CA2785338C - Substituted n-(1h-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as cfms inhibitors - Google Patents

Substituted n-(1h-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as cfms inhibitors Download PDF

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CA2785338C
CA2785338C CA2785338A CA2785338A CA2785338C CA 2785338 C CA2785338 C CA 2785338C CA 2785338 A CA2785338 A CA 2785338A CA 2785338 A CA2785338 A CA 2785338A CA 2785338 C CA2785338 C CA 2785338C
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methyl
indazol
imidazo
pyridine
ethyl
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French (fr)
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CA2785338A1 (en
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Mark Laurence Boys
Michael Bradley
Robert Kirk Delisle
D. David Hennings
April L. Kennedy
Fredrik P. Marmsater
Matthew Medina
Mark C. Munson
Bryson Rast
James P. Rizzi
Martha E. Rodriguez
George T. Topalov
Qian Zhao
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Array Biopharma Inc
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Array Biopharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2785338A 2009-12-21 2010-12-20 Substituted n-(1h-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as cfms inhibitors Active CA2785338C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28872909P 2009-12-21 2009-12-21
US61/288,729 2009-12-21
PCT/US2010/061341 WO2011079076A1 (en) 2009-12-21 2010-12-20 Substituted n-(1h-indazol-4-yl)imidazo[1, 2-a]pyridine-3- carboxamide compounds as cfms inhibitors

Publications (2)

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CA2785338A1 CA2785338A1 (en) 2011-06-30
CA2785338C true CA2785338C (en) 2018-09-18

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CA2785338A Active CA2785338C (en) 2009-12-21 2010-12-20 Substituted n-(1h-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as cfms inhibitors

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US (1) US8841455B2 (enExample)
EP (1) EP2516433B1 (enExample)
JP (2) JP5739448B2 (enExample)
KR (1) KR101779630B1 (enExample)
CN (1) CN102822170B (enExample)
AR (1) AR079541A1 (enExample)
AU (1) AU2010333752B2 (enExample)
BR (1) BR112012017123B1 (enExample)
CA (1) CA2785338C (enExample)
CL (1) CL2012001699A1 (enExample)
CO (1) CO6561821A2 (enExample)
CR (1) CR20120389A (enExample)
DK (1) DK2516433T3 (enExample)
ES (1) ES2494590T3 (enExample)
HR (1) HRP20140770T1 (enExample)
IL (1) IL220544A (enExample)
ME (1) ME01894B (enExample)
MX (1) MX2012007329A (enExample)
MY (1) MY163791A (enExample)
NZ (1) NZ601376A (enExample)
PL (1) PL2516433T3 (enExample)
PT (1) PT2516433E (enExample)
RS (1) RS53500B1 (enExample)
RU (1) RU2562977C2 (enExample)
SG (1) SG181861A1 (enExample)
SI (1) SI2516433T1 (enExample)
SM (1) SMT201400142B (enExample)
TW (1) TWI471326B (enExample)
UA (1) UA108222C2 (enExample)
WO (1) WO2011079076A1 (enExample)
ZA (1) ZA201205505B (enExample)

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CO6561821A2 (es) 2012-11-15
BR112012017123A2 (pt) 2017-10-31
RS53500B1 (sr) 2015-02-27
IL220544A0 (en) 2012-08-30
PL2516433T3 (pl) 2014-10-31
ME01894B (me) 2014-12-20
AU2010333752A2 (en) 2012-09-06
JP2015107999A (ja) 2015-06-11
NZ601376A (en) 2014-03-28
RU2012131129A (ru) 2014-01-27
BR112012017123B1 (pt) 2021-07-20
SI2516433T1 (sl) 2014-09-30
UA108222C2 (xx) 2015-04-10
TWI471326B (zh) 2015-02-01
CR20120389A (es) 2012-08-16
JP2013515070A (ja) 2013-05-02
AR079541A1 (es) 2012-02-01
EP2516433A1 (en) 2012-10-31
RU2562977C2 (ru) 2015-09-10
WO2011079076A1 (en) 2011-06-30
CL2012001699A1 (es) 2013-02-01
HK1176928A1 (en) 2013-08-09
MX2012007329A (es) 2012-10-15
ES2494590T3 (es) 2014-09-15
SG181861A1 (en) 2012-07-30
CN102822170A (zh) 2012-12-12
CN102822170B (zh) 2014-12-10
KR101779630B1 (ko) 2017-09-18
JP5739448B2 (ja) 2015-06-24
IL220544A (en) 2016-05-31
HRP20140770T1 (hr) 2014-11-07
CA2785338A1 (en) 2011-06-30
MY163791A (en) 2017-10-31
EP2516433B1 (en) 2014-05-21
US8841455B2 (en) 2014-09-23
AU2010333752A1 (en) 2012-08-09
AU2010333752B2 (en) 2014-12-04
US20120258952A1 (en) 2012-10-11
ZA201205505B (en) 2013-04-24
PT2516433E (pt) 2014-09-03
SMT201400142B (it) 2014-11-10
DK2516433T3 (da) 2014-08-11
TW201121973A (en) 2011-07-01
KR20120106853A (ko) 2012-09-26

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