JP2013515070A5 - - Google Patents
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- Publication number
- JP2013515070A5 JP2013515070A5 JP2012546120A JP2012546120A JP2013515070A5 JP 2013515070 A5 JP2013515070 A5 JP 2013515070A5 JP 2012546120 A JP2012546120 A JP 2012546120A JP 2012546120 A JP2012546120 A JP 2012546120A JP 2013515070 A5 JP2013515070 A5 JP 2013515070A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyridine
- indazol
- imidazo
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C*C=O)C(*)c1cc2ncc(C(Nc3c(*)ccc4c3c(*)n[n]4*)=O)[n]2cc1* Chemical compound CC(C*C=O)C(*)c1cc2ncc(C(Nc3c(*)ccc4c3c(*)n[n]4*)=O)[n]2cc1* 0.000 description 5
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28872909P | 2009-12-21 | 2009-12-21 | |
| US61/288,729 | 2009-12-21 | ||
| PCT/US2010/061341 WO2011079076A1 (en) | 2009-12-21 | 2010-12-20 | Substituted n-(1h-indazol-4-yl)imidazo[1, 2-a]pyridine-3- carboxamide compounds as cfms inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015010346A Division JP2015107999A (ja) | 2009-12-21 | 2015-01-22 | ｃＦＭＳ阻害剤としての置換Ｎ−（１Ｈ−インダゾール−４−イル）イミダゾ［１，２−ａ］ピリジン−３−カルボキサミド化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515070A JP2013515070A (ja) | 2013-05-02 |
| JP2013515070A5 true JP2013515070A5 (enExample) | 2014-01-30 |
| JP5739448B2 JP5739448B2 (ja) | 2015-06-24 |
Family
ID=43568700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546120A Expired - Fee Related JP5739448B2 (ja) | 2009-12-21 | 2010-12-20 | ｃＦＭＳ阻害剤としての置換Ｎ−（１Ｈ−インダゾール−４−イル）イミダゾ［１，２−ａ］ピリジン−３−カルボキサミド化合物 |
| JP2015010346A Withdrawn JP2015107999A (ja) | 2009-12-21 | 2015-01-22 | ｃＦＭＳ阻害剤としての置換Ｎ−（１Ｈ−インダゾール−４−イル）イミダゾ［１，２−ａ］ピリジン−３−カルボキサミド化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015010346A Withdrawn JP2015107999A (ja) | 2009-12-21 | 2015-01-22 | ｃＦＭＳ阻害剤としての置換Ｎ−（１Ｈ−インダゾール−４−イル）イミダゾ［１，２−ａ］ピリジン−３−カルボキサミド化合物 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8841455B2 (enExample) |
| EP (1) | EP2516433B1 (enExample) |
| JP (2) | JP5739448B2 (enExample) |
| KR (1) | KR101779630B1 (enExample) |
| CN (1) | CN102822170B (enExample) |
| AR (1) | AR079541A1 (enExample) |
| AU (1) | AU2010333752B2 (enExample) |
| BR (1) | BR112012017123B1 (enExample) |
| CA (1) | CA2785338C (enExample) |
| CL (1) | CL2012001699A1 (enExample) |
| CO (1) | CO6561821A2 (enExample) |
| CR (1) | CR20120389A (enExample) |
| DK (1) | DK2516433T3 (enExample) |
| ES (1) | ES2494590T3 (enExample) |
| HR (1) | HRP20140770T1 (enExample) |
| IL (1) | IL220544A (enExample) |
| ME (1) | ME01894B (enExample) |
| MX (1) | MX2012007329A (enExample) |
| MY (1) | MY163791A (enExample) |
| NZ (1) | NZ601376A (enExample) |
| PL (1) | PL2516433T3 (enExample) |
| PT (1) | PT2516433E (enExample) |
| RS (1) | RS53500B1 (enExample) |
| RU (1) | RU2562977C2 (enExample) |
| SG (1) | SG181861A1 (enExample) |
| SI (1) | SI2516433T1 (enExample) |
| SM (1) | SMT201400142B (enExample) |
| TW (1) | TWI471326B (enExample) |
| UA (1) | UA108222C2 (enExample) |
| WO (1) | WO2011079076A1 (enExample) |
| ZA (1) | ZA201205505B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2464232B1 (en) | 2009-08-10 | 2015-10-07 | Samumed, LLC | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| KR101779630B1 (ko) * | 2009-12-21 | 2017-09-18 | 어레이 바이오파마 인크. | ｃＦＭＳ 억제제로서 치환된 Ｎ-（１Ｈ-인다졸-４-일）이미다조［１,２-ａ］피리딘-３-카복사미드 화합물 |
| SMT201700581T1 (it) | 2009-12-21 | 2018-01-11 | Samumed Llc | 1h-pirazolo[3,4-b]piridine e loro usi terapeutici |
| RU2591195C2 (ru) * | 2010-12-13 | 2016-07-10 | Эррэй Биофарма Инк. | Замещенные n-(1h-индазол-4-ил) имидазол [1,2-а]пиридин-3- карбоксамидные соединения в качестве ингибиторов рецепторной тирозинкиназы iii типа |
| AU2012308570B2 (en) | 2011-09-14 | 2016-11-10 | Samumed, Llc | Indazole-3-carboxamides and their use as Wnt/b-catenin signaling pathway inhibitors |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| CA2872147A1 (en) * | 2012-05-02 | 2013-11-07 | Kansas State University Research Foundation | Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3c or 3c-like proteases of picornaviruses, caliciviruses and coronaviruses |
| ME03573B (me) | 2012-05-04 | 2020-07-20 | Samumed Llc | 1H-PIRAZOLO[3,4-B]PIRIDINI l NJIHOVA TERAPEUTSKA UPOTREBA |
| CN105120862A (zh) | 2013-01-08 | 2015-12-02 | 萨穆梅德有限公司 | Wnt信号途径的3-(苯并咪唑-2-基)-吲唑抑制剂及其治疗应用 |
| KR101756934B1 (ko) | 2014-07-08 | 2017-07-12 | 연세대학교 산학협력단 | 피롤로[1,2-a]피라진 유도체, 이의 약학적으로 허용가능한 염, 이들 화합물의 제조방법 및 이를 유효성분으로 함유하는 골다공증 치료 또는 예방용 약학조성물 |
| WO2016040188A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040182A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof |
| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| WO2016040190A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| EA201791421A1 (ru) | 2014-12-22 | 2017-10-31 | Файв Прайм Терапьютикс, Инк. | Антитела против csf1r для лечения pvns |
| CN204833440U (zh) | 2015-07-29 | 2015-12-02 | 山东新北洋信息技术股份有限公司 | 识读组件及纸币清分机 |
| US10195185B2 (en) | 2015-08-03 | 2019-02-05 | Samumed, Llc | 3-(1H-imidazo[4,5-C]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017023988A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| WO2017023980A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| US10383861B2 (en) | 2015-08-03 | 2019-08-20 | Sammumed, LLC | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| WO2017024003A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| WO2017024015A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10519169B2 (en) | 2015-08-03 | 2019-12-31 | Samumed, Llc | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017024004A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10206908B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| WO2017023989A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10604512B2 (en) | 2015-08-03 | 2020-03-31 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof |
| WO2017023993A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10350199B2 (en) | 2015-08-03 | 2019-07-16 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| WO2017024026A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| US10463651B2 (en) | 2015-08-03 | 2019-11-05 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof |
| US10226448B2 (en) | 2015-08-03 | 2019-03-12 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof |
| US10285983B2 (en) | 2015-08-03 | 2019-05-14 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof |
| CN108473491A (zh) | 2015-11-06 | 2018-08-31 | 萨穆梅德有限公司 | 2-(1h-吲唑-3-基)-3h-咪唑并[4,5-c]吡啶以及其抗炎用途 |
| AR108325A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| DK3464285T3 (da) | 2016-06-01 | 2022-12-19 | Biosplice Therapeutics Inc | Fremgangsmåde til fremstilling af n-(5-(3-(7-(3-fluorphenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamid |
| EP3528808B1 (en) | 2016-10-21 | 2021-10-06 | BioSplice Therapeutics, Inc. | Methods of using indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors |
| WO2018083635A2 (en) | 2016-11-04 | 2018-05-11 | Auckland Uniservices Limited | Tricyclic heterocyclic derivatives and uses thereof |
| MA46696A (fr) | 2016-11-07 | 2019-09-11 | Samumed Llc | Formulations injectables à dose unique prêtes à l'emploi |
| KR102374012B1 (ko) * | 2017-05-24 | 2022-03-14 | 아비스코 테라퓨틱스 컴퍼니 리미티드 | N-(아자릴)시클로락탐-1-카르복사미드 유도체 및 합성법과 그 용법 |
| EP4458810A4 (en) | 2021-12-28 | 2025-12-17 | Nippon Shinyaku Co Ltd | INDAZOLE COMPOUND AND PHARMACEUTICAL PRODUCT |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3952101A (en) | 1975-04-14 | 1976-04-20 | Smithkline Corporation | α-Amino methyl-5-hydroxy-2-pyridinemethanols |
| US6723332B2 (en) * | 2000-05-26 | 2004-04-20 | Neurogen Corporation | Oxomidazopyridine-carboxamides |
| CN101146796A (zh) | 2005-01-26 | 2008-03-19 | 先灵公司 | 作为蛋白激酶抑制剂用于治疗癌症的3-(吲唑-5-基)-(1,2,4)三嗪衍生物及相关化合物 |
| CA2608733A1 (en) * | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
| MX2007015905A (es) | 2005-06-24 | 2008-03-06 | Lilly Co Eli | Derivados de tetrahidrocarbazol utiles como moduladores de receptor de androgeno (sarm). |
| JP2009521494A (ja) | 2005-12-22 | 2009-06-04 | アルコン リサーチ， リミテッド | ｒｈｏキナーゼ媒介性疾患および状態を治療するための（インダゾール−５−イル）−ピラジンおよび（１，３−ジヒドロインドール−２−オン）−ピラジン |
| WO2008085302A1 (en) * | 2006-12-20 | 2008-07-17 | Merck & Co., Inc. | Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
| NZ580327A (en) * | 2007-04-03 | 2012-02-24 | Array Biopharma Inc | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS |
| WO2009071483A1 (en) | 2007-12-07 | 2009-06-11 | Via Pharmaceuticals, Inc. | 1- (indaz0l-5-yl) -ureas as diacylglycerol acyltransferase inhibitors |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| EP2280705B1 (en) * | 2008-06-05 | 2014-10-08 | Glaxo Group Limited | Novel compounds |
| KR101779630B1 (ko) * | 2009-12-21 | 2017-09-18 | 어레이 바이오파마 인크. | ｃＦＭＳ 억제제로서 치환된 Ｎ-（１Ｈ-인다졸-４-일）이미다조［１,２-ａ］피리딘-３-카복사미드 화합물 |
| RU2591195C2 (ru) * | 2010-12-13 | 2016-07-10 | Эррэй Биофарма Инк. | Замещенные n-(1h-индазол-4-ил) имидазол [1,2-а]пиридин-3- карбоксамидные соединения в качестве ингибиторов рецепторной тирозинкиназы iii типа |
-
2010
- 2010-12-20 KR KR1020127019199A patent/KR101779630B1/ko not_active Expired - Fee Related
- 2010-12-20 AR ARP100104761A patent/AR079541A1/es active IP Right Grant
- 2010-12-20 RS RSP20140440 patent/RS53500B1/sr unknown
- 2010-12-20 SG SG2012046009A patent/SG181861A1/en unknown
- 2010-12-20 PT PT107986838T patent/PT2516433E/pt unknown
- 2010-12-20 UA UAA201208998A patent/UA108222C2/ru unknown
- 2010-12-20 MY MYPI2012002855A patent/MY163791A/en unknown
- 2010-12-20 RU RU2012131129/04A patent/RU2562977C2/ru active
- 2010-12-20 ES ES10798683.8T patent/ES2494590T3/es active Active
- 2010-12-20 AU AU2010333752A patent/AU2010333752B2/en not_active Ceased
- 2010-12-20 MX MX2012007329A patent/MX2012007329A/es active IP Right Grant
- 2010-12-20 DK DK10798683.8T patent/DK2516433T3/da active
- 2010-12-20 HR HRP20140770AT patent/HRP20140770T1/hr unknown
- 2010-12-20 PL PL10798683T patent/PL2516433T3/pl unknown
- 2010-12-20 CA CA2785338A patent/CA2785338C/en active Active
- 2010-12-20 CN CN201080064462.XA patent/CN102822170B/zh not_active Expired - Fee Related
- 2010-12-20 SI SI201030706T patent/SI2516433T1/sl unknown
- 2010-12-20 BR BR112012017123-2A patent/BR112012017123B1/pt not_active IP Right Cessation
- 2010-12-20 US US13/517,938 patent/US8841455B2/en active Active
- 2010-12-20 NZ NZ601376A patent/NZ601376A/en not_active IP Right Cessation
- 2010-12-20 JP JP2012546120A patent/JP5739448B2/ja not_active Expired - Fee Related
- 2010-12-20 WO PCT/US2010/061341 patent/WO2011079076A1/en not_active Ceased
- 2010-12-20 ME MEP-2014-99A patent/ME01894B/me unknown
- 2010-12-20 EP EP10798683.8A patent/EP2516433B1/en active Active
- 2010-12-21 TW TW99145074A patent/TWI471326B/zh not_active IP Right Cessation
-
2012
- 2012-06-21 IL IL220544A patent/IL220544A/en active IP Right Grant
- 2012-06-21 CL CL2012001699A patent/CL2012001699A1/es unknown
- 2012-07-19 CO CO12122160A patent/CO6561821A2/es unknown
- 2012-07-20 CR CR20120389A patent/CR20120389A/es unknown
- 2012-07-20 ZA ZA2012/05505A patent/ZA201205505B/en unknown
-
2014
- 2014-09-30 SM SM201400142T patent/SMT201400142B/xx unknown
-
2015
- 2015-01-22 JP JP2015010346A patent/JP2015107999A/ja not_active Withdrawn
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