JP2013515690A - アルテミシニンベースの薬剤と他の化学療法薬の抗癌用組合せ - Google Patents

アルテミシニンベースの薬剤と他の化学療法薬の抗癌用組合せ Download PDF

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Publication number
JP2013515690A
JP2013515690A JP2012545201A JP2012545201A JP2013515690A JP 2013515690 A JP2013515690 A JP 2013515690A JP 2012545201 A JP2012545201 A JP 2012545201A JP 2012545201 A JP2012545201 A JP 2012545201A JP 2013515690 A JP2013515690 A JP 2013515690A
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cancer
iminomethylcamptothecin
agent
chemotherapeutic
group
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JP2012545201A
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Japanese (ja)
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JP2013515690A5 (cg-RX-API-DMAC10.html
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クラウディオ・ピサーノ
ロレダナ・ヴェシ
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2012545201A 2009-12-23 2010-12-06 アルテミシニンベースの薬剤と他の化学療法薬の抗癌用組合せ Ceased JP2013515690A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09180666.1 2009-12-23
EP09180666 2009-12-23
PCT/EP2010/068924 WO2011076547A1 (en) 2009-12-23 2010-12-06 Anticancer combination of artemisinin-based drugs and other chemotherapeutic agents

Publications (2)

Publication Number Publication Date
JP2013515690A true JP2013515690A (ja) 2013-05-09
JP2013515690A5 JP2013515690A5 (cg-RX-API-DMAC10.html) 2015-05-21

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JP2012545201A Ceased JP2013515690A (ja) 2009-12-23 2010-12-06 アルテミシニンベースの薬剤と他の化学療法薬の抗癌用組合せ

Country Status (21)

Country Link
US (1) US9023861B2 (cg-RX-API-DMAC10.html)
EP (1) EP2515898A1 (cg-RX-API-DMAC10.html)
JP (1) JP2013515690A (cg-RX-API-DMAC10.html)
KR (1) KR20120096053A (cg-RX-API-DMAC10.html)
CN (1) CN102665711A (cg-RX-API-DMAC10.html)
AR (1) AR079654A1 (cg-RX-API-DMAC10.html)
AU (1) AU2010335422A1 (cg-RX-API-DMAC10.html)
BR (1) BR112012015606A2 (cg-RX-API-DMAC10.html)
CA (1) CA2780591A1 (cg-RX-API-DMAC10.html)
EA (1) EA201200934A1 (cg-RX-API-DMAC10.html)
IL (1) IL220561A0 (cg-RX-API-DMAC10.html)
IN (1) IN2012DN03914A (cg-RX-API-DMAC10.html)
MX (1) MX2012006738A (cg-RX-API-DMAC10.html)
MY (1) MY157475A (cg-RX-API-DMAC10.html)
NZ (1) NZ599878A (cg-RX-API-DMAC10.html)
PH (1) PH12012500893A1 (cg-RX-API-DMAC10.html)
SG (1) SG10201408485SA (cg-RX-API-DMAC10.html)
TW (1) TWI482621B (cg-RX-API-DMAC10.html)
UA (1) UA107691C2 (cg-RX-API-DMAC10.html)
WO (1) WO2011076547A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201205360B (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023514426A (ja) * 2020-02-19 2023-04-05 ジェイエルピー ヘルス ゲーエムベーハー アルテミシニン化合物、５－アミノレブリン酸またはメチル－５－アミノレブリン酸、および化学療法剤の医薬配合物

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US9314473B2 (en) 2011-02-03 2016-04-19 Pop Test Oncology Limited Liability Company System and method for diagnosis and treatment
WO2013177420A2 (en) * 2012-05-23 2013-11-28 St. Jude Children's Research Hospital Methods and compositions for the treatment of bcr-abl positive lymphoblastic leukemias
WO2015168544A1 (en) * 2014-05-02 2015-11-05 Emory University Selective chemotherapy treatments and diagnostic methods related thereto
US9918972B2 (en) * 2014-12-23 2018-03-20 The University Of Maryland, Baltimore Treatment of leukemia with artemisinin derivatives and combinations with other antineoplastic agents
CN105963262B (zh) * 2016-06-06 2018-11-30 北京林业大学 一种两亲性果胶-双氢青蒿素纳米粒子的制备方法
CN110051850A (zh) * 2016-08-26 2019-07-26 宁国市厚普生物科技有限公司 一种复合物在制备用于治疗黑色素瘤的药物中的应用
CN109453156A (zh) * 2018-11-22 2019-03-12 中国中医科学院中药研究所 一种抗肿瘤组合物及其应用、抗肿瘤药物
CN114053276B (zh) * 2020-07-30 2024-05-07 江苏天士力帝益药业有限公司 一种parp抑制剂tsl-1502中间体tsl-1502m的用途
CN114053271B (zh) * 2020-07-30 2024-05-07 江苏天士力帝益药业有限公司 一种含有tsl-1502m的药物组合物及其应用
CN114010643A (zh) * 2021-11-23 2022-02-08 温州医科大学 双氢青蒿素在抗肿瘤药物的制备中的应用

Citations (1)

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CN101856352A (zh) * 2009-04-10 2010-10-13 中国科学院上海生命科学研究院 青蒿素及其衍生物对化疗剂的协同作用

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KR100390332B1 (ko) 2000-08-02 2003-07-07 유원민 항말라리아제와 항암제의 병용투여에 의한 항암제 복합 조성물
ATE485039T1 (de) 2003-02-12 2010-11-15 Univ Georgetown Verwendung von artemisinin zur behandlung von durch onkogene viren gebildeten tumoren und zur behandlung von viralen infektionen
EP1658844A1 (en) 2004-10-19 2006-05-24 Gerold Schuler Use of artemisinin derivatives in the manufacture of a medicament for the treatment of melanoma
TWI375673B (en) 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
US8143284B2 (en) * 2006-10-05 2012-03-27 Abbott Laboratories Poly(ADP-ribose)polymerase inhibitors
TWI519313B (zh) 2006-11-20 2016-02-01 希佛隆公司 使用放射敏感劑放射敏感化腫瘤之方法
CN101125140B (zh) * 2007-09-18 2011-04-13 浙江大学 二氢青蒿素在制备增强化疗药物抗肿瘤疗效的药物中的应用
WO2009114459A2 (en) * 2008-03-10 2009-09-17 The Trustees Of The University Of Pennsylvania Anti-neoplastic combination therapeutic regimen involving co-disruption of parp pathway and mre11/rad50/nbs1 complex and compositons useful therein
CN101380325A (zh) * 2008-10-23 2009-03-11 上海交通大学 青蒿素衍生物与长春瑞滨的组合物及其应用
CN101428034B (zh) * 2008-12-12 2012-02-08 广州市允中投资发展有限公司 具有增效减毒特点的抗肿瘤组合药物

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JPN6014054113; Ｊ．　Ｃｅｌｌ．　Ｍｏｌ．　Ｍｅｄ ｖｏｌ．１３，　ｎｏ．７, 2009, ｐ．１３５８-１３７０ *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023514426A (ja) * 2020-02-19 2023-04-05 ジェイエルピー ヘルス ゲーエムベーハー アルテミシニン化合物、５－アミノレブリン酸またはメチル－５－アミノレブリン酸、および化学療法剤の医薬配合物
JP7719787B2 (ja) 2020-02-19 2025-08-06 ジェイエルピー ヘルス ゲーエムベーハー アルテミシニン化合物、５－アミノレブリン酸またはメチル－５－アミノレブリン酸、および化学療法剤の医薬配合物

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Publication number Publication date
CA2780591A1 (en) 2011-06-30
SG10201408485SA (en) 2015-01-29
EP2515898A1 (en) 2012-10-31
IL220561A0 (en) 2012-08-30
WO2011076547A1 (en) 2011-06-30
US9023861B2 (en) 2015-05-05
NZ599878A (en) 2014-06-27
BR112012015606A2 (pt) 2018-05-29
MY157475A (en) 2016-06-15
AU2010335422A1 (en) 2012-06-07
IN2012DN03914A (cg-RX-API-DMAC10.html) 2015-09-04
UA107691C2 (ru) 2015-02-10
KR20120096053A (ko) 2012-08-29
ZA201205360B (en) 2013-05-29
MX2012006738A (es) 2012-07-03
TWI482621B (zh) 2015-05-01
PH12012500893A1 (en) 2012-11-12
CN102665711A (zh) 2012-09-12
TW201138764A (en) 2011-11-16
AR079654A1 (es) 2012-02-08
US20120258181A1 (en) 2012-10-11
EA201200934A1 (ru) 2012-12-28

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