26 2019-10-25 亚瑞克西斯制药公司 稠合的杂-杂二环化合物及其使用方法
US11274093B2 (en) 2017-01-26 2022-03-15 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
TW201900633A (zh) 2017-05-25 2019-01-01 美商亞瑞克西斯製藥公司 Kras之共價抑制劑
JP2020521740A (ja) 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー 変異体ｋｒａｓ、ｈｒａｓまたはｎｒａｓの調節因子としてのキナゾリン誘導体
CN108191837A (zh) * 2018-01-10 2018-06-22 贵州医科大学 PI3Kα/mTOR双激酶抑制剂及其药物组合物和应用
MX2022007652A (es) * 2019-12-19 2022-09-23 Janssen Pharmaceutica Nv Derivados espiráncos sustituidos de cadena lineal.
JP7654071B2 (ja) * 2020-10-20 2025-03-31 アムジエン・インコーポレーテツド 複素環スピロ化合物及び使用方法
US20250206729A1 (en) * 2023-12-22 2025-06-26 Deciphera Pharmaceuticals, Llc Dual raf and tubulin inhibitors and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008098058A1 (en) * 2007-02-06 2008-08-14 Novartis Ag Pi 3-kinase inhibitors and methods of their use
WO2009053715A1 (en) * 2007-10-26 2009-04-30 F. Hoffmann-La Roche Ag Thienopyrimidiene derivatives as pi3k inhibitors
WO2009140128A2 (en) * 2008-05-13 2009-11-19 Irm Llc Compounds and compositions as kinase inhibitors
WO2009143317A1 (en) * 2008-05-23 2009-11-26 Wyeth Triazine compounds as p13 kinase and mtor inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7071189B2 (en) 2001-04-27 2006-07-04 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and antitumor agent containing the same as active ingredient
MX2007010404A (es) 2005-02-25 2008-01-11 Kudos Pharm Ltd Hidrazinometilo, hidrazonometilo y compuestos heterociclicos de 5 miembros que actuan como inhibidores de mtor y su uso como agentes anti-cancer.
GB0525081D0 (en) 2005-12-09 2006-01-18 Astrazeneca Ab Pyrimidine derivatives
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
WO2008032033A1 (en) 2006-09-14 2008-03-20 Astrazeneca Ab 4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
US20090233926A1 (en) 2006-09-14 2009-09-17 Astrazeneca 2-benzimidazolyl-6-morpholino-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008098058A1 (en) * 2007-02-06 2008-08-14 Novartis Ag Pi 3-kinase inhibitors and methods of their use
JP2010518107A (ja) * 2007-02-06 2010-05-27 ノバルティス アーゲー Ｐｉ３−キナーゼ阻害剤およびその使用方法
WO2009053715A1 (en) * 2007-10-26 2009-04-30 F. Hoffmann-La Roche Ag Thienopyrimidiene derivatives as pi3k inhibitors
JP2011500774A (ja) * 2007-10-26 2011-01-06 エフ．ホフマン−ラ ロシュ アーゲー Ｐｉ３ｋ阻害剤としてのチエノピリミジエン誘導体
WO2009140128A2 (en) * 2008-05-13 2009-11-19 Irm Llc Compounds and compositions as kinase inhibitors
JP2011520887A (ja) * 2008-05-13 2011-07-21 アイアールエム・リミテッド・ライアビリティ・カンパニー キナーゼ阻害剤としての縮合窒素含有ヘテロ環およびその組成物
WO2009143317A1 (en) * 2008-05-23 2009-11-26 Wyeth Triazine compounds as p13 kinase and mtor inhibitors
JP2011520979A (ja) * 2008-05-23 2011-07-21 ワイス・エルエルシー ＰＩ３キナーゼおよびｍＴＯＲ阻害剤としてのトリアジン化合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. ９８（８）, JPN6015000289, 2006, pages 545 - 556, ISSN: 0002979948 *
WUITSCHIK.G ET AL: "Oxetanes in Drug Discovery", A DISSERTATION SUBMITTED TO THE SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZURICH, JPN6015000287, 2008, pages 120 - 124, ISSN: 0002979949 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12234244B2 (en) 2013-10-10 2025-02-25 Araxes Pharma Llc Substituted piperazines as inhibitors of KRAS G12C
US10774343B2 (en) 2014-04-25 2020-09-15 Bluebird Bio, Inc. MND promoter chimeric antigen receptors
US12291722B2 (en) 2014-04-25 2025-05-06 2Seventy Bio, Inc. Methods for manufacturing adoptive cell therapies
JP2020072756A (ja) * 2014-06-06 2020-05-14 ブルーバード バイオ， インコーポレイテッド 改善されたｔ細胞組成物
JP2017518052A (ja) * 2014-06-06 2017-07-06 ブルーバード バイオ， インコーポレイテッド 改善されたｔ細胞組成物
US11560547B2 (en) 2014-06-06 2023-01-24 2Seventy Bio, Inc. Methods of making T cell compositions
US10479975B2 (en) 2014-06-06 2019-11-19 Bluebird Bio, Inc. Methods of making T cell compositions
US10639359B2 (en) 2014-12-12 2020-05-05 Bluebird Bio, Inc. BCMA chimeric antigen receptors
US10646558B2 (en) 2014-12-12 2020-05-12 Bluebird Bio, Inc. BCMA chimeric antigen receptors
US10639358B2 (en) 2014-12-12 2020-05-05 Bluebird Bio, Inc. BCMA chimeric antigen receptors
US10624960B2 (en) 2014-12-12 2020-04-21 Bluebird Bio, Inc. BCMA chimeric antigen receptors
US11479755B2 (en) 2015-12-07 2022-10-25 2Seventy Bio, Inc. T cell compositions
US12109234B2 (en) 2016-11-04 2024-10-08 2Seventy Bio, Inc. Anti-BCMA CAR T cell compositions
JP2021501778A (ja) * 2017-11-06 2021-01-21 メッドシャイン ディスカバリー インコーポレイテッド ｍＴＯＲＣ１／２二重阻害剤としてのピリドピリミジン系化合物
JP7340519B2 (ja) 2017-11-06 2023-09-07 メッドシャイン ディスカバリー インコーポレイテッド ｍＴＯＲＣ１／２二重阻害剤としてのピリドピリミジン系化合物
JP2024149542A (ja) * 2018-08-01 2024-10-18 アラクセス ファーマ エルエルシー がんを処置するための複素環式スピロ化合物およびその使用方法
JP2021532157A (ja) * 2018-08-01 2021-11-25 アラクセス ファーマ エルエルシー がんを処置するための複素環式スピロ化合物およびその使用方法
JP2023505485A (ja) * 2019-12-04 2023-02-09 シーエイチディーアイ ファウンデーション，インコーポレーテッド Ａｔｍキナーゼ阻害剤及び組成物並びにそれらの使用の方法
JP7727627B2 (ja) 2019-12-04 2025-08-21 シーエイチディーアイ ファウンデーション，インコーポレーテッド Ａｔｍキナーゼ阻害剤及び組成物並びにそれらの使用の方法

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