JP2013517224A5 - - Google Patents
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- Publication number
- JP2013517224A5 JP2013517224A5 JP2012548306A JP2012548306A JP2013517224A5 JP 2013517224 A5 JP2013517224 A5 JP 2013517224A5 JP 2012548306 A JP2012548306 A JP 2012548306A JP 2012548306 A JP2012548306 A JP 2012548306A JP 2013517224 A5 JP2013517224 A5 JP 2013517224A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- compound according
- pharmaceutical formulation
- amino acids
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- -1 cyclic organic compound Chemical class 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 102000004310 Ion Channels Human genes 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N ornithyl group Chemical group N[C@@H](CCCN)C(=O)O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000009325 pulmonary function Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000006798 ring closing metathesis reaction Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0004110A AT509267A1 (de) | 2010-01-14 | 2010-01-14 | Organische verbindungen zur regulierung von vektoriellen ionenkanälen |
| ATA41/2010 | 2010-01-14 | ||
| PCT/AT2011/000014 WO2011085423A1 (de) | 2010-01-14 | 2011-01-12 | Zyklische peptide zur regulierung von vektoriellen ionenkanälen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517224A JP2013517224A (ja) | 2013-05-16 |
| JP2013517224A5 true JP2013517224A5 (https=) | 2013-10-17 |
| JP5771220B2 JP5771220B2 (ja) | 2015-08-26 |
Family
ID=43970939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548306A Active JP5771220B2 (ja) | 2010-01-14 | 2011-01-12 | ベクトルイオンチャネルを調節するための有機化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8754049B2 (https=) |
| EP (1) | EP2523968B1 (https=) |
| JP (1) | JP5771220B2 (https=) |
| KR (1) | KR101865420B1 (https=) |
| CN (1) | CN102770442B (https=) |
| AT (1) | AT509267A1 (https=) |
| AU (1) | AU2011206907B2 (https=) |
| BR (1) | BR112012017093A2 (https=) |
| CA (1) | CA2785185C (https=) |
| DK (1) | DK2523968T3 (https=) |
| ES (1) | ES2525381T3 (https=) |
| IL (1) | IL220924B (https=) |
| NZ (1) | NZ600818A (https=) |
| PL (1) | PL2523968T3 (https=) |
| RU (1) | RU2538597C2 (https=) |
| WO (1) | WO2011085423A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2679239A1 (de) * | 2012-06-28 | 2014-01-01 | Apeptico Forschung und Entwicklung GmbH | Pharmazeutische Zusammensetzung zur Behandlung der durch Sauerstoffarmut und verringerten Luftdruck vermittelten pulmonalen Form der Höhenkrankheit |
| KR102113501B1 (ko) * | 2013-04-23 | 2020-05-22 | 아펩티코 포어슝 운트 엔트빅크룽 게엠베하 | 식 ｘ₁－ｇｑｒｅｔｐｅｇａｅａｋｐｗｙ－ｘ₂의 고리 펩티드를 포함하는 제약 조성물 및 체외 폐 치료를 위한 사용 |
| ES2876404T3 (es) * | 2013-04-23 | 2021-11-12 | Apeptico Forschung & Entwicklung Gmbh | Liofilizado que contiene un péptido cíclico de fórmula X1-GQRETPEGAEAKPWY-X2 para el tratamiento de edemas pulmonares |
| US12004506B2 (en) | 2013-04-23 | 2024-06-11 | Apeptico Forschung Und Entwicklung Gmbh | Pharmaceutical composition comprising a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 and use for extracorporeal lung treatment |
| JP6644695B2 (ja) * | 2014-03-04 | 2020-02-12 | アペプティコ フオルシユング ウント アントウィクラング ゲーエムベーハー | 肺内炎症の減弱化 |
| JP7104622B2 (ja) * | 2015-09-14 | 2022-07-21 | アペプティコ フオルシユング ウント アントウィクラング ゲーエムベーハー | Ｐｈａ １ｂ型の治療のための環状ポリペプチド |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017719A (en) * | 1994-06-14 | 2000-01-25 | Nexell Therapeutics, Inc. | Positive and positive/negative cell selection mediated by peptide release |
| AU764992B2 (en) | 1998-08-14 | 2003-09-04 | LUCAS, Rudolf Dr. | TNF-derived peptides for use in treating oedema |
| FR2839514A1 (fr) * | 2002-05-07 | 2003-11-14 | Centre Nat Rech Scient | Nouveaux peptides cycliques, leur utilisation comme agents anti-microbiens |
| CA2575513C (en) * | 2004-08-06 | 2014-09-16 | Altana Pharma Ag | Composition comprising a pulmonary surfactant and a tnf-derived peptide |
| CN101007791A (zh) * | 2007-01-12 | 2007-08-01 | 东华大学 | 一种氨基酸联苯化合物 |
| CN101003520A (zh) * | 2007-01-12 | 2007-07-25 | 陈志龙 | 一种缬氨酸丁酰联苯化合物 |
| EP2009023A1 (en) * | 2007-06-04 | 2008-12-31 | Rentschler Beteiligungs GmbH | Novel peptides and their use for the treatment of edema |
| AT506151B1 (de) * | 2007-12-12 | 2010-01-15 | Apeptico Forschung Und Entwick | Fusionsprotein |
| AT506150B1 (de) * | 2007-12-12 | 2010-01-15 | Apeptico Forschung Und Entwick | Zyklisches und cystein-freies peptid |
| CN101298432B (zh) * | 2008-05-30 | 2010-12-22 | 广州市星业科技发展有限公司 | L-吡咯烷酮羧酸钠的制备方法 |
| WO2009149278A1 (en) * | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AT507953B1 (de) * | 2009-03-05 | 2011-02-15 | Apeptico Forschung & Entwicklung Gmbh | Verfahren zur vermeidung und zur behandlung einer hyperpermeabilität |
| DK2397151T3 (en) * | 2010-06-21 | 2015-05-18 | Apeptico Forschung & Entwicklung Gmbh | The treatment of the vascular complications of diabetes |
-
2010
- 2010-01-14 AT AT0004110A patent/AT509267A1/de not_active Application Discontinuation
-
2011
- 2011-01-12 DK DK11705798.4T patent/DK2523968T3/da active
- 2011-01-12 ES ES11705798.4T patent/ES2525381T3/es active Active
- 2011-01-12 NZ NZ600818A patent/NZ600818A/en not_active IP Right Cessation
- 2011-01-12 BR BR112012017093A patent/BR112012017093A2/pt not_active IP Right Cessation
- 2011-01-12 WO PCT/AT2011/000014 patent/WO2011085423A1/de not_active Ceased
- 2011-01-12 US US13/522,204 patent/US8754049B2/en active Active
- 2011-01-12 AU AU2011206907A patent/AU2011206907B2/en not_active Ceased
- 2011-01-12 PL PL11705798T patent/PL2523968T3/pl unknown
- 2011-01-12 RU RU2012134322/04A patent/RU2538597C2/ru not_active IP Right Cessation
- 2011-01-12 CA CA2785185A patent/CA2785185C/en active Active
- 2011-01-12 CN CN201180005765.9A patent/CN102770442B/zh active Active
- 2011-01-12 KR KR1020127018445A patent/KR101865420B1/ko active Active
- 2011-01-12 EP EP11705798.4A patent/EP2523968B1/de active Active
- 2011-01-12 JP JP2012548306A patent/JP5771220B2/ja active Active
-
2012
- 2012-07-12 IL IL220924A patent/IL220924B/en active IP Right Grant
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