JP2013510856A5 - - Google Patents
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- Publication number
- JP2013510856A5 JP2013510856A5 JP2012538889A JP2012538889A JP2013510856A5 JP 2013510856 A5 JP2013510856 A5 JP 2013510856A5 JP 2012538889 A JP2012538889 A JP 2012538889A JP 2012538889 A JP2012538889 A JP 2012538889A JP 2013510856 A5 JP2013510856 A5 JP 2013510856A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- composition according
- condition
- prostate cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 10
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
- 102000001307 androgen receptors Human genes 0.000 claims 6
- 108010080146 androgen receptors Proteins 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000001404 mediated effect Effects 0.000 claims 6
- 239000002775 capsule Substances 0.000 claims 3
- 201000004384 Alopecia Diseases 0.000 claims 2
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 2
- 206010020112 Hirsutism Diseases 0.000 claims 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 2
- 231100000360 alopecia Toxicity 0.000 claims 2
- 201000003585 eunuchism Diseases 0.000 claims 2
- 229940097043 glucuronic acid Drugs 0.000 claims 2
- 208000037106 male hypogonadism Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- -1 glidants Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 239000002966 varnish Substances 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26126209P | 2009-11-13 | 2009-11-13 | |
| US61/261,262 | 2009-11-13 | ||
| PCT/US2010/055996 WO2011059969A2 (en) | 2009-11-13 | 2010-11-09 | Mammalian metabolites of steroids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013510856A JP2013510856A (ja) | 2013-03-28 |
| JP2013510856A5 true JP2013510856A5 (https=) | 2013-12-26 |
| JP5956928B2 JP5956928B2 (ja) | 2016-07-27 |
Family
ID=43992357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538889A Expired - Fee Related JP5956928B2 (ja) | 2009-11-13 | 2010-11-09 | 哺乳類のステロイドの代謝物質 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20120282331A1 (https=) |
| EP (1) | EP2499151A4 (https=) |
| JP (1) | JP5956928B2 (https=) |
| CN (1) | CN102822190B (https=) |
| AU (1) | AU2010319697B2 (https=) |
| BR (1) | BR112012012167A2 (https=) |
| CA (1) | CA2780365A1 (https=) |
| WO (1) | WO2011059969A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| CN102686600A (zh) | 2009-02-05 | 2012-09-19 | 托凯药业股份有限公司 | 甾体cyp17抑制剂/抗雄激素物质的新型药物前体 |
| WO2010149755A1 (en) | 2009-06-26 | 2010-12-29 | Novartis Ag | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17 |
| US9029399B2 (en) | 2011-04-28 | 2015-05-12 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
| RU2015137617A (ru) * | 2013-03-14 | 2017-04-18 | Юниверсити Оф Мэриленд, Балтимор Офис Оф Текнолоджи Трансфер | Агенты, подавляющие андрогенные рецепторы, и их применение |
| CN105636594A (zh) | 2013-08-12 | 2016-06-01 | 托凯药业股份有限公司 | 使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物 |
| US10675289B2 (en) | 2014-10-02 | 2020-06-09 | University Of Maryland, Baltimore | Methods of treating pancreatic cancer |
| CN105732759A (zh) * | 2015-01-29 | 2016-07-06 | 苏州晶云药物科技有限公司 | (3β)-17-(1H-苯并咪唑-1-基)雄甾-5，16-二烯-3-醇的盐及其制备方法 |
| CN112851741B (zh) * | 2016-02-19 | 2022-10-25 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的甾体类化合物及其应用 |
| CN111454315B (zh) * | 2020-04-15 | 2022-12-09 | 宁波第二激素厂 | 一种雄甾-16-烯-3β-醇的合成方法 |
| CN116621902B (zh) * | 2022-05-18 | 2026-03-27 | 湖南科益新生物医药有限公司 | 17-苯并咪唑基-10α-甲基-甾体衍生物及其制备方法、用途和药物组合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3480621A (en) * | 1967-01-17 | 1969-11-25 | Phytogen Prod Inc | Steroid ketal |
| CA2132449C (en) * | 1992-03-31 | 2002-09-10 | Susan E. Barrie | 17 - substituted steroids useful in cancer treatment |
| DE4232681C2 (de) * | 1992-09-29 | 1994-11-24 | Sigma Tau Ind Farmaceuti | 17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung |
| AU2006218711B2 (en) * | 2005-03-02 | 2010-11-11 | University Of Maryland, Baltimore | Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
| GB2470873A (en) * | 2008-03-12 | 2010-12-08 | Univ Maryland | Androgen receptor inactivation contributes to antitumor efficacy of CYP17 inhibitors in prostrate cancer |
| US20110118219A1 (en) * | 2008-03-25 | 2011-05-19 | University Of Maryland, Baltimore | Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
| WO2010091299A2 (en) * | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals | Novel combination cancer therapies |
-
2010
- 2010-11-09 WO PCT/US2010/055996 patent/WO2011059969A2/en not_active Ceased
- 2010-11-09 US US13/508,726 patent/US20120282331A1/en not_active Abandoned
- 2010-11-09 EP EP10830591A patent/EP2499151A4/en not_active Withdrawn
- 2010-11-09 CN CN201080059467.3A patent/CN102822190B/zh not_active Expired - Fee Related
- 2010-11-09 AU AU2010319697A patent/AU2010319697B2/en not_active Ceased
- 2010-11-09 CA CA2780365A patent/CA2780365A1/en not_active Abandoned
- 2010-11-09 JP JP2012538889A patent/JP5956928B2/ja not_active Expired - Fee Related
- 2010-11-09 BR BR112012012167A patent/BR112012012167A2/pt not_active IP Right Cessation
-
2016
- 2016-09-22 US US15/273,121 patent/US20170008920A1/en not_active Abandoned
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