JP2013512221A5 - - Google Patents
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- Publication number
- JP2013512221A5 JP2013512221A5 JP2012540429A JP2012540429A JP2013512221A5 JP 2013512221 A5 JP2013512221 A5 JP 2013512221A5 JP 2012540429 A JP2012540429 A JP 2012540429A JP 2012540429 A JP2012540429 A JP 2012540429A JP 2013512221 A5 JP2013512221 A5 JP 2013512221A5
- Authority
- JP
- Japan
- Prior art keywords
- crown
- crown ether
- formula
- group
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003983 crown ethers Chemical class 0.000 claims 20
- 125000004043 oxo group Chemical group O=* 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- -1 17-crown-5 Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- BGYBONWLWSMGNV-UHFFFAOYSA-N 1,4,7,10,13,16,19,22-octaoxacyclotetracosane Chemical compound C1COCCOCCOCCOCCOCCOCCOCCO1 BGYBONWLWSMGNV-UHFFFAOYSA-N 0.000 claims 1
- XKEHLMZHBXCJGZ-UHFFFAOYSA-N 1,4,7,10,13,16,19-heptaoxacyclohenicosane Chemical compound C1COCCOCCOCCOCCOCCOCCO1 XKEHLMZHBXCJGZ-UHFFFAOYSA-N 0.000 claims 1
- GOCKDPOEYFOXRC-UHFFFAOYSA-N 1,4,7,10,13-pentaoxacyclohexadecane Chemical compound C1COCCOCCOCCOCCOC1 GOCKDPOEYFOXRC-UHFFFAOYSA-N 0.000 claims 1
- ZYCZHMITGWGHQV-UHFFFAOYSA-N 1,4,7,10-tetraoxacyclotridecane Chemical compound C1COCCOCCOCCOC1 ZYCZHMITGWGHQV-UHFFFAOYSA-N 0.000 claims 1
- PVDDBYSFGBWICV-UHFFFAOYSA-N 1,4,8,11-tetraoxacyclotetradecane Chemical compound C1COCCOCCCOCCOC1 PVDDBYSFGBWICV-UHFFFAOYSA-N 0.000 claims 1
- XQQZRZQVBFHBHL-UHFFFAOYSA-N 12-crown-4 Chemical compound C1COCCOCCOCCO1 XQQZRZQVBFHBHL-UHFFFAOYSA-N 0.000 claims 1
- VFTFKUDGYRBSAL-UHFFFAOYSA-N 15-crown-5 Chemical compound C1COCCOCCOCCOCCO1 VFTFKUDGYRBSAL-UHFFFAOYSA-N 0.000 claims 1
- 150000003990 18-crown-6 derivatives Chemical group 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical group NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 1
- 108091030071 RNAI Proteins 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09014693A EP2332929A1 (en) | 2009-11-25 | 2009-11-25 | Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions |
| EP09014693.7 | 2009-11-25 | ||
| PCT/EP2010/068224 WO2011064300A1 (en) | 2009-11-25 | 2010-11-25 | Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512221A JP2013512221A (ja) | 2013-04-11 |
| JP2013512221A5 true JP2013512221A5 (https=) | 2014-01-09 |
| JP5848708B2 JP5848708B2 (ja) | 2016-01-27 |
Family
ID=42101959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540429A Expired - Fee Related JP5848708B2 (ja) | 2009-11-25 | 2010-11-25 | 医薬および診断組成物用の担体としてのクラウンエーテルのオルトエステル誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8624044B2 (https=) |
| EP (2) | EP2332929A1 (https=) |
| JP (1) | JP5848708B2 (https=) |
| CN (1) | CN102770421B (https=) |
| AU (1) | AU2010323101B2 (https=) |
| BR (1) | BR112012012539B8 (https=) |
| CA (1) | CA2783306C (https=) |
| ES (1) | ES2557916T3 (https=) |
| IL (1) | IL219966A (https=) |
| WO (1) | WO2011064300A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012012945A2 (pt) | 2009-11-25 | 2020-12-29 | Arisgen Sa | Composição de liberação mucosal, seu método de produção, complexo de peptídeo pré-formado, kit e uso de um agente ativo de peptídeo |
| EP2526971A1 (en) * | 2011-05-25 | 2012-11-28 | ArisGen SA | Mucosal delivery of drugs |
| EP3000811B1 (en) | 2014-09-24 | 2017-11-08 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Crown Ether Complexes and Methods for Poducing the Same |
| CN113195005B (zh) * | 2018-10-12 | 2023-07-21 | 国际先进加速器应用公司 | 包含放射性标记的grpr拮抗剂和表面活性剂的药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4113739A (en) * | 1974-01-28 | 1978-09-12 | The Dow Chemical Company | Process for preparation of (poly)cyclic polyethers |
| US4474963A (en) * | 1980-11-03 | 1984-10-02 | W. R. Grace & Co. | Crown ether compositions with sidearms affording enhanced cation binding |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| CA2230492C (en) | 1995-09-21 | 2009-05-26 | Genentech, Inc. | Human growth hormone variants |
| EP1905454A1 (en) * | 2006-09-27 | 2008-04-02 | Paolo Botti | Formulations comprising cyclic compounds |
-
2009
- 2009-11-25 EP EP09014693A patent/EP2332929A1/en not_active Withdrawn
-
2010
- 2010-11-25 EP EP10784504.2A patent/EP2504327B1/en not_active Not-in-force
- 2010-11-25 CN CN201080062354.9A patent/CN102770421B/zh not_active Expired - Fee Related
- 2010-11-25 JP JP2012540429A patent/JP5848708B2/ja not_active Expired - Fee Related
- 2010-11-25 ES ES10784504.2T patent/ES2557916T3/es active Active
- 2010-11-25 BR BR112012012539A patent/BR112012012539B8/pt not_active IP Right Cessation
- 2010-11-25 AU AU2010323101A patent/AU2010323101B2/en not_active Ceased
- 2010-11-25 CA CA2783306A patent/CA2783306C/en active Active
- 2010-11-25 WO PCT/EP2010/068224 patent/WO2011064300A1/en not_active Ceased
- 2010-11-25 US US13/511,837 patent/US8624044B2/en not_active Expired - Fee Related
-
2012
- 2012-05-23 IL IL219966A patent/IL219966A/en active IP Right Grant