JP2013507431A - 組成物および方法、およびそれらに関する使用 - Google Patents
組成物および方法、およびそれらに関する使用 Download PDFInfo
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- JP2013507431A JP2013507431A JP2012533663A JP2012533663A JP2013507431A JP 2013507431 A JP2013507431 A JP 2013507431A JP 2012533663 A JP2012533663 A JP 2012533663A JP 2012533663 A JP2012533663 A JP 2012533663A JP 2013507431 A JP2013507431 A JP 2013507431A
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Abstract
Description
プロバイオティクスは食品工業および飼料工業において長い間利用されているが、未だに、広範囲の症状または病気における、かつ、特定の標的グループに対する、プロバイオティクスの効果を決定する必要がある。本発明はLGGおよびLC705が呼吸器感染症におけるプロバイオティクス効果を有するという知見に属する。またLC705およびLGGは、抗ウイルス性サイトカインの産生を増大し、かつウイルスの増幅を阻止し、それゆえ呼吸器感染症のリスクを減少するための最適な組合せとして機能する。
プロバイオティクスは生きた微生物であり、好ましくはヒトあるいは動物へ適当量を投与した際に宿主のウェルビーイング(well−being)を促進する非病原性の微生物である(Fuller R 1989、J Appl Microbiol 66、365−378)。プロバイオティクスは、十分な量を食品または栄養補助食品として消費された場合、宿主へ有益な健康上の利点をもたらす。
本発明の組成物はLGGおよびLC705プロバイオティクスを含む。プロバイオティクスLGGおよびLC705のみが組成物中に含まれる。本発明の組成物は、食品、動物飼料、栄養製品、栄養補助食品、食品原料、健康食品、医薬品および化粧品からなる群から選択することができるが、これらに限定されるものではない。組成物はまた、例えば毎日の食事もしくは薬剤の都合のよい部分(convenient part)もしくは栄養補助食品として適用できる。本発明の1つの好ましい実施形態において、組成物は医薬品、食品または飼料製品である。本発明の別の実施形態において、組成物は機能性食品、すなわち、何らかの健康促進特性および/または疾患の予防もしくは治療特性を有する食品である。好ましくは、本発明の食品は、乳製品、ベーカリー製品、チョコレートおよび菓子類、砂糖およびガム菓子類、シリアル製品、スナック菓子、ベリーまたは果物ベースの製品、および飲み物/飲料からなる群から選択される。乳製品は、乳、酸乳(sour milk)、ヨーグルトおよびチーズやスプレッドなどの他の発酵乳製品、粉乳、子供用食品、離乳食、幼児用食品、特殊調製粉乳(infant formula)、ジュースおよびスープを含むが、これらに限定されるものではない。
呼吸器感染症は上気道および下気道の両方の感染を含む。上気道感染症は、肺胞を除く鼻から下部呼吸樹への呼吸器粘膜の炎症を含む。それゆえ上気道は、鼻腔(鼻端、洞(sinuses))、咽頭および喉頭を含む。上気道感染症は、一般的な風邪、副鼻腔炎、耳感染症、中耳炎、乳様突起炎、咽頭炎、扁桃炎、喉頭蓋炎、気管炎、喉頭炎および気管支炎からなる群から選択されるが、これらに限定されるものではない。上気道感染症の症状は、鼻閉、咳、鼻炎、鼻詰まり、鼻感冒、咽頭炎、発熱、顔面圧迫感、頭痛、食欲不振および/またはくしゃみを含む。
マクロファージ
健康な献血者から新鮮に回収された白血球豊富な軟膜は、フィンランド赤十字輸血サービス(Finnish Red Cross Blood Transfusion Service)によって供給された。PBMCは密度勾配遠心分離によって単離された。前述の通り、単球は6穴プラスチックプレート(Falcon)への接着によってPBMCから精製され、組換えヒト(rh)GM−CSF(Leucomax、Schering−Plough)の存在下、マクロファージ無血清培地(Gibco Invitrogen)において7日間培養され、マクロファージを獲得した(Miettinen M.ら 2000、J Immunol 164、3733−3740)。
ラクトバチルス・ラムノサス(Lactobacillus rhamnosus) GGおよびラクトバチルス・ラムノサス(Lactobacillus rhamnosus) LC705は、刺激実験におけるそれらの使用の前に、−70℃でスキムミルク中に保存され、前述の通り3回継代された(Miettinen M.ら 1996、Infect Immun 64:5403)。ラクトバチルス(Lactobacillus)はMRS培地(Difco)中で生育させた。刺激実験のために、菌は対数増殖期まで生育させられ、菌細胞の数はペトロフハウザー血球計算盤における計数によって決定された。
刺激実験はRPMI1640培地(シグマ)において行われた。実施例1のマクロファージは、実施例1の生菌を用いて、すなわち1:1の割合(細胞数による)でのLGGまたはLC705単独で、または、マクロファージ細胞に対する菌の割合は1:1のままで、同数の菌細胞数でのLGGおよびLC705を共に用いて、24時間刺激された。マクロファージはそれから、100%の感染をもたらす感染の多重度(MOI)5のインフルエンザウイルスA/北京/353/89ウイルス(0.128 HAU/ml)(健康福祉研究所(THL))を用いて1時間感染させられ、その後、感染細胞はPBSで洗浄され、細胞培養培地は交換され、感染は前述のように総合して9時間または24時間の間続いた(Pirhonen J.ら、1999、J Immunol 162、7322−7329)。細胞および細胞培養上清は刺激の後に回収された。回収サンプルから総RNAまたはタンパク質が単離された。ウイルス性mRNAの量は定量的リアルタイムPCR(qRT−PCR)によって決定され、かつウイルスまたは宿主タンパク質はウェスタンブロットによって検出された。分泌されたサイトカインはELISA法によって測定された。
Claims (21)
- 対象において抗ウイルス効果を有する組成物の調製のためのラクトバチルス・ラムノサス(Lactobacillus rhamnosus) LC705の単独またはラクトバチルス・ラムノサス(Lactobacillus rhamnosus) GGとの併用での使用。
- 組成物が医薬品、食品または飼料製品である、請求項1に記載の使用。
- 組成物が医薬組成物である、請求項2に記載の使用。
- 組成物が、対象における呼吸器感染症の治療および/または予防のためにある、請求項1−3のいずれか1項に記載の使用。
- 対象において抗ウイルス効果を有する組成物であるラクトバチルス・ラムノサス(Lactobacillus rhamnosus) LC705を単独でまたはラクトバチルス・ラムノサス(Lactobacillus rhamnosus) GGとの併用で含む組成物の対象への投与を含む方法であって、対象における呼吸器感染症の治療および/または予防のための方法。
- 組成物が、対象において呼吸器感染症を引き起こすウイルスに対する抵抗力を増大させるためにある、請求項1−5のいずれか1項に記載の使用または方法。
- 組成物が、抗ウイルス性タンパク質の発現を増加する、請求項1−6のいずれか1項に記載の使用または方法。
- 組成物が、呼吸器感染症に感染する、または、感染している対象において、抗ウイルス性サイトカインを増加させるためにある、請求項1−6のいずれか1項に記載の使用または方法。
- 抗ウイルス性サイトカインが、IFN−α、IFN−β、IL−1β、TNF−α、およびIP−10からなる群から選択される、請求項8に記載の使用または方法。
- 呼吸器感染症が一般的な風邪(インフルエンザ)ウイルス、ライノウイルス、アデノウイルス、パラインフルエンザウイルス、呼吸器合胞体ウイルス、エンテロウイルス、コロナウイルスおよびエプスタイン・バール・ウイルスからなる群から選択されるウイルスによって引き起こされる、請求項4−9のいずれか1項に記載の使用または方法。
- 呼吸器感染症がインフルエンザウイルス感染症である、請求項10に記載の使用または方法。
- インフルエンザウイルスがインフルエンザウイルスAおよびインフルエンザウイルスBからなる群から選択される、請求項11に記載の使用または方法。
- 組成物がインフルエンザウイルスの増殖を防ぐため、かつ/または、対象におけるインフルエンザウイルスの複製を減少させ、遅延させ、または阻害するためにある、請求項10−12のいずれか1つに記載の使用または方法。
- 対象が幼児、子供または成人である、請求項1−13のいずれか1項に記載の使用または方法。
- プロバイオティクスとしてラクトバチルス・ラムノサス(Lactobacillus rhamnosus) LC705を含む抗ウイルス性組成物。
- ラクトバチルス・ラムノサス(Lactobacillus rhamnosus) LC705およびラクトバチルス・ラムノサス(Lactobacillus rhamnosus) GGからなるプロバイオティクスを含む抗ウイルス性組成物。
- 対象における呼吸器感染症の治療および/または予防のためのラクトバチルス・ラムノサス(Lactobacillus rhamnosus) LC705単独またはラクトバチルス・ラムノサス(Lactobacillus rhamnosus) GGとの組合せ。
- 対象において呼吸器感染症を引き起こすウイルスに対する抵抗力を増大させるためのラクトバチルス・ラムノサス(Lactobacillus rhamnosus) LC705単独またはラクトバチルス・ラムノサス(Lactobacillus rhamnosus) GGとの組合せ。
- 抗ウイルス性タンパク質の発現を増加させるためのラクトバチルス・ラムノサス(Lactobacillus rhamnosus) LC705単独またはラクトバチルス・ラムノサス(Lactobacillus rhamnosus) GGとの組合せ。
- 呼吸器感染症に感染する、または、感染している対象において、抗ウイルス性サイトカインを増加させるためのラクトバチルス・ラムノサス(Lactobacillus rhamnosus) LC705単独またはラクトバチルス・ラムノサス(Lactobacillus rhamnosus) GGとの組合せ。
- インフルエンザウイルスの増殖を防ぐため、かつ/または、対象におけるインフルエンザウイルスの複製を減少させ、遅延させ、または阻害するためのラクトバチルス・ラムノサス(Lactobacillus rhamnosus) LC705単独またはラクトバチルス・ラムノサス(Lactobacillus rhamnosus) GGとの組合せ。
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CN110122877B (zh) * | 2018-02-09 | 2022-12-23 | 深圳华大基因农业控股有限公司 | 鼠李糖乳杆菌及其用途 |
CN110721204B (zh) * | 2019-11-28 | 2021-06-25 | 南京中医药大学 | 一种益生菌组合物及其制剂与应用 |
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WO2017033925A1 (ja) * | 2015-08-24 | 2017-03-02 | 株式会社ヤクルト本社 | 酪酸産生菌 |
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JP7055814B2 (ja) | 2017-02-28 | 2022-04-18 | プリシジョンバイオティクス・グループ・リミテッド | 呼吸器ウイルス感染症に対する免疫応答を有利に調節することができるビフィドバクテリウム・ロンガム |
US11529381B2 (en) | 2017-02-28 | 2022-12-20 | Precisionbiotics Group Limited | Bifidobacterium longum able to beneficially modulate immune response to respiratory virus infection |
US11590179B2 (en) | 2017-02-28 | 2023-02-28 | Precisionbiotics Group Limited | Bifidobacterium longum able to beneficially modulate immune response to respiratory virus infection |
Also Published As
Publication number | Publication date |
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RU2012119567A (ru) | 2013-11-20 |
FI20096058A0 (fi) | 2009-10-13 |
WO2011045471A1 (en) | 2011-04-21 |
KR20120106943A (ko) | 2012-09-27 |
EP2488188A1 (en) | 2012-08-22 |
CA2776868A1 (en) | 2011-04-21 |
AU2010306529A1 (en) | 2012-06-07 |
CN102665740A (zh) | 2012-09-12 |
US20120201798A1 (en) | 2012-08-09 |
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