JP2013510581A5 - - Google Patents
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- JP2013510581A5 JP2013510581A5 JP2012539007A JP2012539007A JP2013510581A5 JP 2013510581 A5 JP2013510581 A5 JP 2013510581A5 JP 2012539007 A JP2012539007 A JP 2012539007A JP 2012539007 A JP2012539007 A JP 2012539007A JP 2013510581 A5 JP2013510581 A5 JP 2013510581A5
- Authority
- JP
- Japan
- Prior art keywords
- acid sequence
- seq
- variant
- set forth
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26114509P | 2009-11-13 | 2009-11-13 | |
| US61/261,145 | 2009-11-13 | ||
| PCT/US2010/056496 WO2011060242A2 (en) | 2009-11-13 | 2010-11-12 | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013510581A JP2013510581A (ja) | 2013-03-28 |
| JP2013510581A5 true JP2013510581A5 (cg-RX-API-DMAC10.html) | 2013-11-14 |
| JP5876416B2 JP5876416B2 (ja) | 2016-03-02 |
Family
ID=43992414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012539007A Active JP5876416B2 (ja) | 2009-11-13 | 2010-11-12 | フォンウィルブランド因子（ｖＷＦ）含有調製品並びにこれに関連する方法、キット及び使用 |
Country Status (19)
Families Citing this family (51)
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| JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプｒａｍのチエツク方法 |
| MX394440B (es) | 2007-06-01 | 2025-03-24 | Univ Maryland | Agentes de union al receptor de la region constante fc de inmunoglobulina. |
| US9062299B2 (en) | 2009-08-24 | 2015-06-23 | Amunix Operating Inc. | Coagulation factor IX compositions and methods of making and using same |
| CA2780542C (en) | 2009-11-13 | 2020-03-24 | Grifols Therapeutics Inc. | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
| TR201906652T4 (tr) | 2010-07-28 | 2019-05-21 | Gliknik Inc | Kademeli multimerize immünoglobülin fc bileşimleri oluşturmak için doğal insan protein fragmanları içeren füzyon proteinleri. |
| WO2013098676A1 (en) | 2011-12-30 | 2013-07-04 | Grifols, S.A. | Method for purifying factor viii |
| CN109111526A (zh) * | 2012-01-12 | 2019-01-01 | 比奥贝拉蒂治疗公司 | 嵌合因子viii多肽及其用途 |
| EA038705B1 (ru) | 2012-01-12 | 2021-10-07 | Биовератив Терапьютикс Инк. | Способы снижения иммуногенности фактора свёртывания крови viii у пациентов, получающих лечение фактором viii |
| EP3564260B1 (en) | 2012-02-15 | 2022-10-19 | Bioverativ Therapeutics Inc. | Factor viii compositions and methods of making and using same |
| BR112014019901A8 (pt) | 2012-02-15 | 2018-01-02 | Biogen Idec Inc | Proteínas de fator viii recombinante |
| JP2015515482A (ja) * | 2012-04-24 | 2015-05-28 | ノヴォ ノルディスク アー／エス | 血友病の治療に適する化合物 |
| HUE047088T2 (hu) * | 2012-07-11 | 2020-04-28 | Bioverativ Therapeutics Inc | VIII. faktor komplex XTEN-nel és von willebrand-faktor fehérjével, és alkalmazásai |
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| PL2912186T3 (pl) * | 2012-10-24 | 2021-06-14 | Platelet Targeted Therapeutics Llc | Leczenie ukierunkowane na płytki krwi |
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| CN105392495A (zh) * | 2013-06-28 | 2016-03-09 | 比奥根Ma公司 | 具有xten的凝血酶可裂解连接子和其用途 |
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| US10947269B2 (en) | 2013-08-08 | 2021-03-16 | Bioverativ Therapeutics Inc. | Purification of chimeric FVIII molecules |
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| HUE059820T2 (hu) * | 2014-01-10 | 2022-12-28 | Bioverativ Therapeutics Inc | VIII-as faktor kimérafehérjéi és azok alkalmazása |
| US10626164B2 (en) | 2014-07-25 | 2020-04-21 | Csl Limited | Purification of VWF |
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| CN107406493B (zh) * | 2015-03-06 | 2021-08-13 | 康诺贝林伦瑙有限公司 | 具有改善的半衰期的经修饰的血管性血友病因子 |
| CA2986625A1 (en) | 2015-05-22 | 2016-12-01 | Csl Behring Recombinant Facility Ag | Methods for preparing modified von willebrand factor |
| WO2016188907A1 (en) | 2015-05-22 | 2016-12-01 | Csl Behring Recombinant Facility Ag | Truncated von willebrand factor polypeptides for treating hemophilia |
| SI3325011T1 (sl) | 2015-07-24 | 2021-02-26 | Gliknik Inc. | Fuzijski proteini humanih proteinskih fragmentov za tvorbo pravilnih multimeriziranih imunoglobulin FC sestavkov s povečanim vezanjem komplementa |
| IL257231B (en) | 2015-08-03 | 2022-09-01 | Bioverativ Therapeutics Inc | Factor ix fusion proteins and methods of making and using same |
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| CA3008448A1 (en) * | 2016-01-07 | 2017-07-13 | Csl Behring Recombinant Facility Ag | Mutated von willebrand factor |
| EP3464347B1 (en) | 2016-06-07 | 2023-05-31 | Gliknik Inc. | Cysteine-optimized stradomers |
| KR102175878B1 (ko) | 2016-06-24 | 2020-11-06 | 재단법인 목암생명과학연구소 | Fviii 및 vwf 인자를 포함하는 키메라 단백질 및 그 용도 |
| SG10201912360SA (en) | 2016-11-11 | 2020-02-27 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
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| BR112019026743A2 (pt) | 2017-06-22 | 2020-06-30 | CSL Behring Lengnau AG | modulação da imunogenicidade de fviii através de vwf truncado |
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| JP2021514661A (ja) | 2018-03-05 | 2021-06-17 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | サイトカインに連結させたｅｃｍ親和性ペプチドを用いてがんを処置するための方法および組成物 |
| HRP20250709T1 (hr) | 2018-05-18 | 2025-08-15 | Bioverativ Therapeutics Inc. | Postupci liječenja hemofilije a |
| US10654911B1 (en) | 2019-04-02 | 2020-05-19 | Beijing Neoletix Biological Technology Co., Ltd. | Vector co-expressing truncated von Willebrand factor and factor VIII |
| AU2020300820A1 (en) | 2019-07-04 | 2022-03-03 | CSL Behring Lengnau AG | A truncated von willebrand factor (vWF) for increasing the in vitro stability of coagulation factor VIII |
| US20220348637A1 (en) | 2019-11-11 | 2022-11-03 | CSL Behring Lengnau AG | Polypeptides for inducing tolerance to factor viii |
| CN120225678A (zh) * | 2022-11-14 | 2025-06-27 | 赛尔吉恩技术株式会社 | 产生血液第viii凝血因子修饰体的离体基因治疗用细胞 |
| CN116333081B (zh) * | 2022-12-27 | 2025-09-19 | 大连海洋大学 | 长牡蛎CgVg功能域DUF1943和VWD重组蛋白及应用 |
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-
2010
- 2010-11-12 CA CA2780542A patent/CA2780542C/en active Active
- 2010-11-12 WO PCT/US2010/056496 patent/WO2011060242A2/en not_active Ceased
- 2010-11-12 RU RU2012122402/10A patent/RU2579977C2/ru not_active IP Right Cessation
- 2010-11-12 CN CN201080051549.3A patent/CN102648212B/zh active Active
- 2010-11-12 JP JP2012539007A patent/JP5876416B2/ja active Active
- 2010-11-12 KR KR1020127013906A patent/KR101808751B1/ko not_active Expired - Fee Related
- 2010-11-12 ES ES10830777.8T patent/ES2600879T3/es active Active
- 2010-11-12 AU AU2010319425A patent/AU2010319425B2/en active Active
- 2010-11-12 PL PL10830777T patent/PL2499165T3/pl unknown
- 2010-11-12 BR BR112012011740A patent/BR112012011740A2/pt not_active Application Discontinuation
- 2010-11-12 US US13/509,309 patent/US8759293B2/en active Active
- 2010-11-12 HU HUE10830777A patent/HUE029454T2/en unknown
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