JP2013515472A5 - - Google Patents
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- JP2013515472A5 JP2013515472A5 JP2012545347A JP2012545347A JP2013515472A5 JP 2013515472 A5 JP2013515472 A5 JP 2013515472A5 JP 2012545347 A JP2012545347 A JP 2012545347A JP 2012545347 A JP2012545347 A JP 2012545347A JP 2013515472 A5 JP2013515472 A5 JP 2013515472A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 45
- 102000004965 antibodies Human genes 0.000 claims 23
- 108090001123 antibodies Proteins 0.000 claims 23
- 206010024324 Leukaemias Diseases 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010029592 Non-Hodgkin's lymphomas Diseases 0.000 claims 3
- 206010025310 Other lymphomas Diseases 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 206010000880 Acute myeloid leukaemia Diseases 0.000 claims 2
- 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 claims 2
- 208000000429 Leukemia, Lymphocytic, Chronic, B-Cell Diseases 0.000 claims 2
- 208000008456 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Diseases 0.000 claims 2
- 208000007046 Leukemia, Myeloid, Acute Diseases 0.000 claims 2
- 206010026798 Mantle cell lymphomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 208000007660 Residual Neoplasm Diseases 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 108091006028 chimera Proteins 0.000 claims 2
- 201000006934 chronic myeloid leukemia Diseases 0.000 claims 2
- 201000009277 hairy cell leukemia Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 2
- 210000003719 B-Lymphocytes Anatomy 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102100015541 FCGR3A Human genes 0.000 claims 1
- 101710044656 FCGR3A Proteins 0.000 claims 1
- 101710009074 FLT3 Proteins 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 201000005510 acute lymphocytic leukemia Diseases 0.000 claims 1
- 229940121369 angiogenesis inhibitors Drugs 0.000 claims 1
- 230000003388 anti-hormone Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000003293 cardioprotective Effects 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 230000001472 cytotoxic Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- -1 immunostimulators Substances 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 201000011649 lymphoblastic lymphoma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000009251 multiple myeloma Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28952909P | 2009-12-23 | 2009-12-23 | |
| US61/289,529 | 2009-12-23 | ||
| PCT/EP2010/070659 WO2011076922A1 (en) | 2009-12-23 | 2010-12-23 | Anti-flt3 antibodies and methods of using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515472A JP2013515472A (ja) | 2013-05-09 |
| JP2013515472A5 true JP2013515472A5 (US07794700-20100914-C00152.png) | 2014-02-06 |
| JP5944831B2 JP5944831B2 (ja) | 2016-07-05 |
Family
ID=43719470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012545347A Active JP5944831B2 (ja) | 2009-12-23 | 2010-12-23 | 抗ｆｌｔ３抗体及びその使用方法 |
Country Status (14)
Families Citing this family (64)
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| SI2794658T1 (sl) * | 2011-12-19 | 2017-05-31 | Synimmune Gmbh | Bispecifična molekula protitelesa |
| CA2863224A1 (en) * | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
| KR20160029027A (ko) * | 2013-07-04 | 2016-03-14 | 프라운호퍼-게젤샤프트 추르 푀르데룽 데어 안제반텐 포르슝 에 파우 | 급성 골수성 백혈병 세포를 표적으로 하고 치료하는 새로운 융합 단백질 |
| JP2017513818A (ja) | 2014-03-15 | 2017-06-01 | ノバルティス アーゲー | キメラ抗原受容体を使用する癌の処置 |
| CN104288765A (zh) * | 2014-07-03 | 2015-01-21 | 成都中联生科基因科技有限公司 | 一种利用具有中和FLT3生物学活性的McAb应用于肿瘤的靶向治疗的新方法 |
| EP3193915A1 (en) | 2014-07-21 | 2017-07-26 | Novartis AG | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| EP2985294A1 (en) | 2014-08-14 | 2016-02-17 | Deutsches Krebsforschungszentrum | Recombinant antibody molecule and its use for target cell restricted T cell activation |
| CN107250157B (zh) * | 2014-11-21 | 2021-06-29 | 百时美施贵宝公司 | 包含修饰的重链恒定区的抗体 |
| US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| SG11201707195SA (en) * | 2015-03-09 | 2017-10-30 | Agensys Inc | Antibody drug conjugates (adc) that bind to flt3 proteins |
| EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
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| EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| US11549099B2 (en) | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
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| EP3784351A1 (en) | 2018-04-27 | 2021-03-03 | Novartis AG | Car t cell therapies with enhanced efficacy |
| US20210396739A1 (en) | 2018-05-01 | 2021-12-23 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| US20210213063A1 (en) | 2018-05-25 | 2021-07-15 | Novartis Ag | Combination therapy with chimeric antigen receptor (car) therapies |
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| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| EP3623383A1 (en) | 2018-09-11 | 2020-03-18 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Improved bispecific flt3xcd3 antigen binding proteins |
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| JP7483732B2 (ja) | 2019-02-15 | 2024-05-15 | ノバルティス アーゲー | ３－（１－オキソ－５－（ピペリジン－４－イル）イソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用 |
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2010
- 2010-12-23 EA EA201290370A patent/EA027502B1/ru unknown
- 2010-12-23 CN CN201080064659.3A patent/CN102770453B/zh active Active
- 2010-12-23 HU HUE10798340A patent/HUE028629T2/en unknown
- 2010-12-23 DK DK10798340.5T patent/DK2516468T3/en active
- 2010-12-23 ES ES10798340.5T patent/ES2573642T3/es active Active
- 2010-12-23 SI SI201031176A patent/SI2516468T1/sl unknown
- 2010-12-23 WO PCT/EP2010/070659 patent/WO2011076922A1/en active Application Filing
- 2010-12-23 CA CA2785178A patent/CA2785178C/en active Active
- 2010-12-23 EP EP10798340.5A patent/EP2516468B1/en active Active
- 2010-12-23 JP JP2012545347A patent/JP5944831B2/ja active Active
- 2010-12-23 BR BR112012015740-0A patent/BR112012015740B1/pt active IP Right Grant
- 2010-12-23 US US13/518,779 patent/US9023996B2/en active Active
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2013
- 2013-01-02 HK HK13100006.7A patent/HK1172910A1/zh unknown
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2016
- 2016-04-20 HR HRP20160422TT patent/HRP20160422T1/hr unknown
