JP2013519363A5 - - Google Patents

Info

Publication number

JP2013519363A5

JP2013519363A5 JP2012552394A JP2012552394A JP2013519363A5 JP 2013519363 A5 JP2013519363 A5 JP 2013519363A5 JP 2012552394 A JP2012552394 A JP 2012552394A JP 2012552394 A JP2012552394 A JP 2012552394A JP 2013519363 A5 JP2013519363 A5 JP 2013519363A5

Authority

JP

Japan

Prior art keywords

cancer

cells

proinflammatory

mature

proinflammatory mature

Prior art date

2011-02-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004443 dendritic cell Anatomy 0.000 claims 12
• 230000000770 proinflammatory effect Effects 0.000 claims 11
• 206010028980 Neoplasm Diseases 0.000 claims 8
• 201000011510 cancer Diseases 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 4
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 3
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 3
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 3
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
• 206010018338 Glioma Diseases 0.000 claims 2
• 102000006992 Interferon-alpha Human genes 0.000 claims 2
• 108010047761 Interferon-alpha Proteins 0.000 claims 2
• 108010074328 Interferon-gamma Proteins 0.000 claims 2
• 208000005016 Intestinal Neoplasms Diseases 0.000 claims 2
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
• 206010025323 Lymphomas Diseases 0.000 claims 2
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
• 206010060862 Prostate cancer Diseases 0.000 claims 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
• 206010038389 Renal cancer Diseases 0.000 claims 2
• 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 2
• 201000004101 esophageal cancer Diseases 0.000 claims 2
• 208000029824 high grade glioma Diseases 0.000 claims 2
• 201000002313 intestinal cancer Diseases 0.000 claims 2
• 201000010982 kidney cancer Diseases 0.000 claims 2
• 201000011614 malignant glioma Diseases 0.000 claims 2
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
• 201000001441 melanoma Diseases 0.000 claims 2
• 201000008968 osteosarcoma Diseases 0.000 claims 2
• 201000002528 pancreatic cancer Diseases 0.000 claims 2
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims 1
• 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims 1
• 102100037850 Interferon gamma Human genes 0.000 claims 1
• 102000008070 Interferon-gamma Human genes 0.000 claims 1
• 102000000589 Interleukin-1 Human genes 0.000 claims 1
• 108010002352 Interleukin-1 Proteins 0.000 claims 1
• 101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 claims 1
• 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000000762 glandular Effects 0.000 claims 1
• 229960003130 interferon gamma Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• BXNMTOQRYBFHNZ-UHFFFAOYSA-N resiquimod Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CC(C)(C)O)C3=C(N)N=C21 BXNMTOQRYBFHNZ-UHFFFAOYSA-N 0.000 claims 1
• 159000000000 sodium salts Chemical class 0.000 claims 1
• 231100000617 superantigen Toxicity 0.000 claims 1