JP2013510584A5 - - Google Patents

Info

Publication number

JP2013510584A5

JP2013510584A5 JP2012539038A JP2012539038A JP2013510584A5 JP 2013510584 A5 JP2013510584 A5 JP 2013510584A5 JP 2012539038 A JP2012539038 A JP 2012539038A JP 2012539038 A JP2012539038 A JP 2012539038A JP 2013510584 A5 JP2013510584 A5 JP 2013510584A5

Authority

JP

Japan

Prior art keywords

oligonucleotide

seq

composition

item

bases

Prior art date

2010-11-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108091034117 Oligonucleotide Proteins 0.000 claims description 66
• 239000000074 antisense oligonucleotide Substances 0.000 claims description 14
• 238000012230 antisense oligonucleotides Methods 0.000 claims description 14
• 230000000840 anti-viral effect Effects 0.000 claims description 9
• 230000003115 biocidal effect Effects 0.000 claims description 8
• 230000008685 targeting Effects 0.000 claims description 8
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 7
• 241000712461 unidentified influenza virus Species 0.000 claims description 7
• 108091027305 Heteroduplex Proteins 0.000 claims description 6
• 108091093037 Peptide nucleic acid Proteins 0.000 claims description 6
• 241000700605 Viruses Species 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 6
• 230000003612 virological effect Effects 0.000 claims description 6
• 241001500351 Influenzavirus A Species 0.000 claims description 5
• 241001500350 Influenzavirus B Species 0.000 claims description 5
• 241001500343 Influenzavirus C Species 0.000 claims description 5
• 108020004999 messenger RNA Proteins 0.000 claims description 5
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 5
• KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims description 4
• 239000004475 Arginine Substances 0.000 claims description 4
• 208000035143 Bacterial infection Diseases 0.000 claims description 4
• 108020005067 RNA Splice Sites Proteins 0.000 claims description 4
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
• 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
• 150000001875 compounds Chemical class 0.000 claims description 4
• 229910052739 hydrogen Inorganic materials 0.000 claims description 4
• 239000001257 hydrogen Substances 0.000 claims description 4
• 206010022000 influenza Diseases 0.000 claims description 4
• 229920001184 polypeptide Polymers 0.000 claims description 4
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
• 108091081024 Start codon Proteins 0.000 claims description 3
• 230000001580 bacterial effect Effects 0.000 claims description 3
• MHCMWGPPLOSCJY-UHFFFAOYSA-N 4-$l^{1}-azanylmorpholine Chemical compound [N]N1CCOCC1 MHCMWGPPLOSCJY-UHFFFAOYSA-N 0.000 claims description 2
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
• 229930186147 Cephalosporin Natural products 0.000 claims description 2
• 101710163270 Nuclease Proteins 0.000 claims description 2
• 229930182555 Penicillin Natural products 0.000 claims description 2
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 2
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 2
• 108091081021 Sense strand Proteins 0.000 claims description 2
• 125000003545 alkoxy group Chemical group 0.000 claims description 2
• 125000003282 alkyl amino group Chemical group 0.000 claims description 2
• 125000000217 alkyl group Chemical group 0.000 claims description 2
• LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 2
• 229960003022 amoxicillin Drugs 0.000 claims description 2
• 229910052799 carbon Inorganic materials 0.000 claims description 2
• 229940124587 cephalosporin Drugs 0.000 claims description 2
• 150000001780 cephalosporins Chemical class 0.000 claims description 2
• 229960005091 chloramphenicol Drugs 0.000 claims description 2
• WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims description 2
• 229960002227 clindamycin Drugs 0.000 claims description 2
• KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 2
• 238000010494 dissociation reaction Methods 0.000 claims description 2
• 230000005593 dissociations Effects 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
• 208000015181 infectious disease Diseases 0.000 claims description 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
• 108020004707 nucleic acids Proteins 0.000 claims description 2
• 102000039446 nucleic acids Human genes 0.000 claims description 2
• 150000007523 nucleic acids Chemical class 0.000 claims description 2
• 239000002773 nucleotide Substances 0.000 claims description 2
• 125000003729 nucleotide group Chemical group 0.000 claims description 2
• LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 2
• 229940049954 penicillin Drugs 0.000 claims description 2
• 108091033319 polynucleotide Proteins 0.000 claims description 2
• 102000040430 polynucleotide Human genes 0.000 claims description 2
• 239000002157 polynucleotide Substances 0.000 claims description 2
• 208000022218 streptococcal pneumonia Diseases 0.000 claims description 2
• 125000005309 thioalkoxy group Chemical group 0.000 claims description 2
• 150000003952 β-lactams Chemical class 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 12
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
• 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
• 102100034343 Integrase Human genes 0.000 claims 1
• 101710203526 Integrase Proteins 0.000 claims 1
• 108020000999 Viral RNA Proteins 0.000 claims 1
• 230000000721 bacterilogical effect Effects 0.000 claims 1
• 230000015556 catabolic process Effects 0.000 claims 1
• 238000006731 degradation reaction Methods 0.000 claims 1
• 230000010076 replication Effects 0.000 claims 1
• 238000000034 method Methods 0.000 description 9
• 230000000295 complement effect Effects 0.000 description 2
• 241000712431 Influenza A virus Species 0.000 description 1
• XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 1
• 230000000692 anti-sense effect Effects 0.000 description 1
• 230000029812 viral genome replication Effects 0.000 description 1