JP2013516974A - 生体液用回路 - Google Patents
生体液用回路 Download PDFInfo
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- JP2013516974A JP2013516974A JP2012548506A JP2012548506A JP2013516974A JP 2013516974 A JP2013516974 A JP 2013516974A JP 2012548506 A JP2012548506 A JP 2012548506A JP 2012548506 A JP2012548506 A JP 2012548506A JP 2013516974 A JP2013516974 A JP 2013516974A
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/85978—With pump
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- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Bag Frames (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Public Health (AREA)
- Water Supply & Treatment (AREA)
Abstract
Description
2つの可撓性フィルムおよび前記経路指定ネットワークコネクタを含むバッグと、
前記液体経路指定ネットワークのパイプが前記フィルムの間に形成されている状態で前記バッグをクランプ締めする第一シェルおよび第二シェルを含む圧迫部であって、前記第一シェルは各前記パイプのために成形チャネルを含み、前記第二シェルは各前記パイプのために第一シェルの対応する成形チャネルに対向する成形チャネルを含む、圧迫部とを含み、
前記第一シェルは前記パイプのために少なくとも1つのピンチ弁を含み、この弁は可動挟持部材を含むアクチュエータを含み、この弁は、可動部材がパイプを挟持しない後退位置にある開放位置を有するとともに、可動部材がパイプを挟持する延伸位置にある閉鎖位置を有し、
前記弁は、前記可動挟持部材と一致して、弾性圧縮性パッドを含み、このパッドは、可動部材に最も近い第一面と、挟持すべきパイプに最も近い第二面とを有し、このパッドは、弁が開放位置にあるときに、前記第二面が凹状であって、挟持すべきパイプの第一シェル成形チャネルを局所的に区切る、静止形態を有し、弁が閉鎖位置にあるときに、前記第二面が凸状であって、前記パイプおよび前記パッドが挟持すべきパイプの第二シェル成形チャネルと可動挟持部材との間に挟まれている、挟持形態を有することを、特徴とする。
前記パッドは、いくつかのパイプを覆う共通シートの一部を形成し、
前記共通シートは、パッドの近くに少なくとも1つの硬化突起を含み、
前記パッドは、個別局所プレートの一部を形成し、
前記パッドは前記局所個別プレートの中心部を形成し、これは前記中心部を包囲する側壁および横断壁を含み、
前記第一シェルは、前記パッドを少なくとも部分的に受容するようになっている、凹状収容部を含み、
前記パッドは前記第一シェルに固定されており、
前記パッドは、前記第一シェルの対応する開口内に形状の補完性によって固定されている固定ラグを含み、
前記パッドは、一体に成型された弾性圧縮性可撓性プラスチックで形成されており、
前記パッドはシリコンでできており、
アクチュエータの可動部材は、前記パッドを第二シェル成形チャネルに向かって押すようになっている空気膜を含み、
アクチュエータの可動部材は、第二シェル成形チャネルのような形状の末端を有する指状部を含み、
少なくとも1つの前記シェルは、物理化学値の少なくとも1つのセンサを含み、
前記センサおよび前記パッドは前記第一シェル上に設けられている。
一体である代わりに、シェルは、回路の異なる部分を区切るために、互いに結合された1組のモジュール部材によって形成され、部材には、これらが互いに対して正確に配置されることを確実にするための記号または標識が設けられ、記号および標識は、たとえば参照番号またはコードを含み、可能であればRFIDタイプである。
シェルは、たとえばアルミニウム、特に高密度を有するプラスチック、セラミック、または木など、ステンレス鋼以外の材料でできており、
バッグのフィルムはPureFlex(TM)フィルム以外の材料、たとえばHyclone Industries社より入手可能なフィルムであるHyQ(R)CX5−14、またはロンザ(Lonza)社より入手可能なフィルムであるPlatinum UltraPacなど、生体液と適合性のあるいくつかの層を備える別のフィルムでできており、
124などの指状部を作動させるのに役立つ単動式空気ジャッキは複動式空気ジャッキに置き換えられ、および/またはジャッキはたとえば電気など、空気式以外のものであり、
パッドは一体成型品ではない。
Claims (15)
- 複数のコネクタ(2)と、前記コネクタの間で液体を経路指定するためのネットワーク(3;103)とを含む生体液用回路であって、
2つの可撓性フィルム(45、46;145、146)および前記経路指定ネットワークコネクタ(2)を含むバッグ(11;111)と、
前記液体経路指定ネットワーク(3;103)のパイプ(4;104)が前記フィルム(45、46;145、146)の間に形成されている状態で前記バッグ(11;111)をクランプ締めする第一シェル(14;114)および第二シェル(13;113)を含む圧迫部(10;110)であって、前記第一シェル(14;114)は各前記パイプ(4;104)のために成形チャネル(18;118)を含み、前記第二シェル(13;113)は各前記パイプ(4;104)のために第一シェル(14;114)の対応する成形チャネル(18;118)に対向する成形チャネル(16;116)を含む、圧迫部(10;110)とを含み、
前記第一シェル(14;114)は前記パイプ(4;104)のために少なくとも1つのピンチ弁(20;120)を含み、この弁(20;120)は可動挟持部材(24;124)を含むアクチュエータ(21;121)を含み、この弁(20;120)は、可動部材(24;124)がパイプ(4;104)を挟持しない後退位置にある開放位置を有するとともに、可動部材(24;124)がパイプ(4;104)を挟持する延伸位置にある閉鎖位置を有し、
前記弁(20;120)は、前記可動挟持部材(24;124)と一致して、弾性圧縮性パッド(31;131)をさらに含み、このパッド(31;131)は可動部材(24;124)に最も近い第一面(32;132)と、挟持すべきパイプ(4;104)に最も近い第二面(33;133)とを有し、このパッド(31;131)は、弁(20;120)が開放位置にあるときに、前記第二面(33;133)が凹状であって、挟持すべきパイプ(4;104)の第一シェル成形チャネル(18;118)を局所的に区切る、静止形態を有し、弁(20;120)が閉鎖位置にあるときに、前記第二面(33;133)が凸状であって、前記パイプ(4;104)および前記パッド(31;131)が挟持すべきパイプ(4;104)の第二シェル成形チャネル(16;116)と可動挟持部材(24;124)との間に挟まれている、挟持形態を有することを特徴とする、回路。 - 前記挟持すべきパイプ(4;104)が、楕円形輪郭を有することを特徴とする、請求項1に記載の回路。
- 前記パッド(31)が、いくつかのパイプ(4)を覆う共通シート(30)の一部を形成することを特徴とする、請求項1および2のいずれか一項に記載の回路。
- 前記共通シート(30)が、パッド(31)の近くに少なくとも1つの硬化突起(38)を含むことを特徴とする、請求項3に記載の回路。
- 前記パッド(131)が、個別局所プレート130の一部を形成することを特徴とする、請求項1および2のいずれか一項に記載の回路。
- 前記パッド(131)が前記局所個別プレート(130)の中心部を形成し、これは前記中心部を包囲する側壁(171)および横断壁(172)を含むことを特徴とする、請求項5に記載の回路。
- 前記第一シェル(114)が、前記パッド(131)を少なくとも部分的に受容するようになっている、凹状収容部(160)を含むことを特徴とする、請求項1から6のいずれか一項に記載の回路。
- 前記パッド(31;131)が、前記第一シェル(14;114)に固定されていることを特徴とする、請求項1から7のいずれか一項に記載の回路。
- 前記パッド(31;131)が、前記第一シェル(14;114)の対応する開口(36、37;164)内に形状の補完性によって固定されている固定ラグ(34、35;173)を含むことを特徴とする、請求項8に記載の回路。
- 前記パッド(31;131)が、一体に成型された弾性圧縮性可撓性プラスチックで形成されていることを特徴とする、請求項1から9のいずれか一項に記載の回路。
- 前記パッド(31;131)がシリコンでできていることを特徴とする、請求項1から10のいずれか一項に記載の回路。
- アクチュエータ(21)の可動部材が、前記パッド(31)を第二シェル成形チャネル(16)に向かって押すようになっている空気膜(24)を含むことを特徴とする、請求項1から11のいずれか一項に記載の回路。
- アクチュエータ(121)の可動部材が、第二シェル成形チャネル(116)のような形状の末端を有する指状部(124)を含むことを特徴とする、請求項1から11のいずれか一項に記載の回路。
- 少なくとも1つの前記シェル(14)が、物理化学量の少なくとも1つのセンサ(22)を含むことを特徴とする、請求項1から13のいずれか一項に記載の回路。
- 前記センサ(22)および前記パッド(31)が前記第一シェル(14)上に設けられていることを特徴とする、請求項14に記載の回路。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1050209A FR2955119B1 (fr) | 2010-01-13 | 2010-01-13 | Circuit pour liquide biologique |
FR1050209 | 2010-01-13 | ||
PCT/IB2011/050089 WO2011086488A1 (en) | 2010-01-13 | 2011-01-10 | Circuit for biological liquid |
Publications (2)
Publication Number | Publication Date |
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JP2013516974A true JP2013516974A (ja) | 2013-05-16 |
JP5606554B2 JP5606554B2 (ja) | 2014-10-15 |
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Application Number | Title | Priority Date | Filing Date |
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JP2012548506A Active JP5606554B2 (ja) | 2010-01-13 | 2011-01-10 | 生体液用回路 |
Country Status (10)
Country | Link |
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US (2) | US9051929B2 (ja) |
EP (1) | EP2523756B1 (ja) |
JP (1) | JP5606554B2 (ja) |
CN (1) | CN102753270B (ja) |
BR (1) | BR112012017273B1 (ja) |
ES (1) | ES2443190T3 (ja) |
FR (1) | FR2955119B1 (ja) |
IN (1) | IN2012DN06325A (ja) |
SG (1) | SG182380A1 (ja) |
WO (1) | WO2011086488A1 (ja) |
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EP2523756A1 (en) | 2012-11-21 |
FR2955119B1 (fr) | 2012-12-28 |
US20120018018A1 (en) | 2012-01-26 |
SG182380A1 (en) | 2012-08-30 |
WO2011086488A1 (en) | 2011-07-21 |
CN102753270B (zh) | 2014-09-24 |
FR2955119A1 (fr) | 2011-07-15 |
CN102753270A (zh) | 2012-10-24 |
ES2443190T3 (es) | 2014-02-18 |
US9181941B2 (en) | 2015-11-10 |
US9051929B2 (en) | 2015-06-09 |
US20140069537A1 (en) | 2014-03-13 |
EP2523756B1 (en) | 2013-11-27 |
BR112012017273A2 (pt) | 2016-04-19 |
IN2012DN06325A (ja) | 2015-10-02 |
JP5606554B2 (ja) | 2014-10-15 |
BR112012017273B1 (pt) | 2019-12-10 |
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