JP2013510584A - アンチセンス抗ウイルス性化合物およびインフルエンザウイルス感染を処置するための方法 - Google Patents
アンチセンス抗ウイルス性化合物およびインフルエンザウイルス感染を処置するための方法 Download PDFInfo
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- JP2013510584A JP2013510584A JP2012539038A JP2012539038A JP2013510584A JP 2013510584 A JP2013510584 A JP 2013510584A JP 2012539038 A JP2012539038 A JP 2012539038A JP 2012539038 A JP2012539038 A JP 2012539038A JP 2013510584 A JP2013510584 A JP 2013510584A
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Abstract
Description
本願は、米国特許法第119条(e)項の下、2009年11月13日に出願された米国仮特許出願第61/261,278号、2010年1月4日に出願された米国仮特許出願第61/292,056号、および2010年8月26日に出願された米国仮特許出願第61/377,382号の利益を主張し、この米国仮特許出願の全体の内容は、本明細書中に参考として援用される。
本願に付随する配列表は、紙の写しの代わりにテキスト形式で提供してあり、本明細書によって本明細書中に参考として援用される。その配列表を含むテキストファイルの名称は、120178_456PC_SEQUENCE_LISTING.txtである。このテキストファイルは、33KBであり;2010年11月11日に作成され;EFS−Webを介して電子的に提出されている。
本発明は、インフルエンザウイルス感染を処置する際に使用するためのアンチセンスオリゴヌクレオチド、およびそのオリゴヌクレオチドを使用した抗ウイルス処置方法に関する。
インフルエンザウイルスは、有史時代全体を通してヒトの大量死および罹患の主因であり続けている。インフルエンザAウイルスへの感染により、世界中で毎年、数百万の重篤疾病の症例および500,000もの死亡数が生じる。流行は、重症度が大きく異なるが一定間隔で発生し、いつも高齢者集団において最も高い頻度で、著しい死亡率および罹患率をもたらす。マッチしたインフルエンザ株に対するワクチンは、健常成人の60〜80%において疾病を予防することができるが、高リスク群における防御の割合は、それよりもかなり低い。さらに、ワクチン接種は、予想外の株に対しては防御しない(例えば、1997年の香港ならびに2003年および2004年の欧州および東南アジアにおけるH5およびH7トリインフルエンザの大流行)。現行の抗インフルエンザ薬は、防御および治療効果を提供する能力に限りがある(Cox and Subbarao 1999;Cox and Subbarao 2000)。
本発明の実施形態は、1つの態様において、一本鎖のマイナスセンスゲノムを有し、かつInfluenzavirus A属、Influenzavirus B属およびInfluenzavirus C属を含むOrthomyxoviridae科から選択されるRNAウイルスの宿主細胞内での複製を阻害する際に有効な抗ウイルス化合物を含む。その化合物は、以下から選択される領域内のウイルスRNA配列を標的にし得る:1)マイナスセンスウイルスRNAセグメントの5’または3’末端の25塩基;2)プラスセンスcRNAの5’または3’末端の末端の25塩基;3)インフルエンザウイルスのmRNAのAUG開始コドンの周辺の45塩基および;4)選択的スプライシングに供されるインフルエンザmRNAのスプライス供与部位またはスプライス受容部位の周辺の50塩基。
(a)マイナスセンスウイルスRNAの5’もしくは3’末端の25塩基および/または;
(b)プラスセンスmRNAの5’もしくは3’末端の末端の25塩基および/または;
(c)ウイルスmRNAのAUG開始コドンの周辺の45塩基および/または;
(d)選択的スプライシングに供されるインフルエンザmRNAのスプライス供与部位もしくはスプライス受容部位の周辺の50塩基と;
(e)
(i)ヌクレアーゼ抵抗性骨格
(ii)哺乳動物宿主細胞による取り込みが可能であること
(iii)12〜40ヌクレオチド塩基を含むこと
を特徴とするオリゴヌクレオチド
との間に形成されるヘテロ二重鎖複合体を含み、ここで、前記ヘテロ二重鎖複合体は、少なくとも45℃の解離Tmを有する。
定義
別段定義されない限り、本明細書中で使用されるすべての専門用語および科学用語は、本発明が属する分野の当業者が通常理解している意味と同じ意味を有する。本明細書中に記載される方法および材料と類似または等価な任意の方法および材料を本発明の実施または試行において使用することができるが、好ましい方法および材料が記載される。本発明のために、以下の用語が下で定義される。
本発明の実施形態は、(i)1)マイナスセンスウイルスRNAの5’もしくは3’末端の25塩基;2)プラスセンスmRNAの5’もしくは3’末端の末端の30塩基;3)ウイルスmRNAのAUG開始コドンの周辺の45塩基、および/または;4)選択的スプライシングに供されるインフルエンザmRNAのスプライス供与部位もしくはスプライス受容部位の周辺の50塩基を標的にする、アンチセンスオリゴヌクレオチド化合物、ならびに(ii)宿主細胞内でのアンチセンス化合物とウイルスとの有効な相互作用を可能にする物理的特徴および薬物動態学的特徴を有するアンチセンスオリゴヌクレオチド化合物に、インフルエンザウイルスに感染した動物を曝露することによって、一本鎖で分節型のマイナスセンスRNAウイルスの有効な阻害が達成され得るという発見に部分的に基づく。ある特定の実施形態において、そのオリゴマーは、インフルエンザウイルスに感染した哺乳動物被験体を処置する際に使用され得る。
表1:例示的なインフルエンザウイルス核酸標的配列
表2.例示的なアンチセンス標的化配列
上で詳述されたように、アンチセンスオリゴヌクレオチド(用語「アンチセンス」は、その化合物がウイルスのプラスセンス鎖RNAまたはマイナスセンス鎖もしくはマイナス鎖を標的にしていることを示す)は、代表的には、以下のうちの1つ以上;1)マイナスセンスウイルスRNAの5’もしくは3’末端の25塩基;2)プラスセンスvcRNAの5’もしくは3’末端の末端の30塩基;3)ウイルスmRNAのAUG開始コドンの周辺の45塩基、および/または;4)選択的スプライシングに供されるインフルエンザmRNAのスプライス供与部位もしくはスプライス受容部位の周辺の50塩基を含む領域を標的にする塩基配列を含む。さらに、そのオリゴマーは、宿主細胞、例えば、感染した哺乳動物被験体内の宿主細胞に投与されたとき、例えば、標的タンパク質の発現(例えば、M1もしくはM2または両方)を減少させるか、ウイルスの複製を減少させるか、またはその両方によって、感染しているウイルスを効果的に標的にすることができる。この要件は、代表的には、オリゴマー化合物が、(a)哺乳動物細胞によって能動的に取り込まれる能力を有するとき、および(b)いったん取り込まれると、約45℃より高いTmで標的RNAと二重鎖を形成するときに満たされる。
ここで、
Wは、SまたはOであり、好ましくは、Oであり、
X=NR1R2またはOR6であり、
Y=OまたはNR7であり、
そしてオリゴマー内の前記結合の各々は:
(a)非荷電結合(a)(ここで、R1、R2、R6およびR7の各々は、独立して、水素および低級アルキルから選択される);
(b1)カチオン性結合(b1)(ここで、X=NR1R2かつY=Oであり、NR1R2は、必要に応じて置換されるピペラジノ基を表し、R1R2=−CHRCHRN(R3)(R4)CHRCHR−であり、
ここで、
各Rは、独立して、HまたはCH3であり、
R4は、H、CH3または電子対であり、そして
R3は、H、低級アルキル、例えば、CH3、C(=NH)NH2、Z−L−NHC(=NH)NH2および[C(O)CHR’NH]mHから選択され、ここで:Zは、C(O)または直接の結合であり、Lは、アルキル、アルコキシおよびアルキルアミノから選択される結合を有する、最大18原子長、好ましくは、最大12原子長、より好ましくは、最大8原子長の随意のリンカーであり、R’は、天然に存在するアミノ酸の側鎖またはその1炭素もしくは2炭素のホモログであり、mは、1〜6、好ましくは、1〜4である);
(b2)カチオン性結合(b2)(ここで、X=NR1R2かつY=Oであり、R1=HまたはCH3であり、R2=LNR3R4R5であり、ここで、L、R3およびR4は、上で定義されたとおりであり、R5は、H、低級アルキルまたは低級(アルコキシ)アルキルである);および
(b3)カチオン性結合(b3)(ここで、Y=NR7かつX=OR6であり、R7=LNR3R4R5であり、ここで、L、R3、R4およびR5は、上で定義されたとおりであり、R6は、Hまたは低級アルキルである);
から選択され、そして少なくとも1つの前記結合は、カチオン性結合(b1)、(b2)および(b3)から選択される。
ある特定の実施形態において、本発明のアンチセンス化合物は、細胞内への化合物の輸送を増大するのに有効なアルギニンリッチペプチド輸送部分に結合体化されたオリゴヌクレオチド部分を含み得る。その輸送部分は、例えば、図1Cに示されるように、オリゴマーの末端に付着され得る。そのペプチド輸送部分は、好ましくは、Χ’サブユニット、Y’サブユニットおよびZ’サブユニットから選択される6〜16個のサブユニットを含み、ここで、
(a)各Χ’サブユニットは、独立して、リジン、アルギニンまたはアルギニンアナログを表し、前記アナログは、構造R1N=C(NH2)R2(ここで、R1は、HまたはRであり;R2は、R、NH2、NHRまたはNR2であり、Rは、低級アルキルまたは低級アルケニルであり、かつ酸素または窒素をさらに含み得;R1およびR2は、一体となって環を形成し得;側鎖は、R1またはR2を介して前記アミノ酸に連結される)の側鎖を含むカチオン性α−アミノ酸であり;
(b)各Y’サブユニットは、独立して、中性のアミノ酸−C(O)−(CHR)n−NH−(ここで、nは、2〜7であり、各Rは、独立して、Hまたはメチルである)を表し;そして
(c)各Z’サブユニットは、独立して、中性のアラルキル側鎖を有するα−アミノ酸を表し;
ここで、そのペプチドは、(Χ’Y’Χ’)p、(Χ’Y’)m、(Χ’)mおよび(Χ’Z’Z’)pのうちの1つによって表される配列を含み、ここで、pは、2〜5であり、mは、2〜9である。ある特定の実施形態は、(Χ’Y’Χ’)p、(Χ’Y’)m、(Χ’)mおよび/または(Χ’Z’Z’)pから独立して選択される様々な組み合わせ(例えば、配列(Χ’Y’Χ’)(Χ’Ζ’Ζ’)(Χ’Y’Χ’)(Χ’Ζ’Ζ’)(配列番号129)を有するペプチドを含む)を含む。
表5.例示的なペプチドトランスポーター
本明細書中に記載されるインフルエンザ標的領域(例えば、M1、M2;配列番号1〜11)は、種々のRNA干渉に基づく方法によっても標的にされ得る。RNA干渉(RNAi)は、そもそも、線虫Caenorhabditis elegansの研究において発見された進化的に保存された遺伝子サイレンシング機構である(Leeら、Cell 75:843,1993;Reinhartら、Nature 403:901,2000)。RNAiは、適切な分子機構を発現している細胞内にdsRNAを導入することによって引き起こされ得、次いで、そのdsRNAが、対応する内因性のmRNAを分解する。この機構は、dsRNAから短いRNA(リボヌクレアーゼを相同のmRNA標的に導く)への変換を含む(例えば、Ruvkun,Science 2294:797,2001によって要約されている)。
上で詳述されたアンチセンス化合物は、Orthomyxoviridae科の一本鎖マイナスセンス分節型RNAウイルスの複製を阻害する際に有用である。1つの実施形態において、そのような阻害は、これらのウイルスによる宿主動物の感染を処置する際に有効である。したがって、本方法は、1つの実施形態において、特定のウイルスの複製を阻害するのに有効なアンチセンス物質と、そのウイルスに感染した細胞とを接触させる工程を包含する。この実施形態において、そのアンチセンス物質は、適当な薬学的キャリア中において、所与のウイルスに感染した哺乳動物被験体、例えば、ヒトまたは飼育されている動物に投与される。そのアンチセンスオリゴヌクレオチドは、宿主内でRNAウイルスの増殖を停止すると企図される。宿主の正常な成長または発生に対して有害な影響がほとんどまたはまったくなく、そのRNAウイルスは、数が減少し得るか、または排除され得る。
感染を引き起こしている特定のウイルスは、当該分野で公知の方法、例えば、血清学的方法または培養法によって決定され得る。
ある特定の実施形態において、本発明は、本明細書中に記載されるようなアンチセンスオリゴマーの治療上の送達に適した製剤または組成物を提供する。ゆえに、ある特定の実施形態において、本発明は、1つ以上の薬学的に許容され得るキャリア(添加剤)および/または希釈剤とともに製剤化される、本明細書中に記載される治療有効量のオリゴマーの1つ以上を含む薬学的に許容され得る組成物を提供する。本発明のオリゴマーは、単独で投与されることが可能であるが、薬学的製剤(組成物)としてその化合物を投与することが好ましい。
本発明のアンチセンスオリゴヌクレオチドを用いる有効なインビボ処置レジメンは、投与の持続時間、用量、頻度および経路、ならびに処置中の被験体の状態(すなわち、局在性または全身性の感染に応答した投与に対する予防的投与)に応じて、変動し得る。したがって、そのようなインビボ治療は、処置中のウイルス感染の特定のタイプにとって適切な試験によってモニターすること、および最適な治療成績を達成するために用量または処置レジメンの調整を対応させることを必要とすることが多い。処置は、例えば、一般的な感染指標(例えば、全血球計算値(CBC)、核酸検出法、免疫診断試験、ウイルス培養、またはヘテロ二重鎖の検出)によってモニターされ得る。
すべてのペプチドが、Global Peptide Services(Ft.Collins,CO)またはAVI BioPharma(Corvallis,OR)によってカスタム合成され、>90%の純度に精製された(下記の実施例2を参照のこと)。PMOは、例えば、((Summerton and Weller 1997)および米国特許第5,185,444号に記載され、さらにPCT出願番号US08/012804に記載されているような公知の方法に従って、AVI BioPharmaにおいて合成された。そのPMOの例示的な構造は、図1A〜Cに示されているとおりである。2’−OMeオリゴマーは、Integrated DNA Technologies Inc.,Skokie,ILが合成した。LNAオリゴマーは、Biosynthesis,Inc.,Lewisville,TXが生成した。
マウスモデル系におけるインフルエンザAウイルスの阻害
インフルエンザAウイルス感染のマウスモデルを用いて、その感染に関する代表的なアンチセンスオリゴマーのインビボでの有効性を測定した。インフルエンザA亜型H2N3(Port Chalmers/1/73)を用いて、50マイクロリットル体積中約4×104プラーク形成単位の鼻腔内投与により、Balb/c雌マウスに感染させた。この研究では、1群あたり12匹のマウスを使用し、2日目にウイルス力価の測定のために6匹を取り出し、6日目にウイルス力価の測定のために6匹を取り出した。副次エンドポイントには、体重減少の防止および生存が含まれた。
フェレットモデル系におけるインフルエンザAウイルスの阻害
本発明を支持する1つの所見は、新規H1N12009(S−OIV)ウイルスを用いたときの、飼育されているフェレット(Mustela putorius furo)動物モデル系における本発明の化合物の抗ウイルスの有効性の立証だった。フェレットモデルの利点としては、マウス馴化株とは対照的にインフルエンザウイルスの天然のヒト単離株を使用できること、および発熱および鼻汁などのヒトにおいて観察されるほとんどの臨床的徴候の発症が挙げられる(Munster,de Witら、2009)。
スプライス部位を標的にするアンチセンスオリゴマーを用いた、組織培養物中のインフルエンザAウイルスの阻害
本発明のある態様は、M1/M2セグメント内の複数の部位のアンチセンス標的化によるインフルエンザAウイルス複製の阻害である。通常のM1/M2 AUG開始部位を標的にすることによる翻訳の阻害に加えて、スプライス供与部位およびスプライス受容部位もまた、本発明の化合物を用いて標的にされ得る。740位のスプライス受容部位を標的にする2つのPMOを、ペプチド結合体化PPMOであるSA740およびSA746(それぞれ配列番号26および29)として合成し、H1N1 PR8株に対するインビトロ組織培養物複製系に入れた。そのPMOの3’末端に、P007細胞透過性ペプチド(配列番号118)を結合体化した。
ロックト核酸(NULCEIC ACID)オリゴマーを用いた、組織培養物中のインフルエンザAウイルスの阻害
本発明の化合物は、PMOとは異なる化学実体を含むオリゴヌクレオチドアナログを含む。M1/M2セグメントAUG開始部位領域を標的にする一連のロックト核酸を合成し(LNA−AUG1、LNA−AUG12、LNA−AUG13およびLNA−AUG10;それぞれ配列番号63、74、75および72)、上記の実施例3に記載されたようなウイルスRNAおよびM2タンパク質発現に対するアッセイと同じアッセイにおいて試験した。LNAオリゴマーの細胞内送達は、裸の(gymnotic)送達(Stein,Hansenら、2010)を介した。AMJ2−C11細胞を、PR8に1時間感染させ、次いで、洗浄した。次いで細胞を、LNAまたは2’OMe化合物とともに96ウェルプレートにプレーティングし、35℃で一晩インキュベートした。ウイルスのRNAレベルおよびM2タンパク質の発現をその時点で評価した(約18時間という総インキュベーション時間)。図9Aは、ウイルスのRNAレベル(HAセグメント)に対する4つの異なるLNAの作用を示している。7.5マイクロモル濃度において、ウイルスのHA RNAレベルが、LNA−AUG12化合物の場合の約1.5log減少に対して、LNA−AUG1オリゴマーの場合、約3log減少した(それぞれ配列番号74および63)。LNA−AUG1は、20merであるのに対し、LNA−AUG12は、16merである。4つすべてのLNAオリゴマーに対して、長さに従った有効性の順位が存在することから、より長いLNAが、本発明の好ましい実施形態であることが示唆される。この関係性は、LNA−AUG1オリゴが、7.5マイクロモル濃度においてLNA−AUG10化合物と比べて最も有効である(それぞれ配列番号63および72)という、図9Bに示されるM2タンパク質発現の測定結果においても観察される。10塩基の標的化配列からなる相対的に短いLNA−AUG10化合物が、ウイルスのHA RNAアッセイとM2タンパク質発現アッセイの両方において最も有効性が低かった。
2’OMEオリゴマーを用いた、組織培養物中のインフルエンザAウイルスの阻害
本発明の化合物は、ホスホロチオエート結合によって連結された2’OMe残基からなるアンチセンスアナログオリゴマーも含む。3種の2’OMeオリゴである2’OMe−AUG1、2’OMe−AUG2および2’OMe−SA1;それぞれ配列番号12、20および26がIDTによって作製された。これらのオリゴマーは、M1/M2セグメントのAUG開始コドンまたはヌクレオチド740に位置するスプライス受容部位のいずれかを標的にするように設計された。2’OMe−SA1配列(配列番号26)は、上記の実施例3にSA740と記載されたPPMO化合物の配列と一致する。それらの2’OMe化合物を、上記の実施例3および4に記載されたようなウイルスのHA RNAレベルおよびM2タンパク質発現を阻害する能力に対するアッセイと同じアッセイにおいて試験した。細胞内送達は、上記の実施例4においてLNAについて記載されたようなジムノシス(gymnosis)によって行われた。
インビトロでのM1およびM2タンパク質発現の阻害
M1およびM2タンパク質の発現に対する本発明の例示的な化合物の作用を、処置され感染されたAMJ2−C11細胞のウエスタンブロット解析を用いて評価した。本発明の例示的なPPMO化合物(M1/M2PPMO;P007−M1/M2−AUG;3’末端において配列番号118に結合体化された配列番号12)を3マイクロモル濃度で用いて、MDCK細胞を一晩処置した。続いて、それらの細胞をH1N1−PR8に0.01MOIで1時間感染させ、洗浄した。感染の18時間後に、細胞を溶解し、タンパク質を抽出した。M1、M2およびアクチンタンパク質と反応するモノクローナル抗体を用いる標準的な免疫ブロット(ウエスタン)アッセイによるその後の解析にむけて、等量のタンパク質をゲル上に充填した。図11に示されるように、M1タンパク質とM2タンパク質の両方の発現が、未処置コントロールおよび無関係のコントロールPPMO(デング)と比べて減少した。シグナル強度の解析から、図11に示されるように、M1タンパク質の発現よりもM2タンパク質の発現がM1/M2PPMOによって大きく阻害されることが示唆された(すなわち、M1の27%に対するM2の9%)。M1およびM2に対するシグナルの比較は、アクチンコントロールに対して正規化された。
Claims (31)
- 単離された抗ウイルス性アンチセンスオリゴヌクレオチドであって、
a)ヌクレアーゼ抵抗性骨格;
b)12〜40ヌクレオチド塩基、ならびに
c)i)インフルエンザウイルスA、インフルエンザウイルスBおよびインフルエンザウイルスCのマイナスセンスウイルスRNAセグメントの5’または3’末端の25塩基
ii)インフルエンザウイルスA、インフルエンザウイルスBおよびインフルエンザウイルスCのプラスセンスcRNAの5’または3’末端の末端の30塩基
iii)インフルエンザウイルスのmRNAのAUG開始コドンの周辺の45塩基、および
iv)選択的スプライシングに供されるインフルエンザmRNAのスプライス供与部位またはスプライス受容部位の周辺の50塩基
から選択される標的領域にハイブリダイズする少なくとも10塩基長の標的化配列
を含む、単離された抗ウイルス性アンチセンスオリゴヌクレオチド。 - 前記オリゴヌクレオチドが、ウイルス標的領域とヘテロ二重鎖構造を形成する能力により特徴付けられ、ここで、前記ヘテロ二重鎖構造が:
a)前記ウイルスのプラスセンス鎖またはマイナスセンス鎖および前記オリゴヌクレオチド化合物から構成され、そして
b)少なくとも45℃の解離Tmにより特徴付けられる、
請求項1に記載のオリゴヌクレオチド。 - 前記オリゴヌクレオチドが、
i)インフルエンザウイルスA、インフルエンザウイルスBおよびインフルエンザウイルスCのM1またはM2領域のマイナスセンスウイルスRNAセグメントの5’または3’末端の25塩基、
ii)インフルエンザウイルスA、インフルエンザウイルスBおよびインフルエンザウイルスCのM1またはM2領域のプラスセンスcRNAの5’または3’末端の末端の30塩基
iii)インフルエンザのM1またはM2 mRNAのAUG開始コドンの周辺の45塩基、および
iv)インフルエンザM1またはM2 RNAのスプライス供与部位またはスプライス受容部位の周辺の50塩基
から選択される標的領域と相補的な少なくとも10塩基を含む、請求項1に記載のオリゴヌクレオチド。 - 前記オリゴヌクレオチドが、1つのサブユニットのモルホリノ窒素を隣接サブユニットの5’環外炭素に結合する非荷電のリン(III)含有サブユニット間結合によって連結されたモルホリノサブユニットを含む、請求項1に記載のオリゴヌクレオチド。
- X=NR2であり、各Rは、独立して水素またはメチルであり、正に帯電した結合の場合、Xは、1−ピペラジンである、請求項5に記載のオリゴヌクレオチド。
- 少なくとも2つかつサブユニット間結合の総数の半数以下が、正に帯電している、請求項6に記載のオリゴヌクレオチド。
- 前記モルホリノオリゴマーが、配列番号13に示されるような正に帯電したサブユニット間結合を含む、請求項6に記載のオリゴヌクレオチド。
- 前記ウイルス標的領域が、配列番号1〜11のうちのいずれか1つ以上を含む、請求項1に記載のオリゴヌクレオチド。
- 前記ウイルス標的領域が、配列番号2または4を含む、請求項1に記載のオリゴヌクレオチド。
- 前記オリゴヌクレオチドが、配列番号12〜47のうちのいずれか1つ以上の少なくとも10個連続した塩基を含む、請求項1に記載のオリゴヌクレオチド。
- 前記オリゴヌクレオチドが、配列番号12または13を含む、請求項1に記載のオリゴヌクレオチド。
- 前記オリゴヌクレオチドが、ペプチド核酸(PNA)である、請求項1に記載のオリゴヌクレオチド。
- 配列番号48〜62のうちのいずれか1つ以上の少なくとも10個連続した塩基を含む、請求項13に記載のPNAオリゴヌクレオチド。
- 配列番号48〜62のうちの1つ以上から本質的になる、請求項14に記載のオリゴヌクレオチド。
- 1つ以上のロックト核酸(LNA)サブユニットを含む、請求項1に記載のオリゴヌクレオチド。
- LNAサブユニットから本質的になる、請求項16に記載のオリゴヌクレオチド。
- 配列番号63〜114のうちのいずれか1つ以上の少なくとも10個連続した塩基を含む、請求項16に記載のオリゴヌクレオチド。
- 配列番号63〜114のうちの1つ以上から本質的になる、請求項18に記載のオリゴヌクレオチド。
- 前記オリゴヌクレオチドが、宿主細胞内への前記化合物の取り込みを増大させるアルギニンリッチポリペプチドに結合体化されている、請求項1に記載のオリゴヌクレオチド。
- 前記アルギニンリッチポリペプチドが、配列番号115〜128からなる群から選択される、請求項20に記載のオリゴヌクレオチド。
- インフルエンザウイルスの複製を減少させる方法であって、前記方法は、インフルエンザウイルスに感染した細胞を、請求項1〜21のいずれか1項に記載の抗ウイルス性アンチセンスオリゴヌクレオチドと接触させる工程を包含する、方法。
- 前記細胞が、被験体内の細胞であり、前記方法が、前記被験体に前記アンチセンスオリゴヌクレオチドを投与する工程を包含する、請求項22に記載の方法。
- 前記被験体が、二次的細菌感染を有し、細菌用抗生物質を、前記抗ウイルス性アンチセンスオリゴヌクレオチドと別個に、またはそれと同時に併用して投与する工程をさらに包含する、請求項23に記載の方法。
- 前記二次的細菌感染が、連鎖球菌性肺炎への感染である、請求項24に記載の方法。
- 前記抗生物質が、ベータ−ラクタムである、請求項24に記載の方法。
- 前記抗生物質が、ペニシリン、アモキシシリン、セファロスポリン、クロラムフェニコールおよびクリンダマイシンから選択される、請求項24に記載の方法。
- 前記抗ウイルス性アンチセンスオリゴヌクレオチドと別個に、またはそれと同時に併用して、CD200またはCD200レセプターをコードするRNA分子を標的とするアンチセンスオリゴヌクレオチドを投与する工程をさらに包含する、請求項23または請求項24に記載の方法。
- 請求項1〜21のいずれか1項に記載のアンチセンスオリゴヌクレオチドおよび薬学的に許容され得るキャリアを含む、薬学的組成物。
- 細菌用抗生物質をさらに含む、請求項29に記載の薬学的組成物。
- CD200またはCD200レセプターをコードするRNA分子を標的とするアンチセンスオリゴヌクレオチドをさらに含む、請求項29に記載の薬学的組成物。
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Cited By (2)
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JP2019511471A (ja) * | 2016-03-02 | 2019-04-25 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | インフルエンザウイルスに対する汎遺伝子型薬剤及びその使用方法 |
JP2023071635A (ja) * | 2021-11-11 | 2023-05-23 | 杭州痴創生物科技有限公司 | 分子標的薬nCoVshRNA・2ACE2の合成方法 |
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BR112012011381A2 (pt) | 2017-06-20 |
AU2010319314A1 (en) | 2012-05-24 |
NZ599706A (en) | 2014-07-25 |
CA2779830A1 (en) | 2011-05-19 |
US9394323B2 (en) | 2016-07-19 |
WO2011060320A1 (en) | 2011-05-19 |
AU2010319314B2 (en) | 2016-03-03 |
JP5991922B2 (ja) | 2016-09-14 |
BR112012011381B1 (pt) | 2020-12-22 |
KR101944119B1 (ko) | 2019-01-30 |
IL219700B (en) | 2018-02-28 |
US20140303073A1 (en) | 2014-10-09 |
EP2499248A1 (en) | 2012-09-19 |
KR20120104551A (ko) | 2012-09-21 |
CA2779830C (en) | 2020-07-21 |
JP2016105738A (ja) | 2016-06-16 |
TW201121550A (en) | 2011-07-01 |
US8697858B2 (en) | 2014-04-15 |
EP2499248B1 (en) | 2017-01-04 |
CN107312777B (zh) | 2020-11-13 |
CN102712928B (zh) | 2017-08-04 |
CN102712928A (zh) | 2012-10-03 |
IL219700A0 (en) | 2012-07-31 |
BR112012011381B8 (pt) | 2021-05-25 |
CN107312777A (zh) | 2017-11-03 |
TWI495473B (zh) | 2015-08-11 |
AU2010319314C1 (en) | 2016-09-01 |
US20110118334A1 (en) | 2011-05-19 |
EP3199634A1 (en) | 2017-08-02 |
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