JP2013508292A - ＥｐｈＡ３に対する抗体 - Google Patents

ＥｐｈＡ３に対する抗体 Download PDF

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JP2013508292A
JP2013508292A JP2012534368A JP2012534368A JP2013508292A JP 2013508292 A JP2013508292 A JP 2013508292A JP 2012534368 A JP2012534368 A JP 2012534368A JP 2012534368 A JP2012534368 A JP 2012534368A JP 2013508292 A JP2013508292 A JP 2013508292A
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seq
antibody
region
amino acid
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JP2013508292A5 (enExample
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ケニス リュールセン
デイビッド マルチネス
クリスティーナ イ
クリストファー アール． ベッビントン
ジェフリー ティー． ヤラントン
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カロバイオス ファーマシューティカルズ インコーポレイティッド
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Publication of JP2013508292A publication Critical patent/JP2013508292A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2012534368A 2009-10-14 2010-10-14 ＥｐｈＡ３に対する抗体 Pending JP2013508292A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25166809P 2009-10-14 2009-10-14
US61/251,668 2009-10-14
PCT/US2010/052725 WO2011053465A1 (en) 2009-10-14 2010-10-14 Antibodies to epha3

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015229465A Division JP2016094424A (ja) 2009-10-14 2015-11-25 ＥｐｈＡ３に対する抗体

Publications (2)

Publication Number Publication Date
JP2013508292A true JP2013508292A (ja) 2013-03-07
JP2013508292A5 JP2013508292A5 (enExample) 2013-11-28

Family

ID=43499991

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012534368A Pending JP2013508292A (ja) 2009-10-14 2010-10-14 ＥｐｈＡ３に対する抗体
JP2015229465A Pending JP2016094424A (ja) 2009-10-14 2015-11-25 ＥｐｈＡ３に対する抗体

Family Applications After (1)

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JP2015229465A Pending JP2016094424A (ja) 2009-10-14 2015-11-25 ＥｐｈＡ３に対する抗体

Country Status (11)

Country Link
US (2) US8664365B2 (enExample)
EP (1) EP2488554B1 (enExample)
JP (2) JP2013508292A (enExample)
CN (1) CN102666589B (enExample)
AU (1) AU2010313621C1 (enExample)
CA (1) CA2777068C (enExample)
DK (1) DK2488554T3 (enExample)
ES (1) ES2743558T3 (enExample)
PL (1) PL2488554T3 (enExample)
PT (1) PT2488554T (enExample)
WO (1) WO2011053465A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011123819A2 (en) * 2010-04-01 2011-10-06 Kalobios Pharmaceuticals, Inc. Epha3 antibodies for the treatment of multiple myeloma
WO2011160132A2 (en) * 2010-06-18 2011-12-22 Kalobios Pharmaceuticals, Inc. Detection of epha3 as a marker of the presence of a solid tumor
JP2014527054A (ja) 2011-08-12 2014-10-09 カロバイオス ファーマシューティカルズ インコーポレイティッド 骨髄内の異常血管系上に発現したＥｐｈＡ３を標的とすることによる、血液増殖性疾患を処置する方法
RU2698061C2 (ru) * 2013-08-01 2019-08-21 Файв Прайм Терапьютикс, Инк. АФУКОЗИЛИРОВАННЫЕ АНТИТЕЛА К РЕЦЕПТОРУ ФАКТОРА РОСТА ФИБРОБЛАСТОВ FGFR2IIIb
CN116327924A (zh) 2015-11-23 2023-06-27 戊瑞治疗有限公司 用于癌症治疗的单独fgfr2抑制剂或与免疫刺激剂的组合
EP3512883A1 (en) * 2016-09-13 2019-07-24 Humanigen, Inc. Epha3 antibodies for the treatment of pulmonary fibrosis
CA3062177A1 (en) 2017-05-16 2018-11-22 Five Prime Therapeutics, Inc. Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
US11795221B2 (en) 2018-02-28 2023-10-24 WuXi Biologics Ireland Limited Monoclonal antibody against human LAG-3, method for preparing the same, and use thereof
IL291937A (en) * 2019-10-09 2022-06-01 Council Queensland Inst Medical Res Targeting epha3 and uses thereof
US20220395532A1 (en) * 2019-11-08 2022-12-15 Humanigen, Inc. Epha3 directed car-t cells for treatment of tumors
EP4232470A4 (en) * 2020-10-23 2025-01-15 Atreca, Inc. ANTIBODIES AGAINST CORONAVIRUS SARS-COV-2
KR102888870B1 (ko) * 2021-08-06 2025-11-21 한국생명공학연구원 신규한 항-EphA2 키메릭 항원 수용체 및 이를 발현하는 면역세포

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20050255552A1 (en) * 2004-01-20 2005-11-17 Kalobios, Inc. Antibody specificity transfer using minimal essential binding determinants
WO2008112192A2 (en) * 2007-03-08 2008-09-18 Kalobios Pharmaceuticals, Inc. Epha3 antibodies for the treatment of solid tumors

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NO175798C (no) 1992-07-22 1994-12-07 Sinvent As Fremgangsmåte og anordning til aktiv stöydemping i et lokalt område
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WO2008112192A2 (en) * 2007-03-08 2008-09-18 Kalobios Pharmaceuticals, Inc. Epha3 antibodies for the treatment of solid tumors

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Title
JPN5012017541; Ａｒｒｕｇａ　Ｆｒａｎｃｅｓｃａ　ｅｔ　ａｌ．: '"ＥｐｈＡ３　ｉｓ　ａｂｎｏｒｍａｌｌｙ　ｅｘｐｒｅｓｓｅｄ　ｉｎ　ｃｈｒｏｎｉｃ　ｍｙｅｌｏｐｒｏｌｉｐｈｅｒａｔｉｖｅ　ｄｉｓｏｒｄｅｒｓ　ａｎｄ　ｃｏｕｌｄ　ｒｅｐｒｅｓｅｎｔ　ａ　ｎｅｗ　ｍｏ' ＰＲＯＣＥＥＤＩＮＧＳ　ＯＦ　ＴＨＥ　ＡＮＮＵＡＬ　ＭＥＥＴＩＮＧ　ＯＦ　ＴＨＥ　ＡＭＥＲＩＣＡＮ　ＡＳＳＯＣＩＡＴＩＯＮ　ＦＯＲ　ＣＡＮＣＥＲ　ＲＥＳＥＡＲＣＨ ｖｏｌ．　５０，　１, 20090401, ｐ．　６９２, ＡＭＥＲＩＣＡＮ　ＡＳＳＯＣＩＡＴＩＯＮ　ＦＯＲ　ＣＡＮ&# *
JPN5012017542; Ｃｉｌｌｏｎｉ　Ｄａｎｉｅｌａ　ｅｔ　ａｌ．: '"ＥｐｈＡ３　Ｋｉｎａｓｅ　Ｉｓ　Ｃｏｎｓｔｉｔｕｔｉｖｅｌｙ　Ａｃｔｉｖａｔｅｄ　ｉｎ　Ｃｈｒｏｎｉｃ　Ｍｙｅｌｏｉｄ　Ｌｅｕｋａｅｍｉａ　ｄｕｒｉｎｇ　Ｐｒｏｇｒｅｓｓｉｏｎ　ｔｏ　Ａｃｃｅｌｅｒ' ＢＬＯＯＤ ｖｏｌ．　１１２，　ｎｏ．　１１, 20081101, ｐ．　３９９, ＡＭＥＲＩＣＡＮ　ＳＯＣＩＥＴＹ　ＯＦ　ＨＥＭＡＴＯＬＯＧＹ *
JPN6014049912; Ｌｉｓｔ　Ａ: '"Ｄｅｖｅｌｏｐｍｅｎｔａｌ　ｔｈｅｒａｐｅｕｔｉｃｓ　ｆｏｒ　ＭＤＳ"' ＬＥＵＫＥＭＩＡ　ＲＥＳＥＡＲＣＨ ｖｏｌ．　３３，　ｎｏ．　Ｓｕｐｐｌ．　１, 200905, ｐ．　Ｓ２７-Ｓ２８ *

Also Published As

Publication number Publication date
DK2488554T3 (da) 2019-09-02
EP2488554B1 (en) 2019-07-24
CA2777068A1 (en) 2011-05-05
AU2010313621A1 (en) 2012-05-03
JP2016094424A (ja) 2016-05-26
WO2011053465A1 (en) 2011-05-05
AU2010313621B2 (en) 2015-07-30
AU2010313621C1 (en) 2015-11-26
CN102666589A (zh) 2012-09-12
US20140120114A1 (en) 2014-05-01
CN102666589B (zh) 2014-08-20
US9290571B2 (en) 2016-03-22
US20110123549A1 (en) 2011-05-26
US8664365B2 (en) 2014-03-04
CA2777068C (en) 2020-05-26
EP2488554A1 (en) 2012-08-22
PL2488554T3 (pl) 2020-03-31
PT2488554T (pt) 2019-09-13
ES2743558T3 (es) 2020-02-19

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